Drosophila tissue and organ development: Eye and antenna

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The Eye-Antenna Disc and Eye Morphogenesis

Genes involved in tissue
and organ development

Structure of the eye

The Drosophila Adult Ommatidium:
Illustration and explanation with Quicktime animation

Specification of the eye versus the antenna

Development of the eye

Genes expressed in eye morphogenesis

Genes expressed in antennal differentiation

Genes expressed in the development of Bolwig's organ (the larval eye)

Proteins involved in visual signal transduction

Image: Specification of the eye disc primordium and establishment of dorsal/ventral asymmetry

Cellular mechanisms in the development of the arista

Progression of the morphogenetic furrow across the eye disc

Genes involved in eye morphogenesis
*** indicates a special link to eye specific information

Genes acting in formation of the optic placode during embryonic development
- buttonhead
- clift (common alternative name: eyes absent) | ***
- crumbs
- distal-less
- empty spiracles
- eyeless | ***
- labial
- orthodenticle
- optomotor blind
- polyhomeotic
- sina oculis | ***
- tailless
Secreted proteins involved in progression of the furrow
- decapentaplegic
- hedgehog | ***
- wingless | ***
Genes acting in front of the morphogenetic furrow
- atonal | ***
- bunched (common alternative name: shortsighted)
- dachshund
- daughterless
- Delta
- Deltex
- cubitus interruptus
- Cyclin E
- disc proliferation abnormal
- E2F
- E2F transcription factor 2
- Enhancer of split
- 18 wheeler
- eyegone | ***
- eyeless | ***
- extra machrochaetae
- eyelid | ***
- fat facets | ***
- fringe | ***
- hairy
- homothorax | ***
- mirror | ***
- hopscotch | ***
- Mothers against dpp
- neuralized
- Notch
- Optix
- orthodenticle
- outstretched | ***
- pannier | ***
- Protein kinase A
- scabrous | ***
- schnurri
- seven in absentia (sina) (required for R7 determination) | ***
- sine oculis | ***
- spitz | ***
- STAT | ***
- string
- Suppressor of Hairless
- teashirt
- tolloid related 1
- ultraspiracle | ***
- wingless | ***
Other transcription factors involved in eye morphogenesis
- AP-2
- Arrowhead
- Beadex
- Bearded
- broad (common alternative name: Broad Complex)
- clift (also known as eyes absent) | ***
- combgap
- Dichaete
- distal antenna & distal antenna-related
- Domina
- Ecdysone-induced protein 74EF
- Ecdysone receptor
- Eip93F
- E(spl) region transcript m7
- erect wing
- Grunge
- klumpfuss
- lilliputian
- lozenge | ***
- Lyra
- Medea
- onecut
- pangolin
- pipsqueak
- PvuII-PstI homology 13
- pygopus
- rotund
- SANT domain protein
- scribbler
- sequoia
- sparkling | ***
- alpha Spectrin
- spineless
- TBP-associated factor 250kD
- tramtrack | ***
- ultraspiracle | ***
Other intracellular signaling and scaffold proteins

Genes regulating the cell cycle
- cdc2 (Synonym: p34cdc2)
- cdc2c (See Cyclin E)
- cyclin A | ***
- cyclin B
- cyclin D
- Cyclin-dependent kinase 4/6
- cyclin E
- dacapo
- fizzy related
- geminin
- gigas | ***
- Origin recognition complex subunit 1
- polo
- Regulator of cyclin A1
- Retinoblastoma-family protein | ***
- roughex | ***
Genes regulating the patterning of R8 photoreceptors
- argos and rhomboid and other components of the EGF-R pathway
- atonal and rough acting as the proneural gene and repressor respectively
- scabrous, Notch and other components of the Notch pathway acting acting to negatively regulate atonal

Boss - Sevenless and EGF-R pathway and targets involved in photoreceptor maturation
- argos | ***
- Boss | ***
- Cbl | ***
- corkscrew | ***
- ebi
- EGF-Receptor (torpedo) | *** (required reiteratively to trigger the differentiation of each type of photoreceptor)
- GTPase-activating protein 1
- Jun | ***
- leonardo | ***
- phyllopod | *** (required for R1, R6 and R7 determination)
- pointed
- Ras oncogene at 85D | ***
- rhomboid
- rolled - also known as MAP kinase | ***
- roughoid
- Sevenless (required fo R7 determination) | ***
- Seven-up (required for R3/4 and R1/6 determination) | ***
- small wing | ***
- spitz (required for formation of each photoreceptor except R8) | ***
- sprouty | ***
- Star | ***
- vein
- yan | ***
Surface and secreted proteins involved in photoreceptor maturation
- argos | ***
- 18 wheeler
- frizzled | ***
- longitudinal lacking
- multiple edematous wings (see myospheroid)
- myospheroid
- Neurotactin
Transcription factors involved in photoreceptor maturation
- BarH1 and BarH2 (required for R1 and R6 determination)
- Enhancer of split complex
- glass | ***
- mastermind
- orthodenticle | ***
- reversed polarity
- rough (required for R2 and R5 determination) | ***
- scratch
- seven up | ***
Other genes
- arrow
- bantam
- big brain
- Cadherin-N
- crossveinless 2
- dachsous
- discs lost
- dispatched
- bereft
- division abnormally delayed
- Dynein heavy chain 64C
- echinoid & friend of echinoid
- eiger
- embryonic lethal, abnormal vision (synonym: elav)
- E(spl) region transcript m4
- fat
- fat facets
- Fmr1
- four-jointed
- fringe
- frizzled3
- furrowed | ***
- heartless
- hephaestus
- hibris
- hyperplastic discs
- Inositol 1,4,5,-tris-phosphate receptor
- Insulin-like receptor
- karst (also known as betaHeavy Spectrin) | ***
- kekkon-1
- kuzbanian
- Laminin A
- lethal (2) giant discs 1
- Lissencephaly-1
- nemo
- Neurofibromin 1
- O-fucosyltransferase 1
- outstretched
- peanut
- Presenilin
- RNA on the X-1
- roughest
- sightless
- Smad on X
- alpha Spectrin
- split ends
- starry night
- strabismus | ***
- strawberry notch
- Syntaxin 1A
- terribly reduced optic lobes
- TNF-receptor-associated factor 1
- betaTubulin60D (beta3 tubulin)
- unc-13
- zipper - Myosin II or non-muscle myosin

Antenna

Related sites: Odorant Receptors and Auditory apparatus of Drosophila

Genes involved in antennal differentiation

*** indicates a special link to antenna specific information

Genes expressed in the antenna section of the eye antennal disc

Bolwig's organ

Genes involved in the development of Bolwig's organ (the larval eye)

For information on Bolwig's organ cell fate determination see the tailless Biological Overview Bolwig's organ

Genes expressed in Bolwig's organ
- abstrakt
- argos
- atonal
- beaten path - expressed in optic lobe - required for Bolwig's organ axon pathfinding
- castor
- Dscam
- Epidermal growth factor receptor
- eyes absent
- eyeless
- Fasciclin 2
- glass
- Hedgehog
- Kruppel
- Nitric oxide synthase (expressed in Bolwig's nerve)
- orthodenticle
- pointed
- PvuII-PstI homology 13
- Rhodopsin 3
- rhomboid
- Protein tyrosine phosphatase 69D
- rolled
- sine oculis
- spitz
- tailless

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