inscuteable

Akiyama-Oda, Y., et al. (2000). Mechanism of glia-neuron cell-fate switch in the Drosophila thoracic neuroblast 6-4 lineage. Development 127: 3513-3522

Akong, K., McCartney, B. M. and Peifer, M. (2002). Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. Dev. Bio. 250: 71-90. Medline abstract: 12297097

Ashraf, S. I. and Ip, Y. T. (2001). The Snail protein family regulates neuroblast expression of inscuteable and string, genes involved in asymmetry and cell division in Drosophila. Development 128: 4757-4767. Medline abstract: 11731456

Broadus, J. and Doe, C. Q. (1997). Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts. Curr. Biol. 7(11): 827-835. Medline abstract: 98044319

Buescher, M., et al. (1998). Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells. Genes Dev. 12(12): 1858-1870. Medline abstract: 98301441

Bulgheresi, S., Kleiner, E. and Knoblich, J. A. (2001). Inscuteable-dependent apical localization of the microtubule-binding protein Cornetto suggests a role in asymmetric cell division. J. Cell Sci. 114: 3655-3662. Medline abstract: 11707517

Burchard, S., et al. (1995). The mutant not enough muscles (nem) reveals reduction of the Drosophila embryonic muscle pattern. J. Cell Sci. 108( Pt 4):1443-1454. Medline abstract: 95340674

Cai, Y., Chia, W. and Yang, X. (2001). A family of Snail-related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisions. EMBO J. 20: 1704-1714. Medline abstract: 11285234

Cai, Y., et al. (2003). Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions. Cell 112: 51-62. Medline abstract: 12526793

Carmena, A., et al. (1998). inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis. Genes Dev. 12(3): 304-315. Medline abstract: 98119829

Ceron, J., Gonzalez, C. and Tejedor, F. J. (2001). Patterns of cell division and expression of asymmetric cell fate determinants in postembryonic neuroblast lineages of Drosophila. Dev. Bio. 230: 125-138. Medline abstract: 11161567

Doe, C. Q. (1992). Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system. Development 116: 855-863. Medline abstract: 93202009

Kaltschmidt, J. A., et al. (2000). Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system. Nat. Cell Biol. 2: 7-12. Medline abstract: 20089045

Knirr, S., Breuer, S., Paululat, A. and Renkawitz-Pohl, R. (1997). Somatic mesoderm differentiation and the development of a subset of pericardial cells depend on the not enough muscles (nem) locus, which contains the inscuteable gene and the intron located gene, skittles. Mech. Dev. 67(1): 69-81. Medline abstract: 98006139

Knoblich, J. A., Jan, L. Y. and Jan, Y. N. (1999). Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization. Curr. Biol. 9(3): 155-8. Medline abstract: 99147108

Kraut, R., and Campos-Ortega, J. A. (1996a). inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeletal adaptor protein. Dev. Biol. 174: 66-81 Medline abstract

Kraut, R., K. et al. (1996b). Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383: 50-55. Medline abstract: 96373416

Li, P., et al. (1997). Inscuteable and Staufen mediate asymmetric localization and segregation of prospero RNA during Drosophila neuroblast cell divisions. Cell 90(3): 437-447. Medline abstract: 97410309

Lin, H. and Spradling, A. C. (1995). Fusome asymmetry and oocyte determination in Drosophila. Dev. Genet. 1645: 6-12. Medline abstract: 95277994

Lu, B., Rothenberg, M., Jan, L. Y. and Jan, Y. N. (1998). Partner of numb colocalizes with numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors. Cell 95: 225-23. Medline abstract: 99005190

Lu, B., Ackerman, L., Jan, L. Y., Jan, Y. N. (1999). Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast division. Molec. Cell 4: 883-891. Medline abstract: 20101231

Lu, B., et al. (2001). Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature 409: 522-525. Medline abstract: 11206549

Mehta, B. and Bhat, K. M. (2001). Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS. Development 128: 3161-3168. Medline abstract: 11688564

Orgogozo, V., Schweisguth, F. and Bellaiche, Y. (2001). Lineage, cell polarity and inscuteable function in the peripheral nervous system of the Drosophila embryo. Development 128: 631-643. Medline abstract: 11171389

Petronczki, M. and Knoblich, J. A. (2001). Par-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Nat. Cell Biol. 3: 43-49. Medline abstract: 11146625

Roegiers, F., et al. (2001). Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage. Nature Cell Bio. 3: 58-67 . Medline abstract: 11146627

Schaefer, M., Shevchenko, A. and Knoblich, J. A. (2000). A protein complex containing inscuteable and the galpha-binding protein pins orients asymmetric cell divisions in Drosophila. Curr Biol. 10(7): 353-62. Medline abstract: 20219655

Schaefer, M., et al. (2001). Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell 107: 183-194. Medline abstract: 11672526

Schober, M., Schaefer, M. and Knoblich, J. A. (1999). Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature 402(6761): 548-51. Medline abstract: 20057174

Shen, C.-P., Jan, L. Y. and Jan, Y. N. (1997). Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila. Cell 90: 449-458. Medline abstract: 97410310

Shen, C. P., et al. (1998). Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila. Genes Dev. 12(12): 1837-1846. Medline abstract: 98301439

Tio, M., et al. (1999). A functional analysis of Inscuteable and its roles during Drosophila asymmetric cell divisions. J. Cell Sci. 112(Pt 10): 1541-1551. Medline abstract: 99230342

Tio, M., et al. (2001). cdc2 links the Drosophila cell cycle and asymmetric division machineries. Nature 409: 1063-1067. Medline abstract: 11234018

Wodarz, A., et al. (1999). Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts. Nature 402(6761): 544-7. Medline abstract: 20057173

Wodarz, A., et al., (2000). Drosophila atypical protein kinase c associates with Bazooka and controls polarity of epithelia and neuroblasts. J. Cell Bio. 150: 1361-1374. Medline abstract: 10995441

Yu, F., et al. (2000). Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in Inscuteable apical localization. Cell 100: 399-409. Medline abstract: 20155424

date revised: 10 May 2004

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