Drosophila Genes

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Drosophila genes listed by biochemical function

Miscellaneous proteins

abnormal spindle

microtubule binding protein - required for the integrity of microtubule organizing centers - may organize microtubules during cytokinesis

adrift

novel protein involved in tracheal branching

A kinase anchor protein 200

Involved in Protein kinase A localization - PKA in turn regulates the function of specialized actin structures during oogenesis

arc

PDZ domain protein

bag of marbles

novel protein involved in oogenesis and spermatogenesis

bazooka

PDZ domain protein involved in cell polarity and asymmetric cell division

bereft

potentially an untranslated RNA - mutants exhibit defects in the peripheral nervous system

Bicaudal-D

alpha helical coiled coiled protein that interacts with the cytoskeleton

bifocal

codes for a novel protein that interacts with f-actin - functions downstream of misshapen to reorganize the actin cytoskeleton

big brain

aquaporin - MIP family signature

blistery

tensin homolog - at focal adhesion sites participates in a protein complex that establishes transmembrane linkage between the extracellular matrix and cytoskeletal actin filaments

brainiac

novel protein - secreted - oogenesis and EGF-R signaling

canoe

glgf/dhr motif scaffolding protein

clift (common alternative name: eyes absent)

novel protein - eyes absent family - cell survival factor

comatose

developmentally regulated N-ethylmaleimide-sensitive fusion (NSF) gene - required in disassembly or rearrangement of the SNARE complex at the plasma membrane after vesicule fusion

Cyclin A

a G2-M phase cyclin - dimerization partner of cdc2 kinase

Cyclin B

a G2-M phase cyclin - dimerization partner of cdc2 kinase

Cyclin D

a G1-S phase cyclin

Cyclin E

a G1-S phase cyclin - dimerization partner of cdc2c kinase

dachshund

novel nuclear protein of unknown function

diaphanous

Formin homology domain protein required for cytokinesis

discs large 1

Links septate junctions to cytoskeleton - Guanylate kinase signature and Src homology 3 domain

discs lost

conserved protein of unknown function - required for cell survival and cell cycle progression - implicated in modification of olfactory behavior

division abnormally delayed

membrane bound glypican related proteoglycan

double parked

conserved protein required for DNA replication

ebi

Trp-Asp (WD) repeats protein - regulates Egfr pathway & protein degradation

enabled

VASP homolog and SH3 domain protein - cytoskeletal adaptor protein

eyes absent (preferred name: clift)

novel protein - eyes absent family - cell survival factor

fat facets

conserved Cys and His domains - ubiquitin-specific protease

14-3-3zeta (common alternative name: leonardo)

a 14-3-3zeta isoform - a phosphoserine/threonine interacting protein

futsch

microtubule-associated protein

headcase

novel basic protein

head involution defective (preferred name: Wrinkled)

death domain protein - programmed cell death

G protein salpha 60A

s-alpha subunit of heterotrimeric G protein

Grip

Scaffolding and signaling protein - participates in the reception of an attractive signal that emanates from muscle epidermal attachment sites to direct the motility of developing muscles

GUK-holder

Scaffolding protein involved in synaptic budding - interacts with the GUK domain of Discs large - required for the proper synaptic localization of Scribbled

homer

scaffolding protein required for the function of neural networks controlling locomotor activity and behavioral plasticity

inscuteable

novel protein - SH3 binding domain, ankyrin repeats and cytoskeletal attachment domain

jaguar - Drosophila myosin VI, a pointed end directed molecular motor -

involved in asymmetric cell division - regulates actin dynamics during sperm individualization

kakapo - preferred name: short stop

cytoskeletal cross-linker protein

karst (also known as betaHeavy Spectrin)

cytoskeletal protein - structural and docking protein

kelch

cytoskeletal protein - actin cross-linker - during oogenesis, phosphorylation of Kelch is critical for the proper morphogenesis of actin during ring canal growth

Lamin

an intermediate filament protein - chromatin associated protein

latheo

ORC3 homolog and synaptic protein of unknown function

lava lamp

coiled-coil cytoskeletal component involved in cellularization

legless

a scaffold protein that physically links Pygopus to ß-catenin - the recruitement of Pygopus permits ß-catenin to activate Wnt target genes

leonardo (preferred name: 14-3-3zeta)

a 14-3-3zeta isoform - a phosphoserine/threonine interacting protein

lethal (2) giant discs 1 (common alternative name: lethal giant discs)

tumor suppressor - required to restrict the activity of Notch to the D/V boundary of the wing imaginal disc

lethal (2) giant larvae (common alternative name: lethal giant larvae)

novel conserved cytoskeletal element

lines

novel segment polarity gene

lin-19-like (common alternative name: Cullin1)

a major component of a series of multimeric ubiquitin ligases that control the degradation of a broad range of proteins

Lissencephaly-1

component of Dynein complex, Beta-transducin family Trp-Asp repeats protein

mastermind

novel - neurogenic

microRNA encoding gene mir-14

a cell death suppressor - regulates fat metabolism

miranda

novel - required for subcellular localization of prospero

morula

APC2 subunit of the anaphase promoting complex - regulates protein degradation and cell cycle

Muscle LIM protein at 60A

cytoskeletal LIM-domain protein, Cys-rich protein

myoblast city

a docking protein: DOCK180 homolog

NEM-sensitive fusion protein 2

developmentally regulated N-ethylmaleimide-sensitive fusion (NSF) gene - mutants are defective in the synaptic growth and maturation that occurs during larval development

non-stop

ubiquitin-specific protease expressed in glia - involved in development of laminal glia

Origin recognition complex 2

A subunit of the Origin recognition complex, involved in initiation of DNA replication

ovarian tumor

novel protein required in oogenesis

par-6

PDZ domain protein required for asymmetric cell division of neuroblasts and for the maintenance of oocyte cell fate

partner of inscuteable

involved in asymmetric cell divisions and establishment of cell polarity

peanut

a septin

pimples

novel protein required for sister chromatid separation in mitosis - shares functional similarities to securin a protein that acts to premature activation of separins

piwi

a novel protein involved in stem cell renewal

pod-1

WD repeat protein - crosslinks actin and microtubules - proper levels of Pod-1 must be maintained in the growth cone for correct axon guidance

polychaetoid

scaffolding protein, PDZ domain protein, MAGUK

prickle

LIM domain protein

quick-to-court

an alpha-helical coiled-coiled protein - mutants exhibit altered male courtship behavior

roughex

novel regulator of cell cycle

short stop

cytoskeletal cross-linker protein

shutdown

immunophilin - FK506-binding protein domain and a tetratricopeptide repeat

sickle

novel apoptosis activator - contains an N-terminal inhibitor of apoptosis motif

singed

fascin homolog - crosslinks actin filaments

skpA

component of protein degradation complex - regulates centrosome duplication

slow as molasses

novel protein that is essential for polarized growth of the plasma membrane during cellularization

alpha Spectrin

cytoskeletal protein - structural and docking protein

betaHeavy Spectrin (preferred name: karst)

cytoskeletal protein - structural and docking protein

sprouty

membrane associated or secreted antagonist of FGF signaling

stardust

codes for a regulatory component of the subapical complex of cellular junctions - crucial in the control of epithelial cell polarity

stoned A and stoned B

a dicistronic locus encoding two proteins involved in synaptic vesicle recycling

Strawberry notch

nuclear protein in the Notch pathway

supernumerary limbs

beta-transducin family Trp-Asp repeats family - protein degradation

Talin

essential for integrin function - crosslinks extracellular matrix-linked integrins to the cytoskeleton

torsolike

terminal system - follicle cell protein

beta1 Tubulin

beta Tubulin56D - ubiquitious component of cytoskeleton

beta2 Tubulin

beta Tubulin85D - sperm tubulin

beta3 Tubulin

beta Tubulin60D - microtubular cytoskeleton

gamma Tubulin

gamma Tubulin at 23C - microtubule nucleating factor

g-Tubulin at 37C

microtubule nucleating factor - eggs produced by mutant mothers show an arrest of nuclear divisions during early embryogenesis and a disruption in the anterior-posterior axis - required for bicoid mRNA localization

Wrinkled (common alternative name: head involution defective)

death domain protein - programmed cell death

Drosophila genes listed by biochemical function

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