Drosophila Genes

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Drosophila genes listed by biochemical function

Enzymes and cofactors exclusive of transmembrane receptor tyrosine kinases and signaling proteins

absent, small, or homeotic discs 1

histone methyl transferase that indirectly prevents gene silencing - provides a specific signal for establishment of active transcription

armitage

RNA helicase involved in posttranscriptional gene silencing - mutations disrupt mRNA translational silencing of oskar in the oocyte and silencing of Stellate in male germ cells

courtless

ubiquitin conjugation enzyme - plays a role in protein degradation - mutation disrupts early steps of courtship behavior

in Drosophila males and the development of their sperm

cryptochrome

potential transcription factor - light response protein - cryptochrome/photolyase

Death caspase-1

ICE/CED-3 protease involved in apoptosis

Death related ced-3/Nedd2-like protein

ICE/CED-3 protease involved in apoptosis

Dicer-1

ribonuclease III family, double-stranded RNA domain binding domain, DEAD/DEAH box helicase, PAZ domain -

an enzyme involved in degrading RNA - involved in double-stranded RNA interference (RNAi) and post-transcriptional gene regulation (PTGS)

Dicer-2

DEAD/DEAH box helicase - mutants are defective in processing small interfering RNAs

dodo

peptidylprolyl isomerase - facilitates the degradation of the transcription factor CF2, which regulates expression of the rhomboid gene in follicle cells

Dynein heavy chain 64C

a molecular motor

easter

required for establishment of embryonic polarity - serine protease, trypsin family - generates processed Späzle, which in turn acts as the Toll ligand

eyes closed

a fly homolog of p47, a protein co-factor of the p97 ATPase involved in membrane fusion - mutation results in a lethal failure of nuclear envelope assembly

in early zygotic divisons and results in defective photoreceptor morphogenesis

fat facets

conserved Cys and His domains - ubiquitin-specific protease

gastrulation-defective

a protease involved in establishment of dorsal/ventral polarity - targets Snake

hiiragi

poly(A) polymerase involved in both nuclear and cytoplasmic polyadenylation of mRNA

hyperplastic discs

a HECT domain E3 ubiquitin ligase that is likely to act by targeting Cubitus interruptus and an unknown activator of hedgehog expression for proteolysis

Ice

a dowstream effector caspase - activated during spermatogenesis and necessary for the removal of cytoplasm and the generation of functional sperm

Kinesin heavy chain

plus end directed vesicular transport motor protein

mutagen-sensitive 209 (common alternative name: Proliferating cell nuclear antigen)

Polymerase-delta/epsilon processivity factor

myosin II(preferred name: zipper)

non-muscle myosin

Nedd2-like caspase

cysteine protease - a functional homolog of CED-3/caspase-9 - involved in programmed cell death

neurotic (preferred name: O-fucosyltransferase 1)

modifies Notch by attaching fucose within EGF domains - positively required for Notch signaling,

essential for the physical interaction of Notch with its ligand Delta and for the ability of Fringe to modulate this interaction

nicastrin

component of a proteolytic complex, along with Presenilin, that targets Notch and ß amyloid protein - Zn-dependent exopeptidase

Nitric oxide synthase

Ca++/Calmodulin sensitive enzyme

no receptor potential A

phosphatidylinositol-specific phospholipase C used in visual and odor signal transduction

non-stop

ubiquitin-specific protease expressed in glia - involved in development of laminal glia

Nucleolar protein at 60B

pseudouridylate synthase - enzymatically modifies ribosomal RNA - required for maintenance of germ-line stem cells

nudel

serine protease - docking protein - dorsal group

Nucleosome assembly protein

Histone chaperone - chromatin assembly

O-fucosyltransferase 1 (alternative name: neurotic)

modifies Notch by attaching fucose within EGF domains - positively required for Notch signaling,

essential for the physical interaction of Notch with its ligand Delta and for the ability of Fringe to modulate this interaction

okra

DNA helicase involved in DNA repair - required for meiosis

Ornithine decarboxylase antizyme (common alternative name: gutfeeling)

modifies the activity of Ornithine decarboxylase - regulates the nuclear entry and overall levels of Sex-lethal in early germ cells

parkin

ubiquitin protein ligase - degrades proteins with aberrant conformations - mutants exhibit muscle degeneration, male sterility, and defects in brain dopaminergic cells

pavarotti

a kinesin motor protein - required both to establish the structure of the telophase spindle to provide a framework

for assembly of the contractile ring and to mobilize mitotic regulator proteins

Peptidylglycine-alpha-hydroxylating monooxygenase

an enzyme that targets neuropeptides

phyllopod

novel target of ras pathway - protein degradation cofactor

pipe

heparan sulfate 2-O-sulfotransferase

poly(A) polymerase (preferred name: hiiragi)

involved in both nuclear and cytoplasmic polyadenylation of mRNA

pr-set

Set domain protein - methyltransferase that targets Histone H4 - helps maintain silent chromatin by a histone modification that precludes neighboring acetylation of the H4 tail

Proliferating cell nuclear antigen (preferred name: Mutagen-sensitive 209)

Polymerase-delta/epsilon processivity factor

pumpless

glycine cleavage system H protein - involved in appetite control

Rad51-like (common alternative name: spindle A)

checkpoint protein essential for recombinational repair of double-stranded DNA breaks (DSBs) in somatic cells and during meiosis in germ cells

shaggy (common alternative name: zeste white 3)

glycogen synthase kinase - segment polarity - functions in the Wingless signaling pathway

sightless

acetyltransferase acting to acylate Hedgehog or to promote other modifications or trafficking events necessary for Hedgehog function

Sir2

histone deacetylase required for euchromatic and heterochromatic silencing - interacts genetically and physically with members

of the Hairy/Deadpan/E(Spl) family of bHLH euchromatic repressors

smallminded

AAA-protein family - ATPase

Separase

endopeptidase required for sister chromatid separation during mitosis

serpin-27A

protease inhibitor functioning in the immune response - regulates melanization cascade through specific inhibition

of the terminal protease (prophenoloxidase-activating enzyme)

Seven in absentia

targets proteins to degradation - C3HC4 RING zinc-finger motif

Smurf1

ubiquitin-protein ligase that regulates Decapentaplegic pathway signaling by targeting Mothers against Dpp for degradation

Stellate

ß subunit of Casein kinase II - a normally inactive gene which, when active, leads to male sterility - a target of post-transcriptional gene regulation

stem cell tumor (also known as rhomboid-2)

Rhomboid-related transmembrane protein - serine-type protease - activates the oocyte-specific Gurken ligand and

thereby participate in defining posterior cell fates in the early follicular epithelium

Suppressor of variegation 3-9

involved in gene silencing - a modifier of position effect variegation - methylates histone H3 thus providing a mark for the association of HP1 to heterochromatin

zipper

Myosin II or non-muscle myosin

Drosophila genes listed by biochemical function

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