GENR { RETE|ID 1 FBgn0025724 CLA 1 Gene NAM 1 &bgr;'-coatomer protein GSYM 1 &bgr;'Cop DT 1 14 Aug 03 RESZ 3775 DBA 15 HG 5 Caenorhabditis elegans F38E11.5 WP:CE18673 FNC 5 ER to Golgi transport CEL 3 COPI vesicle coat CLOC 1 34B9 ALESR 1 REF 9 GSYM|&bgr;'Cop DT|14 Aug 03 ID|FBgn0025724 UAB|Duplication: Dp(2;2)GYL (inferred from cytology) SYN|CG6699 |CG6699 |beta'-COP |d&bgr;'COP NAM|&bgr;'-coatomer protein KLOC|43135 CLOC|34B9 |Limits computationally determined from genome sequence between l(2)k00302 and l(2)03782/l(2)k14817 CYC|Experimentally determined: 34B5--9 FNC|ER to Golgi transport ; GO:0006888 | non-traceable author statement |golgi membrane budding ; GO:newterm | non-traceable author statement |retrograde (Golgi to ER) transport ; GO:0006890 | non-traceable author statement |retrograde (Golgi to ER) transport ; GO:0006890 | non-traceable author statement |retrograde (Golgi to ER) transport ; GO:0006890 | non-traceable author statement CEL|COPI vesicle coat ; GO:0030126 | non-traceable author statement |COPI vesicle coat ; GO:0030126 | non-traceable author statement |COPI vesicle coat ; GO:0030126 | non-traceable author statement DBA|NA:AA264134 |BDGP:LD07733 |NA:AE003639 |PA:AAF53294 |NA:AI293311 |BDGP-DGC:GH16479 |NA:AJ006523 |PA:CAA07084 |NA:AJ006524 |PA:CAA07085 |NA:AW940627 |BDGP-DGC:GH16479 |NA:AY119527 |PA:AAM50181 |BDGP-DGC:GH16479 PAC|SWP:O62621 HG|species == Caenorhabditis elegans; gene == F38E11.5; WP:CE18673; score == 1047.8; expect == 0 |species == Homo sapiens; gene == 'coatomer protein complex, subunit &bgr; 2 (&bgr; prime)'; gi:4758032; score == 1208.6; expect == 0 |species == Mus musculus; gene == '&bgr; prime coatomer protein'; EMBL:AF043120; gi:2809537; score == 465; expect == 1.e-130 |species == Rattus; gene == 'COATOMER BETA' SUBUNIT (BETA'-COAT PROTEIN) (BETA'-COP) (P102)'; SWP:O35142; gi:3023522; score == 1209.3; expect == 0 |species == Saccharomyces cerevisiae; gene == SEC27; SGDID:L0001848; score == 685.2; expect == 0 ASQ|FBan0006699 REF { REFM|FBrf0106031 |Merdes |1998.12.20 |9 REFM|FBrf0118012 |Merdes |1998.6.2 |9 REFM|FBrf0118011 |Merdes |1998.6.2 |9 REFM|FBrf0146969 |Dunne et al. |2002 |0 REFM|FBrf0126702 |Zheng |1999.11 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0126671 |Guan |1999.11 |9 REFM|FBrf0131779 |SwissProt Project Members |2000.10.1 |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|732402166 FNC|ER to Golgi transport ; GO:0006888 | non-traceable author statement |retrograde (Golgi to ER) transport ; GO:0006890 | non-traceable author statement CEL|COPI vesicle coat ; GO:0030126 | non-traceable author statement } REFDSR { RDID|FBrf0106031 |Merdes |1998.12.20 CLOC|34B5--9 (determined by in situ hybridization) } REFDSR { RDID|FBrf0118011 |Merdes |1998.6.2 SYN|beta'-COP } REFDSR { RDID|FBrf0118012 |Merdes |1998.6.2 FNC|retrograde (Golgi to ER) transport ; GO:0006890 | non-traceable author statement CEL|COPI vesicle coat ; GO:0030126 | non-traceable author statement GPD|coatomer, &bgr;'-subunit SYN|beta'-COP } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH16479 (BDGP-DGC) } REFDSR { RDID|FBrf0126671 |Guan |1999.11 AM|Source for identity of: &bgr;'Cop CG6699 } REFDSR { RDID|FBrf0131779 |SwissProt Project Members |2000.10.1 FNC|retrograde (Golgi to ER) transport ; GO:0006890 | non-traceable author statement CEL|COPI vesicle coat ; GO:0030126 | non-traceable author statement } REFDSR { RDID|FBrf0146969 |Dunne et al. |2002 MD|Identified with: LD07733 SYN|CG6699 |d&bgr;'COP } ALESR { ASYM|&bgr;'Cop+ ID|FBal0093738 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0043467 CLA 1 Gene GSYM 1 064Ya DT 1 14 Aug 03 RESZ 874 FNC 1 behavioral response to ethanol CLOC 1 XLt--XRt ALESR 2 REF 1 GSYM|064Ya DT|14 Aug 03 ID|FBgn0043467 FNC|behavioral response to ethanol ; GO:0048149 | inferred from mutant phenotype CLOC|XLt--XRt REF { REFM|FBrf0131396 |Scholz et al. |2000 |0 } REFDSR { RDID|FBrf0131396 |Scholz et al. |2000 CLOC|XLt--XRt FNC|behavioral response to ethanol ; GO:0048149 | inferred from mutant phenotype SYN|unnamed } ALESR { ASYM|064Ya064Ya SYN|064Y ID|FBal0119724 PHC|chemical sensitive PHI|Mutants exhibit a reduced tolerance to ethanol. REF|FBrf0131396 REFDSR { RDID|FBrf0131396 |Scholz et al. |2000 TRN|FBti0016904 == P{GAL4}064Ya064Ya PHC|chemical sensitive PHI|Mutants exhibit a reduced tolerance to ethanol. SYN|064Y } } ALESR { ASYM|064Ya+ ID|FBal0120253 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0010347 CLA 1 Gene GSYM 1 1.28 DT 1 14 Aug 03 RESZ 4336 PTD 1 DBA 4 FNC 2 specification of segmental identity, maxillary segment CLOC 1 42B2 ALESR 3 REF 16 GSYM|1.28 PTD DT|14 Aug 03 ID|FBgn0010347 UAB|Deficiency: Df(2R)cn88b (inferred from cytology) |Duplication: Dp(2;Y)cn+ (inferred from cytology) SYN|CG9397 |CG9397 |CG9397 |deformed KLOC|53022 CLOC|42B2 |Limits computationally determined from genome sequence between l(2)k09848/EP(2)0407 and l(2)k14019/l(2)01349 CYC|Experimentally determined: 42B FNC|specification of segmental identity, maxillary segment ; GO:0007382 | inferred from expression pattern |specification of segmental identity, maxillary segment ; GO:0007382 | inferred from genetic interaction with FLYBASE:Dfd; FB:FBgn0000439 DBA|NA:AE003789 |PA:AAF57355 |NA:L07262 |PA:AAA03084 PAC|SPTREMBL:Q24300 |SPTREMBL:Q9V9D6 WTI|Dfd ASQ|FBan0009397 REF { REFM|FBrf0079168 |Pederson and Mahaffey |1995 |1 REFM|FBrf0076134 |Mohler et al. |1995 |0 REFM|FBrf0137489 |Mount |2001.8.14 |9 REFM|FBrf0068222 |Mahaffey et al. |1994 |1 REFM|FBrf0092336 |LaFollette et al. |1997 |1 REFM|FBrf0117645 |Mahaffey |1992 |9 REFM|FBrf0075267 |Mahaffey |1993 |9 REFM|FBrf0064596 |Mahaffey et al. |1993 |0 REFM|FBrf0132330 |Mahaffey et al. |2001 |0 REFM|FBrf0068424 |Botas |1993 |2 REFM|FBrf0130258 |Pederson et al. |2000 |0 REFM|FBrf0090735 |Pederson et al. |1996 |0 REFM|FBrf0078949 |Mahato and Mahaffey |1995 |1 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0136026 |Dobie and Karpen |2001.4.18 |9 REFM|FBrf0085725 |Pederson et al. |1996 |1 } REFDSR { RDID|FBrf0064596 |Mahaffey et al. |1993 CLOC|42B (determined by in situ hybridization) FNC|specification of segmental identity, maxillary segment ; GO:0007382 | inferred from expression pattern |specification of segmental identity, maxillary segment ; GO:0007382 | inferred from genetic interaction with FLYBASE:Dfd; FB:FBgn0000439 WT|Identified in an enhancer trap screen for target genes of homeoproteins. |The 1.28 gene is a target gene that is activated by @Dfd@. @Dfd@ is required |to activate 1.28 in the maxillary segment, but ectopic expression of |@Dfd@ is incapable of activating @1.28@ elsewhere. WTI|Dfd } REFDSR { RDID|FBrf0079168 |Pederson and Mahaffey |1995 WT|The @1.28@ gene is directly activated by @Dfd@ in the maxillary segment |but not in the mandibular segment. Four @Dfd@-product binding sites |have been identified within a 664bp fragment of the @1.28@ regulatory |region, in addition to a @Dfd@ epidermal autoactivation element (DEAE). WTI|Dfd } REFDSR { RDID|FBrf0105495 |FlyBase |1992- } REFDSR { RDID|FBrf0117645 |Mahaffey |1992 CLOC|42B SYN|deformed } REFDSR { RDID|FBrf0136026 |Dobie and Karpen |2001.4.18 AM|"1.28" may correspond to "Scim21". |Sequence analysis off ends of @P{SUPor-P}@ in Scim insertion mutant |places "Scim21" near/in "1.28". SYN|CG9397 } REFDSR { RDID|FBrf0137489 |Mount |2001.8.14 SYN|CG9397 } ALESR { ASYM|1.28P ID|FBal0121022 REF|FBrf0130258 REFDSR { RDID|FBrf0130258 |Pederson et al. |2000 MD|@P{lacW}@ insertion into the @Deaf1@ binding region of the @1.28@ regulatory |sequences. TRN|FBti0003587 == P{lacW}1.28P } } ALESR { ASYM|1.28rv13 SYN|line 13 ID|FBal0121021 REF|FBrf0130258 REFDSR { RDID|FBrf0130258 |Pederson et al. |2000 MD|Mobilization of the @P{lacW}@ element, resulting in a deletion of approximately |1kb upstream of the original @P{lacW}@ element insertion site. PRG|1.28P MU|&Dgr;2-3 SYN|line 13 } } ALESR { ASYM|1.28+ ID|FBal0066314 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0026615 CLA 1 Gene GSYM 1 10-4 DT 1 14 Aug 03 RESZ 1135 ALESR 1 REF 1 GSYM|10-4 DT|14 Aug 03 ID|FBgn0026615 MD|In dividing precursor cells of the developing nervous system the |correct asymmetric apical localization of @10-4@ mRNA depends on |@insc@. @10-4@ protein localization to the apical cytoplasm occurs |when @insc@ protein disappears, in anaphase. In telophase @10-4@ |protein forms a tight apical crescent. REF { REFM|FBrf0106275 |Bulgheresi and Knoblich |1999 |1 } REFDSR { RDID|FBrf0106275 |Bulgheresi and Knoblich |1999 MD|In dividing precursor cells of the developing nervous system the |correct asymmetric apical localization of @10-4@ mRNA depends on |@insc@. @10-4@ protein localization to the apical cytoplasm occurs |when @insc@ protein disappears, in anaphase. In telophase @10-4@ |protein forms a tight apical crescent. OTH|Identification: Defined in a yeast two hybrid assay for genes whose |products interact with the 364 amino acid domain of @insc@ that |are required and sufficient for all the known @insc@ functions. } ALESR { ASYM|10-4+ ID|FBal0096586 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0011557 CLA 1 Gene GSYM 1 107.1 DT 1 14 Aug 03 RESZ 1143 ALESR 1 REF 3 GSYM|107.1 DT|14 Aug 03 ID|FBgn0011557 WTI|tub REF { REFM|FBrf0068202 |West and Anderson |1994 |1 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0079611 |West and Anderson |1995 |1 } REFDSR { RDID|FBrf0068202 |West and Anderson |1994 WTI|tub PHP|@107.1@ behaves as a dominant gain of function enhancer of all alleles |of @tub@, @107.1@ regulates @tub@ at post-transcriptional level. @107.1@ |acts in trans to disrupt accumulation of maternal @tub@ transcript. |Females homozygous for @107.1@ lack maternal @tub@ transcript and |yield completely dorsalized embryos. } REFDSR { RDID|FBrf0079611 |West and Anderson |1995 PHP|@107.1@ may define a regulator of @tub@ transcript levels, the recessive |maternal effect dorsalizing mutation exhibits loss of @tub@ message |that can be completely rescued with excess @tub@. } ALESR { ASYM|107.1+ ID|FBal0066315 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0010339 CLA 1 Gene NAM 1 upstream of RpIII128 GSYM 1 128up DT 1 14 Aug 03 RESZ 4882 PDOM 1 SCOP:52540 == P-loop containing nucleotide triphosphate hydrolases PTD 1 DBA 10 HG 5 Caenorhabditis elegans C02F5.3 WP:CE00039 CLOC 1 48D8 ALESR 1 REF 13 GSYM|128up PTD MMP DT|14 Aug 03 ID|FBgn0010339 UAB|Duplication: Dp(2;2)Y3b (inferred from cytology) SYN|CG8340 |CG8340 |GTP-bp |X71866 ID2|FBgn0010196 NAM|upstream of RpIII128 KLOC|60399 GLOC|2- CLOC|48D8 |Limits computationally determined from genome sequence between l(2)k06612 and l(2)k05644 CYC|Experimentally determined: 48E PDOM|SCOP:52540 == P-loop containing nucleotide triphosphate hydrolases; 128up|FBgn0010339|pp-CT24591|FBan0008340 MD|Identified with: SD05004 (BDGP-DGC) ENZ|GTP binding ; GO:0005525 | inferred from direct assay |GTP binding ; GO:0005525 | non-traceable author statement |hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ; GO:0016818 ; EC:3.6.1.- | inferred from electronic annotation |GTP binding ; GO:0005525 | inferred from sequence similarity with Swiss-Prot:P43690 DBA|NA:AE003823 |PA:AAF58591 |NA:AI533247 |BDGP-DGC:SD05004 |NA:AX093898 |NA:AY069810 |PA:AAL39955 |BDGP-DGC:SD05004 |NA:X71866 |PA:CAA50701 PAC|PIR:S33467 |PIR:S42582 |SPTREMBL:Q9V648 |SWP:P32234 HG|species == Caenorhabditis elegans; gene == C02F5.3; WP:CE00039; score == 372; expect == 1.e-102 |species == Homo sapiens; gene == 'neural precursor cell expressed, developmentally down-regulated 3'; gi:4758796; score == 547; expect == 1.e-155 |species == Mus musculus; gene == Nedd3; MGI:97296; score == 546; expect == 1.e-154 |species == Saccharomyces cerevisiae; gene == 'HYPOTHETICAL 40.7 KD PROTEIN IN PYK1-SNC1 INTERGENIC REGION'; SWP:P39729; gi:731276; score == 434; expect == 1.e-121 |species == Xenopus laevis; gene == 'DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN DRG (XDRG)'; SWP:P43690; gi:1169421; score == 544; expect == 1.e-154 ASQ|FBan0008340 REF { REFM|FBrf0067209 |Sommer et al. |1994 |0 REFM|FBrf0102347 |Kliman and Eyre-Walker |1998 |0 REFM|FBrf0126686 |Milshina |1999.11 |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|-1505380982 |0 |Patent: WO 0118547-A 15-MAR-2001; REFM|FBrf0058389 |Sommer et al. |1993 |1 REFM|FBrf0147137 |Brody et al. |2002 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0146674 |Roth and Foulger |2002.4.24 |9 REFM|FBrf0155515 |Ptak and Petrov |2002 |0 REFM|FBrf0156694 |9 REFM|FBrf0090923 |Seifarth |1991 |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0058389 |Sommer et al. |1993 WT|@RpIII128@ gene is flanked by an upstream transcription unit, @128up@. |@128up@ is transcribed in the same direction as @RpIII128@ and they |are separated by a short intergenic region. Bacterially expressed |@128up@, in fusion with maltose binding protein (MBP), specifically |binds GTP. } REFDSR { RDID|995280021 |Davies |2001.3.30 OTH|Area matching Drosophila GTP-binding protein, Acc. No. X71866. } REFDSR { RDID|FBrf0067209 |Sommer et al. |1994 ENZ|GTP binding ; GO:0005525 | inferred from direct assay WT|Bacterially expressed @128up@ is capable of binding GTP and the protein |is primarily located in the perinuclear region. GPD|GTP binding protein } REFDSR { RDID|FBrf0090923 |Seifarth |1991 CLOC|48E (determined by in situ hybridization) } REFDSR { RDID|FBrf0102347 |Kliman and Eyre-Walker |1998 OTH|In a sample of 79 genes with multiple introns, 33 showed significant |heterogeneity in G+C content among introns of the same gene and significant |positive correspondence between the intron and the third codon position |G+C content within genes. These results are consistent with selection |adding against preferred codons at the start of genes. SYN|GTP-bp } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|GTP binding ; GO:0005525 | inferred from sequence similarity with Swiss-Prot:P43690 } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: SD05004 (BDGP-DGC) } REFDSR { RDID|FBrf0146674 |Roth and Foulger |2002.4.24 ENZ|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ; GO:0016818 ; EC:3.6.1.- | inferred from electronic annotation } REFDSR { RDID|FBrf0147137 |Brody et al. |2002 SYN|CG8340 } REFDSR { RDID|FBrf0155515 |Ptak and Petrov |2002 SYN|X71866 } REFDSR { RDID|FBrf0156694 ENZ|GTP binding ; GO:0005525 | non-traceable author statement } ALESR { ASYM|128up+ ID|FBal0066316 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0005673 CLA 1 transposable element NAM 1 1360 element GSYM 1 1360 DT 1 14 Aug 03 RESZ 7727 DBA 19 WT 5 In situ hybridization to polytene chromosomes shows variable REF 46 GSYM|1360 MMP DT|14 Aug 03 ID|FBgn0005673 CLA|transposable_element SYN|hoppel |hopel |Hoppel |hoppel-like |Dr. D |protop |protop_b |Hoppel-like |DmHoppel |Dm1360 |EG:23E12.4 |anon-CH(3)336 ID2|FBgn0004180 |FBgn0013399 NAM|1360 element TE|element type: IR |terminal repeat length in bp: 37 |total length in bp: 1176 |target site duplication length in bp: 6 |number of copies in genome: >25 WT|In situ hybridization to polytene chromosomes shows variable, |strain-specific location in the euchromatic parts of the arms and heavy |labeling of the 12E region of the X chromosome, chromosome bases |(20A--20F, 40A--40F, 41A--41F, 80A--80C and 81F), the chromocenter and |chromosome 4. DBA|NA:AF533772 |NA:AF540061 |NA:AJ000473 |NA:AJ441085 |NA:AL031884 |NA:AY138841 |NA:L36596 |NA:M55078 |NA:U66884 |NA:X59157 |NA:X78388 |NA:Z11734 |NA:Z11735 |NA:Z31905 |dbSTS:4444 |NA:Z32073 |dbSTS:4624 |NA:Z32074 |dbSTS:4625 REF { REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0134799 |van Steensel et al. |2001 |9 REFM|FBrf0053529 |Leibovich et al. |1991 |0 REFM|FBrf0053528 |Leibovich |1991 |0 REFM|FBrf0159203 |Reiss et al. |2003 |0 REFM|FBrf0105803 |Cryderman et al. |1998 |0 REFM|FBrf0155500 |Maggert and Golic |2002 |0 REFM|FBrf0144916 |Rizzon et al. |2002 |0 REFM|FBrf0071734 |EDGP Project Members |1994- |9 REFM|FBrf0046087 |Kholodilov et al. |1987 |0 REFM|FBrf0105798 |Coelho et al. |1998 |0 REFM|FBrf0149015 |Yan et al. |2002 |0 REFM|FBrf0106872 |Locke et al. |1999 |9 REFM|FBrf0151607 |Kapitonov and Jurka |1997- |9 REFM|FBrf0137315 |Galindo et al. |2001 |0 REFM|FBrf0106421 |Dimitri et al. |1999 |1 REFM|FBrf0080514 |Zhang and Spradling |1995 |0 REFM|FBrf0080225 |Madueno et al. |1995 |0 REFM|FBrf0135796 |Pardue and Debaryshe |2000 |2 REFM|FBrf0149106 |Bartolome et al. |2002 |0 REFM|FBrf0125039 |Bejarano and Gonzalez |1999 |0 REFM|FBrf0135794 |Wallrath |2000 |2 REFM|FBrf0135792 |Gvozdev et al. |2000 |2 REFM|FBrf0123109 |Locke et al. |1999 |0 REFM|FBrf0128554 |Locke et al. |2000 |0 REFM|FBrf0101830 |Locke et al. |1998 |1 REFM|FBrf0083001 |Almeida Coelho and Sunkel |1995 |1 REFM|FBrf0052018 |Kurenova et al. |1990 |0 REFM|FBrf0057400 |Balakireva et al. |1992 |0 REFM|FBrf0126011 |Aravin et al. |2000 |1 REFM|FBrf0137496 |Misra |2001.8.16 |9 REFM|FBrf0151627 |Ashburner |2002.8.15 |9 REFM|FBrf0135823 |Benos et al. |2001 |0 REFM|FBrf0047691 |Kholodilov et al. |1988 |0 REFM|FBrf0117093 |Kurenova |1994.5.6 |9 REFM|FBrf0112417 |Ahmed |1996.8.14 |9 REFM|FBrf0121135 |Sunkel |1997.7.15 |9 REFM|FBrf0109548 |Cryderman et al. |1999 |0 REFM|FBrf0101859 |Wallrath et al. |1998 |1 REFM|FBrf0100583 |Kalmykova et al. |1998 |0 REFM|FBrf0151719 |Tulin et al. |2002 |0 REFM|FBrf0117473 |Livak |1992.2.24 |9 REFM|FBrf0117472 |Livak |1992.2.24 |9 REFM|FBrf0158933 |Marsano et al. |2003 |0 REFM|FBrf0137199 |Aravin et al. |2001 |0 REFM|FBrf0099762 |Deak et al. |1997 |0 } REFDSR { RDID|FBrf0047691 |Kholodilov et al. |1988 WT|In situ hybridization to polytene chromosomes shows variable, |strain-specific location in the euchromatic parts of the arms and heavy |labeling of the 12E region of the X chromosome, chromosome bases |(20A--20F, 40A--40F, 41A--41F, 80A--80C and 81F), the chromocenter and |chromosome 4. } REFDSR { RDID|FBrf0052018 |Kurenova et al. |1990 PHP|A @1360@ element has been cloned and sequenced. It is flanked by short |inverted repeats. The @1360@ element is present in approximately 10-30 |euchromatic sites and also in numerous heterochromatic sites (in the |chromocenter, pericentric heterochromatin, the fourth chromosome and |at the telomeres) in the D.melanogaster genome. At least 6 variant |@1360@ elements differing in the length of the central region have |been detected. The @1360@ element has ARS activity, similar to the |@P-element@. SYN|hoppel } REFDSR { RDID|FBrf0053528 |Leibovich |1991 SYN|hopel } REFDSR { RDID|FBrf0053529 |Leibovich et al. |1991 SYN|hopel } REFDSR { RDID|FBrf0080514 |Zhang and Spradling |1995 } REFDSR { RDID|FBrf0083001 |Almeida Coelho and Sunkel |1995 SYN|Hoppel } REFDSR { RDID|FBrf0099762 |Deak et al. |1997 SYN|hoppel } REFDSR { RDID|FBrf0101830 |Locke et al. |1998 SYN|Hoppel } REFDSR { RDID|FBrf0101859 |Wallrath et al. |1998 SYN|hoppel } REFDSR { RDID|FBrf0105803 |Cryderman et al. |1998 SYN|hoppel } REFDSR { RDID|FBrf0106421 |Dimitri et al. |1999 SYN|hoppel } REFDSR { RDID|FBrf0106872 |Locke et al. |1999 SYN|Hoppel } REFDSR { RDID|FBrf0109548 |Cryderman et al. |1999 SYN|hoppel } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 SYN|hoppel } REFDSR { RDID|FBrf0112417 |Ahmed |1996.8.14 SYN|unnamed } REFDSR { RDID|FBrf0117093 |Kurenova |1994.5.6 SYN|hoppel } REFDSR { RDID|FBrf0117472 |Livak |1992.2.24 SYN|unnamed } REFDSR { RDID|FBrf0117473 |Livak |1992.2.24 SYN|unnamed } REFDSR { RDID|FBrf0121135 |Sunkel |1997.7.15 SYN|hoppel-like } REFDSR { RDID|FBrf0123109 |Locke et al. |1999 TE|The "Dr. D" repetitive sequence (described in FBrf0048918) contains |sequences of both @INE-1@ and @1360@ transposable elements. SYN|hoppel } REFDSR { RDID|FBrf0125039 |Bejarano and Gonzalez |1999 SYN|hoppel } REFDSR { RDID|FBrf0126011 |Aravin et al. |2000 SYN|hoppel } REFDSR { RDID|FBrf0128554 |Locke et al. |2000 SYN|Dr. D |Hoppel } REFDSR { RDID|FBrf0134799 |van Steensel et al. |2001 SYN|hoppel } REFDSR { RDID|FBrf0135792 |Gvozdev et al. |2000 SYN|hoppel } REFDSR { RDID|FBrf0135794 |Wallrath |2000 SYN|hoppel } REFDSR { RDID|FBrf0135796 |Pardue and Debaryshe |2000 SYN|Hoppel } REFDSR { RDID|FBrf0137199 |Aravin et al. |2001 SYN|hoppel } REFDSR { RDID|FBrf0144916 |Rizzon et al. |2002 SYN|Hoppel } REFDSR { RDID|FBrf0151607 |Kapitonov and Jurka |1997- SYN|protop |protop_b } REFDSR { RDID|FBrf0151719 |Tulin et al. |2002 SYN|hoppel } REFDSR { RDID|FBrf0155500 |Maggert and Golic |2002 SYN|hoppel } REFDSR { RDID|FBrf0158933 |Marsano et al. |2003 SYN|Hoppel-like |DmHoppel } } # EOR GENR { RETE|ID 1 FBgn0066320 CLA 1 transposable element gene GSYM 1 1360\T DT 1 14 Aug 03 RESZ 264 DBA 2 ALESR 1 REF 1 GSYM|1360\T DT|14 Aug 03 ID|FBgn0066320 CLA|transposable_element_gene DBA|NA:AF533772 |PA:AAN39288 REF { REFM|FBrf0159203 |Reiss et al. |2003 |0 } ALESR { ASYM|1360\T+ ID|FBal0146588 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0020238 CLA 1 Gene GSYM 1 14-3-3&egr; DT 1 14 Aug 03 RESZ 28385 PTD 1 DBA 18 FNC 4 DNA damage response, signal transduction resulting in cell cycle arrest WT 2 @14-3-3&egr;@ is required to time mitosis in undisturbed post-blastoderm CLOC 1 90F7--8 ALESR 10 SK 2 REF 42 GSYM|14-3-3&egr; PTD ARGS DT|14 Aug 03 ID|FBgn0020238 UAB|Deficiency: Df(3R)P14 |Duplication: Dp(3;3)C123.3 (inferred from cytology) SYN|CG31196 |SR3-9 |14-3-3 |d14-3-3&egr; |14-3-3epsilon |14-3-3e |CT24092 |EK3-5 |D14-3-3&egr; |14-3-3-e |D14-3-3e |par-5 |Su(Raf)3B |l(3)j2B10 |Suppressor of Ras85D 3-9 ID2|FBgn0011329 |FBgn0016739 |FBgn0016743 |FBgn0051196 |FBgn0064146 KLOC|116346-11439 CLOC|90F7--8 |Limits computationally determined from genome sequence between l(3)s2956 and EP(3)3634 CYC|Experimentally determined: 90E--F, 90F6--7 FNC|DNA damage response, signal transduction resulting in cell cycle arrest ; GO:0000077 | inferred from mutant phenotype |DNA damage response, signal transduction resulting in cell cycle arrest ; GO:0000077 | inferred from mutant phenotype |regulation of mitosis ; GO:0007088 | inferred from mutant phenotype |response to external stimulus ; GO:0009605 | inferred from mutant phenotype GLC|Maps 0.4 +/- 0.2 cM from a P{w+} insertion into 90E. WT|@14-3-3&egr;@ is required to time mitosis in undisturbed post-blastoderm |cell cycles and to delay mitosis following irradiation in embryos. ENZ|diacylglycerol-activated/phospholipid dependent protein kinase C inhibitor activity ; GO:0004863 | non-traceable author statement DBA|NA:AE003721 |PA:AAF55519 |PA:AAN13764 |PA:AAN13765 |PA:AAN13766 |NA:AI107648 |BDGP-DGC:GH05443 |NA:AQ026302 |BDGP:l(3)j2B10 |NA:AW940197 |BDGP-DGC:GH05443 |NA:AY058293 |PA:AAL13522 |BDGP-DGC:GH05443 |NA:U84897 |PA:AAC47519 |NA:U84898 |PA:AAC47520 PAC|SPTREMBL:Q8IN86 |SPTREMBL:Q8IN87 |SWP:P92177 ASQ|FBan0031196 REV|FBrf0158832 |FBrf0127283 |FBrf0111327 REF { REFM|FBrf0154848 |1 REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0091142 |Perrimon et al. |1996 |0 REFM|FBrf0158832 |Ahringer |2003 |2 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0111327 |Baek and Lee |1999 |2 REFM|FBrf0131405 |Therrien et al. |2000 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0126669 |Gong |1999.11 |9 REFM|FBrf0126349 |Su |2000 |1 REFM|FBrf0134532 |Walworth |2000 |2 REFM|FBrf0127357 |Teeter et al. |2000 |0 REFM|FBrf0104620 |Rommel and Hafen |1998 |2 REFM|FBrf0108031 |Tien et al. |1999 |0 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0133450 |Acevedo and Skoulakis |2001 |1 REFM|FBrf0083714 |Meister and Braun |1995.10 |9 REFM|FBrf0145821 |Acevedo and Skoulakis |2002 |1 REFM|FBrf0139721 |Su et al. |2001 |0 REFM|FBrf0151887 |Rebay |2002 |2 REFM|FBrf0159706 |Hacker et al. |2003 |0 REFM|FBrf0127283 |Raabe |2000 |2 REFM|FBrf0113722 |Chang |1997.1.11 |9 REFM|FBrf0113721 |Chang |1997.1.10 |9 REFM|FBrf0108153 |Chen and Chien |1999 |0 REFM|FBrf0102393 |Rubin et al. |1997 |2 REFM|FBrf0126913 |Bayraktaroglu |2000.4.13 |9 REFM|FBrf0126651 |Ashburner |1999.11 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126680 |Lei |1999.11 |9 REFM|FBrf0127025 |Brodsky et al. |2000 |0 REFM|FBrf0149093 |Johannes and Preiss |2002 |0 REFM|FBrf0124174 |SwissProt Project Members |1998.2.1 |9 REFM|FBrf0145847 |Skoulakis and Acevedo |2002 |1 REFM|FBrf0159690 |Chen et al. |2003 |0 REFM|FBrf0133630 |Purdy et al. |2001 |1 REFM|FBrf0087493 |Karim et al. |1996 |0 REFM|FBrf0155512 |Pellettieri and Seydoux |2002 |2 REFM|FBrf0129944 |Li et al. |2000 |0 REFM|FBrf0086382 |Dickson et al. |1996 |0 REFM|FBrf0130073 |Sekelsky et al. |2000 |0 REFM|FBrf0093395 |Chang and Rubin |1997 |0 } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|90F6--7 LOI|14-3-3&egr;j2B10 BMD|Df(3R)P14 } REFDSR { RDID|FBrf0086382 |Dickson et al. |1996 GLC|Maps 0.4 +/- 0.2 cM from a P{w+} insertion into 90E. WTI|phl (data from @14-3-3&egr;18A2@) PHP|Identified in a genetic screen for modifiers of the @phl::tor12D.sev@ |rough eye mutant phenotype. } REFDSR { RDID|FBrf0087493 |Karim et al. |1996 GLOC|3- CLOC|90E--F CYC|On basis of meiotic mapping (details unspecified). WTI|Dsor1 (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@) |Ras85D (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@) |aop (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@) |phl (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@) PHP|Identified on the basis of genetic interaction with @Ras85DV12.sev@. SYN|SR3-9: Suppressor of Ras85D 3-9 } REFDSR { RDID|FBrf0091142 |Perrimon et al. |1996 CLOC|90F6--7 (determined by in situ hybridization) PHP|The autosomal "FLP-DFS" technique (using the @P{ovoD1-18}@ @P{FRT(whs)}@ |@P{hsFLP}@ chromosomes) has been used to identify the specific maternal |effect phenotype for the zygotic lethal mutation. @14-3-3&egr;@ gene |expression during oogenesis is not critical to embryonic development, |but the gene function may be essential for fertilization and/or completion |of meiosis. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 GLOC|3-62.0 WTI|14-3-3&zgr; (data from @14-3-3&egr;j2B10@) |Ras85D (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@, @14-3-3&egr;j2B10@) |phl (data from @14-3-3&egr;18A2@, @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@, @14-3-3&egr;j2B10@) PHP|@14-3-3&egr;@ has been cloned and characterized. Genetic studies suggest |that @14-3-3&egr;@ functions in multiple receptor tyrosine kinase pathways, |acting downstream or parallel to @phl@, but upstream of @aop@ and @phyl@, |two nuclear factors involved in @Ras85D@ signaling. } REFDSR { RDID|FBrf0104620 |Rommel and Hafen |1998 SYN|14-3-3 } REFDSR { RDID|FBrf0108031 |Tien et al. |1999 BMD|Df(3R)P14 SYN|d14-3-3&egr; } REFDSR { RDID|FBrf0108153 |Chen and Chien |1999 SYN|d14-3-3&egr; } REFDSR { RDID|FBrf0111327 |Baek and Lee |1999 SYN|14-3-3 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 CLOC|90F6--7 (determined by in situ hybridization) LOI|14-3-3&egr;j2B10 BMD|Df(3R)P14 SYN|14-3-3epsilon } REFDSR { RDID|FBrf0113721 |Chang |1997.1.10 ENZ|diacylglycerol-activated/phospholipid dependent protein kinase C inhibitor activity ; GO:0004863 | non-traceable author statement CLOC|90F6--7 FNC|RAS protein signal transduction ; GO:0007265 | non-traceable author statement GPD|14-3-3-protein SYN|14-3-3e } REFDSR { RDID|FBrf0113722 |Chang |1997.1.11 SYN|14-3-3e } REFDSR { RDID|FBrf0124174 |SwissProt Project Members |1998.2.1 FNC|RAS protein signal transduction ; GO:0007265 | non-traceable author statement } REFDSR { RDID|FBrf0126669 |Gong |1999.11 AM|Source for identity of: 14-3-3&egr; CG8045 } REFDSR { RDID|FBrf0126913 |Bayraktaroglu |2000.4.13 SYN|CT24092 } REFDSR { RDID|FBrf0127025 |Brodsky et al. |2000 FNC|DNA damage response, signal transduction resulting in cell cycle arrest ; GO:0000077 | inferred from mutant phenotype } REFDSR { RDID|FBrf0127283 |Raabe |2000 SYN|14-3-3 } REFDSR { RDID|FBrf0129944 |Li et al. |2000 WTI|phl (data from @14-3-3&egr;&Dgr;24@) } REFDSR { RDID|FBrf0130073 |Sekelsky et al. |2000 FNC|DNA damage response, signal transduction resulting in cell cycle arrest ; GO:0000077 | traceable author statement } REFDSR { RDID|FBrf0131405 |Therrien et al. |2000 WTI|ksr |Ras85D (data from @14-3-3&egr;unspecified@) |phl (data from @14-3-3&egr;unspecified@) SYN|EK3-5 } REFDSR { RDID|FBrf0133450 |Acevedo and Skoulakis |2001 SYN|D14-3-3&egr; } REFDSR { RDID|FBrf0134532 |Walworth |2000 FNC|imaginal disc development ; GO:0007444 | traceable author statement |mitotic checkpoint ; GO:0007093 | traceable author statement |response to radiation ; GO:0009314 | traceable author statement SYN|14-3-3e } REFDSR { RDID|FBrf0139721 |Su et al. |2001 FNC|DNA damage response, signal transduction resulting in cell cycle arrest ; GO:0000077 | inferred from mutant phenotype |regulation of mitosis ; GO:0007088 | inferred from mutant phenotype WT|@14-3-3&egr;@ is required to time mitosis in undisturbed post-blastoderm |cell cycles and to delay mitosis following irradiation in embryos. } REFDSR { RDID|FBrf0145821 |Acevedo and Skoulakis |2002 SYN|D14-3-3&egr; } REFDSR { RDID|FBrf0145847 |Skoulakis and Acevedo |2002 FNC|response to external stimulus ; GO:0009605 | inferred from mutant phenotype SYN|D14-3-3&egr; } REFDSR { RDID|FBrf0149093 |Johannes and Preiss |2002 SYN|14-3-3-e } REFDSR { RDID|FBrf0151887 |Rebay |2002 SYN|14-3-3 } REFDSR { RDID|FBrf0154848 SYN|D14-3-3e } REFDSR { RDID|FBrf0155512 |Pellettieri and Seydoux |2002 SYN|par-5 } REFDSR { RDID|FBrf0159706 |Hacker et al. |2003 SYN|14-3-3 } ALESR { ASYM|14-3-3&egr;&Dgr;24 ID|FBal0122336 REF|FBrf0129944 REFDSR { RDID|FBrf0129944 |Li et al. |2000 GIC2|lethal with @phlSu2@ } } ALESR { ASYM|14-3-3&egr;18A2 SYN|14-3-3&egr;Y214F |18A2 ID|FBal0049166 REF|FBrf0093395 |FBrf0086382 REFDSR { RDID|FBrf0086382 |Dickson et al. |1996 MU|ethyl methanesulfonate GIC|suppressor | dominant of visible phenotype of @phl::tor12D.sev@ GIA|suppressor | dominant of eye phenotype of @phl::tor12D.sev@ |suppressor | dominant of photoreceptor cell R7 phenotype of @phl::tor12D.sev@ GIC2|lethal | dominant with @phl12@ GII|Dominantly suppresses the rough eye phenotype of |@phl::tor12D.sev@. Synthetic lethal in combination with @phl12@. PHC|viable |female fertile ALC|antimorph PHI|Homozygous viable with no obvious defects in eye development. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 MD|Amino acid replacement: Y214F. MU|ethyl methanesulfonate GIC2|lethal | dominant with @phl12@ PHC|viable |fertile PHI|Homozygotes have no detectable phenotype in a wild-type background. SYN|14-3-3&egr;Y214F |18A2 } } ALESR { ASYM|14-3-3&egr;ex4 ID|FBal0148514 ALC|loss of function REF|FBrf0159690 REFDSR { RDID|FBrf0159690 |Chen et al. |2003 MD|Imprecise mobilization of the @P{lacW}14-3-3&egr;j2B10@ element has |created this allele. PRG|14-3-3&egr;j2B10 MU|P-element activity ALC|loss of function } } ALESR { ASYM|14-3-3&egr;j2B10 SYN|l(3)j2B10 |l(3)2B10 |14-3-3&egr;j2b10 |14-3-3-ej2B10 ID|FBal0010913 TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10 |BDGP:l(3)j2B10 MU|P-element activity REF|FBrf0067338 |FBrf0127025 |FBrf0093395 |FBrf0108153 |FBrf0159690 |FBrf0149093 |FBrf0083714 |FBrf0091142 |FBrf0111489 |FBrf0139721 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 OTH|Complements: @repo03702@. |Complements: @l(3)0582205822@. |Complements: @Trap80s2956@. TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10 |BDGP:l(3)j2B10 } REFDSR { RDID|FBrf0091142 |Perrimon et al. |1996 PHC|lethal | larval | recessive |lethal | embryonic | maternal effect PHM|cuticle | embryonic | maternal effect PHI|Germline clones produce normal eggs with no cuticle development. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 AFC|14-3-3&egr;S-696 MD|Insertion of a @P{lacW}@ element within the first intron. OTH|The rough eye and missing photoreceptor cell phenotype of @14-3-3&egr;S-696@/@14-3-3&egr;j2B10@ |flies is reverted by mobilization of the @P-element@ in @14-3-3&egr;j2B10@. |The recessive lethality of the @14-3-3&egr;j2B10@ chromosome is not |associated with the @P-element@ insertion. TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10 |BDGP:l(3)j2B10 MU|P-element activity GIC|suppressor | recessive of visible phenotype of @Ras85DV12.sev@ GIC2|lethal | recessive with @14-3-3&zgr;P2355@/+ |visible | recessive with @14-3-3&zgr;X1@/+ |visible | recessive with @14-3-3&zgr;2.3@/+ |lethal | dominant with @phl12@ GIA|suppressor | recessive of eye phenotype of @Ras85DV12.sev@ |suppressor | recessive of ommatidium phenotype of @Ras85DV12.sev@ GIA2|ommatidium with @14-3-3&zgr;X1@/+ |ommatidium with @14-3-3&zgr;2.3@/+ |posterior crossvein with @14-3-3&zgr;2.3@ |eye with @14-3-3&zgr;2.3@ |photoreceptor cell with @14-3-3&zgr;2.3@ |posterior crossvein with @14-3-3&zgr;X1@ |eye with @14-3-3&zgr;X1@ |photoreceptor cell with @14-3-3&zgr;X1@ GII|Homozygotes but not heterozygotes suppress the @Ras85DV12.sev@ |rough eye phenotype. |@14-3-3&zgr;X1@/+ @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ or |@14-3-3&zgr;2.3@/+ @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ flies |have slightly roughened eyes, a low penetrance of missing |photoreceptors and a gap in the posterior crossvein of the wings in |more than 50% of cases. PHC|viable |sterile | recessive |(with 14-3-3&egr;S-696) visible PHM|(with 14-3-3&egr;S-696) eye |(with 14-3-3&egr;S-696) photoreceptor cell |(with 14-3-3&egr;S-696) ommatidium ALC|loss of function PHI|Homozygotes have normal eyes but are sterile. |@14-3-3&egr;S-696@/@14-3-3&egr;j2B10@ flies have rough eyes and |a low penetrance of missing photoreceptors in the ommatidia. SYN|l(3)j2B10 } REFDSR { RDID|FBrf0108153 |Chen and Chien |1999 GIA2|(with Df(3R)P14) photoreceptor cell R8 with @EgfrE1@ GII|R8 photoreceptor cells fail to form in @EgfrE1@/+ ; @14-3-3&egr;j2B10@/@Df(3R)P14@ |eye discs. SYN|l(3)2B10 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10 |BDGP:l(3)j2B10 PHC|lethal | recessive SYN|l(3)j2B10 } REFDSR { RDID|FBrf0127025 |Brodsky et al. |2000 PHI|In the absence of irradiation, @14-3-3&egr;j2B10@ animals have a |normal external appearance, normal imaginal disc morphology and normal |numbers of mitotic cells in the discs. After irradiation, the number |of mitotic cells in @14-3-3&egr;j2B10@ discs is greater than the |number found in irradiated wild-type discs. SYN|14-3-3&egr;j2b10 } REFDSR { RDID|FBrf0139721 |Su et al. |2001 TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10 |BDGP:l(3)j2B10 PHC|mitotic | recessive PHM|embryonic cycle 14 PHI|Embryos derived from a cross of @14-3-3&egr;j2B10@/@Df(3R)Cha7@ females |to @14-3-3&egr;j2B10@/@Df(3R)Cha7@ males progress through the first |13 mitotic cycles and cellularize without obvious defects. Cells enter |mitosis 14 prematurely compared to wild type so that the division pattern |of mutant embryos in gastrulation is more advanced than in wild-type |embryos of similar gastrulation but is similar to wild-type embryos |of more advanced gastrulation. The entire schedule of mitosis is advanced |without disrupting the relative order of mitosis in different positions |within the embryo. The rate of germ-band elongation is indistinguishable |from wild type. Mutant embryos do not show a delay of entry into mitosis |14 after irradiation, in contrast to wild-type embryos. SYN|l(3)j2B10 } REFDSR { RDID|FBrf0149093 |Johannes and Preiss |2002 SYN|14-3-3-ej2B10 } REFDSR { RDID|FBrf0159690 |Chen et al. |2003 TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10 |BDGP:l(3)j2B10 } SK|FBstBL-12142 |y[1] w[*]; P{w[+mC]=lacW}14-3-3epsilon[j2B10]/TM3, Sb[1] } ALESR { ASYM|14-3-3&egr;PL00784 SYN|l(3)PL00784 ID|FBal0148516 PHC|lethal | embryonic | maternal effect | germ-line clone PHM|embryo | maternal effect | germ-line clone PHI|@14-3-3&egr;PL00784@ germ-line clones produce embryos that die before |they produce a larval cuticle and appear as 'empty eggs'. REF|FBrf0159706 REFDSR { RDID|FBrf0159706 |Hacker et al. |2003 MD|The PBac{UASp-3xP3-EYFP,p-GAL4&Dgr;-K10} insertion is in the first |intron of @14-3-3&egr;@. TRN|&o insertion PHC|lethal | embryonic | maternal effect | germ-line clone PHM|embryo | maternal effect | germ-line clone PHI|@14-3-3&egr;PL00784@ germ-line clones produce embryos that die before |they produce a larval cuticle and appear as 'empty eggs'. SYN|l(3)PL00784 } } ALESR { ASYM|14-3-3&egr;S-696 SYN|14-3-3&egr;E183K |SR3-9696 ID|FBal0048994 REF|FBrf0093395 |FBrf0087493 |FBrf0131405 REFDSR { RDID|FBrf0087493 |Karim et al. |1996 MU|ethyl methanesulfonate GIC|suppressor of visible phenotype of @Ras85DV12.sev@ |suppressor of @phl::tor13D.hs.sev@ |suppressor of @Ras85D::Src64BV12.&Dgr;CAAX.sev@ |enhancer of @Ras85DN17.sev@ |enhancer of lethal phenotype of @phl12@ |enhancer of visible phenotype of @phl12@ |enhancer of visible phenotype of @Dsor1XS520@ |enhancer of visible phenotype of @aopS2382@ GIA|suppressor of eye phenotype of @Ras85DV12.sev@ |enhancer of eye phenotype of @phl12@ |enhancer of eye phenotype of @Dsor1XS520@ |enhancer of eye phenotype of @aopS2382@ GII|Suppresses the rough eye phenotype of @Ras85DV12.sev@. PHC|viable | poor PHI|Homozygotes are subviable. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 AFC|14-3-3&egr;j2B10 MD|Amino acid replacement: E183K. MU|ethyl methanesulfonate GIC|suppressor | dominant of @Ras85DV12.sev@ GIC2|lethal | dominant with @phl12@ GIC|suppressor | dominant of @phl::tor13D.hs.sev@ GII|@14-3-3&egr;S-696@ does not show any dominant interaction with @aopyan-1@ |or @phylhs.sev@. PHC|lethal | recessive | partially |(with 14-3-3&egr;j2B10) visible PHM|(with Df(3R)P14) ommatidium |(with 14-3-3&egr;j2B10) eye |(with 14-3-3&egr;j2B10) photoreceptor cell |(with 14-3-3&egr;j2B10) ommatidium |ommatidium |photoreceptor cell |posterior crossvein PHI|62.5% of ommatidia are normal in homozygous escapers, with the remaining |ommatidia lacking some photoreceptor cells, and 69.1% of ommatidia |are normal in @14-3-3&egr;S-696@/@Df(3R)P14@ flies. Homozygous escapers |often have gaps in the posterior crossveins of the wings. |@14-3-3&egr;S-696@/@14-3-3&egr;j2B10@ flies have rough eyes and |a low penetrance of missing photoreceptors in the ommatidia. SYN|14-3-3&egr;E183K |SR3-9696 } SK|FBstBL-6565 |14-3-3epsilon[S-696]/TM3, P{ry[+t7.2]=sevRas1.V12}FK2, Sb[1] } ALESR { ASYM|14-3-3&egr;S-1259 SYN|14-3-3&egr;F199Y |SR3-91259 ID|FBal0048993 REF|FBrf0093395 |FBrf0087493 REFDSR { RDID|FBrf0087493 |Karim et al. |1996 MU|ethyl methanesulfonate GIC|suppressor of visible phenotype of @Ras85DV12.sev@ |suppressor of @phl::tor13D.hs.sev@ |suppressor of @Ras85D::Src64BV12.&Dgr;CAAX.sev@ |enhancer of lethal phenotype of @phl12@ |enhancer of visible phenotype of @phl12@ |enhancer of @Ras85DN17.sev@ |enhancer of visible phenotype of @Dsor1XS520@ |enhancer of visible phenotype of @aopS2382@ GIA|suppressor of eye phenotype of @Ras85DV12.sev@ |enhancer of eye phenotype of @phl12@ |enhancer of eye phenotype of @Dsor1XS520@ |enhancer of eye phenotype of @aopS2382@ GIC|suppressor | dominant of @Ras85DV12.sev@ GII|Suppresses the rough eye phenotype of @Ras85DV12.sev@. PHC|viable | poor PHI|Homozygotes are subviable. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 MD|Amino acid replacement: F199Y. MU|ethyl methanesulfonate GIC|suppressor | dominant of @Ras85DV12.sev@ GIC2|lethal | dominant with @phl12@ PHC|viable |fertile PHI|Homozygotes have no detectable phenotype in a wild-type background. SYN|14-3-3&egr;F199Y |SR3-91259 } } ALESR { ASYM|14-3-3&egr;Scer\UAS.cCa ID|FBal0148515 PHI|When @14-3-3&egr;Scer\UAS.cCa@ is driven by @Scer\GAL4GMR.PF@ no |deleterious effects are seen. REF|FBrf0159690 REFDSR { RDID|FBrf0159690 |Chen et al. |2003 NAM|Saccharomyces cerevisiae UAS construct a of Chen MD|@Scer\UAS@ sequences drive expression of @14-3-3&egr;@. CNS|FBtp0017453 == P{UAS-14-3-3&egr;.C} GIC2|lethal with @Hsap\ATX182Q.Scer\UAS@ |lethal with @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@ |lethal with @Hsap\ATX182Q.Scer\UAS@ |lethal with @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@ GIA|enhancer of eye phenotype of @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@ |enhancer of retina phenotype of @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@ |enhancer of rhabdomere phenotype of @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@ GII|The addition of @14-3-3&egr;Scer\UAS.cCa@ enhances the eye phenotypes |seen in @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@ animals alone. |They have profoundly disordered ommatidia, a thin and disorganized |retina layer, and grossly abnormal rhabdomeres. PHI|When @14-3-3&egr;Scer\UAS.cCa@ is driven by @Scer\GAL4GMR.PF@ no |deleterious effects are seen. } } ALESR { ASYM|14-3-3&egr;unspecified ID|FBal0121020 PHC|lethal | recessive REF|FBrf0131405 REFDSR { RDID|FBrf0131405 |Therrien et al. |2000 GIA|enhancer | dominant of eye phenotype of @ksr::tor&Dgr;Nksr.hs.sev@ |suppressor | dominant of eye phenotype of @Ras85DV12.sev@ GIC|enhancer | dominant of lethal phenotype of @phl12@ |enhancer | dominant of visible phenotype of @ksr::tor&Dgr;Nksr.hs.sev@ |suppressor | dominant of visible phenotype of @Ras85DV12.sev@ PHC|lethal | recessive } } ALESR { ASYM|14-3-3&egr;+ ID|FBal0079281 CLA|wild-type generic REF|FBrf0105495 } SKC|2 } # EOR GENR { RETE|ID 1 FBgn0004907 CLA 1 Gene GSYM 1 14-3-3&zgr; DT 1 14 Aug 03 RESZ 60579 PTD 1 DBA 31 HG 5 Caenorhabditis elegans F52D10.3 WP:CE03389 FNC 2 RAS protein signal transduction CLOC 1 46E6--8 ALESR 27 SK 2 REF 76 GSYM|14-3-3&zgr; PTD ARGS DT|14 Aug 03 ID|FBgn0004907 UAB|Deficiency: Df(2R)stan1 (inferred from cytology) |Duplication: Dp(2;2)Y3b (inferred from cytology) SYN|CG17870 |549 |2G1 |leonardo |leo: leonardo |D14-3-3&zgr; |14-3-3 |14-3-3zeta |Leonardo-13-3-3 |4-3-3 zeta |par-5 |D14-3-3: D14 3 3 protein |l(2)07103 |leo |D14 3 3 protein ID2|FBgn0010635 |FBgn0064146 KLOC|57933-11245 CLOC|46E6--8 |Limits computationally determined from genome sequence between l(2)07103 and l(2)06339/l(2)03221 CYC|Experimentally determined: 46E, 46E--F, 46E4--8 FNC|RAS protein signal transduction ; GO:0007265 | inferred from sequence similarity with SGD_LOCUS:BMH2; SGD:S0002506 |tryptophan hydroxylase activation ; GO:0006588 | inferred from sequence similarity with MGD:Ywhaz; MGI:MGI:109484 ENZ|tryptophan hydroxylase activator activity ; GO:0016483 | inferred from sequence similarity with MGD:Ywhaz; MGI:MGI:109484 |protein kinase C inhibitor activity ; GO:0008426 | non-traceable author statement |diacylglycerol-activated/phospholipid dependent protein kinase C inhibitor activity ; GO:0004863 | inferred from sequence similarity with MGD:Ywhaz; MGI:MGI:109484 DBA|NA:AA538817 |BDGP-DGC:LD18434 |NA:AE003831 |PA:AAF58842 |PA:AAF58843 |PA:AAM71060 |PA:AAM71061 |PA:AAM71062 |PA:AAM71063 |PA:AAM71064 |NA:AQ025662 |BDGP:l(2)07103 |NA:AW942482 |BDGP-DGC:LD18434 |NA:AY095521 |PA:AAM12253 |BDGP-DGC:LD18434 |NA:BH840513 |BDGP:KG02642 |NA:BI564632 |BDGP-DGC:RH61958 |NA:BT001855 |PA:AAN71617 |BDGP-DGC:RH61958 |NA:M77518 |PA:AAA28324 |NA:Y12573 |PA:CAA73153 |PA:CAA73152 |NA:Z32177 |dbSTS:4728 PAC|PIR:JC1122 |SPTREMBL:Q8IGB9 |SPTREMBL:Q8MKV5 |SPTREMBL:Q8SWR6 |SWP:P29310 HG|species == Caenorhabditis elegans; gene == F52D10.3; WP:CE03389; score == 471; expect == 2.e-80 |species == Homo sapiens; gene == 'tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide'; gi:4507953; score == 478; expect == 6.e-80 |species == Mus musculus; gene == Ywhaz; MGI:109484; score == 478; expect == 7.e-81 |species == Saccharomyces cerevisiae; gene == BMH2; SGDID:L0000186; score == 374; expect == 3.e-57 |species == rat; gene == '14-3-3 protein isoform zeta'; PIR:JC5232; gi:2143553; score == 481; expect == 7.e-81 ASQ|FBan0017870 REV|FBrf0158832 |FBrf0137068 |FBrf0127283 REF { REFM|FBrf0093395 |Chang and Rubin |1997 |0 REFM|FBrf0159690 |Chen et al. |2003 |0 REFM|FBrf0102616 |Connolly and Tully |1998 |2 REFM|FBrf0101184 |Hermon et al. |1998 |1 REFM|FBrf0084992 |Edwards and Wasserman |1996 |1 REFM|FBrf0102121 |Broadie |1998 |2 REFM|FBrf0101416 |Amanai et al. |1998 |1 REFM|FBrf0056086 |Swanson and Ganguly |1992 |0 REFM|FBrf0057515 |Ganguly et al. |1992 |0 REFM|FBrf0126651 |Ashburner |1999.11 |9 REFM|FBrf0145821 |Acevedo and Skoulakis |2002 |1 REFM|FBrf0099136 |Broadie et al. |1997 |1 REFM|FBrf0133630 |Purdy et al. |2001 |1 REFM|FBrf0155512 |Pellettieri and Seydoux |2002 |2 REFM|FBrf0096484 |Tully et al. |1996 |2 REFM|FBrf0134535 |Zars |2000 |2 REFM|FBrf0147137 |Brody et al. |2002 |0 REFM|FBrf0099525 |Skoulakis et al. |1997 |1 REFM|FBrf0090801 |Skoulakis and Davis |1996 |0 REFM|FBrf0129944 |Li et al. |2000 |0 REFM|FBrf0058506 |McConnell and Hodges |1993 |9 REFM|FBrf0108310 |Zhou et al. |1999 |0 REFM|FBrf0139731 |Philip et al. |2001 |0 REFM|FBrf0159020 |Zhou et al. |2003 |0 REFM|FBrf0055263 |Swanson and Ganguly |1992 |1 REFM|FBrf0083714 |Meister and Braun |1995.10 |9 REFM|FBrf0125895 |Tallman et al. |2000 |1 REFM|FBrf0137492 |Oliver |2001.8.16 |9 REFM|FBrf0141765 |Waddell and Quinn |2001 |2 REFM|FBrf0100355 |Grotewiel et al. |1998 |0 REFM|FBrf0141665 |Sokolowski |2001 |2 REFM|FBrf0139721 |Su et al. |2001 |0 REFM|FBrf0093851 |Mlodzik |1997.5.10 |9 REFM|FBrf0037869 |Levy and Manning |1982 |0 REFM|FBrf0037868 |Levy et al. |1982 |0 REFM|FBrf0110590 |Prokop |1999 |2 REFM|FBrf0092060 |Amanai et al. |1997 |1 REFM|FBrf0123915 |SwissProt Project Members |1992.12.1 |9 REFM|FBrf0089671 |Han et al. |1996 |0 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0098203 |Broadie et al. |1997 |0 REFM|FBrf0130073 |Sekelsky et al. |2000 |0 REFM|FBrf0132177 |Gene Disruption Project members |2001- |9 REFM|FBrf0126031 |Johnson Hamlet and Perkins |2000 |1 REFM|FBrf0101895 |Dubnau and Tully |1998 |2 REFM|FBrf0099365 |Li et al. |1997 |0 REFM|FBrf0099854 |Belvin and Yin |1997 |2 REFM|FBrf0151992 |Jauch et al. |2002 |0 REFM|FBrf0107641 |Casci et al. |1999 |0 REFM|FBrf0052826 |Hyde et al. |1990 |0 REFM|FBrf0085952 |Skoulakis and Davis |1996 |1 REFM|FBrf0085951 |Skoulakis and Davis |1996 |1 REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0093549 |Kockel et al. |1997 |0 REFM|FBrf0079774 |Skoulakis |1995 |9 REFM|FBrf0111327 |Baek and Lee |1999 |2 REFM|FBrf0084657 |Amanai and Shearn |1996 |1 REFM|FBrf0050680 |Palazzolo et al. |1989 |0 REFM|FBrf0079419 |Skoulakis and Davis |1995 |1 REFM|FBrf0127283 |Raabe |2000 |2 REFM|FBrf0092345 |Li et al. |1997 |1 REFM|FBrf0137171 |Roman and Davis |2001 |2 REFM|FBrf0099843 |Isaksson et al. |1997 |0 REFM|FBrf0101626 |Skoulakis |1998 |1 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0107534 |Zhang et al. |1999 |0 REFM|FBrf0158832 |Ahringer |2003 |2 REFM|FBrf0103626 |Amanai et al. |1998 |1 REFM|FBrf0133552 |Skoulakis and Philip |2001 |1 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0133450 |Acevedo and Skoulakis |2001 |1 REFM|FBrf0098932 |Anonymous |1997 |2 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0104620 |Rommel and Hafen |1998 |2 REFM|FBrf0137068 |Davis |2001 |2 REFM|FBrf0095439 |Kockel et al. |1997 |0 } REFDSR { RDID|FBrf0037868 |Levy et al. |1982 CLOC|46E (determined by in situ hybridization) PHP|Identified as a cDNA clone that is expressed at a low frequency in |the body but abundantly in the head of the adult. SYN|549 } REFDSR { RDID|FBrf0037869 |Levy and Manning |1982 PHP|Developmental expression pattern of the cDNA clone is examined. SYN|549 } REFDSR { RDID|FBrf0050680 |Palazzolo et al. |1989 PHP|Identified as a cDNA clone that is expressed exclusively or predominantly |in the adult visual system. SYN|unnamed } REFDSR { RDID|FBrf0052826 |Hyde et al. |1990 CLOC|46E (determined by in situ hybridization) PHP|Identified as a cDNA clone that is expressed exclusively or predominantly |in the adult visual system. SYN|2G1 |549 } REFDSR { RDID|FBrf0056086 |Swanson and Ganguly |1992 CLOC|46E (determined by in situ hybridization) PHP|D14-3-3 has been characterized: gene expression is developmentally |regulated and predominantly expressed in the neural tissues of the |fly. } REFDSR { RDID|FBrf0057515 |Ganguly et al. |1992 SYN|549 } REFDSR { RDID|FBrf0058506 |McConnell and Hodges |1993 PHP|The alternate 5' end of Egfr reported by Schejter et al. (Cell 46: |1091--1101) is a cloning artefact and is actually from D14-3-3 of Swanson |and Ganguly (Gene 113: 183--190). } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|46E4--8 LOI|14-3-3&zgr;07103 MD|Identified with: D1325 BMD|Df(2R)X1 BMDD|Df(2R)12 BMDD|Df(2R)X3 } REFDSR { RDID|FBrf0079774 |Skoulakis |1995 CLOC|46E--F (determined by in situ hybridization) } REFDSR { RDID|FBrf0085951 |Skoulakis and Davis |1996 SYN|leonardo } REFDSR { RDID|FBrf0085952 |Skoulakis and Davis |1996 SYN|leonardo } REFDSR { RDID|FBrf0089671 |Han et al. |1996 SYN|unnamed } REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 CLOC|46E (determined by in situ hybridization) LOI|14-3-3&zgr;P1.3H |14-3-3&zgr;P1188 |14-3-3&zgr;P1375 PHP|@14-3-3&zgr;@ has a biological role in mushroom body-mediated learning and |memory processes. } REFDSR { RDID|FBrf0092060 |Amanai et al. |1997 SYN|leo } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 WTI|14-3-3&egr; (data from @14-3-3&zgr;2.3@, @14-3-3&zgr;P2355@, @14-3-3&zgr;X1@) SYN|leo } REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 PHP|Genetic studies indicate that @14-3-3&zgr;@ acts downstream of @Ras85D@ |and upstream of @phl@ in the developing eye disc. SYN|D14-3-3&zgr; } REFDSR { RDID|FBrf0095439 |Kockel et al. |1997 BMD|Df(2R)E73 } REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 WT|@14-3-3&zgr;@ may function in the activity-dependent regulation of synaptic |vesicle dynamics to control the pool of releaseable transmitter vesicles |at presynaptic fusion sites. OTH|@14-3-3&zgr;@ is strongly and specifically expressed in the presynaptic |boutons of the neuro muscular junction. PHP|In mutants the basic processes of synaptogenesis and excitation-secretion |coupling are not perturbed, but properties of synaptic modulation such |as transmission augmentation, high frequency transmission fidelity |and post-tetanic potentiation (PTP) are strongly impaired. SYN|leo } REFDSR { RDID|FBrf0099136 |Broadie et al. |1997 SYN|leonardo } REFDSR { RDID|FBrf0099365 |Li et al. |1997 WTI|faf |tor (data from @14-3-3&zgr;hs.PL@) SYN|leo } REFDSR { RDID|FBrf0099525 |Skoulakis et al. |1997 SYN|leo } REFDSR { RDID|FBrf0099843 |Isaksson et al. |1997 WTI|faf (data from @14-3-3&zgr;E16@) } REFDSR { RDID|FBrf0101184 |Hermon et al. |1998 SYN|14-3-3 } REFDSR { RDID|FBrf0101416 |Amanai et al. |1998 SYN|leo } REFDSR { RDID|FBrf0101626 |Skoulakis |1998 SYN|14-3-3 |leonardo } REFDSR { RDID|FBrf0102121 |Broadie |1998 SYN|leo } REFDSR { RDID|FBrf0102616 |Connolly and Tully |1998 SYN|14-3-3 } REFDSR { RDID|FBrf0104620 |Rommel and Hafen |1998 SYN|14-3-3 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|diacylglycerol-activated/phospholipid dependent protein kinase C inhibitor activity ; GO:0004863 | inferred from sequence similarity with MGD:Ywhaz; MGI:MGI:109484 |tryptophan hydroxylase activator activity ; GO:0016483 | inferred from sequence similarity with MGD:Ywhaz; MGI:MGI:109484 FNC|RAS protein signal transduction ; GO:0007265 | inferred from sequence similarity with SGD_LOCUS:BMH2; SGD:S0002506 |tryptophan hydroxylase activation ; GO:0006588 | inferred from sequence similarity with MGD:Ywhaz; MGI:MGI:109484 MD|Maps to clone: DS05181 GPD|14-3-3-protein } REFDSR { RDID|FBrf0107534 |Zhang et al. |1999 WTI|Src42A (data from @14-3-3&zgr;07103@) SYN|14-3-3 } REFDSR { RDID|FBrf0107641 |Casci et al. |1999 SYN|leo } REFDSR { RDID|FBrf0108310 |Zhou et al. |1999 MD|@14-3-3&zgr;@ can interact with and modulate @slo@ via @Slob@. The |binding between @14-3-3&zgr;@ and @Slob@ is regulated by calcium/calmodulin-dependent |kinase II phosphorylation. } REFDSR { RDID|FBrf0110590 |Prokop |1999 SYN|leo } REFDSR { RDID|FBrf0111327 |Baek and Lee |1999 SYN|14-3-3 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 CLOC|46E4--8 (determined by in situ hybridization) LOI|14-3-3&zgr;07103 BMD|Df(2R)X1 BMDD|Df(2R)12 BMDD|Df(2R)X3 SYN|14-3-3zeta } REFDSR { RDID|FBrf0123915 |SwissProt Project Members |1992.12.1 FNC|RAS protein signal transduction ; GO:0007265 | non-traceable author statement |cell proliferation ; GO:0008283 | non-traceable author statement |photoreceptor differentiation (sensu Drosophila) ; GO:0007467 | non-traceable author statement } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD18434 (BDGP-DGC) |Identified with: RH61958 (BDGP-DGC) |Identified with: RH57960 (BDGP-DGC) } REFDSR { RDID|FBrf0125895 |Tallman et al. |2000 MD|Gene order: Overall orientation not stated: Pfk? 14-3-3&zgr;? SYN|14-3-3 } REFDSR { RDID|FBrf0126031 |Johnson Hamlet and Perkins |2000 SYN|leonardo } REFDSR { RDID|FBrf0127283 |Raabe |2000 SYN|14-3-3 } REFDSR { RDID|FBrf0129944 |Li et al. |2000 SYN|leo } REFDSR { RDID|FBrf0133450 |Acevedo and Skoulakis |2001 SYN|D14-3-3&zgr; |leo } REFDSR { RDID|FBrf0133552 |Skoulakis and Philip |2001 SYN|leo } REFDSR { RDID|FBrf0134535 |Zars |2000 SYN|Leonardo-13-3-3 } REFDSR { RDID|FBrf0137068 |Davis |2001 SYN|leo } REFDSR { RDID|FBrf0137171 |Roman and Davis |2001 FNC|olfactory learning ; GO:0008355 | non-traceable author statement SYN|leo } REFDSR { RDID|FBrf0137492 |Oliver |2001.8.16 } REFDSR { RDID|FBrf0139721 |Su et al. |2001 FNC|chromosome segregation ; GO:0007059 | inferred from mutant phenotype WT|@14-3-3&zgr;@ is required for normal chromosome separation during syncytial |mitoses in the embryo. } REFDSR { RDID|FBrf0139731 |Philip et al. |2001 FNC|learning and/or memory ; GO:0007611 | inferred from mutant phenotype WT|Both isoforms of the @14-3-3&zgr;@ gene are required acutely (as opposed |to developmentally) for normal learning and memory. SYN|leo } REFDSR { RDID|FBrf0141665 |Sokolowski |2001 ENZ|protein kinase C inhibitor activity ; GO:0008426 | non-traceable author statement FNC|learning and/or memory ; GO:0007611 | non-traceable author statement } REFDSR { RDID|FBrf0141765 |Waddell and Quinn |2001 SYN|leo: leonardo } REFDSR { RDID|FBrf0145821 |Acevedo and Skoulakis |2002 SYN|leonardo } REFDSR { RDID|FBrf0147137 |Brody et al. |2002 SYN|4-3-3 zeta } REFDSR { RDID|FBrf0151992 |Jauch et al. |2002 SYN|leo } REFDSR { RDID|FBrf0155512 |Pellettieri and Seydoux |2002 SYN|par-5 } REFDSR { RDID|FBrf0158832 |Ahringer |2003 SYN|leo } REFDSR { RDID|FBrf0159690 |Chen et al. |2003 SYN|leo } ALESR { ASYM|14-3-3&zgr;07103 SYN|l(2)-07103 |l(2)K07103 |l(2)k07103 |leo07103 |14-3-307103 |l(2)0710307103 ID|FBal0008125 DBA|NA:Y12573 DIS|A. Spradling. TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 MU|P-element activity REF|FBrf0067338 |FBrf0159690 |FBrf0095439 |FBrf0093549 |FBrf0083714 |FBrf0093851 |FBrf0111489 |FBrf0107534 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 OTH|Complements: @CCS03221@. |Complements: @TER9403775@. |Complements: @Pfk06339@. |Complements: @l(2)k03610k03610@. |Complements: @l(2)k03610k03703@. |Complements: @l(2)k04308k04308@. |Complements: @l(2)k16104k16104@. TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 } REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 AMSO|The lethality is rescued by @14-3-3&zgr;arm.PK@. ARB|14-3-3&zgr;arm.PK MD|@P{PZ}@ insertion into the first intron, 1633bp downstream of the splice |donor site of exon I'. TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 MU|P-element activity PHC|lethal | recessive PHM|photoreceptor cell | somatic clone ALC|hypomorph PHI|Homozygous clones are recovered at low frequency and are small. Clones |in the eye frequently lack some photoreceptor cells in the ommatidia. SYN|l(2)-07103 } REFDSR { RDID|FBrf0095439 |Kockel et al. |1997 MD|@P{PZ}@ insertion in the 5' noncoding region. OTH|Insertion is 2.8kb downstream of the @Jra@ transcription unit. TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 MU|P-element activity } REFDSR { RDID|FBrf0107534 |Zhang et al. |1999 TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 GIC|suppressor | dominant of @Src42ASu(phl)1-1@ GII|Dominantly suppresses the ability of @Src42ASu(phl)1-1@ to suppress |the lethality of @phl1@/Y flies. SYN|l(2)K07103 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 PHC|lethal | recessive SYN|l(2)k07103 } REFDSR { RDID|FBrf0159690 |Chen et al. |2003 TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103 |BDGP:l(2)07103 SYN|leo07103 } SK|FBstBL-12335 |P{ry[+t7.2]=PZ}14-3-3zeta[07103] cn[1]/CyO; ry[506] } ALESR { ASYM|14-3-3&zgr;12BL SYN|14-3-312BL ID|FBal0065577 PHC|lethal | embryonic | recessive |neurophysiology defective PHM|epidermis | embryonic | lateral |epidermis | embryonic | dorsal ALC|loss of function PHI|Homozygous embryos exhibit incomplete dorsal migration of the lateral |epidermis and failure of dorsal epidermal closure. CNS and neuromusculature |appear morphologically normal and the mutant embryos exhibit coordinated |muscle movements similar to those observed in wild-type locomotion. |Synaptogenesis at the neuromuscular junction (NMJ) is largely normal. |Embryos also exhibit near normal physiological development and basal |excitation-secretion function at the NMJ. The amplitude and frequency |of endogenous excitatory junctional currents (EJCs) is reduced relative |to wild type. This reduced function originates in a presynaptic defect, |basal presynaptic function is mildly impaired. MEJC (miniature EJCs) |amplitude is not altered. NMJ exhibits a transmission defect, the |calcium dependence curve is shifted to the right indicating a higher |level of external calcium is required to achieve the given level of |secretion. Synaptic transmission fidelity and fatigue resistance properties |are impaired. Short-term facilitation is strengthened but synaptic |augmentation an potentiation are disrupted. REF|FBrf0098203 REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 MD|One partially deleted insertion in the first intron and the second |partially deleted insertion resides in the original location. PRG|14-3-3&zgr;P1.3H MU|P-element activity PHC|lethal | embryonic | recessive |neurophysiology defective PHM|epidermis | embryonic | lateral |epidermis | embryonic | dorsal ALC|loss of function PHI|Homozygous embryos exhibit incomplete dorsal migration of the lateral |epidermis and failure of dorsal epidermal closure. CNS and neuromusculature |appear morphologically normal and the mutant embryos exhibit coordinated |muscle movements similar to those observed in wild-type locomotion. |Synaptogenesis at the neuromuscular junction (NMJ) is largely normal. |Embryos also exhibit near normal physiological development and basal |excitation-secretion function at the NMJ. The amplitude and frequency |of endogenous excitatory junctional currents (EJCs) is reduced relative |to wild type. This reduced function originates in a presynaptic defect, |basal presynaptic function is mildly impaired. MEJC (miniature EJCs) |amplitude is not altered. NMJ exhibits a transmission defect, the |calcium dependence curve is shifted to the right indicating a higher |level of external calcium is required to achieve the given level of |secretion. Synaptic transmission fidelity and fatigue resistance properties |are impaired. Short-term facilitation is strengthened but synaptic |augmentation an potentiation are disrupted. } } ALESR { ASYM|14-3-3&zgr;2.3 SYN|leo2.3 |leo23 |14-3-32.3 ID|FBal0059634 REF|FBrf0093395 |FBrf0139731 |FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Deletion of the @P{lArB}@ insertion and portions of genomic sequence. PRG|14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|(with 14-3-3&zgr;P1375) memory defective |viable |memory defective PHI|Exhibits a decrement in the 3 to 240 minute memory performance. Transheterozygotes |with @14-3-3&zgr;P1375@ show a highly significant reduction in 3 minute memory. |Odor avoidance (octanol and benzaldehyde) is normal. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 GIC2|visible | dominant with @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ GIA2|ommatidium with @14-3-3&egr;j2B10@ |posterior crossvein with @14-3-3&egr;j2B10@ |eye with @14-3-3&egr;j2B10@ |photoreceptor cell with @14-3-3&egr;j2B10@ GII|@14-3-3&zgr;2.3@/+ @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ flies have slightly |roughened eyes, a low penetrance of missing photoreceptors and a gap |in the posterior crossvein of the wings in more than 50% of cases. SYN|leo2.3 } REFDSR { RDID|FBrf0139731 |Philip et al. |2001 ARB|14-3-3&zgr;LI.15.hs |14-3-3&zgr;LII.2.hs MD|Deletion in the intron between exons 1' and 2 of @14-3-3&zgr;@. PHC|viable |learning defective |memory defective PHI|No neuroanatomical aberrations are evident during development of the |brain. Flies show reduced performance in a modified olfactory trap |assay, using geraniol as the attractive odor, both immediately after |training and 90 mins after training. SYN|leo23 } } ALESR { ASYM|14-3-3&zgr;5.9 SYN|14-3-35.9 ID|FBal0059633 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. REF|FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Deletion of the @P{lArB}@ insertion and portions of genomic sequence. PRG|14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. } } ALESR { ASYM|14-3-3&zgr;7B SYN|14-3-37B ID|FBal0059632 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. REF|FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Deletion of a portion of the @P{lArB}@ insertion and genomic sequence. PRG|14-3-3&zgr;P1375 TRN|FBti0012515 == P{?lArB}14-3-3&zgr;7B MU|&Dgr;2-3 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. } } ALESR { ASYM|14-3-3&zgr;7BL SYN|14-3-37BL ID|FBal0065576 PHC|lethal | embryonic | recessive |neurophysiology defective PHM|epidermis | embryonic | lateral |epidermis | embryonic | dorsal ALC|hypomorph PHI|Homozygous embryos exhibit incomplete dorsal migration of the lateral |epidermis and failure of dorsal epidermal closure. CNS and neuromusculature |appear morphologically normal and the mutant embryos exhibit coordinated |muscle movements similar to those observed in wild-type locomotion. |Synaptogenesis at the neuromuscular junction (NMJ) is largely normal. |Embryos also exhibit near normal physiological development and basal |excitation-secretion function at the NMJ. The amplitude and frequency |of endogenous excitatory junctional currents (EJCs) is reduced relative |to wild type. This reduced function originates in a presynaptic defect, |basal presynaptic function is mildly impaired. MEJC (miniature EJCs) |amplitude is not altered. NMJ exhibits a transmission defect, the |calcium dependence curve is shifted to the right indicating a higher |level of external calcium is required to achieve the given level of |secretion. Synaptic transmission fidelity and fatigue resistance properties |are impaired. Short-term facilitation is strengthened but synaptic |augmentation an potentiation are disrupted. REF|FBrf0098203 REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 MD|Partially deleted insertion at the original location and a 500bp deletion |in intron two. PRG|14-3-3&zgr;P1375 MU|P-element activity PHC|lethal | embryonic | recessive |neurophysiology defective PHM|epidermis | embryonic | lateral |epidermis | embryonic | dorsal ALC|hypomorph PHI|Homozygous embryos exhibit incomplete dorsal migration of the lateral |epidermis and failure of dorsal epidermal closure. CNS and neuromusculature |appear morphologically normal and the mutant embryos exhibit coordinated |muscle movements similar to those observed in wild-type locomotion. |Synaptogenesis at the neuromuscular junction (NMJ) is largely normal. |Embryos also exhibit near normal physiological development and basal |excitation-secretion function at the NMJ. The amplitude and frequency |of endogenous excitatory junctional currents (EJCs) is reduced relative |to wild type. This reduced function originates in a presynaptic defect, |basal presynaptic function is mildly impaired. MEJC (miniature EJCs) |amplitude is not altered. NMJ exhibits a transmission defect, the |calcium dependence curve is shifted to the right indicating a higher |level of external calcium is required to achieve the given level of |secretion. Synaptic transmission fidelity and fatigue resistance properties |are impaired. Short-term facilitation is strengthened but synaptic |augmentation an potentiation are disrupted. } } ALESR { ASYM|14-3-3&zgr;9.8 SYN|14-3-39.8 ID|FBal0059631 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. REF|FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Deletion of the @P{lArB}@ insertion and portions of genomic sequence. PRG|14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. } } ALESR { ASYM|14-3-3&zgr;E16 SYN|E-16 |14-3-3E16 ID|FBal0060814 DBA|NA:Y12573 REF|FBrf0099843 |FBrf0093549 |FBrf0093851 REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 AMSO|The lethality is rescued by @14-3-3&zgr;tKa@ but not by @14-3-3&zgr;arm.PK@. ANRB|14-3-3&zgr;arm.PK ARB|14-3-3&zgr;tKa ARG2|FBgn0004907. MD|Imprecise excision of the @P{PZ}@ element, deleting 1957bp, including |exons I and I'. PRG|14-3-3&zgr;07103 MU|P-element activity PHC|lethal | recessive PHI|Homozygous clones are not recovered in a wild-type background or in |flies carrying @Ras85DV12.sev@, but are recovered in flies carrying |@phl::tor12D.hs.sev@. SYN|E-16 } REFDSR { RDID|FBrf0093851 |Mlodzik |1997.5.10 PRG|14-3-3&zgr;07103 MU|P-element activity } REFDSR { RDID|FBrf0099843 |Isaksson et al. |1997 GIA|suppressor | dominant of photoreceptor cell R1 | ectopic phenotype of @fafBX4@ |suppressor | dominant of photoreceptor cell R2 | ectopic phenotype of @fafBX4@ |suppressor | dominant of photoreceptor cell R3 | ectopic phenotype of @fafBX4@ |suppressor | dominant of photoreceptor cell R4 | ectopic phenotype of @fafBX4@ |suppressor | dominant of photoreceptor cell R5 | ectopic phenotype of @fafBX4@ |suppressor | dominant of photoreceptor cell R6 | ectopic phenotype of @fafBX4@ GII|The extra outer photoreceptor cell phenotype seen in @fafBX4@ homozygotes |is dominantly suppressed by @14-3-3&zgr;E16@, with the average number |of outer photoreceptor cells per ommatidium being reduced to 6.4. PHC|lethal | recessive } } ALESR { ASYM|14-3-3&zgr;E73 SYN|14-3-3E73 ID|FBal0063650 REF|FBrf0095439 REFDSR { RDID|FBrf0095439 |Kockel et al. |1997 MD|Deletion of the transcription start site and first exons. PRG|14-3-3&zgr;07103 MU|&Dgr;2-3 ABA|FBab0027145 == Df(2R)E73 SYN|unnamed } } ALESR { ASYM|14-3-3&zgr;KG02642 ID|FBal0137676 REF|FBrf0132177 REFDSR { RDID|FBrf0132177 |Gene Disruption Project members |2001- TRN|FBti0023409 == P{SUPor-P}14-3-3&zgr;KG02642 |BDGP:KG02642 } SK|FBstBL-14085 |y[1]; P{y[+mDint2] w[BR.E.BR]=SUPor-P}14-3-3zeta[KG02642]; ry[506] } ALESR { ASYM|14-3-3&zgr;P1188 SYN|leoP1188 |P1188 |14-3-3P1188 ID|FBal0059629 REF|FBrf0098203 |FBrf0089671 |FBrf0099365 |FBrf0129944 |FBrf0139731 |FBrf0090801 |FBrf0139721 REFDSR { RDID|FBrf0089671 |Han et al. |1996 PRG|FBti0004638 == FBti0000841 == P{lArB}A4.1M2 TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188 MU|&Dgr;2-3 SYN|unnamed } REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 PRG|FBti0004638 == FBti0000841 == P{lArB}A4.1M2 TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188 MU|&Dgr;2-3 PHC|lethal | embryonic | recessive PHI|Heterozygotes exhibit normal 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. SYN|unnamed } REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 MD|@P{lArB}@ insertion in the first intron. TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188 PHC|lethal | recessive |neurophysiology defective ALC|hypomorph PHI|Embryos do not exhibit a dorsal closure defect. |The amplitude and frequency of endogenous excitatory junctional currents |(EJCs) is reduced relative to wild type and the NMJ exhibits a transmission |defect, the calcium dependence curve is shifted to the right indicating |a higher level of external calcium is required to achieve the given |level of secretion. } REFDSR { RDID|FBrf0099365 |Li et al. |1997 PHM|embryonic/first instar larval cuticle | germ-line clone |denticle belt | germ-line clone |syncytial blastoderm | germ-line clone PHI|Embryos derived from homozygous female germline clones show a variable |phenotype that is not significantly different whether or not the embryos |contain a wild-type copy of @14-3-3&zgr;@ from the father. Approximately |50% of the embryos do not develop cuticles, and the remainder develop |cuticles with various segmentation defects including missing and/or |fused denticle bands. The Filzkorper appear normal. Approximately |50% of the embryos appear to stop development during the syncytial |blastoderm stage, and contain many fewer nuclei compared to wild-type. |Some of these nuclei appear fused. |18% of embryos carrying @14-3-3&zgr;hbNRE.RpII15@ and derived from homozygous |@14-3-3&zgr;P1188@ female germline clones have a wild-type anterior region |but are missing all or part of the posterior region. 56% of these |'anteriorly rescued' embryos have shortened Filzkorper. SYN|leoP1188 } REFDSR { RDID|FBrf0129944 |Li et al. |2000 SYN|leoP1188 } REFDSR { RDID|FBrf0139721 |Su et al. |2001 TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188 PHC|mitotic | recessive | maternal effect PHM|mitotic cycle | maternal effect PHI|Homozygous embryos show no apparent defects in the timing of mitotic |cycle 14 and show delayed mitosis after irradiation (as occurs in wild |type). |69 +/- 9% of mutant embryos derived from homozygous female germline |clones fail to cellularize. 54/59 of the embryos have defects in cell |division, including DNA bridges between telophase sister nuclei, asynchrony |in division within a single embryo, free microtubule-organizing centers |that are not associated with nuclei, loss of nuclei from the cortical |monolayer of nuclei and larger than normal yolk DNA masses. Chromosome |bridges interconnecting DNA masses are seen as early as telophase of |the fourth embryonic mitosis. Mitotic spindles do appear to be formed |in these embryos (as judged by the segregation of chromosome masses |that are still linked by DNA bridges to opposite spindle poles), and |attempts at the formation of mid-bodies are seen between segregating |nuclei, despite the presence of chromosome bridges. |Approximately 30% of embryos cellularize. These embryos have severe |gastrulation defects. SYN|P1188 } REFDSR { RDID|FBrf0139731 |Philip et al. |2001 ANRB|(with 14-3-3&zgr;P1375) 14-3-3&zgr;LII.2.hs |(with 14-3-3&zgr;P2335) 14-3-3&zgr;LII.2.hs |14-3-3&zgr;LI.15.hs |14-3-3&zgr;LII.2.hs APRB|(with 14-3-3&zgr;P1375) 14-3-3&zgr;LI.15.hs |(with 14-3-3&zgr;P2335) 14-3-3&zgr;LI.15.hs ARB|(with 14-3-3&zgr;P1375) 14-3-3&zgr;LI.15.hs |(with 14-3-3&zgr;P2335) 14-3-3&zgr;LI.15.hs MD|Insertion, in forward orientation, of @P{lArB}@ into the intron between |exons 1' and 2 of @14-3-3&zgr;@. TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188 PHC|lethal |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1375) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1375) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1375) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1375) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P2335) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P2335) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P2335) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P2335) learning defective PHI|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@ |and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning, |comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration |of learning by the transgenes decays back to mutant levels 60-70 hr |later. SYN|leoP1188 } } ALESR { ASYM|14-3-3&zgr;P1375 SYN|leoP1375 |14-3-3P1375 ID|FBal0059628 REF|FBrf0098203 |FBrf0089671 |FBrf0139731 |FBrf0090801 REFDSR { RDID|FBrf0089671 |Han et al. |1996 PRG|FBti0004638 == FBti0000841 == P{lArB}A4.1M2 TRN|FBti0009359 == P{lArB}14-3-3&zgr;P1375 MU|&Dgr;2-3 SYN|unnamed } REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 PRG|FBti0004638 == FBti0000841 == P{lArB}A4.1M2 TRN|FBti0009359 == P{lArB}14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|lethal | embryonic | recessive |(with 14-3-3&zgr;2.3) memory defective |(with 14-3-3&zgr;X1) memory defective PHI|Heterozygotes exhibit normal 3 minute memory performance. Transheterozygotes |with @14-3-3&zgr;X1@ or @14-3-3&zgr;2.3@ show a highly significant reduction in |3 minute memory. |Odor avoidance (octanol and benzaldehyde) is normal. SYN|unnamed } REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 MD|@P{lArB}@ insertion in the first intron. TRN|FBti0009359 == P{lArB}14-3-3&zgr;P1375 PHC|lethal | recessive } REFDSR { RDID|FBrf0139731 |Philip et al. |2001 ANRB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LII.2.hs |(with 14-3-3&zgr;P2335) 14-3-3&zgr;LII.2.hs APRB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LI.15.hs |14-3-3&zgr;LI.15.hs ARB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LI.15.hs |(with 14-3-3&zgr;P2335) 14-3-3&zgr;LI.15.hs |14-3-3&zgr;LI.15.hs |14-3-3&zgr;LII.2.hs MD|Insertion, in forward orientation, of @P{lArB}@ into the intron between |exons 1' and 2 of @14-3-3&zgr;@. TRN|FBti0009359 == P{lArB}14-3-3&zgr;P1375 PHC|lethal |(with 14-3-3&zgr;LI.15.hs) viable |(with 14-3-3&zgr;LI.15.hs) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) learning defective PHI|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@ |and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning, |comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration |of learning by the transgenes decays back to mutant levels 60-70 hr |later. SYN|leoP1375 } } ALESR { ASYM|14-3-3&zgr;P2335 SYN|leoP2335 ID|FBal0134434 PHC|lethal |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) learning defective PHI|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@ |and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning, |comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration |of learning by the transgenes decays back to mutant levels 60-70 hr |later. REF|FBrf0139731 REFDSR { RDID|FBrf0139731 |Philip et al. |2001 ANRB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LII.2.hs |(with 14-3-3&zgr;P1375) 14-3-3&zgr;LII.2.hs |14-3-3&zgr;LI.15.hs |14-3-3&zgr;LII.2.hs APRB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LI.15.hs ARB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LI.15.hs |(with 14-3-3&zgr;P1375) 14-3-3&zgr;LI.15.hs MD|Insertion, in forward orientation, of @P{?}@ into the intron between |exons 1' and 2 of @14-3-3&zgr;@. TRN|FBti0023266 == P{?}14-3-3&zgr;P2335 PHC|lethal |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) learning defective |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) viable |(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) learning defective PHI|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@ |and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning, |comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration |of learning by the transgenes decays back to mutant levels 60-70 hr |later. SYN|leoP2335 } } ALESR { ASYM|14-3-3&zgr;P2355 SYN|leoP2355 |14-3-3P2355 ID|FBal0062288 PHC|lethal | recessive PHI|Heterozygosity for @14-3-3&zgr;P2355@ does not alter the @Ras85DV12.sev@ |phenotype. REF|FBrf0093395 REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 GIC2|lethal | dominant with @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ PHC|lethal | recessive PHI|Heterozygosity for @14-3-3&zgr;P2355@ does not alter the @Ras85DV12.sev@ |phenotype. SYN|leoP2355 } } ALESR { ASYM|14-3-3&zgr;P1.3H SYN|14-3-3P1.3H ID|FBal0059630 REF|FBrf0098203 |FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|@P{lArB}@ insertion into the second intron. OTH|Weak @14-3-3&zgr;@ mutation. PRG|14-3-3&zgr;P1375 TRN|FBti0009381 == P{lArB}14-3-3&zgr;P1.3H MU|&Dgr;2-3 PHC|viable |memory defective PHI|Exhibits a decrement in the 3 and 45 minute memory performance. Memory |performance at 90 and 240 minutes is the same as controls. |Odor avoidance (octanol and benzaldehyde) is normal. } REFDSR { RDID|FBrf0098203 |Broadie et al. |1997 MD|Hop of the @P{lArB}@ insertion into intron 2. PRG|14-3-3&zgr;P1375 TRN|FBti0009381 == P{lArB}14-3-3&zgr;P1.3H MU|P-element activity PHC|viable } } ALESR { ASYM|14-3-3&zgr;R1 SYN|14-3-3R1 ID|FBal0059627 PHC|viable PHI|Normal memory performance over 3 to 240 minutes. |Odor avoidance (octanol and benzaldehyde) is normal. REF|FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Precise excision of the @P{lArB}@ insertion. PRG|14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|viable PHI|Normal memory performance over 3 to 240 minutes. |Odor avoidance (octanol and benzaldehyde) is normal. } } ALESR { ASYM|14-3-3&zgr;R2 SYN|14-3-3R2 ID|FBal0059626 PHC|viable PHI|Normal 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. REF|FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Precise excision of the @P{lArB}@ insertion. PRG|14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|viable PHI|Normal 3 minute memory performance. |Odor avoidance (octanol and benzaldehyde) is normal. } } ALESR { ASYM|14-3-3&zgr;X1 SYN|leoX.1 |leoX1 |14-3-3X1 ID|FBal0059625 REF|FBrf0093395 |FBrf0139731 |FBrf0090801 REFDSR { RDID|FBrf0090801 |Skoulakis and Davis |1996 MD|Deletion of the @P{lArB}@ insertion and portions of genomic sequence. PRG|14-3-3&zgr;P1375 MU|&Dgr;2-3 PHC|(with 14-3-3&zgr;P1375) memory defective |viable |memory defective PHI|Exhibits a decrement in the 3 minute memory performance. Transheterozygotes |with @14-3-3&zgr;P1375@ show a highly significant reduction in 3 minute memory. |Odor avoidance (octanol and benzaldehyde) is normal. } REFDSR { RDID|FBrf0093395 |Chang and Rubin |1997 GIC2|visible | dominant with @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ GIA2|ommatidium with @14-3-3&egr;j2B10@ |posterior crossvein with @14-3-3&egr;j2B10@ |eye with @14-3-3&egr;j2B10@ |photoreceptor cell with @14-3-3&egr;j2B10@ GII|@14-3-3&zgr;X1@/+ @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ flies have slightly |roughened eyes, a low penetrance of missing photoreceptors and a gap |in the posterior crossvein of the wings in more than 50% of cases. SYN|leoX.1 } REFDSR { RDID|FBrf0139731 |Philip et al. |2001 ARB|14-3-3&zgr;LI.15.hs |14-3-3&zgr;LII.2.hs MD|Deletion in the intron between exons 1' and 2 of @14-3-3&zgr;@. PHC|viable |learning defective |memory defective PHI|No neuroanatomical aberrations are evident during development of the |brain. Flies show reduced performance in a modified olfactory trap |assay, using geraniol as the attractive odor, both immediately after |training and 90 mins after training. SYN|leoX1 } } ALESR { ASYM|14-3-3&zgr;a.sev SYN|14-3-3a.sev ID|FBal0062287 PHM|photoreceptor cell PHI|Flies carrying @14-3-3&zgr;a.sev@ have a weakly penetrant loss of photoreceptor |cell phenotype. The outer photoreceptor cells are more severely affected. |Mode of assay: In transgenic Drosophila REF|FBrf0093549 REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 NAM|antisense sevenless promoter construct MD|Construct: A 1.0kb @14-3-3&zgr;@ cDNA fragment containing the complete open reading |frame is expressed in the antisense orientation under the control of |a @sev@ enhancer. MU|in vitro construct | regulatory fusion CNS|FBtp0008239 == P{sE.anti-14-3-3} PHM|photoreceptor cell PHI|Flies carrying @14-3-3&zgr;a.sev@ have a weakly penetrant loss of photoreceptor |cell phenotype. The outer photoreceptor cells are more severely affected. |Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|14-3-3&zgr;arm.PK SYN|14-3-3arm.PK ID|FBal0062286 PHC|wild-type PHI|Mode of assay: In transgenic Drosophila REF|FBrf0093549 REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 NAM|armadillo promoter construct of Kockel ARS|14-3-3&zgr;07103 AFS|14-3-3&zgr;E16 MD|Construct: A 1.0kb @14-3-3&zgr;@ cDNA fragment containing the complete open reading |frame is expressed under the control of an @arm@ promoter. MU|in vitro construct | regulatory fusion CNS|FBtp0015025 == P{arm-14-3-3&zgr;.K} PHC|wild-type PHI|Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|14-3-3&zgr;hbNRE.RpII15 SYN|14-3-3hbNRE.RpII15 ID|FBal0083670 PHM|embryo | posterior | germ-line clone |filzkorper | germ-line clone PHI|18% of embryos carrying @14-3-3&zgr;hbNRE.RpII15@ and derived from homozygous |@14-3-3&zgr;P1188@ female germline clones have a wild-type anterior region |but are missing all or part of the posterior region. 56% of these |'anteriorly rescued' embryos have shortened Filzkorper. |Mode of assay: In transgenic Drosophila REF|FBrf0099365 REFDSR { RDID|FBrf0099365 |Li et al. |1997 MD|Construct: A 1.4kb @RpII15@ promoter fragment drives expression of a 780bp @14-3-3&zgr;@ |cDNA which has a 150bp fragment from the @hb@ 3' untranslated region, |containing a @nos@-response element (NRE), fused to its 3' end. MU|in vitro construct | regulatory fusion CNS|FBtp0009043 == P{RpII15-14-3-3.hbNRE} PHM|embryo | posterior | germ-line clone |filzkorper | germ-line clone PHI|18% of embryos carrying @14-3-3&zgr;hbNRE.RpII15@ and derived from homozygous |@14-3-3&zgr;P1188@ female germline clones have a wild-type anterior region |but are missing all or part of the posterior region. 56% of these |'anteriorly rescued' embryos have shortened Filzkorper. |Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|14-3-3&zgr;hs.PL SYN|14-3-3hs.PL ID|FBal0083669 PHM|denticle belt PHI|Overexpression of @14-3-3&zgr;hs.PL@ in wild-type embryos results in deletion |of denticle bands. |Mode of assay: In transgenic Drosophila REF|FBrf0099365 REFDSR { RDID|FBrf0099365 |Li et al. |1997 NAM|heat shock construct of Li MD|Construct: A 780bp @14-3-3&zgr;@ cDNA is expressed under the control of an Hsp70 promoter. MU|in vitro construct | regulatory fusion CNS|FBtp0009042 == P{hs-14-3-3.L} GIA|suppressor | partially of embryonic/first instar larval cuticle phenotype of @torrv66@ GII|Overexpression of @14-3-3&zgr;hs.PL@ partly rescues the cuticle of |embryos derived from @torrv66@ females. PHM|denticle belt PHI|Overexpression of @14-3-3&zgr;hs.PL@ in wild-type embryos results in deletion |of denticle bands. |Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|14-3-3&zgr;LI.15.hs ID|FBal0134436 PHC|(with 14-3-3&zgr;P1375) learning defective |(with 14-3-3&zgr;P1375) viable |wild-type PHI|Mode of assay: In transgenic Drosophila REF|FBrf0139731 REFDSR { RDID|FBrf0139731 |Philip et al. |2001 AFS|14-3-3&zgr;P1188 |14-3-3&zgr;P2335 APR|(with 14-3-3&zgr;LII.2.hs) 14-3-3&zgr;P1375 |(with 14-3-3&zgr;LII.2.hs) 14-3-3&zgr;P1375/14-3-3&zgr;P1188 |(with 14-3-3&zgr;LII.2.hs) 14-3-3&zgr;P1375/14-3-3&zgr;P2335 |(with 14-3-3&zgr;LII.2.hs) 14-3-3&zgr;P1188/14-3-3&zgr;P2335 |14-3-3&zgr;P1188/14-3-3&zgr;P2335 |14-3-3&zgr;P1375 |14-3-3&zgr;P1375/14-3-3&zgr;P1188 ARS|14-3-3&zgr;2.3 |14-3-3&zgr;P1188/14-3-3&zgr;P2335 |14-3-3&zgr;P1375/14-3-3&zgr;P1188 |14-3-3&zgr;P1375/14-3-3&zgr;P2335 |14-3-3&zgr;X1 |14-3-3&zgr;P1375 AMSO|Induction with two 30 min heat shocks daily through embryonic, larval |and pupal stages rescues the lethal phenotype of @14-3-3&zgr;P1375@. |A single heat shock daily can also rescue to adulthood. |Shows heat-shock specific rescue of the learning and memory defects |of @14-3-3&zgr;X1@ and @14-3-3&zgr;2.3@. |Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@ |and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning, |comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration |of learning by the transgenes decays back to mutant levels 60-70 hr |later. MD|Construct: Expression of a @14-3-3&zgr;@ cDNA exons 1-6,7 is driven by a heat |shock promoter. MU|in vitro construct | regulatory fusion CNS|FBtp0015596 == P{hs-14-3-3&zgr;.LI.15} PHC|(with 14-3-3&zgr;P1375) learning defective |(with 14-3-3&zgr;P1375) viable |wild-type PHI|Mode of assay: In transgenic Drosophila } } ALESR { ASYM|14-3-3&zgr;LII.2.hs ID|FBal0134435 PHC|wild-type PHI|Mode of assay: In transgenic Drosophila REF|FBrf0139731 REFDSR { RDID|FBrf0139731 |Philip et al. |2001 AFS|14-3-3&zgr;P1188 |14-3-3&zgr;P1188/14-3-3&zgr;P2335 |14-3-3&zgr;P1375/14-3-3&zgr;P1188 |14-3-3&zgr;P1375/14-3-3&zgr;P2335 |14-3-3&zgr;P2335 APR|(with 14-3-3&zgr;LI.15.hs) 14-3-3&zgr;P1375 |(with 14-3-3&zgr;LI.15.hs) 14-3-3&zgr;P1375/14-3-3&zgr;P1188 |(with 14-3-3&zgr;LI.15.hs) 14-3-3&zgr;P1375/14-3-3&zgr;P2335 |(with 14-3-3&zgr;LI.15.hs) 14-3-3&zgr;P1188/14-3-3&zgr;P2335 ARS|14-3-3&zgr;2.3 |14-3-3&zgr;X1 |14-3-3&zgr;P1375 AMSO|Induction with two 30 min heat shocks daily through embryonic, larval |and pupal stages rescues the lethal phenotype of @14-3-3&zgr;P1375@. |A single heat shock daily can also rescue to adulthood. |Shows heat-shock specific rescue of the learning and memory defects |of @14-3-3&zgr;X1@ and @14-3-3&zgr;2.3@. |Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ and @14-3-3&zgr;LII.2.hs@ |show a 25-30% decrement in olfactory learning, comparable to that of |(rescued) @14-3-3&zgr;2.3@. The restoration of learning by the transgenes |decays back to mutant levels 60-70 hr later. MD|Construct: Expression of a @14-3-3&zgr;@ cDNA exons 1-6',7 is driven by a heat |shock promoter. MU|in vitro construct | regulatory fusion CNS|FBtp0015595 == P{hs-14-3-3&zgr;.LII.2} PHC|wild-type PHI|Mode of assay: In transgenic Drosophila } } ALESR { ASYM|14-3-3&zgr;sev.PK SYN|14-3-3sev.PK ID|FBal0062285 PHI|Flies carrying @14-3-3&zgr;a.sev@ appear wild-type. |Mode of assay: In transgenic Drosophila REF|FBrf0093549 REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 NAM|sevenless promoter construct of Kockel MD|Construct: A 1.0kb @14-3-3&zgr;@ cDNA fragment containing the complete open reading |frame is expressed in the sense orientation under the control of a |@sev@ enhancer. MU|in vitro construct | regulatory fusion CNS|FBtp0008238 == P{sE.14-3-3} PHI|Flies carrying @14-3-3&zgr;a.sev@ appear wild-type. |Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|14-3-3&zgr;tKa SYN|14-3-3tKa ID|FBal0062284 PHC|wild-type PHI|Mode of assay: In transgenic Drosophila REF|FBrf0093549 REFDSR { RDID|FBrf0093549 |Kockel et al. |1997 ARS|14-3-3&zgr;E16 MD|Construct: 13.5kb genomic fragment containing the entire coding region and 1.7kb |of upstream and downstream sequences. MU|in vitro construct | rescue fragment CNS|FBtp0008237 == P{14-3-3&zgr;tKa} PHC|wild-type PHI|Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|14-3-3&zgr;+ ID|FBal0066544 CLA|wild-type generic REF|FBrf0105495 } IFL|../torstoll/leonrd1.htm SKC|2 } # EOR GENR { RETE|ID 1 FBgn0010340 CLA 1 Gene NAM 1 upstream of RpII140 GSYM 1 140up DT 1 14 Aug 03 RESZ 5571 PTD 1 DBA 16 FNC 1 biological_process unknown CEL 1 cellular_component unknown CLOC 1 88A9 ALESR 5 REF 11 GSYM|140up PTD ARGS DT|14 Aug 03 ID|FBgn0010340 UAB|Deficiency: Df(3R)red-P52 |Duplication: Dp(3;2)ry+ (inferred from cytology) SYN|CG9852 |DmRP140-upstream |l(3)Z6 |DmRP140up |l(3)88Ba ID2|FBgn0004843 NAM|upstream of RpII140 KLOC|112472 CLOC|88A9 |Limits computationally determined from genome sequence between l(3)01949 and l(3)j14A6/l(3)00347 FNC|biological_process unknown ; GO:0000004 | no biological data available CEL|cellular_component unknown ; GO:0008372 | no biological data available GLOC|Maps to the right of RpII140: 0.02 GLC|@140upZ6@ maps 0.02cM from @RpII140Z24@, with @140up@ probably |lying proximal to @RpII140@. ENZ|molecular_function unknown ; GO:0005554 | no biological data available DBA|NA:AA941870 |BDGP-DGC:LD27182 |NA:AC007441 |BDGP:BACR10E03 |NA:AC007904 |BDGP:BACR01H04 |NA:AE003703 |PA:AAF55023 |NA:AW942742 |BDGP-DGC:LD27182 |NA:AY058577 |PA:AAL13806 |BDGP-DGC:LD27182 |NA:M62973 |NA:M62975 |PA:AAD40352 PAC|SWP:P81928 PHP|All known alleles are recessive lethals. ASQ|FBan0009852 REF { REFM|FBrf0120782 |Sitzler |1999.8.31 |9 REFM|FBrf0058600 |Hamilton et al. |1993 |0 REFM|FBrf0120781 |Sitzler |1999.8.31 |9 REFM|FBrf0126702 |Zheng |1999.11 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0056267 |Mortin et al. |1992 |0 REFM|FBrf0054010 |Sitzler et al. |1991 |0 REFM|FBrf0092726 |Wiedemann et al. |1997 |0 REFM|FBrf0058349 |Oldenburg et al. |1993 |1 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0054607 |Breen and Harte |1991 |0 } REFDSR { RDID|FBrf0054010 |Sitzler et al. |1991 SYN|DmRP140-upstream } REFDSR { RDID|FBrf0054607 |Breen and Harte |1991 BMD|Df(3R)JY19 BMD|Df(3R)red-P52 BMDD|Df(3R)JY28 BMDD|Df(3R)red-P6 BMDD|Df(3R)red-P93 BMDD|Df(3R)red2l BMDD|Df(3R)su(Hw)V BMDD|Df(3R)trxE12 BMDD|T(Y;3)redP4 SYN|l(3)Z6 } REFDSR { RDID|FBrf0056267 |Mortin et al. |1992 BMD|Df(3R)red-P1 BMD|Df(3R)red-P52 BMDD|Df(3R)293&ggr;5 BMDD|Df(3R)red-P6 BMDD|Df(3R)red-P93 BMDD|Df(3R)su(Hw)V } REFDSR { RDID|FBrf0058600 |Hamilton et al. |1993 GLOC|Maps to the right of RpII140: 0.02 GLC|@140upZ6@ maps 0.02cM from @RpII140Z24@, with @140up@ probably |lying proximal to @RpII140@. } REFDSR { RDID|-1793994161 ENZ|molecular_function unknown ; GO:0005554 | no biological data available FNC|biological_process unknown ; GO:0000004 | no biological data available CEL|cellular_component unknown ; GO:0008372 | no biological data available } REFDSR { RDID|FBrf0092726 |Wiedemann et al. |1997 PHP|Sequences important for the transcription of @RpII140@ are located |in the untranslated leader of the divergently transcribed @140up@ gene. SYN|DmRP140up } REFDSR { RDID|FBrf0105495 |FlyBase |1992- MD|Maps to clone: BACR01H04 |Maps to clone: BACR10E03 } REFDSR { RDID|FBrf0120781 |Sitzler |1999.8.31 SYN|unnamed } REFDSR { RDID|FBrf0120782 |Sitzler |1999.8.31 MD|Gene order: Overall orientation not stated: 140up- RpII140+ SYN|DmRP140-upstream } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD27182 (BDGP-DGC) } REFDSR { RDID|FBrf0126702 |Zheng |1999.11 AM|Source for identity of: 140up CG9852 } ALESR { ASYM|140upM13 ID|FBal0031933 PHC|lethal | recessive REF|FBrf0056267 REFDSR { RDID|FBrf0056267 |Mortin et al. |1992 MU|ethyl methanesulfonate PHC|lethal | recessive } } ALESR { ASYM|140upZ6 SYN|Z6 ID|FBal0031936 PHC|lethal | recessive REF|FBrf0054607 |FBrf0058600 |FBrf0056267 REFDSR { RDID|FBrf0056267 |Mortin et al. |1992 MU|ethyl methanesulfonate PHC|lethal | recessive } REFDSR { RDID|FBrf0058600 |Hamilton et al. |1993 SYN|Z6 } } ALESR { ASYM|140upZ29 SYN|Z29 ID|FBal0031934 PHC|lethal | recessive REF|FBrf0058600 |FBrf0056267 REFDSR { RDID|FBrf0056267 |Mortin et al. |1992 MU|ethyl methanesulfonate PHC|lethal | recessive } REFDSR { RDID|FBrf0058600 |Hamilton et al. |1993 SYN|Z29 } } ALESR { ASYM|140upZ30 SYN|Z30 ID|FBal0031935 PHC|lethal | recessive REF|FBrf0058600 |FBrf0056267 REFDSR { RDID|FBrf0056267 |Mortin et al. |1992 MU|ethyl methanesulfonate PHC|lethal | recessive } REFDSR { RDID|FBrf0058600 |Hamilton et al. |1993 SYN|Z30 } } ALESR { ASYM|140up+ ID|FBal0066317 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0004951 CLA 1 repetitive element NAM 1 1.688 satellite-related 10Ea GSYM 1 1688-10Ea DT 1 14 Aug 03 RESZ 1081 DBA 3 WT 3 Euchromatic sequences of unknown function similar CLOC 1 10E1--2 REF 3 GSYM|1688-10Ea DT|14 Aug 03 ID|FBgn0004951 CLA|repetitive_element UAB|Deficiency: Df(1)HA85 (inferred from cytology) |Duplication: Dp(1;2)v+65b (inferred from cytology) SYN|1.688 |1688-10Ed NAM|1.688 satellite-related 10Ea KLOC|14316-2402 GLOC|1-[36] CLOC|10E1--2 |Right limit from molecular mapping relative to 1688-10Eb (FBrf0057386) WT|Euchromatic sequences of unknown function similar, in their sequence, to |the 1.688 @satDNA@ repeat. It has been suggested (FBrf0057386) that they |may be required for some sex chromosome specific function. DBA|NA:X62938 |NA:Z50388 |dbSTS:24350 REF { REFM|FBrf0057386 |DiBartolomeis et al. |1992 |0 REFM|FBrf0080225 |Madueno et al. |1995 |0 REFM|FBrf0100592 |Law et al. |1998 |0 } REFDSR { RDID|FBrf0057386 |DiBartolomeis et al. |1992 OTH|The X linked SR sequences may be required for sex chromosome specific functions. } REFDSR { RDID|FBrf0080225 |Madueno et al. |1995 SYN|1.688 } } # EOR GENR { RETE|ID 1 FBgn0004952 CLA 1 repetitive element NAM 1 1.688 satellite-related 10Eb GSYM 1 1688-10Eb DT 1 14 Aug 03 RESZ 1274 DBA 3 WT 3 Euchromatic sequences of unknown function similar CLOC 1 10E1--2 REF 4 GSYM|1688-10Eb DT|14 Aug 03 ID|FBgn0004952 CLA|repetitive_element UAB|Deficiency: Df(1)HA85 (inferred from cytology) |Duplication: Dp(1;2)v+65b (inferred from cytology) SYN|1.688 |1688-10Ep NAM|1.688 satellite-related 10Eb KLOC|14316-2402 GLOC|1-[36] CLOC|10E1--2 |Left limit from in situ hybridization (FBrf0057386) |Right limit from in situ hybridization (FBrf0057386) CYC|Experimentally determined: 10E1--2 WT|Euchromatic sequences of unknown function similar, in their sequence, to |the 1.688 @satDNA@ repeat. It has been suggested (FBrf0057386) that they |may be required for some sex chromosome specific function. DBA|NA:X62937 |NA:Z32192 |dbSTS:4743 REF { REFM|FBrf0057386 |DiBartolomeis et al. |1992 |0 REFM|FBrf0071734 |EDGP Project Members |1994- |9 REFM|FBrf0080225 |Madueno et al. |1995 |0 REFM|FBrf0100592 |Law et al. |1998 |0 } REFDSR { RDID|FBrf0057386 |DiBartolomeis et al. |1992 CLOC|10E1--2 (determined by in situ hybridization) OTH|The X linked SR sequences may be required for sex chromosome specific functions. } REFDSR { RDID|FBrf0080225 |Madueno et al. |1995 SYN|1.688 } } # EOR GENR { RETE|ID 1 FBgn0004953 CLA 1 repetitive element NAM 1 1.688 satellite-related 11EF GSYM 1 1688-11EF DT 1 14 Aug 03 RESZ 1034 WT 3 Euchromatic sequences of unknown function similar CLOC 1 11E--F REF 4 GSYM|1688-11EF DT|14 Aug 03 ID|FBgn0004953 CLA|repetitive_element UAB|Deficiency: Df(1)C246 (inferred from cytology) |Duplication: Dp(1;3)rasv (inferred from cytology) SYN|1.688 NAM|1.688 satellite-related 11EF KLOC|15780-16183 GLOC|1-[41] CLOC|11E--F WT|Euchromatic sequences of unknown function similar, in their sequence, to |the 1.688 @satDNA@ repeat. It has been suggested (FBrf0057386) that they |may be required for some sex chromosome specific function. REF { REFM|FBrf0057386 |DiBartolomeis et al. |1992 |0 REFM|FBrf0047217 |Waring and Pollack |1987 |0 REFM|FBrf0080225 |Madueno et al. |1995 |0 REFM|FBrf0100592 |Law et al. |1998 |0 } REFDSR { RDID|FBrf0057386 |DiBartolomeis et al. |1992 OTH|The X linked SR sequences may be required for sex chromosome specific functions. } REFDSR { RDID|FBrf0080225 |Madueno et al. |1995 SYN|1.688 } } # EOR GENR { RETE|ID 1 FBgn0027098 CLA 1 repetitive element GSYM 1 1688-2E DT 1 14 Aug 03 RESZ 186 DBA 1 REF 1 GSYM|1688-2E DT|14 Aug 03 ID|FBgn0027098 CLA|repetitive_element DBA|NA:AJ238704 REF { REFM|FBrf0107580 |Alatortsev et al. |1998 |0 } } # EOR GENR { RETE|ID 1 FBgn0004950 CLA 1 repetitive element NAM 1 1.688 satellite-related 3C GSYM 1 1688-3C DT 1 14 Aug 03 RESZ 1232 DBA 3 WT 3 Euchromatic sequences of unknown function similar CLOC 1 3C REF 4 GSYM|1688-3C DT|14 Aug 03 ID|FBgn0004950 CLA|repetitive_element UAB|Deficiency: Df(1)z1 (inferred from cytology) |Duplication: Dp(1;Y)w+303 (inferred from cytology) SYN|1.688 NAM|1.688 satellite-related 3C KLOC|3069 GLOC|1-[1.5] CLOC|3C |Left limit from in situ hybridization (FBrf0057386) |Right limit from in situ hybridization (FBrf0057386) CYC|Experimentally determined: 3C WT|Euchromatic sequences of unknown function similar, in their sequence, to |the 1.688 @satDNA@ repeat. It has been suggested (FBrf0057386) that they |may be required for some sex chromosome specific function. DBA|NA:X62939 |NA:Z32250 |dbSTS:4802 REF { REFM|FBrf0057386 |DiBartolomeis et al. |1992 |0 REFM|FBrf0071734 |EDGP Project Members |1994- |9 REFM|FBrf0080225 |Madueno et al. |1995 |0 REFM|FBrf0100592 |Law et al. |1998 |0 } REFDSR { RDID|FBrf0057386 |DiBartolomeis et al. |1992 CLOC|3C (determined by in situ hybridization) OTH|The X linked SR sequences may be required for sex chromosome specific functions. } REFDSR { RDID|FBrf0080225 |Madueno et al. |1995 SYN|1.688 } } # EOR GENR { RETE|ID 1 FBgn0000004 CLA 1 transposable element NAM 1 17.6 element GSYM 1 17.6 DT 1 14 Aug 03 RESZ 9320 DBA 29 WT 3 A retroviral-like transposable element REF 73 GSYM|17.6 DT|14 Aug 03 ID|FBgn0000004 CLA|transposable_element SYN|17.6S |176 |Dme176V NAM|17.6 element AM|encoded genes: @17.6\env@, @17.6\gag@, @17.6\pol@ TE|element type: LTR retrotransposon |terminal repeat length in bp: 512 |total length in bp: 7439 |target site duplication length in bp: 4 |number of copies in genome: 40 (FBrf0040123) WT|A retroviral-like transposable element. First described by Saigo et al. |(FBrf0036029) as a sequence inserted into histone genes and hybridizing to |@297@ elements. DBA|NA:AL008791 |dbSTS:53385 |NA:L39084 |NA:M31561 |NA:M31562 |NA:M31563 |NA:M31564 |NA:M31565 |NA:M31566 |NA:M31567 |NA:M31569 |NA:M31570 |NA:M31571 |NA:M31573 |NA:M31574 |NA:V01517 |NA:V01518 |NA:X01472 |NA:X79394 |NA:Z31854 |dbSTS:4392 |NA:Z32251 |dbSTS:4803 |NA:Z32339 |dbSTS:4891 |NA:Z70850 |dbSTS:33719 |NA:Z71029 |dbSTS:33525 PAC|MEROPS:A02.052 REV|FBrf0100335 |FBrf0152077 REF { REFM|FBrf0131051 |Marin and Llorens |2000 |0 REFM|FBrf0151719 |Tulin et al. |2002 |0 REFM|FBrf0057228 |Kulkosky et al. |1992 |0 REFM|FBrf0116414 |Inouye |1995.1.24 |9 REFM|FBrf0128568 |Maside et al. |2000 |0 REFM|FBrf0055613 |de Frutos et al. |1992 |0 REFM|FBrf0116412 |Inouye |1995.1.24 |9 REFM|FBrf0116411 |Inouye |1995.1.24 |9 REFM|FBrf0116410 |Inouye |1995.1.24 |9 REFM|FBrf0056185 |von Sternberg et al. |1992 |2 REFM|FBrf0040123 |Kugimiya et al. |1983 |0 REFM|FBrf0111953 |Losada et al. |1999 |0 REFM|FBrf0053865 |Arkhipova and Ilyin |1991 |0 REFM|FBrf0151415 |Lerat et al. |2002 |9 REFM|FBrf0116409 |Inouye |1995.1.24 |9 REFM|FBrf0116408 |Inouye |1995.1.24 |9 REFM|FBrf0116407 |Inouye |1995.1.24 |9 REFM|FBrf0116406 |Inouye |1995.1.24 |9 REFM|FBrf0116405 |Inouye |1995.1.24 |9 REFM|FBrf0048585 |Huijser et al. |1988 |0 REFM|FBrf0116404 |Inouye |1995.1.24 |9 REFM|FBrf0071734 |EDGP Project Members |1994- |9 REFM|FBrf0116403 |Inouye |1995.1.24 |9 REFM|FBrf0116402 |Inouye |1995.1.24 |9 REFM|FBrf0106414 |Desset et al. |1999 |0 REFM|FBrf0144916 |Rizzon et al. |2002 |0 REFM|FBrf0111944 |Lerat and Capy |1999 |0 REFM|FBrf0051101 |Sandmeyer et al. |1990 |2 REFM|FBrf0079059 |Mozer and Benzer |1993 |1 REFM|FBrf0079058 |Mozer and Benzer |1991 |1 REFM|FBrf0080225 |Madueno et al. |1995 |0 REFM|FBrf0054202 |Kim and Belyaeva |1991 |0 REFM|FBrf0059271 |Delpuech et al. |1993 |0 REFM|FBrf0152077 |Pelisson et al. |2002 |2 REFM|FBrf0079937 |Charlesworth et al. |1994 |0 REFM|FBrf0099812 |Terzian et al. |1997 |0 REFM|FBrf0041561 |Saigo et al. |1984 |0 REFM|FBrf0054653 |McClure |1991 |0 REFM|FBrf0079992 |Ding and Lipshitz |1994 |0 REFM|FBrf0074490 |Sniegowski and Charlesworth |1994 |0 REFM|FBrf0036029 |Saigo et al. |1981 |0 REFM|FBrf0102359 |Makarova et al. |1995 |0 REFM|FBrf0129733 |Biemont et al. |1999 |2 REFM|FBrf0125337 |Boeke and Corces |1989 |2 REFM|FBrf0073975 |Mozer and Benzer |1994 |0 REFM|FBrf0138423 |Bowen and McDonald |2001 |0 REFM|FBrf0052837 |Harada et al. |1990 |0 REFM|FBrf0054937 |Jarrell and Meselson |1991 |0 REFM|FBrf0125292 |Xiong and Eickbush |1990 |0 REFM|FBrf0111330 |Biemont and Cizeron |1999 |0 REFM|FBrf0041549 |Inouye et al. |1984 |0 REFM|FBrf0134868 |Haoudi and Mason |2000 |2 REFM|FBrf0078388 |Finnegan |1992 |0 REFM|FBrf0127032 |Canizares et al. |2000 |0 REFM|FBrf0083460 |Suh et al. |1995 |0 REFM|FBrf0057833 |Kanda and Saigo |1993 |0 REFM|FBrf0098551 |Suh et al. |1994 |1 REFM|FBrf0100335 |Britten |1997 |2 REFM|FBrf0105736 |Kanapin and Ivanov |1998 |0 REFM|FBrf0127224 |Marsano et al. |2000 |0 REFM|FBrf0149106 |Bartolome et al. |2002 |0 REFM|FBrf0057534 |Waters et al. |1992 |0 REFM|FBrf0149104 |Vieira et al. |2002 |0 REFM|FBrf0051918 |Voelker et al. |1990 |0 REFM|FBrf0111776 |Andrianov et al. |1999 |0 REFM|FBrf0052879 |Scheinker et al. |1990 |0 REFM|FBrf0111510 |Vieira et al. |1999 |0 REFM|FBrf0130256 |Lerat et al. |1999 |0 REFM|FBrf0045140 |Inouye et al. |1986 |0 REFM|FBrf0109043 |Rutsov et al. |1999 |0 REFM|FBrf0054718 |Kim and Belyaeva |1991 |0 REFM|FBrf0055481 |Arkhipova and Ilyin |1992 |2 REFM|FBrf0108981 |Pantazidis et al. |1999 |0 } REFDSR { RDID|FBrf0052837 |Harada et al. |1990 OTH|Transposition rates of mobile elements in lines AW and JH, in which |spontaneous mutations have accumulated for about 400 generations, are |studied. @412@ and @17.6@ elements rate of transposition is very low, |@I-element@ and @hobo@ insertions occur much more frequently. } REFDSR { RDID|FBrf0059271 |Delpuech et al. |1993 WT|Presence or absence of a long terminal repeat of 17.6 does not correlate |with resistance or susceptibility to DDT in 31 strains of D.melanogaster |and D.simulans from around the world. } REFDSR { RDID|FBrf0074490 |Sniegowski and Charlesworth |1994 WT|Element copy numbers on inversion and standard chromosomes has been |determined. The copy number is significantly higher within low frequency |inversions than within the corresponding standard chromosome regions. } REFDSR { RDID|FBrf0079937 |Charlesworth et al. |1994 WT|Estimating the genomic numbers of transposable elements demonstrates |many families of element are over-represented in heterochromatin. } REFDSR { RDID|FBrf0079992 |Ding and Lipshitz |1994 WT|The spatial and temporal expression patterns of fifteen families of |retrotransposons are analyzed during embryogenesis and are found to |be conserved. Results suggest that all families carry cis-acting elements |that control their spatial and temporal expression patterns. } REFDSR { RDID|FBrf0083460 |Suh et al. |1995 PHP|The chromosomal distribution of a number of retrotransposons in an |isolated population of D.melanogaster (from Ishigaki Island, Okinawa, |Japan) has been determined. } REFDSR { RDID|FBrf0099812 |Terzian et al. |1997 OTH|Used in an investigation to address the relationship between retrotransposons |and retroviruses and the coadaptation of these retroelements to their |host genomes. Results indicate retrotransposons are heterogeneous |in contrast to retroviruses, suggesting different modes of evolution |by slippage-like mechanisms. } REFDSR { RDID|FBrf0116402 |Inouye |1995.1.24 SYN|17.6S } REFDSR { RDID|FBrf0116403 |Inouye |1995.1.24 SYN|17.6S } REFDSR { RDID|FBrf0116404 |Inouye |1995.1.24 SYN|17.6S } REFDSR { RDID|FBrf0116405 |Inouye |1995.1.24 SYN|17.6S } REFDSR { RDID|FBrf0116406 |Inouye |1995.1.24 SYN|17.6S } REFDSR { RDID|FBrf0116407 |Inouye |1995.1.24 SYN|17.6S } REFDSR { RDID|FBrf0116408 |Inouye |1995.1.24 SYN|17.6S } REFDSR { RDID|FBrf0116409 |Inouye |1995.1.24 SYN|17.6S } REFDSR { RDID|FBrf0116410 |Inouye |1995.1.24 SYN|17.6S } REFDSR { RDID|FBrf0116411 |Inouye |1995.1.24 SYN|17.6S } REFDSR { RDID|FBrf0116412 |Inouye |1995.1.24 SYN|17.6S } REFDSR { RDID|FBrf0116414 |Inouye |1995.1.24 SYN|17.6S } REFDSR { RDID|FBrf0151719 |Tulin et al. |2002 SYN|176 } REFDSR { RDID|FBrf0152077 |Pelisson et al. |2002 SYN|Dme176V } } # EOR GENR { RETE|ID 1 FBgn0027624 CLA 1 transposable element gene GSYM 1 17.6\env DT 1 14 Aug 03 RESZ 572 DBA 2 ALESR 1 REF 4 GSYM|17.6\env DT|14 Aug 03 ID|FBgn0027624 CLA|transposable_element_gene AM|encoded by: @17.6@ DBA|NA:X01472 |PA:CAA25703 PAC|PIR:A03326 |SWP:P04283 REV|FBrf0152077 REF { REFM|FBrf0106414 |Desset et al. |1999 |0 REFM|FBrf0152077 |Pelisson et al. |2002 |2 REFM|FBrf0130256 |Lerat et al. |1999 |0 REFM|FBrf0111944 |Lerat and Capy |1999 |0 } ALESR { ASYM|17.6\env+ ID|FBal0105454 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0044339 CLA 1 transposable element gene GSYM 1 17.6\gag DT 1 14 Aug 03 RESZ 393 PDOM 3 INTERPRO:IPR001584 == Integrase, catalytic core DBA 2 ALESR 1 GSYM|17.6\gag DT|14 Aug 03 ID|FBgn0044339 CLA|transposable_element_gene AM|encoded by: @17.6@ PDOM|IPR001584 == Integrase, catalytic core |IPR001969 == Eukaryotic and viral aspartic protease active site |IPR001995 == Retroviral-type aspartic protease DBA|NA:X01472 |PA:CAA25701 PAC|PIR:A03325 |SWP:P04282 ALESR { ASYM|17.6\gag+ ID|FBal0122862 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0014453 CLA 1 transposable element gene NAM 1 17.6 element transposase GSYM 1 17.6\pol DT 1 14 Aug 03 RESZ 938 PDOM 1 INTERPRO:IPR000477 == RNA-directed DNA polymerase (Reverse transcriptase) DBA 2 WT 1 The transposase encoded by the @17.6@ element ALESR 1 REF 3 GSYM|17.6\pol DT|14 Aug 03 ID|FBgn0014453 CLA|transposable_element_gene SYN|17.6\T |17.6 element transposase AM|encoded by: @17.6@ WT|The transposase encoded by the @17.6@ element. PDOM|IPR000477 == RNA-directed DNA polymerase (Reverse transcriptase) NAM|17.6 element transposase DBA|NA:X01472 |PA:CAA25702 PAC|PIR:A03971 |SWP:P04323 REF { REFM|FBrf0106414 |Desset et al. |1999 |0 REFM|FBrf0111944 |Lerat and Capy |1999 |0 REFM|FBrf0073975 |Mozer and Benzer |1994 |0 } REFDSR { RDID|FBrf0073975 |Mozer and Benzer |1994 NAM|17.6 element transposase WT|The regulation of transcription of the @17.6@ retrotransposon provides |a model for the study of innervation-dependent gene expression in postsynaptic |cells during neurogenesis. } ALESR { ASYM|17.6\pol+ ID|FBal0105302 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0000007 CLA 1 transposable element NAM 1 1731 element GSYM 1 1731 DT 1 14 Aug 03 RESZ 10484 DBA 3 WT 5 A retroviral-like transposable element REF 65 GSYM|1731 DT|14 Aug 03 ID|FBgn0000007 CLA|transposable_element SYN|17.31 NAM|1731 element AM|encoded genes: @1731\LTR@, @1731\RTase@, @1731\gag@ TE|element type: LTR retrotransposon |terminal repeat length in bp: 336 |number of copies in genome: 10 |total length in bp: 4648 (FBrf0045155) |target site duplication length in bp: 5 (FBrf0045155) WT|A retroviral-like transposable element. The first @1731@ element was |identified because its transcription in tissue-culture cells is reduced in |the presence of 20-hydroxyecdysone (FBrf0045155). In cell lines the |transcription of @1731@ is down-regulated by ecdysteroids (FBrf0053421; |FBrf0054856). DBA|NA:X04686 |NA:X04874 |NA:X07656 REF { REFM|FBrf0058493 |Kim et al. |1993 |0 REFM|FBrf0134799 |van Steensel et al. |2001 |9 REFM|FBrf0105935 |Slama-Schwok et al. |1998 |0 REFM|FBrf0067697 |Fourcade-Peronnet et al. |1994 |1 REFM|FBrf0057228 |Kulkosky et al. |1992 |0 REFM|FBrf0090548 |Faure et al. |1996 |0 REFM|FBrf0056591 |Fourcade-Peronnet et al. |1992 |0 REFM|FBrf0079108 |Nuzhdin and Mackay |1995 |9 REFM|FBrf0064626 |Nahon et al. |1993 |0 REFM|FBrf0055481 |Arkhipova and Ilyin |1992 |2 REFM|FBrf0155500 |Maggert and Golic |2002 |0 REFM|FBrf0144916 |Rizzon et al. |2002 |0 REFM|FBrf0059024 |Montchamp-Moreau et al. |1993 |0 REFM|FBrf0128568 |Maside et al. |2000 |0 REFM|FBrf0054856 |Ziarczyk and Best-Belpomme |1991 |0 REFM|FBrf0079937 |Charlesworth et al. |1994 |0 REFM|FBrf0105736 |Kanapin and Ivanov |1998 |0 REFM|FBrf0149015 |Yan et al. |2002 |0 REFM|FBrf0053421 |Becker et al. |1991 |0 REFM|FBrf0111510 |Vieira et al. |1999 |0 REFM|FBrf0058488 |Codani-Simonart et al. |1993 |0 REFM|FBrf0108387 |Dimitri and Junakovic |1999 |2 REFM|FBrf0130256 |Lerat et al. |1999 |0 REFM|FBrf0079992 |Ding and Lipshitz |1994 |0 REFM|FBrf0086400 |Faure et al. |1996 |0 REFM|FBrf0125292 |Xiong and Eickbush |1990 |0 REFM|FBrf0098518 |Haoudi et al. |1997 |0 REFM|FBrf0138423 |Bowen and McDonald |2001 |0 REFM|FBrf0129733 |Biemont et al. |1999 |2 REFM|FBrf0105955 |Whalen and Grigliatti |1998 |0 REFM|FBrf0141542 |Maside et al. |2001 |0 REFM|FBrf0149106 |Bartolome et al. |2002 |0 REFM|FBrf0111953 |Losada et al. |1999 |0 REFM|FBrf0149104 |Vieira et al. |2002 |0 REFM|FBrf0099812 |Terzian et al. |1997 |0 REFM|FBrf0056166 |di Franco et al. |1992 |0 REFM|FBrf0099810 |Flavell et al. |1997 |0 REFM|FBrf0056194 |di Franco et al. |1992 |0 REFM|FBrf0080187 |Lacoste and Fourcade-Peronnet |1995 |0 REFM|FBrf0056004 |Champion et al. |1992 |0 REFM|FBrf0050727 |Ziarczyk et al. |1989 |0 REFM|FBrf0151629 |Flavell et al. |1992 |0 REFM|FBrf0137949 |Alonso-Gonzalez et al. |2001 |1 REFM|FBrf0129880 |Kalmykova et al. |1999 |0 REFM|FBrf0049432 |di Franco et al. |1989 |0 REFM|FBrf0045155 |Peronnet et al. |1986 |0 REFM|FBrf0055722 |Ribaudo et al. |1992 |0 REFM|FBrf0084234 |Nuzhdin |1995 |0 REFM|FBrf0110995 |Vieira et al. |1999 |1 REFM|FBrf0077988 |Arnault and Dufournel |1994 |2 REFM|FBrf0058311 |Lacoste et al. |1993 |1 REFM|FBrf0111944 |Lerat and Capy |1999 |0 REFM|FBrf0076524 |Kim et al. |1994 |0 REFM|FBrf0048831 |Fourcade-Peronnet et al. |1988 |0 REFM|FBrf0085408 |Lacoste et al. |1995 |0 REFM|FBrf0078389 |Finnegan |1992 |0 REFM|FBrf0151719 |Tulin et al. |2002 |0 REFM|FBrf0074490 |Sniegowski and Charlesworth |1994 |0 REFM|FBrf0111330 |Biemont and Cizeron |1999 |0 REFM|FBrf0052451 |Jakubczak et al. |1990 |0 REFM|FBrf0129815 |Fortunati and Junakovic |1999 |0 REFM|FBrf0134868 |Haoudi and Mason |2000 |2 REFM|FBrf0085174 |Haoudi et al. |1995 |0 REFM|FBrf0137199 |Aravin et al. |2001 |0 REFM|FBrf0099793 |Alberola et al. |1997 |0 } REFDSR { RDID|FBrf0049432 |di Franco et al. |1989 WT|The genomic distribution of transposable elements in somatic tissues and |during development is homogeneous. } REFDSR { RDID|FBrf0054856 |Ziarczyk and Best-Belpomme |1991 TE|element type: LTR retrotransposon |total length in bp: 4648 |target site duplication length in bp: 5 |terminal repeat length in bp: 336 } REFDSR { RDID|FBrf0056166 |di Franco et al. |1992 WT|Stability of 11 transposable element families compared by Southern |blotting among individuals of lines that had been subjected to 30 |generations of sister sib matings. @412@, @roo@, @blood@, @297@, @1731@ |and @G-element@ all appear stable, whereas @copia@, @hobo@, @I-element@, |@gypsy@ and @jockey@ elements show instability. } REFDSR { RDID|FBrf0056591 |Fourcade-Peronnet et al. |1992 WTI|NssBF } REFDSR { RDID|FBrf0058488 |Codani-Simonart et al. |1993 PHP|The behavior of the LTR is analyzed after transfer to human monocytes. } REFDSR { RDID|FBrf0059024 |Montchamp-Moreau et al. |1993 WT|The distribution of @1731@ retrotransposon-hybridizing sequences reveals |the sequences are widespread within both the Sophophora and Drosophila |subgenera. The @1731@ retrotransposon family appears to have a long |evolutionary history in the Drosophilidae genome. } REFDSR { RDID|FBrf0064626 |Nahon et al. |1993 PHP|@Top2@ is involved in different functions of the @1731@ LTR. } REFDSR { RDID|FBrf0074490 |Sniegowski and Charlesworth |1994 WT|Element copy numbers on inversion and standard chromosomes has been |determined. The copy number is significantly higher within low frequency |inversions than within the corresponding standard chromosome regions. } REFDSR { RDID|FBrf0076524 |Kim et al. |1994 WT|The @1731@ promoter is active in Pleurodeles waltl oocytes suggesting |in the case of horizontal transfer @1731@ can be expressed in vertebrate |organisms. } REFDSR { RDID|FBrf0079108 |Nuzhdin and Mackay |1995 PHP|The distribution of a number of transposable elements has been studied |in 10 Harwich mutation accumulation lines. } REFDSR { RDID|FBrf0079937 |Charlesworth et al. |1994 WT|Estimating the genomic numbers of transposable elements demonstrates |many families of element are over-represented in heterochromatin. } REFDSR { RDID|FBrf0079992 |Ding and Lipshitz |1994 WT|The spatial and temporal expression patterns of fifteen families of |retrotransposons are analyzed during embryogenesis and are found to |be conserved. Results suggest that all families carry cis-acting elements |that control their spatial and temporal expression patterns. } REFDSR { RDID|FBrf0080187 |Lacoste and Fourcade-Peronnet |1995 PHP|In vitro transcription of the @1731@ element promoter is repressed |by @NssBF@ element binding protein(s). } REFDSR { RDID|FBrf0084234 |Nuzhdin |1995 PPC|The distribution of transposable elements in D.simulans is similar |to that found in D.melanogaster, though total copy number is lower. } REFDSR { RDID|FBrf0085408 |Lacoste et al. |1995 WT|Overexpression of @Ssb-c31a@ in transfected cells represses the @1731@ |element promoter. } REFDSR { RDID|FBrf0090548 |Faure et al. |1996 PHP|UVB-irradiation activation of @1731@-LTR requires a short sequence |of the U3 region, the sequence is active in human or Schneider cell |line. Sequence is similar to the binding sequence of members of the |nuclear factor &kgr;B (NF-&kgr;B)/rel family. } REFDSR { RDID|FBrf0098518 |Haoudi et al. |1997 OTH|Expression of @1731@ is regulated not only at the transcriptional level |but also at the translational level, this regulation is different in |the two sexes. } REFDSR { RDID|FBrf0099812 |Terzian et al. |1997 OTH|Used in an investigation to address the relationship between retrotransposons |and retroviruses and the coadaptation of these retroelements to their |host genomes. Results indicate retrotransposons are heterogeneous |in contrast to retroviruses, suggesting different modes of evolution |by slippage-like mechanisms. } REFDSR { RDID|FBrf0129880 |Kalmykova et al. |1999 TE|Two classes of @1731@ element are present in the genome. The first |class uses conventional translational frameshifting to ensure expression |of the @1731\RTase@ open reading frame. Most of the genomic copies |are related to the second class where the frameshift is prevented as |a result of a substitution of a rare codon recognizing a rare tRNA |by a codon preferred by the host genome and the @1731\RTase@ ORF is |restored by a downstream single nucleotide deletion. } REFDSR { RDID|FBrf0149104 |Vieira et al. |2002 SYN|17.31 } } # EOR GENR { RETE|ID 1 FBgn0020768 CLA 1 transposable element gene NAM 1 1731 element gag GSYM 1 1731\gag DT 1 14 Aug 03 RESZ 2286 DBA 2 ALESR 3 REF 3 GSYM|1731\gag DT|14 Aug 03 ID|FBgn0020768 CLA|transposable_element_gene SYN|ORF1 |1731 element gag AM|encoded by: @1731@ NAM|1731 element gag DBA|NA:X07656 |PA:CAA30502 PAC|PIR:S00953 REF { REFM|FBrf0129880 |Kalmykova et al. |1999 |0 REFM|FBrf0058493 |Kim et al. |1993 |0 REFM|FBrf0085174 |Haoudi et al. |1995 |0 } REFDSR { RDID|FBrf0058493 |Kim et al. |1993 WT|Translation of the gag protein is studied by transfection of the protein |into cultured cells. } REFDSR { RDID|FBrf0085174 |Haoudi et al. |1995 NAM|1731 element gag WT|The largest @1731\gag@ polypeptides are present in the virus-like particles |extracted from a D.melanogaster cell line, and a short @1731\gag@ |polypeptide is associated to the cell nucleus. SYN|ORF1 } REFDSR { RDID|FBrf0129880 |Kalmykova et al. |1999 SYN|ORF1 } ALESR { ASYM|1731\gaga.T:Ecol\lacZ SYN|1731\gaga.T:lacZ ID|FBal0062283 PHI|Mode of assay: Drosophila cell culture REF|FBrf0058493 REFDSR { RDID|FBrf0058493 |Kim et al. |1993 MD|Construct: An entire @1731@ harboring the first 9/10 of the ORF1 fused in frame |with a KpnI-BamHI fragment of @Ecol\lacZ@ in antisense orientation. OTH|Carried in plasmid pKM8-, expressed in S2 cells, D.virilis DV1 cels |and D.hydei KUN-DH3 cells to study translation of the gag protein. MU|in vitro construct | coding region fusion PHI|Mode of assay: Drosophila cell culture } } ALESR { ASYM|1731\gags.T:Ecol\lacZ SYN|1731\gags.T:lacZ ID|FBal0062282 PHI|Mode of assay: Drosophila cell culture REF|FBrf0058493 REFDSR { RDID|FBrf0058493 |Kim et al. |1993 MD|Construct: An entire @1731@ harboring the first 9/10 of the ORF1 fused in frame |with a KpnI-BamHI fragment of @Ecol\lacZ@ in sense orientation. OTH|Carried in plasmid pKM8+, expressed in S2 cells, D.virilis DV1 cels |and D.hydei KUN-DH3 cells to study translation of the gag protein. MU|in vitro construct | coding region fusion PHI|Mode of assay: Drosophila cell culture } } ALESR { ASYM|1731\gag+ ID|FBal0105349 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0044507 CLA 1 transposable element gene GSYM 1 1731\LTR DT 1 14 Aug 03 RESZ 225 DBA 4 ALESR 1 GSYM|1731\LTR DT|14 Aug 03 ID|FBgn0044507 CLA|transposable_element_gene AM|encoded by: @1731@ DBA|NA:X04686 |PA:CAA28388 |NA:X04874 |PA:CAA28563 ALESR { ASYM|1731\LTR+ ID|FBal0123540 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0012032 CLA 1 transposable element gene NAM 1 1731-repetitive-element reverse transcriptase GSYM 1 1731\RTase DT 1 14 Aug 03 RESZ 998 DBA 2 ALESR 1 REF 4 GSYM|1731\RTase DT|14 Aug 03 ID|FBgn0012032 CLA|transposable_element_gene SYN|ORF2 |1731-repetitive-element reverse transcriptase AM|encoded by: @1731@ NAM|1731-repetitive-element reverse transcriptase DBA|NA:X07656 |PA:CAA30503 PAC|PIR:S00954 REF { REFM|FBrf0056004 |Champion et al. |1992 |0 REFM|FBrf0129880 |Kalmykova et al. |1999 |0 REFM|FBrf0111944 |Lerat and Capy |1999 |0 REFM|FBrf0085174 |Haoudi et al. |1995 |0 } REFDSR { RDID|FBrf0056004 |Champion et al. |1992 NAM|1731-repetitive-element reverse transcriptase PHP|The protein co-sediments |with virus-like particles that exhibit reverse transcriptase activity. } REFDSR { RDID|FBrf0085174 |Haoudi et al. |1995 SYN|ORF2 } REFDSR { RDID|FBrf0129880 |Kalmykova et al. |1999 SYN|ORF2 } ALESR { ASYM|1731\RTase+ ID|FBal0105270 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0061475 CLA 1 multicopy cytosolic ribosomal RNA gene GSYM 1 18SrRNA DT 1 14 Aug 03 RESZ 3306 DBA 32 CEL 1 cytosolic small ribosomal subunit (sensu Eukarya) ALESR 1 REF 17 GSYM|18SrRNA DT|14 Aug 03 ID|FBgn0061475 CLA|multicopy_cytosolic_ribosomal_RNA_gene SYN|18S rRNA |18S rDNA |18S RNA |18S |18SRNA AM|encoded by: @bb@, @Ybb@ |component genes: @18SrRNA:CR40456@ CEL|cytosolic small ribosomal subunit (sensu Eukarya) ; GO:0005843 | inferred from sequence similarity DBA|NA:AI124285 |NA:K01281 |NA:K01286 |NA:K01287 |NA:M20062 |NA:M20063 |NA:M20064 |NA:M21017 |NA:M26817 |NA:S80141 |NA:X15707 |NA:X97143 |NA:Z31795 |dbSTS:4332 |NA:Z31941 |dbSTS:4479 |NA:Z32130 |dbSTS:4682 |NA:Z32170 |dbSTS:4721 |NA:Z32171 |dbSTS:4722 |NA:Z32197 |dbSTS:4748 |NA:Z32373 |dbSTS:4935 |NA:Z32374 |dbSTS:4936 |NA:Z50228 |dbSTS:24192 |NA:Z50229 |dbSTS:24193 REF { REFM|FBrf0120332 |Schlotterer |1997.2.11 |9 REFM|FBrf0094147 |Benevolenskaya et al. |1997 |0 REFM|FBrf0138565 |Giribet et al. |2001 |0 REFM|FBrf0128400 |Bhadra et al. |2000 |0 REFM|FBrf0155623 |2 REFM|FBrf0108854 |Krasnov et al. |1999 |0 REFM|FBrf0121292 |Tautz |1990.3.15 |9 REFM|FBrf0055058 |Houck et al. |1991 |0 REFM|FBrf0094743 |Friedrich and Tautz |1997 |0 REFM|FBrf0154285 |Ashburner |2003.2.5 |9 REFM|FBrf0114952 |Field |1988 |9 REFM|FBrf0114951 |Field |1988 |9 REFM|FBrf0114950 |Field |1988 |9 REFM|FBrf0125039 |Bejarano and Gonzalez |1999 |0 REFM|FBrf0108186 |Giordano et al. |1999 |0 REFM|FBrf0159270 |Yuan et al. |2003 |0 REFM|FBrf0111435 |Morel et al. |1999 |0 } REFDSR { RDID|FBrf0055058 |Houck et al. |1991 OTH|Samples of the semiparasitic mite Proctolaelaps regalis that have been |in contact with D.melanogaster contain @bb@ sequences. SYN|18S rRNA } REFDSR { RDID|FBrf0094147 |Benevolenskaya et al. |1997 SYN|18S rDNA } REFDSR { RDID|FBrf0094743 |Friedrich and Tautz |1997 SYN|18S rRNA } REFDSR { RDID|FBrf0108186 |Giordano et al. |1999 SYN|18S rRNA } REFDSR { RDID|FBrf0108854 |Krasnov et al. |1999 SYN|18S RNA } REFDSR { RDID|FBrf0111435 |Morel et al. |1999 SYN|18S } REFDSR { RDID|FBrf0114950 |Field |1988 SYN|18S rRNA } REFDSR { RDID|FBrf0114951 |Field |1988 SYN|18S rRNA } REFDSR { RDID|FBrf0114952 |Field |1988 SYN|18S rRNA } REFDSR { RDID|FBrf0120332 |Schlotterer |1997.2.11 SYN|18S rRNA } REFDSR { RDID|FBrf0121292 |Tautz |1990.3.15 CEL|cytosolic small ribosomal subunit (sensu Eukarya) ; GO:0005843 | inferred from sequence similarity GPD|ribosomal-RNA-18S SYN|18S rRNA } REFDSR { RDID|FBrf0125039 |Bejarano and Gonzalez |1999 SYN|18S rRNA } REFDSR { RDID|FBrf0128400 |Bhadra et al. |2000 SYN|18S rRNA } REFDSR { RDID|FBrf0138565 |Giribet et al. |2001 SYN|18S } ALESR { ASYM|18SrRNA+ ID|FBal0142210 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0058456 CLA 1 existence-uncertain gene GSYM 1 18SrRNA:CR40456 DT 1 14 Aug 03 RESZ 259 ALESR 1 GSYM|18SrRNA:CR40456 DT|14 Aug 03 ID|FBgn0058456 CLA|existence-uncertain gene SYN|CR40456 AM|member gene of: @18SrRNA@ ASQ|FBan0040456 ALESR { ASYM|18SrRNA:CR40456+ ID|FBal0143098 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0004364 CLA 1 Gene NAM 1 18 wheeler GSYM 1 18w DT 1 14 Aug 03 RESZ 23981 PDOM 5 INTERPRO:IPR000157 == TIR domain PTD 1 DBA 13 HG 5 Caenorhabditis elegans 'coded for by C. elegans cDNA yk132e5.5 EMBL:U39996 FNC 1 cell adhesion CEL 4 cytoplasm WT 1 @18w@ is a critical component of the humoral immune response CLOC 1 56F8 ALESR 16 SK 2 REF 61 GSYM|18w PTD ARGS DT|14 Aug 03 ID|FBgn0004364 UAB|Deficiency: Df(2R)017 |Duplication: Dp(2;Y)53D;57C (inferred from cytology) SYN|CG8896 |tlr |18-wheeler |wheeler |18-Wheeler |18W |CT25100 |18 Wheeler |toll |l(2)00053 |Toll like receptor NAM|18 wheeler KLOC|71679 CLOC|56F8 |Limits computationally determined from genome sequence between l(2)k08002 and l(2)k10809 CYC|Experimentally determined: 56F6--9, 56F8--12 FNC|cell adhesion ; GO:0007155 | inferred from direct assay CEL|cytoplasm ; GO:0005737 | inferred from direct assay |membrane fraction ; GO:0005624 | inferred from direct assay |plasma membrane ; GO:0005886 | inferred from direct assay |plasma membrane ; GO:0005886 | inferred from sequence similarity with FLYBASE:Tl; FB:FBgn0003717 PDOM|IPR000157 == TIR domain |SCOP:52047 == RNI-like; 18w|FBgn0004364|pp-CT25100|FBan0008896 |SCOP:52058 == L domain-like; 18w|FBgn0004364|pp-CT25100|FBan0008896 |SCOP:52075 == Outer arm dynein light chain 1; 18w|FBgn0004364|pp-CT25100|FBan0008896 |SCOP:52200 == Toll/Interleukin receptor TIR domain; 18w|FBgn0004364|pp-CT25100|FBan0008896 WT|@18w@ is a critical component of the humoral immune response. ENZ|transmembrane receptor activity ; GO:0004888 | inferred from sequence similarity |cell adhesion molecule activity ; GO:0005194 | inferred from direct assay |transmembrane receptor activity ; GO:0004888 | inferred from sequence similarity with FLYBASE:Tl; FB:FBgn0003717 |transmembrane receptor activity ; GO:0004888 | inferred from sequence similarity with FLYBASE:Toll-7; FB:FBgn0034476 DBA|NA:AE003793 |PA:AAF57509 |NA:AI403917 |BDGP-DGC:GH23463 |NA:AQ025714 |BDGP:l(2)k02701 |NA:AY051592 |PA:AAK93016 |BDGP-DGC:GH23463 |NA:L23171 |PA:AAA79208 |NA:S76155 |PA:AAB33383 PAC|PIR:T13852 |PIR:T13887 |SPTREMBL:Q24591 |SPTREMBL:Q961H0 |SPTREMBL:Q9V8Z5 HG|species == Caenorhabditis elegans; gene == 'coded for by C. elegans cDNA yk132e5.5; coded for by C. elegans cDNA yk132e5.3;'; EMBL:U39996; gi:1055120; score == 297.9; expect == 3.e-28 |species == Homo sapiens; gene == 'slit (Drosophila) homolog 1'; gi:4507061; score == 571.1; expect == 9.e-37 |species == Mus musculus; gene == Igfals; MGI:107973; score == 414.8; expect == 3.e-35 |species == Rattus norvegicus; gene == 'MEGF4'; EMBL:AB011530; protein_id:BAA32460; gi:3449290; score == 556.7; expect == 3.e-35 |species == Saccharomyces cerevisiae; gene == CYR1; SGDID:L0000467; score == 161.2; expect == 5.e-15 ASQ|FBan0008896 REV|FBrf0139665 |FBrf0123023 |FBrf0156068 REF { REFM|FBrf0110608 |Qureshi et al. |1999 |2 REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0130108 |Tauszig et al. |2000 |0 REFM|FBrf0129777 |Cox et al. |2000 |0 REFM|FBrf0101460 |Dushay et al. |1998 |1 REFM|FBrf0123023 |Govind |1999 |2 REFM|FBrf0114849 |Eldon |1993 |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0073029 |Eldon et al. |1994 |0 REFM|FBrf0156068 |2 REFM|FBrf0101333 |Williams et al. |1998 |1 REFM|FBrf0102791 |Syed et al. |1998 |1 REFM|FBrf0127298 |Rubin et al. |2000 |0 REFM|FBrf0055359 |Eldon and Bellen |1992 |1 REFM|FBrf0098260 |Hoffmann and Reichhart |1997 |2 REFM|FBrf0100706 |Rock et al. |1998 |2 REFM|FBrf0075178 |Eldon and Bellen |1992 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0100705 |Medzhitov and Janeway |1998 |2 REFM|FBrf0132250 |Hedengren et al. |2000 |0 REFM|FBrf0139665 |Silverman and Maniatis |2001 |2 REFM|FBrf0125817 |Janeway and Medzhitov |1999 |2 REFM|FBrf0129898 |Khush and Lemaitre |2000 |2 REFM|FBrf0159908 |Janssens and Beyaert |2002 |2 REFM|FBrf0106457 |Eldon et al. |1999 |1 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0075393 |Eldon et al. |1991 |1 REFM|FBrf0130159 |Wasserman |2000 |2 REFM|FBrf0100021 |Engstrom |1998 |2 REFM|FBrf0108800 |Hoffmann et al. |1999 |2 REFM|FBrf0113821 |Chiang |1995.7.26 |9 REFM|FBrf0151661 |Deal-Herr and Cook |2002.9.10 |9 REFM|FBrf0141541 |Takeda and Akira |2001 |2 REFM|FBrf0128847 |Nappi and Ottaviani |2000 |2 REFM|FBrf0111089 |Williams et al. |1999 |1 REFM|FBrf0125032 |Beaton |1999.12.12 |9 REFM|FBrf0126490 |Eldon et al. |2000 |1 REFM|FBrf0126686 |Milshina |1999.11 |9 REFM|FBrf0133282 |Lemaitre |2000.12.20 |9 REFM|FBrf0132111 |Hynes and Zhao |2000 |9 REFM|FBrf0068276 |Williams et al. |1994 |1 REFM|FBrf0157223 |Kambris |2002 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0098089 |Mitcham et al. |1996 |0 REFM|FBrf0079825 |Eldon |1995 |9 REFM|FBrf0131060 |Aderem and Ulevitch |2000 |2 REFM|FBrf0091791 |Williams et al. |1997 |1 REFM|FBrf0076940 |Chiang and Beachy |1994 |0 REFM|FBrf0099002 |Williams et al. |1997 |0 REFM|FBrf0101953 |Mathey-Prevot and Perrimon |1998 |2 REFM|FBrf0100558 |Dushay and Eldon |1998 |2 REFM|FBrf0141274 |Mi et al. |2001.12.13 |9 REFM|FBrf0128867 |Syed and Eldon |2000 |1 REFM|FBrf0100747 |Wu and Anderson |1998 |0 REFM|FBrf0106857 |Liebermann and Hoffman |1998 |2 REFM|FBrf0079625 |Williams et al. |1995 |1 REFM|FBrf0079624 |Williams et al. |1994 |1 REFM|FBrf0155700 |Solano et al. |2003 |0 REFM|FBrf0088024 |Botas and Auwers |1996 |0 REFM|FBrf0084996 |Eldon and Williams |1996 |1 REFM|FBrf0126670 |Gu |1999.11 |9 } REFDSR { RDID|FBrf0055359 |Eldon and Bellen |1992 CLOC|56F6--9 (determined by in situ hybridization) } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|56F6--9 LOI|18w00053 |18wk02701 BMD|Df(2R)017 } REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 ENZ|cell adhesion molecule activity ; GO:0005194 | inferred from direct assay |transmembrane receptor activity ; GO:0004888 | inferred from sequence similarity with FLYBASE:Tl; FB:FBgn0003717 FNC|cell adhesion ; GO:0007155 | inferred from direct assay |morphogenesis ; GO:0009653 | inferred from mutant phenotype CEL|membrane fraction ; GO:0005624 | inferred from direct assay |plasma membrane ; GO:0005886 | inferred from sequence similarity with FLYBASE:Tl; FB:FBgn0003717 OTH|Etymology: named "18 wheeler" on basis of 18 stripes of expression |during early gastrulation. PHP|Molecular and phenotypic analysis suggests @18w@ participates in the |developmental program specified by segmentation and homeotic genes |as a cell adhesion or receptor molecule that facilitates cell movements. } REFDSR { RDID|FBrf0075178 |Eldon and Bellen |1992 CLOC|56F8--12 (determined by in situ hybridization) } REFDSR { RDID|FBrf0075393 |Eldon et al. |1991 PHP|@18w@ open reading frame encodes a protein with significant similarities |to both @Tl@ and @chp@. } REFDSR { RDID|FBrf0076940 |Chiang and Beachy |1994 PHP|@18w@ encodes a protein that contains multiple leucine rich motifs |(LRR) in its presumed extracellular domain. @18w@ may be involved in |cell-to-cell interactions. SYN|tlr: Toll like receptor } REFDSR { RDID|FBrf0079625 |Williams et al. |1995 PHP|The @18w@ protein functions as a receptor mediating intercellular communication |during various developmental events, including pattern formation, imaginal |cell determination and the larval immune response. Expression of @18w@ |protein in non-adhesive Schneider 2 cells promotes heterophilic cell |aggregation as seen in similar experiments with @Tl@ and other receptor-ligand |molecules. } REFDSR { RDID|FBrf0079825 |Eldon |1995 PHP|@18w@ protein is 1389 amino aids in length. } REFDSR { RDID|FBrf0088024 |Botas and Auwers |1996 SYN|18-wheeler } REFDSR { RDID|FBrf0099002 |Williams et al. |1997 FNC|antibacterial humoral response (sensu Invertebrata) ; GO:0006961 | inferred from mutant phenotype |immune response ; GO:0006955 | inferred from expression pattern CEL|cytoplasm ; GO:0005737 | inferred from direct assay |plasma membrane ; GO:0005886 | inferred from direct assay WT|@18w@ is a critical component of the humoral immune response. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- MD|Maps to clone: DS08132 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 CLOC|56F6--9 (determined by in situ hybridization) BMD|Df(2R)017 } REFDSR { RDID|FBrf0113821 |Chiang |1995.7.26 SYN|tlr } REFDSR { RDID|FBrf0114849 |Eldon |1993 SYN|wheeler } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH23463 (BDGP-DGC) } REFDSR { RDID|FBrf0125817 |Janeway and Medzhitov |1999 SYN|18-Wheeler } REFDSR { RDID|FBrf0126686 |Milshina |1999.11 AM|Source for identity of: 18w CG8896 } REFDSR { RDID|FBrf0128847 |Nappi and Ottaviani |2000 SYN|18-wheeler } REFDSR { RDID|FBrf0130108 |Tauszig et al. |2000 SYN|18W } REFDSR { RDID|FBrf0130159 |Wasserman |2000 SYN|18-wheeler } REFDSR { RDID|FBrf0132111 |Hynes and Zhao |2000 SYN|CT25100 } REFDSR { RDID|FBrf0133282 |Lemaitre |2000.12.20 ENZ|transmembrane receptor activity ; GO:0004888 | inferred from sequence similarity FNC|antibacterial humoral response (sensu Invertebrata) ; GO:0006961 | non-traceable author statement |signal transduction ; GO:0007165 | inferred from sequence similarity CEL|integral to membrane ; GO:0016021 | inferred from sequence similarity GPD|Toll receptor-like SYN|18 Wheeler } REFDSR { RDID|FBrf0141274 |Mi et al. |2001.12.13 ENZ|transmembrane receptor activity ; GO:0004888 | inferred from sequence similarity with FLYBASE:Toll-7; FB:FBgn0034476 } REFDSR { RDID|FBrf0151661 |Deal-Herr and Cook |2002.9.10 BMD|Df(2R)BSC22 } REFDSR { RDID|FBrf0155700 |Solano et al. |2003 SYN|18W } REFDSR { RDID|FBrf0159908 |Janssens and Beyaert |2002 SYN|toll } ALESR { ASYM|18w&Dgr;1-11 ID|FBal0038075 PHC|lethal | recessive ALC|loss of function REF|FBrf0073029 REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 MD|Internal excision within PZ element. PRG|18w00053 MU|&Dgr;2-3 PHC|lethal | recessive ALC|loss of function } } ALESR { ASYM|18w&Dgr;1-14 ID|FBal0038077 PHC|lethal | recessive ALC|loss of function PHI|Lethality is not complete. In uncrowded conditions 0.5% of the flies |survive. REF|FBrf0073029 REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 MD|Excision plus possible additional defect. PRG|18w00053 MU|&Dgr;2-3 PHC|lethal | recessive ALC|loss of function PHI|Lethality is not complete. In uncrowded conditions 0.5% of the flies |survive. } } ALESR { ASYM|18w&Dgr;1-15 ID|FBal0038078 PHC|lethal | recessive ALC|loss of function PHI|Lethality is not complete. In uncrowded conditions 3% of the flies |survive. REF|FBrf0073029 REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 MD|Internal excision within PZ element. PRG|18w00053 MU|&Dgr;2-3 PHC|lethal | recessive ALC|loss of function PHI|Lethality is not complete. In uncrowded conditions 3% of the flies |survive. } } ALESR { ASYM|18w&Dgr;1-24 ID|FBal0038079 PHC|lethal | recessive ALC|loss of function REF|FBrf0073029 REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 MD|Internal excision within PZ element. PRG|18w00053 MU|&Dgr;2-3 PHC|lethal | recessive ALC|loss of function } } ALESR { ASYM|18w&Dgr;1-82 ID|FBal0038080 PHC|lethal | larval | recessive PHM|leg |antenna |wing |haltere ALC|loss of function PHI|Lethality is not complete. In uncrowded conditions 4% of the flies |survive. Survivors eclose later than their sibs and die within a |few days. Survivors typically show morphological defects in at least |one appendage. REF|FBrf0073029 REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 MD|Deletion of PZ element and genomic DNA removing the transcription start |site as well as most or all of the leader. PRG|18w00053 MU|&Dgr;2-3 PHC|lethal | larval | recessive PHM|leg |antenna |wing |haltere ALC|loss of function PHI|Lethality is not complete. In uncrowded conditions 4% of the flies |survive. Survivors eclose later than their sibs and die within a |few days. Survivors typically show morphological defects in at least |one appendage. } } ALESR { ASYM|18w&Dgr;2-62 ID|FBal0038081 PHC|lethal | recessive ALC|loss of function REF|FBrf0073029 REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 MD|Internal excision within PZ element. PRG|18w00053 MU|&Dgr;2-3 PHC|lethal | recessive ALC|loss of function } } ALESR { ASYM|18w&Dgr;2-63 ID|FBal0038082 PHC|lethal | recessive ALC|loss of function REF|FBrf0073029 REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 MD|Internal excision within PZ element. PRG|18w00053 MU|&Dgr;2-3 PHC|lethal | recessive ALC|loss of function } } ALESR { ASYM|18w&Dgr;6-81 ID|FBal0038083 PHC|lethal | recessive ALC|loss of function REF|FBrf0073029 REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 MD|Internal excision within PZ element. PRG|18w00053 MU|&Dgr;2-3 PHC|lethal | recessive ALC|loss of function } } ALESR { ASYM|18w&Dgr;7-35 SYN|18w7-35 ID|FBal0033274 REF|FBrf0076940 |FBrf0151661 |FBrf0073029 |FBrf0132250 |FBrf0099002 REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 MD|Deletion of PZ element and 2.2kb of genomic DNA removing approximately |2.2kb of open reading frame. PRG|18w00053 MU|&Dgr;2-3 PHC|lethal | larval | recessive PHM|leg |antenna |wing |haltere ALC|loss of function PHI|Lethality is not complete. In uncrowded conditions 0.5% of the flies |survive. Survivors eclose later than their sibs and die within a few |days. Survivors typically show morphological defects in at least one |appendage. } REFDSR { RDID|FBrf0076940 |Chiang and Beachy |1994 GII|In a @hhbar3@/@hh6@ background |@18w&Dgr;7-35@ produces a dominant reduction in eye size |resulting in a concave shape or nick at the anterior eye margin. PHC|lethal | recessive } REFDSR { RDID|FBrf0099002 |Williams et al. |1997 MD|Imprecise excision of the @P{PZ}@ element present in @18w00053@, |resulting in a 2.2kb deletion extending from the site of the @P{PZ}@ |insertion into the @18w@ open reading frame. PRG|18w00053 MU|P-element activity PHC|immune response defective | recessive PHI|Only 56% of homozygous @18w&Dgr;7-35@ third instar larvae are still |alive 24 hours after infection with either E.coli or Enterobacter |cloacae, compared to 90% survival for @18w&Dgr;7-35@ heterozygotes, |@18w&Dgr;1-12@ homozygotes or wild-type third instar larvae. Homozygous |@18w&Dgr;7-35@ third instar larvae show 100% survival 24 hours after |wounding with a sterile pyrogen-free needle. SYN|18w7-35 } REFDSR { RDID|FBrf0132250 |Hedengren et al. |2000 SYN|18w7-35 } SK|FBstBL-4372 |y[1] w[*]; 18w[Delta7-35]/CyO } ALESR { ASYM|18w&Dgr;7-43 ID|FBal0038084 PHC|lethal | recessive ALC|loss of function PHI|Lethality is not complete. In uncrowded conditions 2% of the flies |survive. REF|FBrf0073029 REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 MD|Internal excision within PZ element. PRG|18w00053 MU|&Dgr;2-3 PHC|lethal | recessive ALC|loss of function PHI|Lethality is not complete. In uncrowded conditions 2% of the flies |survive. } } ALESR { ASYM|18w00053 SYN|l(2)00053 |l(2)0005300053 ID|FBal0007942 DIS|A. Spradling. TRN|FBti0003351 == P{PZ}18w00053 |BDGP:l(2)00053 MU|P-element activity REF|FBrf0067338 |FBrf0125032 |FBrf0073029 |FBrf0111489 |FBrf0099002 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 ACM|18wk02701 AFC|18wk02701 OTH|Complements: @hts01103@. |Complements: @mus20902448@. |Complements: @mus20902697@. |Complements: @5SrRNA03068@. |Complements: @sm05338@. |Complements: @mus20906652@. |Complements: @l(2)k08002k08002@. |Complements: @l(2)k10809k10809@. |Complements: @htsk14523@. |Complements: @mus209s1534@. |Complements: @l(2)s1866s1866@. TRN|FBti0003351 == P{PZ}18w00053 |BDGP:l(2)00053 } REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 MD|P element insertion at 5' end of @18w@ transcription unit, 26bp from |the predicted transcription start site, with the @Ecol\lacZ@ in the same transcriptional |orientation as @18w@. TRN|FBti0003351 == P{PZ}18w00053 |BDGP:l(2)00053 MU|P-element activity PHC|lethal | recessive ALC|hypomorph PHI|Lethality is not complete. In uncrowded conditions 8-10% of the flies |survive. Survivors are small, have morphological defects, are unable |to fly or jump and have low fertility. } REFDSR { RDID|FBrf0099002 |Williams et al. |1997 MD|Insertion of a @P{PZ}@ element approximately 400bp 5' of the @18w@ |open reading frame. TRN|FBti0003351 == P{PZ}18w00053 |BDGP:l(2)00053 MU|P-element activity SYN|l(2)00053 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0003351 == P{PZ}18w00053 |BDGP:l(2)00053 PHC|lethal | recessive SYN|l(2)00053 } } ALESR { ASYM|18wk02701 SYN|l(2)k02701 ID|FBal0065575 REF|FBrf0067338 |FBrf0125032 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 ACM|18w00053 AFC|18w00053 DIS|I. Kiss. OTH|Complements: @mus20902448@. |Complements: @l(2)k08002k08002@. |Complements: @l(2)k10809k10809@. |Complements: @htsk14523@. |Complements: @l(2)s1866s1866@. TRN|FBti0007254 == P{lacW}18wk02701 |BDGP:l(2)k02701 MU|P-element activity PHC|lethal | recessive } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0007254 == P{lacW}18wk02701 |BDGP:l(2)k02701 PHC|lethal | recessive SYN|l(2)k02701 } SK|FBstBL-10518 |y[1] w[67c23]; P{w[+mC]=lacW}18w[k02701]/CyO } ALESR { ASYM|18wunspecified ID|FBal0118616 REF|FBrf0129777 REFDSR { RDID|FBrf0129777 |Cox et al. |2000 GIC|non-suppressor of @arm3@ } } ALESR { ASYM|18wfl.cEa ID|FBal0038085 PHI|Schneider cells that express @18w@ show heterophilic cell adhesion |properties. |Mode of assay: Drosophila cell culture REF|FBrf0073029 REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 NAM|full length construct a of Eldon MD|Construct: 5.2kb PvuI-SSpI fragment including @18w@ coding region, in pRmHa3 expression |vector. OTH|Carried in plasmid, used to transfect S2 cells. MU|in vitro construct | other PHI|Schneider cells that express @18w@ show heterophilic cell adhesion |properties. |Mode of assay: Drosophila cell culture } } ALESR { ASYM|18w&Dgr;1-12 SYN|18w1-12 ID|FBal0038076 REF|FBrf0073029 |FBrf0099002 REFDSR { RDID|FBrf0073029 |Eldon et al. |1994 MD|Precise or near precise excision of PZ element. PRG|18w00053 MU|&Dgr;2-3 ALC|wild-type PHI|No obvious morphological or behavioral defects. } REFDSR { RDID|FBrf0099002 |Williams et al. |1997 MD|Precise excision of the @P{PZ}@ element. AMIS|Revertant. PRG|18w00053 MU|P-element activity PHC|wild-type |viable PHI|90% of homozygous @18w&Dgr;1-12@ third instar larvae are still alive |24 hours after infection with either E.coli or E.cloacae. SYN|18w1-12 } } ALESR { ASYM|18w+ ID|FBal0066318 CLA|wild-type generic REF|FBrf0105495 } IFL|../dbzhnsky/eghtnw1.htm SKC|2 } # EOR GENR { RETE|ID 1 FBgn0043464 CLA 1 fusion gene GSYM 1 18w::Tl DT 1 14 Aug 03 RESZ 740 ALESR 1 REF 1 GSYM|18w::Tl DT|14 Aug 03 ID|FBgn0043464 CLA|fusion_gene REF { REFM|FBrf0130108 |Tauszig et al. |2000 |0 } ALESR { ASYM|18w::Tl&Dgr;LRR.T:Zzzz\FLAG ID|FBal0119723 PHI|Mode of assay: Drosophila cell culture REF|FBrf0130108 REFDSR { RDID|FBrf0130108 |Tauszig et al. |2000 MD|The truncated ectodomain from @Tl&Dgr;LRR.T:Zzzz\FLAG@ is fused to |the transmembrane and intracytoplasmic domains of @18w@. OTH|Carried in a plasmid and transfected into S2 cells. MU|in vitro construct | coding region fusion PHI|Mode of assay: Drosophila cell culture } } } # EOR GENR { RETE|ID 1 FBgn0022715 CLA 1 Gene GSYM 1 19w DT 1 14 Aug 03 RESZ 946 ALESR 2 REF 2 GSYM|19w DT|14 Aug 03 ID|FBgn0022715 REF { REFM|FBrf0098656 |Omelyanchuk and Lebedeva |1997 |1 REFM|FBrf0105495 |FlyBase |1992- |9 } ALESR { ASYM|19w1 ID|FBal0065574 PHC|mitotic PHM|larval brain |chromosome PHI|Abnormal mitotic activity as assayed in the larval brain. |Highly condensed chromsomes in metaphase. REF|FBrf0098656 REFDSR { RDID|FBrf0098656 |Omelyanchuk and Lebedeva |1997 TRN|FBti0007253 == P{lArB}19w1 MU|Js PHC|mitotic PHM|larval brain |chromosome PHI|Abnormal mitotic activity as assayed in the larval brain. |Highly condensed chromsomes in metaphase. } } ALESR { ASYM|19w+ ID|FBal0081522 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0015579 CLA 1 Gene GSYM 1 2.1 DT 1 14 Aug 03 RESZ 654 WT 1 Isolated as an interactor with the @Pcl@ protein ALESR 1 REF 4 GSYM|2.1 DT|14 Aug 03 ID|FBgn0015579 WT|Isolated as an interactor with the @Pcl@ protein. WTI|Pcl REF { REFM|FBrf0091914 |Coulson et al. |1997 |1 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0101842 |Coulson et al. |1998 |1 REFM|FBrf0084907 |Coulson et al. |1996 |1 } REFDSR { RDID|FBrf0084907 |Coulson et al. |1996 WT|Isolated as an interactor with the @Pcl@ protein. } ALESR { ASYM|2.1+ ID|FBal0075461 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0043850 CLA 1 Gene GSYM 1 2033 DT 1 14 Aug 03 RESZ 759 ALESR 2 REF 1 GSYM|2033 DT|14 Aug 03 ID|FBgn0043850 REF { REFM|FBrf0131272 |Chanut et al. |2000 |0 } ALESR { ASYM|20332033 ID|FBal0121019 PHC|visible | dominant PHM|eye |morphogenetic furrow |ommatidium PHI|Stop furrow mutant phenotype. REF|FBrf0131272 REFDSR { RDID|FBrf0131272 |Chanut et al. |2000 PHC|visible | dominant PHM|eye |morphogenetic furrow |ommatidium PHI|Stop furrow mutant phenotype. } } ALESR { ASYM|2033+ ID|FBal0121460 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0022714 CLA 1 Gene GSYM 1 22w DT 1 14 Aug 03 RESZ 1962 CLOC 1 42A ALESR 2 REF 5 GSYM|22w DT|14 Aug 03 ID|FBgn0022714 UAB|Deficiency: Df(2R)nap1 (inferred from cytology) |Duplication: Dp(2;Y)cn+ (inferred from cytology) KLOC|52493 CLOC|42A |Left limit from in situ hybridization (FBrf0098656) |Right limit from in situ hybridization (FBrf0098656) CYC|Experimentally determined: 42A REF { REFM|FBrf0098656 |Omelyanchuk and Lebedeva |1997 |1 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0105088 |Omel'yanchuk et al. |1997 |0 REFM|FBrf0102993 |Omel'ianchuk and Lebedeva |1998 |0 REFM|FBrf0100614 |Omel'yanchuk et al. |1997 |0 } REFDSR { RDID|FBrf0098656 |Omelyanchuk and Lebedeva |1997 CLOC|42A (determined by in situ hybridization) LOI|22w1 } REFDSR { RDID|FBrf0102993 |Omel'ianchuk and Lebedeva |1998 PHP|Mutation in @22w@ blocks the cell cycle in metaphase. } ALESR { ASYM|22w1 SYN|22w ID|FBal0065573 REF|FBrf0102993 |FBrf0098656 REFDSR { RDID|FBrf0098656 |Omelyanchuk and Lebedeva |1997 TRN|FBti0007252 == P{lArB}22w1 MU|Js PHC|mitotic PHM|larval brain |chromosome PHI|Abnormal mitotic activity as assayed in the larval brain. |Highly condensed chromosomes, increased metaphase index with rare anaphase. } REFDSR { RDID|FBrf0102993 |Omel'ianchuk and Lebedeva |1998 TRN|FBti0007252 == P{lArB}22w1 PHM|chromosome PHI|Flies show a block in metaphase (and rarely anaphase). The chromosomes |have an abnormal morphology. SYN|22w } } ALESR { ASYM|22w+ ID|FBal0081521 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0066319 CLA 1 Gene GSYM 1 24D1 DT 1 14 Aug 03 RESZ 423 ALESR 1 REF 1 GSYM|24D1 DT|14 Aug 03 ID|FBgn0066319 REF { REFM|FBrf0157136 |Jung and Bonini |2003 |1 } REFDSR { RDID|FBrf0157136 |Jung and Bonini |2003 OTH|Identification: as a mutation that suppresses polyQ-induced neurodegeneration in Drosophila. PHP|Mutations in @24D1@ are viable. } ALESR { ASYM|24D1+ ID|FBal0146587 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0028967 CLA 1 Gene GSYM 1 26-29kD-proteinase DT 1 14 Aug 03 RESZ 4955 DBA 11 HG 4 Caenorhabditis elegans 'predicted using Genefinder EMBL:Z92812 CLOC 1 70C10 ALESR 3 SK 1 REF 9 GSYM|26-29kD-proteinase DT|14 Aug 03 ID|FBgn0028967 UAB|Deficiency: Df(3L)fz-GF3b (inferred from cytology) |Duplication: Dp(3;3)M71 (inferred from cytology) SYN|CG8947 |l(3)s3635 |26,29kDa proteinase |26/29kD-proteinase ID2|FBgn0024586 KLOC|90933 CLOC|70C10 |Limits computationally determined from genome sequence between EP(3)3392/EP(3)3561 and l(3)02402/l(3)00208 CYC|Experimentally determined: 70C, 70C4--6 MD|Identified with: RE18380 (BDGP-DGC) ENZ|cathepsin K activity ; GO:0004216 ; EC:3.4.22.38 | inferred from sequence similarity with EMBL:AJ006033; protein_id:CAA06825 DBA|NA:AB011376 |PA:BAA86910 |NA:AE003536 |PA:AAF49777 |NA:AQ026395 |BDGP:l(3)s3635 |NA:AY122222 |PA:AAM52734 |BDGP-DGC:RE18380 |NA:BI213067 |BDGP-DGC:RE18380 PAC|SPTREMBL:Q9V3U6 HG|species == Caenorhabditis elegans; gene == 'predicted using Genefinder; similar to cathepsin-like protease; cD'; EMBL:Z92812; protein_id:CAB07275; gi:3879367; score == 221; expect == 1.e-56 |species == Homo sapiens; gene == 'cathepsin K (pycnodysostosis)'; gi:4503151; score == 234; expect == 1.e-60 |species == Mus musculus; gene == 'cathepsin K'; EMBL:AJ006033; protein_id:CAA06825; gi:3550487; score == 237; expect == 2.e-61 |species == Sarcophaga peregrina; gene == '26,29kDa proteinase'; EMBL:AB011375; protein_id:BAA76272.1; gi:4521167; score == 942; expect == 0 ASQ|FBan0008947 REF { REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0108756 |Fujimoto et al. |1999 |0 REFM|FBrf0115090 |Fujimoto |1998.2.19 |9 REFM|FBrf0126656 |Butler |1999.11 |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0157314 |Levis |2003.4.25 |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|70C4--6 LOI|26-29kD-proteinases3635 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|cathepsin K activity ; GO:0004216 ; EC:3.4.22.38 | inferred from sequence similarity with EMBL:AJ006033; protein_id:CAA06825 GPD|cathepsin K } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 CLOC|70C4--6 (determined by in situ hybridization) LOI|26-29kD-proteinases3635 SYN|l(3)s3635 } REFDSR { RDID|FBrf0115090 |Fujimoto |1998.2.19 CLOC|70C SYN|26,29kDa proteinase } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: RE18380 (BDGP-DGC) } REFDSR { RDID|FBrf0157314 |Levis |2003.4.25 AM|Source for merge of: 26-29kD-proteinase l(3)s3635 } ALESR { ASYM|26-29kD-proteinaseKG00154 ID|FBal0145254 PHC|viable |fertile REF|FBrf0157314 REFDSR { RDID|FBrf0157314 |Levis |2003.4.25 MD|Insertion maps to position \+8 of the release 3 @26-29kD-proteinase@ annotation. OTH|Insertions in @P{lacW}26-29kD-proteinases3635@ (lethal) and P{lacW}26-29kD-proteinaseKG00154 |(viable) map to identical positions, raising possibility that lethality |of @26-29kD-proteinases3635@ maps to elsewhere in genome. TRN|FBti0020878 == P{lacW}26-29kD-proteinaseKG00154 PHC|viable |fertile } } ALESR { ASYM|26-29kD-proteinases3635 SYN|l(3)s3635s3635 |l(3)s3635 ID|FBal0087042 REF|FBrf0067338 |FBrf0157314 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 OTH|Complements: @l(3)j2E11j2E11@. TRN|FBti0009968 == P{lacW}26-29kD-proteinases3635 |BDGP:l(3)s3635 MU|P-element activity PHC|lethal | recessive SYN|l(3)s3635s3635 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0009968 == P{lacW}26-29kD-proteinases3635 |BDGP:l(3)s3635 PHC|lethal | recessive SYN|l(3)s3635 } REFDSR { RDID|FBrf0157314 |Levis |2003.4.25 MD|Insertion maps to position \+8 of the release 3 @26-29kD-proteinase@ annotation. OTH|Insertions in @P{lacW}26-29kD-proteinases3635@ (lethal) and P{lacW}26-29kD-proteinaseKG00154 |(viable) map to identical positions, raising possibility that lethality |of @26-29kD-proteinases3635@ maps to elsewhere in genome. TRN|FBti0009968 == P{lacW}26-29kD-proteinases3635 |BDGP:l(3)s3635 PHC|lethal } SK|FBstBL-10178 |w[1118]; P{w[+mC]=lacW}26-29kD-proteinase[s3635]/TM6C, Antp[Hu] Sb[1] Tb[1] } ALESR { ASYM|26-29kD-proteinase+ ID|FBal0123362 CLA|wild-type generic } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0066318 CLA 1 Gene GSYM 1 26D19 DT 1 14 Aug 03 RESZ 1185 ALESR 2 REF 1 GSYM|26D19 DT|14 Aug 03 ID|FBgn0066318 REF { REFM|FBrf0155698 |Reuter et al. |2003 |0 } REFDSR { RDID|FBrf0155698 |Reuter et al. |2003 OTH|Identification: in a screen to isolate genes required for normal neuronal |morphogenesis in larval mushroom body neurons. } ALESR { ASYM|26D1926D19 SYN|26D19 ID|FBal0145253 PHM|larval mushroom body | somatic clone PHI|Distribution of a membrane marker in mushroom body neurons derived |from mutant mushroom body neuroblast clones generated in newly hatched |larvae and examined in the wandering third instar is abnormal. REF|FBrf0155698 REFDSR { RDID|FBrf0155698 |Reuter et al. |2003 MU|ethyl methanesulfonate PHM|larval mushroom body | somatic clone PHI|Distribution of a membrane marker in mushroom body neurons derived |from mutant mushroom body neuroblast clones generated in newly hatched |larvae and examined in the wandering third instar is abnormal. SYN|26D19 } } ALESR { ASYM|26D19+ ID|FBal0146586 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0061474 CLA 1 multicopy cytosolic ribosomal RNA gene GSYM 1 28SrRNA DT 1 14 Aug 03 RESZ 4107 DBA 30 CEL 1 cytosolic large ribosomal subunit (sensu Eukarya) ALESR 1 REF 24 GSYM|28SrRNA DT|14 Aug 03 ID|FBgn0061474 CLA|multicopy_cytosolic_ribosomal_RNA_gene SYN|28S rDNA |28S RNA |28S rRNA |28S ribosomal RNA |28S |28SRNA AM|encoded by: @bb@, @Ybb@ |component genes: @28SrRNA:CR40459@ CEL|cytosolic large ribosomal subunit (sensu Eukarya) ; GO:0005842 | non-traceable author statement DBA|NA:AF059864 |NA:AF191294 |NA:AF191295 |NA:AY319386 |NA:K00467 |NA:K01574 |NA:K01575 |NA:K01576 |NA:K01577 |NA:K01578 |NA:K01579 |NA:K01580 |NA:K01581 |NA:K01582 |NA:K01583 |NA:K01584 |NA:K01585 |NA:K01586 |NA:K01587 |NA:K03138 |NA:K03139 |NA:K03140 |NA:K03141 |NA:M21017 |NA:V00232 |NA:V00245 |NA:X15707 |NA:X51922 |NA:X71158 |NA:X71159 REF { REFM|FBrf0152043 |Perez-Gonzalez and Eickbush |2002 |0 REFM|FBrf0102893 |Belyaeva et al. |1998 |0 REFM|FBrf0138565 |Giribet et al. |2001 |0 REFM|FBrf0155623 |2 REFM|FBrf0119344 |Rae |1996.10.2 |9 REFM|FBrf0159270 |Yuan et al. |2003 |0 REFM|FBrf0087464 |Jakubczak et al. |1991 |0 REFM|FBrf0123212 |Talbert and Henikoff |2000 |0 REFM|FBrf0134799 |van Steensel et al. |2001 |9 REFM|FBrf0117678 |Mandal |1992.2.28 |9 REFM|FBrf0094743 |Friedrich and Tautz |1997 |0 REFM|FBrf0111478 |Rodriguez-Trelles et al. |1999 |0 REFM|FBrf0108186 |Giordano et al. |1999 |0 REFM|FBrf0068470 |Ding and Lipshitz |1993 |2 REFM|FBrf0119477 |Remsen |1998.4.9 |9 REFM|FBrf0154285 |Ashburner |2003.2.5 |9 REFM|FBrf0053438 |Smoller et al. |1991 |0 REFM|FBrf0121292 |Tautz |1990.3.15 |9 REFM|FBrf0123005 |Eickbush et al. |2000 |0 REFM|FBrf0123171 |Reim et al. |1999 |0 REFM|FBrf0120864 |Solignac |1993.2.2 |9 REFM|FBrf0120863 |Solignac |1993.2.2 |9 REFM|FBrf0128400 |Bhadra et al. |2000 |0 REFM|FBrf0155734 |Ye et al. |2002 |0 } REFDSR { RDID|FBrf0053438 |Smoller et al. |1991 SYN|28S rDNA } REFDSR { RDID|FBrf0068470 |Ding and Lipshitz |1993 SYN|28S RNA } REFDSR { RDID|FBrf0087464 |Jakubczak et al. |1991 SYN|28S RNA } REFDSR { RDID|FBrf0094743 |Friedrich and Tautz |1997 SYN|28S rRNA } REFDSR { RDID|FBrf0102893 |Belyaeva et al. |1998 SYN|28S rRNA } REFDSR { RDID|FBrf0108186 |Giordano et al. |1999 SYN|28S rRNA } REFDSR { RDID|FBrf0117678 |Mandal |1992.2.28 SYN|28S rRNA } REFDSR { RDID|FBrf0119344 |Rae |1996.10.2 SYN|28S rRNA } REFDSR { RDID|FBrf0119477 |Remsen |1998.4.9 SYN|28S ribosomal RNA } REFDSR { RDID|FBrf0120863 |Solignac |1993.2.2 SYN|28S ribosomal RNA } REFDSR { RDID|FBrf0120864 |Solignac |1993.2.2 SYN|28S ribosomal RNA } REFDSR { RDID|FBrf0121292 |Tautz |1990.3.15 CEL|cytosolic large ribosomal subunit (sensu Eukarya) ; GO:0005842 | non-traceable author statement GPD|ribosomal-RNA-28S SYN|28S rRNA } REFDSR { RDID|FBrf0123005 |Eickbush et al. |2000 SYN|28S } REFDSR { RDID|FBrf0123171 |Reim et al. |1999 SYN|28S rRNA } REFDSR { RDID|FBrf0123212 |Talbert and Henikoff |2000 SYN|28S rDNA } REFDSR { RDID|FBrf0128400 |Bhadra et al. |2000 SYN|28S rRNA } REFDSR { RDID|FBrf0134799 |van Steensel et al. |2001 SYN|28S } REFDSR { RDID|FBrf0138565 |Giribet et al. |2001 SYN|28S } REFDSR { RDID|FBrf0155734 |Ye et al. |2002 SYN|28S rDNA } ALESR { ASYM|28SrRNA+ ID|FBal0142209 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0058459 CLA 1 existence-uncertain gene GSYM 1 28SrRNA:CR40459 DT 1 14 Aug 03 RESZ 259 ALESR 1 GSYM|28SrRNA:CR40459 DT|14 Aug 03 ID|FBgn0058459 CLA|existence-uncertain gene SYN|CR40459 AM|member gene of: @28SrRNA@ ASQ|FBan0040459 ALESR { ASYM|28SrRNA:CR40459+ ID|FBal0143097 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0000005 CLA 1 transposable element NAM 1 297 element GSYM 1 297 DT 1 14 Aug 03 RESZ 12451 DBA 17 REF 90 GSYM|297 DT|14 Aug 03 ID|FBgn0000005 CLA|transposable_element SYN|Dm297 |T1/T2 |BarA |Dme297V |EG:EG0007.2 NAM|297 element AM|encoded genes: @297\env@, @297\gag@, @297\pol@ TE|element type: LTR retrotransposon |terminal repeat length in bp: 415 |total length in bp: 6995 |target site duplication length in bp: 4 |number of copies in genome: Approximately 30 (FBrf0032823) |@297@ elements were first described by Potter et al. (FBrf0032823) |but were originally identified by Wensink and Rubin as being |complementary to abundant polyA RNA in tissue-culture cells. DBA|NA:AB010261 |NA:AL033125 |NA:J01062 |NA:J01063 |NA:X03431 |NA:Z31754 |dbSTS:4290 |NA:Z31755 |dbSTS:4291 |NA:Z31802 |dbSTS:4339 |NA:Z32058 |dbSTS:4609 |NA:Z32434 |dbSTS:4220 |NA:Z50314 |dbSTS:24278 PAC|MEROPS:A02.951 REV|FBrf0152077 REF { REFM|FBrf0137949 |Alonso-Gonzalez et al. |2001 |1 REFM|FBrf0131051 |Marin and Llorens |2000 |0 REFM|FBrf0108232 |Lukacsovich et al. |1999 |0 REFM|FBrf0151719 |Tulin et al. |2002 |0 REFM|FBrf0056287 |Pasyukova and Nuzhdin |1992 |0 REFM|FBrf0128568 |Maside et al. |2000 |0 REFM|FBrf0055613 |de Frutos et al. |1992 |0 REFM|FBrf0079108 |Nuzhdin and Mackay |1995 |9 REFM|FBrf0099793 |Alberola et al. |1997 |0 REFM|FBrf0056185 |von Sternberg et al. |1992 |2 REFM|FBrf0045130 |Inouye et al. |1986 |0 REFM|FBrf0040123 |Kugimiya et al. |1983 |0 REFM|FBrf0111953 |Losada et al. |1999 |0 REFM|FBrf0053865 |Arkhipova and Ilyin |1991 |0 REFM|FBrf0032823 |Potter et al. |1979 |0 REFM|FBrf0151415 |Lerat et al. |2002 |9 REFM|FBrf0038638 |Ikenaga and Saigo |1982 |0 REFM|FBrf0074051 |Nuzhdin and Mackay |1994 |0 REFM|FBrf0058967 |Kimura et al. |1993 |0 REFM|FBrf0071734 |EDGP Project Members |1994- |9 REFM|FBrf0044281 |Inouye et al. |1986 |0 REFM|FBrf0106414 |Desset et al. |1999 |0 REFM|FBrf0084234 |Nuzhdin |1995 |0 REFM|FBrf0144916 |Rizzon et al. |2002 |0 REFM|FBrf0111944 |Lerat and Capy |1999 |0 REFM|FBrf0046121 |Baumann et al. |1987 |0 REFM|FBrf0051101 |Sandmeyer et al. |1990 |2 REFM|FBrf0080225 |Madueno et al. |1995 |0 REFM|FBrf0054202 |Kim and Belyaeva |1991 |0 REFM|FBrf0152077 |Pelisson et al. |2002 |2 REFM|FBrf0079937 |Charlesworth et al. |1994 |0 REFM|FBrf0099812 |Terzian et al. |1997 |0 REFM|FBrf0127056 |Dominguez and Albornoz |1999 |0 REFM|FBrf0079992 |Ding and Lipshitz |1994 |0 REFM|FBrf0056166 |di Franco et al. |1992 |0 REFM|FBrf0074490 |Sniegowski and Charlesworth |1994 |0 REFM|FBrf0057261 |Norris et al. |1992 |0 REFM|FBrf0089687 |Hoogland and Biemont |1996 |0 REFM|FBrf0076430 |Alexandrov and Alexandrova |1994 |0 REFM|FBrf0085614 |Moriyama et al. |1996 |1 REFM|FBrf0102359 |Makarova et al. |1995 |0 REFM|FBrf0036022 |Rubin et al. |1981 |0 REFM|FBrf0125337 |Boeke and Corces |1989 |2 REFM|FBrf0129733 |Biemont et al. |1999 |2 REFM|FBrf0035709 |Spradling and Rubin |1981 |2 REFM|FBrf0084471 |Vasil'eva et al. |1995 |0 REFM|FBrf0078390 |Finnegan |1992 |0 REFM|FBrf0138423 |Bowen and McDonald |2001 |0 REFM|FBrf0054937 |Jarrell and Meselson |1991 |0 REFM|FBrf0125292 |Xiong and Eickbush |1990 |0 REFM|FBrf0111330 |Biemont and Cizeron |1999 |0 REFM|FBrf0141652 |Carr et al. |2001 |0 REFM|FBrf0080105 |Houle et al. |1994 |0 REFM|FBrf0127290 |Reese et al. |2000 |0 REFM|FBrf0149015 |Yan et al. |2002 |0 REFM|FBrf0055733 |Aleksandrova and Alexandrov |1992 |0 REFM|FBrf0127032 |Canizares et al. |2000 |0 REFM|FBrf0083460 |Suh et al. |1995 |0 REFM|FBrf0056148 |Charlesworth et al. |1992 |0 REFM|FBrf0056146 |Charlesworth et al. |1992 |0 REFM|FBrf0073800 |Mackay et al. |1994 |0 REFM|FBrf0088079 |Dominguez and Albornoz |1996 |0 REFM|FBrf0100592 |Law et al. |1998 |0 REFM|FBrf0056140 |Higashijima et al. |1992 |0 REFM|FBrf0098551 |Suh et al. |1994 |1 REFM|FBrf0111326 |Ashburner et al. |1999 |0 REFM|FBrf0105736 |Kanapin and Ivanov |1998 |0 REFM|FBrf0127224 |Marsano et al. |2000 |0 REFM|FBrf0127289 |Reese et al. |2000 |0 REFM|FBrf0052039 |Leibovich |1990 |0 REFM|FBrf0149106 |Bartolome et al. |2002 |0 REFM|FBrf0149104 |Vieira et al. |2002 |0 REFM|FBrf0125415 |Albornoz and Dominguez |1999 |0 REFM|FBrf0111776 |Andrianov et al. |1999 |0 REFM|FBrf0141542 |Maside et al. |2001 |0 REFM|FBrf0056332 |Jiang and Gibson |1992 |0 REFM|FBrf0057399 |Cuticchia et al. |1992 |0 REFM|FBrf0111510 |Vieira et al. |1999 |0 REFM|FBrf0052879 |Scheinker et al. |1990 |0 REFM|FBrf0130256 |Lerat et al. |1999 |0 REFM|FBrf0117580 |Lukacsovich |1998.1.8 |9 REFM|FBrf0056195 |Biemont |1992 |0 REFM|FBrf0056194 |di Franco et al. |1992 |0 REFM|FBrf0056098 |Higashijima et al. |1992 |0 REFM|FBrf0109043 |Rutsov et al. |1999 |0 REFM|FBrf0054718 |Kim and Belyaeva |1991 |0 REFM|FBrf0055481 |Arkhipova and Ilyin |1992 |2 REFM|FBrf0051081 |Engels |1989 |0 REFM|FBrf0108981 |Pantazidis et al. |1999 |0 REFM|FBrf0146932 |Carr et al. |2002 |0 } REFDSR { RDID|FBrf0052039 |Leibovich |1990 SYN|Dm297 } REFDSR { RDID|FBrf0056098 |Higashijima et al. |1992 SYN|T1/T2 } REFDSR { RDID|FBrf0056140 |Higashijima et al. |1992 SYN|T1/T2 } REFDSR { RDID|FBrf0056146 |Charlesworth et al. |1992 PPC|In a study of the distribution in the genome of 9 families of |transposable element among chromosomes 2 and 3 of a natural population, it |was found that the elements were distributed randomly in the distal section |of chromosome arms, whereas some linkage disequilibrium was detected in |proximal regions. Different elements tend to occupy different sites. The |more proximal the site, the more likely the element was to show a |non-random distribution. } REFDSR { RDID|FBrf0056148 |Charlesworth et al. |1992 PHP|Distribution of 9 families of transposable elements in a natural |population was studied and the hypothesis that transposable element |abundance is regulated primarily by deleterious fitness consequences of |ectopic meiotic exchange was supported. Proximal euchromatin may only |infrequently undergo exchange, and elements detected in population surveys |of this kind tend to be inserted into sites where there is negligible |effect on fitness. } REFDSR { RDID|FBrf0056166 |di Franco et al. |1992 WT|Stability of 11 transposable element families compared by Southern |blotting among individuals of lines that had been subjected to 30 |generations of sister sib matings. @412@, @roo@, @blood@, @297@, @1731@ |and @G-element@ all appear stable, whereas @copia@, @hobo@, @I-element@, |@gypsy@ and @jockey@ elements show instability. } REFDSR { RDID|FBrf0056287 |Pasyukova and Nuzhdin |1992 WT|One substock of inbred lines shows considerable heterogeneity of |insertion sites of @copia@ (frequency of insertions is 12% per haploid genome |per generation) whereas @mdg1@, @mdg2@, @mdg3@, @gypsy@, @297@ and |@HMS-Beagle@ were stable in all stocks examined. } REFDSR { RDID|FBrf0057261 |Norris et al. |1992 SYN|BarA } REFDSR { RDID|FBrf0074051 |Nuzhdin and Mackay |1994 OTH|Rates of transposition and excision of the @297@ |element have been determined. } REFDSR { RDID|FBrf0074490 |Sniegowski and Charlesworth |1994 WT|Element copy numbers on inversion and standard chromosomes has been |determined. The copy number is significantly higher within low frequency |inversions than within the corresponding standard chromosome regions. } REFDSR { RDID|FBrf0079108 |Nuzhdin and Mackay |1995 PHP|The distribution of a number of transposable elements has been studied |in 10 Harwich mutation accumulation lines. } REFDSR { RDID|FBrf0079937 |Charlesworth et al. |1994 WT|Estimating the genomic numbers of transposable elements demonstrates |many families of element are over-represented in heterochromatin. } REFDSR { RDID|FBrf0079992 |Ding and Lipshitz |1994 WT|The spatial and temporal expression patterns of fifteen families of |retrotransposons are analyzed during embryogenesis and are found to |be conserved. Results suggest that all families carry cis-acting elements |that control their spatial and temporal expression patterns. } REFDSR { RDID|FBrf0083460 |Suh et al. |1995 PHP|The chromosomal distribution of a number of retrotransposons in an |isolated population of D.melanogaster (from Ishigaki Island, Okinawa, |Japan) has been determined. } REFDSR { RDID|FBrf0084234 |Nuzhdin |1995 PPC|The distribution of transposable elements in D.simulans is similar |to that found in D.melanogaster, though total copy number is lower. } REFDSR { RDID|FBrf0089687 |Hoogland and Biemont |1996 WT|Study of TE distribution (@P-element@, @hobo@, @I-element@, @copia@, |@mdg1@, @mdg3@, @412@, @297@ and @roo@) along chromosome arms shows |no global tendency for the TE site occupancy frequency to negatively |follow the recombination rate, except for the 3L arm. The tendency |for TE insertion number to increase from base to tip of some chromosome |arms is simply explicable by a positive relationship with DNA content |along the chromosomes. So for all TEs, except @hobo@, there is no |relationship between distribution of TE insertion numbers weighted |by DNA content and recombination rate. @hobo@ insertion site number |is positively correlated with recombination rate. } REFDSR { RDID|FBrf0099812 |Terzian et al. |1997 OTH|Used in an investigation to address the relationship between retrotransposons |and retroviruses and the coadaptation of these retroelements to their |host genomes. Results indicate retrotransposons are heterogeneous |in contrast to retroviruses, suggesting different modes of evolution |by slippage-like mechanisms. } REFDSR { RDID|FBrf0117580 |Lukacsovich |1998.1.8 SYN|unnamed } REFDSR { RDID|FBrf0152077 |Pelisson et al. |2002 SYN|Dme297V } } # EOR GENR { RETE|ID 1 FBgn0027623 CLA 1 transposable element gene GSYM 1 297\env DT 1 14 Aug 03 RESZ 569 DBA 2 ALESR 1 REF 4 GSYM|297\env DT|14 Aug 03 ID|FBgn0027623 CLA|transposable_element_gene AM|encoded by: @297@ DBA|NA:X03431 |PA:CAB57797 PAC|PIR:C24872 |SWP:P20829 REV|FBrf0152077 REF { REFM|FBrf0106414 |Desset et al. |1999 |0 REFM|FBrf0152077 |Pelisson et al. |2002 |2 REFM|FBrf0130256 |Lerat et al. |1999 |0 REFM|FBrf0111944 |Lerat and Capy |1999 |0 } ALESR { ASYM|297\env+ ID|FBal0105453 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0044338 CLA 1 transposable element gene GSYM 1 297\gag DT 1 14 Aug 03 RESZ 390 PDOM 3 INTERPRO:IPR001584 == Integrase, catalytic core DBA 2 ALESR 1 GSYM|297\gag DT|14 Aug 03 ID|FBgn0044338 CLA|transposable_element_gene AM|encoded by: @297@ PDOM|IPR001584 == Integrase, catalytic core |IPR001969 == Eukaryotic and viral aspartic protease active site |IPR001995 == Retroviral-type aspartic protease DBA|NA:X03431 |PA:CAA27159 PAC|PIR:A24872 |SWP:P20828 ALESR { ASYM|297\gag+ ID|FBal0122861 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027622 CLA 1 transposable element gene GSYM 1 297\pol DT 1 14 Aug 03 RESZ 459 PDOM 1 INTERPRO:IPR000477 == RNA-directed DNA polymerase (Reverse transcriptase) DBA 2 ALESR 1 REF 2 GSYM|297\pol DT|14 Aug 03 ID|FBgn0027622 CLA|transposable_element_gene AM|encoded by: @297@ PDOM|IPR000477 == RNA-directed DNA polymerase (Reverse transcriptase) DBA|NA:X03431 |PA:CAB57796 PAC|PIR:B24872 |SWP:P20825 REF { REFM|FBrf0106414 |Desset et al. |1999 |0 REFM|FBrf0111944 |Lerat and Capy |1999 |0 } ALESR { ASYM|297\pol+ ID|FBal0105452 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0066317 CLA 1 Gene GSYM 1 29B70 DT 1 14 Aug 03 RESZ 1185 ALESR 2 REF 1 GSYM|29B70 DT|14 Aug 03 ID|FBgn0066317 REF { REFM|FBrf0155698 |Reuter et al. |2003 |0 } REFDSR { RDID|FBrf0155698 |Reuter et al. |2003 OTH|Identification: in a screen to isolate genes required for normal neuronal |morphogenesis in larval mushroom body neurons. } ALESR { ASYM|29B7029B70 SYN|29B70 ID|FBal0145252 PHM|larval mushroom body | somatic clone PHI|Distribution of a membrane marker in mushroom body neurons derived |from mutant mushroom body neuroblast clones generated in newly hatched |larvae and examined in the wandering third instar is abnormal. REF|FBrf0155698 REFDSR { RDID|FBrf0155698 |Reuter et al. |2003 MU|ethyl methanesulfonate PHM|larval mushroom body | somatic clone PHI|Distribution of a membrane marker in mushroom body neurons derived |from mutant mushroom body neuroblast clones generated in newly hatched |larvae and examined in the wandering third instar is abnormal. SYN|29B70 } } ALESR { ASYM|29B70+ ID|FBal0146585 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0022713 CLA 1 Gene GSYM 1 2Ab17 DT 1 14 Aug 03 RESZ 464 ALESR 1 REF 3 GSYM|2Ab17 DT|14 Aug 03 ID|FBgn0022713 SYN|p2Ab17 REF { REFM|FBrf0065443 |Johansen et al. |1993 |1 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0078732 |Johansen et al. |1994 |1 } REFDSR { RDID|FBrf0065443 |Johansen et al. |1993 SYN|p2Ab17 } ALESR { ASYM|2Ab17+ ID|FBal0081520 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0067331 CLA 1 Gene GSYM 1 2D5 DT 1 14 Aug 03 RESZ 1317 GLOC 1 2- ALESR 2 REF 1 GSYM|2D5 DT|14 Aug 03 ID|FBgn0067331 KLOC|29816 GLOC|2- GLC|Maps to 2L. REF { REFM|FBrf0158983 |Vegh and Basler |2003 |0 } REFDSR { RDID|FBrf0158983 |Vegh and Basler |2003 GLOC|2- GLC|Maps to 2L. OTH|1 allele of @2D5@ been recovered in a screen for mutations with mutant |phenotypes in clones in the wing. } ALESR { ASYM|2D52D5 ID|FBal0148513 PHC|visible | somatic clone |viable PHM|wing vein | somatic clone PHI|Homozygous clones in the wing induced by using @Scer\FLP1Scer\UAS.cCa@ |expressed under the control of @Scer\GAL4vg.int2.1@ can result in |partial up to complete loss of all veins except L3. REF|FBrf0158983 REFDSR { RDID|FBrf0158983 |Vegh and Basler |2003 MU|ethyl methanesulfonate PHC|visible | somatic clone |viable PHM|wing vein | somatic clone PHI|Homozygous clones in the wing induced by using @Scer\FLP1Scer\UAS.cCa@ |expressed under the control of @Scer\GAL4vg.int2.1@ can result in |partial up to complete loss of all veins except L3. } } ALESR { ASYM|2D5+ ID|FBal0150111 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0067330 CLA 1 Gene GSYM 1 2F26 DT 1 14 Aug 03 RESZ 1473 GLOC 1 2- ALESR 2 REF 1 GSYM|2F26 DT|14 Aug 03 ID|FBgn0067330 KLOC|29816 GLOC|2- GLC|Maps to 2L. REF { REFM|FBrf0158983 |Vegh and Basler |2003 |0 } REFDSR { RDID|FBrf0158983 |Vegh and Basler |2003 GLOC|2- GLC|Maps to 2L. OTH|6 alleles of @2F26@ have been recovered in a screen for mutations with |mutant phenotypes in clones in the wing. } ALESR { ASYM|2F26unspecified ID|FBal0148512 PHC|visible | somatic clone PHM|wing vein | ectopic | somatic clone |wing | somatic clone |wing vein L3 | somatic clone PHI|Homozygous clones in the wing induced by using @Scer\FLP1Scer\UAS.cCa@ |expressed under the control of @Scer\GAL4vg.int2.1@ can result in |massive ectopic veins between L3 and L4 or on L3. REF|FBrf0158983 REFDSR { RDID|FBrf0158983 |Vegh and Basler |2003 PHC|visible | somatic clone PHM|wing vein | ectopic | somatic clone |wing | somatic clone |wing vein L3 | somatic clone PHI|Homozygous clones in the wing induced by using @Scer\FLP1Scer\UAS.cCa@ |expressed under the control of @Scer\GAL4vg.int2.1@ can result in |massive ectopic veins between L3 and L4 or on L3. } } ALESR { ASYM|2F26+ ID|FBal0150110 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0021755 CLA 1 Gene GSYM 1 2R-F DT 1 14 Aug 03 RESZ 2266 GLOC 1 2- ALESR 2 SK 1 REF 3 GSYM|2R-F DT|14 Aug 03 ID|FBgn0021755 KLOC|29816 GLOC|2- GLC|Located on 2R. REF { REFM|FBrf0093664 |Prout et al. |1997 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0099001 |Prout |1997.3.19 |9 } REFDSR { RDID|FBrf0093664 |Prout et al. |1997 GLOC|2- GLC|Located on 2R. OTH|Identification: Genetic screen for autosomal mutations that produce |blisters in somatic wing clones. 1 allele of @2R-F@ has been isolated. WTI|mys (data from @2R-F2R-22@) } ALESR { ASYM|2R-F2R-22 ID|FBal0065570 REF|FBrf0093664 |FBrf0099001 REFDSR { RDID|FBrf0093664 |Prout et al. |1997 MU|X ray GIC|non-suppressor of @mysb9@ |enhancer | dominant of visible phenotype of @mys8@ |non-enhancer of @mysb9@ GIA|enhancer | dominant of wing phenotype of @mys8@ GII|Shows a weak genetic interaction with @mys8@; the frequency of |wing blisters is increased from approximately 10% in @mys8@ single |hemizygotes to approximately 20% in @mys8@ hemizygotes that are |also heterozygous for @2R-F2R-22@. PHC|viable |visible | recessive |visible | recessive | somatic clone PHM|wing | somatic clone |wing PHI|Homozygous clones in the wing produce discrete, round blisters of variable |size. These blisters can be located anywhere on the wing. Wing venation |is normal. Homozygotes have fluid filled or collapsed wings. SYN|unnamed } REFDSR { RDID|FBrf0099001 |Prout |1997.3.19 PHC|viable |visible | somatic clone PHM|wing | somatic clone PHI|Homozygous clones in the wing produce a blistered phenotype. } SK|FBstBL-2280 |y[1] w[1]; P{neoFRT}42D 2R-F[2R-22] P{w[+t*] ry[+t*]=white-un1}47A/CyO, P{w[+mC]=act-lacZ.B}CB1 } ALESR { ASYM|2R-F+ ID|FBal0080607 CLA|wild-type generic REF|FBrf0105495 } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0021754 CLA 1 Gene GSYM 1 2R-L DT 1 14 Aug 03 RESZ 2122 GLOC 1 2- ALESR 2 SK 1 REF 3 GSYM|2R-L DT|14 Aug 03 ID|FBgn0021754 KLOC|29816 GLOC|2- GLC|Located on 2R. REF { REFM|FBrf0093664 |Prout et al. |1997 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0099001 |Prout |1997.3.19 |9 } REFDSR { RDID|FBrf0093664 |Prout et al. |1997 GLOC|2- GLC|Located on 2R. OTH|Identification: Genetic screen for autosomal mutations that produce |blisters in somatic wing clones. 1 allele of @2R-L@ has been isolated. WTI|mys (data from @2R-L84-2@) } ALESR { ASYM|2R-L84-2 ID|FBal0065569 REF|FBrf0093664 |FBrf0099001 REFDSR { RDID|FBrf0093664 |Prout et al. |1997 MU|X ray GIC|non-suppressor of @mysb9@ |enhancer | dominant of visible phenotype of @mys8@ |non-enhancer of @mysb9@ GIA|enhancer | dominant of wing phenotype of @mys8@ GII|Shows a weak genetic interaction with @mys8@; the frequency |of wing blisters is increased from approximately 10% in @mys8@ single |hemizygotes to approximately 20% in @mys8@ hemizygotes that are also |heterozygous for @2R-L84-2@. PHC|lethal | larval | recessive |visible | somatic clone PHM|wing | somatic clone PHI|Homozygous clones in the wing produce discrete, round blisters of variable |size. These blisters can be located anywhere on the wing. Wing venation |is normal. SYN|unnamed } REFDSR { RDID|FBrf0099001 |Prout |1997.3.19 PHC|visible | somatic clone PHM|wing | somatic clone PHI|Homozygous clones in the wing produce a blistered phenotype. } SK|FBstBL-2295 |y[1] w[1]; P{neoFRT}42D 2R-L[84-2] P{w[+t*] ry[+t*]=white-un1}47A/CyO, P{w[+mC]=act-lacZ.B}CB1 } ALESR { ASYM|2R-L+ ID|FBal0080606 CLA|wild-type generic REF|FBrf0105495 } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0065042 CLA 1 multicopy cytosolic ribosomal RNA gene GSYM 1 2SrRNA DT 1 14 Aug 03 RESZ 1281 DBA 4 CEL 1 cytosolic large ribosomal subunit (sensu Eukarya) ALESR 1 REF 7 GSYM|2SrRNA DT|14 Aug 03 ID|FBgn0065042 CLA|multicopy_cytosolic_ribosomal_RNA_gene SYN|5.8S and 2S ribosomal rRNA |2S rRNA |2SRNA AM|encoded by: @bb@, @Ybb@ |component genes: @2SrRNA:CR40455@, @2SrRNA:CR40458@ CEL|cytosolic large ribosomal subunit (sensu Eukarya) ; GO:0005842 | non-traceable author statement DBA|NA:AF083522 |NA:M21017 |NA:U20145 |NA:V00236 REF { REFM|FBrf0154285 |Ashburner |2003.2.5 |9 REFM|FBrf0127122 |Hori et al. |2000 |0 REFM|FBrf0030092 |Jordan and Glover |1977 |0 REFM|FBrf0029053 |Jordan et al. |1976 |0 REFM|FBrf0115021 |Fox |1995.1.20 |9 REFM|FBrf0026290 |Jordan |1974 |0 REFM|FBrf0121292 |Tautz |1990.3.15 |9 } REFDSR { RDID|FBrf0115021 |Fox |1995.1.20 SYN|5.8S and 2S ribosomal rRNA } REFDSR { RDID|FBrf0121292 |Tautz |1990.3.15 CEL|cytosolic large ribosomal subunit (sensu Eukarya) ; GO:0005842 | non-traceable author statement GPD|ribosomal-RNA-2S SYN|2S rRNA } REFDSR { RDID|FBrf0127122 |Hori et al. |2000 SYN|2S rRNA } ALESR { ASYM|2SrRNA+ ID|FBal0143096 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0058455 CLA 1 existence-uncertain gene GSYM 1 2SrRNA:CR40455 DT 1 14 Aug 03 RESZ 256 ALESR 1 GSYM|2SrRNA:CR40455 DT|14 Aug 03 ID|FBgn0058455 CLA|existence-uncertain gene SYN|CR40455 AM|member gene of: @2SrRNA@ ASQ|FBan0040455 ALESR { ASYM|2SrRNA:CR40455+ ID|FBal0143095 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0058458 CLA 1 existence-uncertain gene GSYM 1 2SrRNA:CR40458 DT 1 14 Aug 03 RESZ 256 ALESR 1 GSYM|2SrRNA:CR40458 DT|14 Aug 03 ID|FBgn0058458 CLA|existence-uncertain gene SYN|CR40458 AM|member gene of: @2SrRNA@ ASQ|FBan0040458 ALESR { ASYM|2SrRNA:CR40458+ ID|FBal0143094 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027933 CLA 1 Gene NAM 1 3-oxoacid CoA-transferase GSYM 1 3-oxoacid-CoA-transferase DT 1 14 Aug 03 RESZ 1188 PTD 1 ALESR 1 REF 1 GSYM|3-oxoacid-CoA-transferase PTD DT|14 Aug 03 ID|FBgn0027933 SYN|cDNA B |3-oxoacid CoA-transferase |citric acid synthetase NAM|3-oxoacid CoA-transferase MD|Gene order: In direction of increasing cytology: mu2- anon-62BCa+ 3-oxoacid-CoA-transferase+ anon-62BCb- 3-oxoacid-CoA-transferase+ |Gene order: anon-62BCb- ENZ|3-oxoacid CoA-transferase activity ; GO:0008260 ; EC:2.8.3.5 | inferred from sequence similarity REF { REFM|FBrf0110051 |Kasravi et al. |1999 |0 } REFDSR { RDID|FBrf0110051 |Kasravi et al. |1999 ENZ|3-oxoacid CoA-transferase activity ; GO:0008260 ; EC:2.8.3.5 | inferred from sequence similarity NAM|3-oxoacid CoA-transferase MD|Gene order: In direction of increasing cytology: mu2- anon-62BCa+ 3-oxoacid-CoA-transferase+ anon-62BCb- 3-oxoacid-CoA-transferase+ |Gene order: anon-62BCb- GPD|3-oxoacid CoA-transferase OTH|Identification: transcription unit identified during molecular analysis |of the @mu2@ genomic region. SYN|cDNA B: citric acid synthetase } ALESR { ASYM|3-oxoacid-CoA-transferase+ ID|FBal0099791 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0029514 CLA 1 Gene GSYM 1 312 DT 1 14 Aug 03 RESZ 1281 DBA 11 HG 2 Caenorhabditis elegans K12H4.2 WP:CE00267 CLOC 1 61F7 ALESR 1 REF 3 GSYM|312 DT|14 Aug 03 ID|FBgn0029514 UAB|Deficiency: Df(3L)Ar14-8 (inferred from cytology) SYN|CG9166 ID2|FBgn0035214 KLOC|79305 CLOC|61F7 |Limits computationally determined from genome sequence between l(3)02640 and EP(3)3704 MD|Identified with: GH16625 (BDGP-DGC) DBA|NA:AE003471 |PA:AAF47489 |NA:AF209778 |PA:AAF23489 |NA:AI386522 |BDGP-DGC:GH16625 |NA:AW941820 |BDGP-DGC:GH16625 |NA:AY060311 |PA:AAL25350 |BDGP-DGC:GH16625 PAC|SPTREMBL:Q9U3Y9 |SPTREMBL:Q9W0F9 HG|species == Caenorhabditis elegans; gene == K12H4.2; WP:CE00267; score == 55.4; expect == 5.e-07 |species == Escherichia coli; gene == ybeB; ECOGENE:EG11255; score == 62.1; expect == 5.e-09 ASQ|FBan0009166 REF { REFM|FBrf0137492 |Oliver |2001.8.16 |9 REFM|FBrf0129568 |Bayraktaroglu |2000.8.7 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH16625 (BDGP-DGC) } REFDSR { RDID|FBrf0129568 |Bayraktaroglu |2000.8.7 AM|Source for merge of: 312 CG9166 } REFDSR { RDID|FBrf0137492 |Oliver |2001.8.16 } ALESR { ASYM|312+ ID|FBal0103396 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027097 CLA 1 Gene GSYM 1 31B8 DT 1 14 Aug 03 RESZ 1117 GLOC 1 2- ALESR 2 REF 1 GSYM|31B8 DT|14 Aug 03 ID|FBgn0027097 KLOC|29816 GLOC|2- REF { REFM|FBrf0108422 |Liu and Montell |1999 |0 } REFDSR { RDID|FBrf0108422 |Liu and Montell |1999 GLOC|2- } ALESR { ASYM|31B831B8 SYN|31B8 ID|FBal0097443 PHM|border follicle cell PHI|Heterozygotes show defects in border cell migration; the border cells |fail to initiate migration and remain at or near the anterior tip of |the egg chamber even in stage 10. REF|FBrf0108422 REFDSR { RDID|FBrf0108422 |Liu and Montell |1999 AMIS|Selected as: a mutation that causes defects in border cell migration |when homozygous clones are induced in the follicle cells. MU|ethyl methanesulfonate PHM|border follicle cell PHI|Heterozygotes show defects in border cell migration; the border cells |fail to initiate migration and remain at or near the anterior tip of |the egg chamber even in stage 10. SYN|31B8 } } ALESR { ASYM|31B8+ ID|FBal0097825 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0024507 CLA 1 Gene GSYM 1 33-13 DT 1 14 Aug 03 RESZ 1147 CEL 1 nucleus CLOC 1 65A1--6 ALESR 1 REF 4 GSYM|33-13 DT|14 Aug 03 ID|FBgn0024507 UAB|Deficiency: Df(3L)v65c (inferred from cytology) |Duplication: Dp(3;3)M67C+1 (inferred from cytology) KLOC|83492-7054 CLOC|65A1--6 |Left limit from (method unavailable) (FBrf0101248) |Right limit from (method unavailable) (FBrf0101248) CYC|Experimentally determined: 65A1--6 CEL|nucleus ; GO:0005634 | inferred from direct assay ENZ|DNA binding ; GO:0003677 | inferred from direct assay REF { REFM|FBrf0101248 |Dietrich and Krause |1998 |1 REFM|FBrf0138231 |Anholt and Mackay |2001 |0 REFM|FBrf0106419 |Dietrich and Krause |1999 |1 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0101248 |Dietrich and Krause |1998 ENZ|DNA binding ; GO:0003677 | inferred from direct assay CLOC|65A1--6 CEL|nucleus ; GO:0005634 | inferred from direct assay OTH|Identification: Yeast two hybrid screen for proteins that interact |with @ftz@. SYN|unnamed } ALESR { ASYM|33-13+ ID|FBal0088441 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0061473 CLA 1 Gene GSYM 1 34-20 DT 1 14 Aug 03 RESZ 401 ALESR 1 REF 1 GSYM|34-20 DT|14 Aug 03 ID|FBgn0061473 REF { REFM|FBrf0144706 |Ward and Desai |2001 |1 } REFDSR { RDID|FBrf0144706 |Ward and Desai |2001 OTH|Identification: In a screen for dominant phenotypic modifiers of |a @Ptp69D@ phenotype. WTI|Ptp69D } ALESR { ASYM|34-20+ ID|FBal0133952 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0022951 CLA 1 Gene GSYM 1 36w DT 1 14 Aug 03 RESZ 1100 CLOC 1 28A--B ALESR 2 REF 2 GSYM|36w DT|14 Aug 03 ID|FBgn0022951 UAB|Deficiency: Df(2L)spd (inferred from cytology) |Duplication: Dp(2;2)C619 (inferred from cytology) KLOC|36868-37098 CLOC|28A--B |Left limit from in situ hybridization (FBrf0099036) |Right limit from in situ hybridization (FBrf0099036) CYC|Experimentally determined: 28A--B REF { REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0099036 |Omelyanchuk |1997.10.10 |9 } REFDSR { RDID|FBrf0099036 |Omelyanchuk |1997.10.10 CLOC|28A--B (determined by in situ hybridization) LOI|36w1 } ALESR { ASYM|36w1 ID|FBal0066287 PHC|female sterile | partially REF|FBrf0099036 REFDSR { RDID|FBrf0099036 |Omelyanchuk |1997.10.10 TRN|FBti0007275 == P{lArB}36w1 MU|P-element activity PHC|female sterile | partially } } ALESR { ASYM|36w+ ID|FBal0081720 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0028551 CLA 1 Gene GSYM 1 3Cy(2)2 DT 1 14 Aug 03 RESZ 1086 CLOC 1 38E--F ALESR 2 REF 1 GSYM|3Cy(2)2 DT|14 Aug 03 ID|FBgn0028551 UAB|Deficiency: Df(2L)pr-A14 (inferred from cytology) |Duplication: Dp(2;f)Bl (inferred from cytology) KLOC|48074-48409 CLOC|38E--F |Left limit from (method unavailable) (FBrf0110768) |Right limit from (method unavailable) (FBrf0110768) CYC|Experimentally determined: 38E--F REF { REFM|FBrf0110768 |Senger et al. |1999 |1 } REFDSR { RDID|FBrf0110768 |Senger et al. |1999 CLOC|38E--F LOI|3Cy(2)21 } ALESR { ASYM|3Cy(2)21 SYN|3Cy(2)2 ID|FBal0100469 PHC|lethal | embryonic | recessive PHI|Homozygotes die during late embryogenesis. REF|FBrf0110768 REFDSR { RDID|FBrf0110768 |Senger et al. |1999 TRN|FBti0013981 == P{lacZ}3Cy(2)21 MU|P-element activity PHC|lethal | embryonic | recessive PHI|Homozygotes die during late embryogenesis. SYN|3Cy(2)2 } } ALESR { ASYM|3Cy(2)2+ ID|FBal0101098 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0067329 CLA 1 Gene GSYM 1 3F43 DT 1 14 Aug 03 RESZ 1204 GLOC 1 3- ALESR 2 REF 1 GSYM|3F43 DT|14 Aug 03 ID|FBgn0067329 KLOC|79136 GLOC|3- REF { REFM|FBrf0158983 |Vegh and Basler |2003 |0 } REFDSR { RDID|FBrf0158983 |Vegh and Basler |2003 GLOC|3- OTH|2 alleles of @3F43@ been recovered in a screen for mutations with mutant |phenotypes in clones in the wing. } ALESR { ASYM|3F43unspecified ID|FBal0148511 PHC|visible | somatic clone PHM|wing sensillum | ectopic | somatic clone PHI|Homozygous clones in the wing induced by using @Scer\FLP1Scer\UAS.cCa@ |expressed under the control of @Scer\GAL4vg.int2.1@ can result in |ectopic bristles in the wing. REF|FBrf0158983 REFDSR { RDID|FBrf0158983 |Vegh and Basler |2003 PHC|visible | somatic clone PHM|wing sensillum | ectopic | somatic clone PHI|Homozygous clones in the wing induced by using @Scer\FLP1Scer\UAS.cCa@ |expressed under the control of @Scer\GAL4vg.int2.1@ can result in |ectopic bristles in the wing. } } ALESR { ASYM|3F43+ ID|FBal0150109 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0021753 CLA 1 Gene GSYM 1 3L-B DT 1 14 Aug 03 RESZ 1604 GLOC 1 3- ALESR 2 SK 1 REF 3 GSYM|3L-B DT|14 Aug 03 ID|FBgn0021753 KLOC|79136 GLOC|3- REF { REFM|FBrf0093664 |Prout et al. |1997 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0099001 |Prout |1997.3.19 |9 } REFDSR { RDID|FBrf0093664 |Prout et al. |1997 GLOC|3- OTH|Identification: Genetic screen for autosomal mutations that produce |blisters in somatic wing clones. 1 allele of @3L-B@ has been isolated. } ALESR { ASYM|3L-B3L-27 ID|FBal0065568 REF|FBrf0093664 |FBrf0099001 REFDSR { RDID|FBrf0093664 |Prout et al. |1997 MU|X ray GII|Shows no interaction with @mysb9@ or @mys8@. GIC|non-enhancer of @mys8@ |non-enhancer of @mysb9@ |non-suppressor of @mys8@ |non-suppressor of @mysb9@ PHC|viable |visible | dominant PHM|wing PHI|Heterozygotes and homozygotes have small wings with blisters. SYN|unnamed } REFDSR { RDID|FBrf0099001 |Prout |1997.3.19 PHC|viable |visible | dominant PHM|wing PHI|Heterozygotes have a wing blister phenotype. } SK|FBstBL-2300 |y[1] w[1]; 3L-B[3L-27] P{neoFRT}80B/TM6B, P{w[+mC]=iab-2(1.7)lacZ}6B, Tb[1] } ALESR { ASYM|3L-B+ ID|FBal0080605 CLA|wild-type generic REF|FBrf0105495 } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0067328 CLA 1 Gene GSYM 1 3N5 DT 1 14 Aug 03 RESZ 1249 GLOC 1 3- ALESR 2 REF 1 GSYM|3N5 DT|14 Aug 03 ID|FBgn0067328 KLOC|79136 GLOC|3- REF { REFM|FBrf0158983 |Vegh and Basler |2003 |0 } REFDSR { RDID|FBrf0158983 |Vegh and Basler |2003 GLOC|3- OTH|1 allele of @3N5@ been recovered in a screen for mutations with mutant |phenotypes in clones in the wing. } ALESR { ASYM|3N53N5 ID|FBal0148510 PHC|visible | somatic clone PHM|wing | posterior compartment | somatic clone PHI|Homozygous clones in the wing induced by using @Scer\FLP1Scer\UAS.cCa@ |expressed under the control of @Scer\GAL4vg.int2.1@ can result in |partial loss of the posterior compartment of the wing. REF|FBrf0158983 REFDSR { RDID|FBrf0158983 |Vegh and Basler |2003 PHC|visible | somatic clone PHM|wing | posterior compartment | somatic clone PHI|Homozygous clones in the wing induced by using @Scer\FLP1Scer\UAS.cCa@ |expressed under the control of @Scer\GAL4vg.int2.1@ can result in |partial loss of the posterior compartment of the wing. } } ALESR { ASYM|3N5+ ID|FBal0150108 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0021751 CLA 1 Gene GSYM 1 3R-C DT 1 14 Aug 03 RESZ 1920 GLOC 1 3- ALESR 2 SK 1 REF 4 GSYM|3R-C DT|14 Aug 03 ID|FBgn0021751 KLOC|79136 GLOC|3- GLC|Located on 3R. REF { REFM|FBrf0104793 |Walsh and Brown |1998 |0 REFM|FBrf0093664 |Prout et al. |1997 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0099001 |Prout |1997.3.19 |9 } REFDSR { RDID|FBrf0093664 |Prout et al. |1997 GLOC|3- GLC|Located on 3R. OTH|Identification: Genetic screen for autosomal mutations that produce |blisters in somatic wing clones. 1 allele of @3R-C@ has been isolated. } ALESR { ASYM|3R-C3R-11 ID|FBal0065566 REF|FBrf0093664 |FBrf0099001 REFDSR { RDID|FBrf0093664 |Prout et al. |1997 MU|X ray GII|Shows no interaction with @mysb9@ or @mys8@. GIC|non-enhancer of @mys8@ |non-enhancer of @mysb9@ |non-suppressor of @mys8@ |non-suppressor of @mysb9@ PHC|lethal | pupal | recessive |visible | somatic clone PHM|wing | somatic clone |wing vein PHI|Homozygous clones in the wing produce discrete, round blisters of variable |size. These blisters can be located anywhere on the wing and are associated |with abnormalities in venation. SYN|unnamed } REFDSR { RDID|FBrf0099001 |Prout |1997.3.19 PHC|visible | somatic clone PHM|wing | somatic clone PHI|Homozygous clones in the wing produce a blistered phenotype. } SK|FBstBL-2306 |P{neoFRT}82B 3R-C[3R-11] P{w[+t*] ry[+t*]=white-un1}90E/TM6B, P{w[+mC]=iab-2(1.7)lacZ}6B, Tb[1] } ALESR { ASYM|3R-C+ ID|FBal0080603 CLA|wild-type generic REF|FBrf0105495 } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0061472 CLA 1 Gene GSYM 1 3R-I256 DT 1 14 Aug 03 RESZ 1183 GLOC 1 3- ALESR 2 REF 1 GSYM|3R-I256 DT|14 Aug 03 ID|FBgn0061472 KLOC|79136 GLOC|3- GLC|Maps to 3R. Mutation maps to a 307kb interval between SNP markers |3R121 and 3R125. REF { REFM|FBrf0141677 |Berger et al. |2001 |0 } REFDSR { RDID|FBrf0141677 |Berger et al. |2001 GLOC|3- GLC|Maps to 3R. Mutation maps to a 307kb interval between SNP markers |3R121 and 3R125. OTH|Identification: mutation isolated in a mosaic screen for abnormal patterns |of neuronal connectivity in the adult visual system. } ALESR { ASYM|3R-I2563R-I256 SYN|3R-I256 ID|FBal0131823 PHM|neuron | somatic clone PHI|Mosaics show visual system connectivity defects. REF|FBrf0141677 REFDSR { RDID|FBrf0141677 |Berger et al. |2001 AMIS|Selected as: a mutation that shows abnormal patterns of neuronal connectivity |in the adult visual system in a mosaic screen. MU|chemical mutagenesis PHM|neuron | somatic clone PHI|Mosaics show visual system connectivity defects. SYN|3R-I256 } } ALESR { ASYM|3R-I256+ ID|FBal0133951 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0005384 CLA 1 transposable element NAM 1 3S18 element GSYM 1 3S18 DT 1 14 Aug 03 RESZ 4893 DBA 6 WT 8 A retroviral-like transposable element REF 27 GSYM|3S18 DT|14 Aug 03 ID|FBgn0005384 CLA|transposable_element SYN|BEL: BEL element |bel |Bel |Belshazar/3S18 |Motu 4 |BEL |BEL element ID2|FBgn0000172 NAM|3S18 element AM|encoded genes: @3S18\ORF@ TE|element type: LTR retrotransposon |total length in bp: 6126 (FBrf0081893) |terminal repeat length in bp: 361 (FBrf0081893) |target site duplication length in bp: 5 (FBrf0041384) |number of copies in genome: Approximately 15 (FBrf0043377) or approximately 25 (FBrf0040134) WT|A retroviral-like transposable element. Described as an insertion |associated with the @wa4@ mutation by Goldberg et al. |(FBrf0040134) (as BEL), and as an insertion within the non-transcribed |spacer of an rDNA repeat by Bell et al. (FBrf0043377) and Fabijanski and |Pellegrini (FBrf0038558). In situ hybridization experiments indicate that |@3S18@ elements are located at about twenty-five sites throughout the |genome and that their distribution differs from one strain to another. The |ends of this element hybridize to each other. DBA|NA:AY183921 |NA:U23420 |NA:Z50268 |dbSTS:24232 |NA:Z83532 |dbSTS:47480 REF { REFM|FBrf0043377 |Bell et al. |1985 |0 REFM|FBrf0051920 |Zhang and Hawley |1990 |0 REFM|FBrf0134631 |Frame et al. |2001 |0 REFM|FBrf0073744 |Lim and Simmons |1994 |2 REFM|FBrf0041384 |O'Hare et al. |1984 |0 REFM|FBrf0040134 |Goldberg et al. |1983 |0 REFM|FBrf0111510 |Vieira et al. |1999 |0 REFM|FBrf0138423 |Bowen and McDonald |2001 |0 REFM|FBrf0155821 |Sun et al. |2003 |0 REFM|FBrf0049635 |Rabinow and Birchler |1989 |0 REFM|FBrf0078393 |Finnegan |1992 |0 REFM|FBrf0078391 |Finnegan |1992 |0 REFM|FBrf0100260 |Sun et al. |1997 |0 REFM|FBrf0038558 |Fabijanski and Pellegrini |1982 |0 REFM|FBrf0149106 |Bartolome et al. |2002 |0 REFM|FBrf0144916 |Rizzon et al. |2002 |0 REFM|FBrf0041457 |Mattox and Davidson |1984 |0 REFM|FBrf0055613 |de Frutos et al. |1992 |0 REFM|FBrf0114405 |Davis |1995.3.24 |9 REFM|FBrf0050555 |Georgiev and Gerasimova |1989 |0 REFM|FBrf0136848 |Mozer |2001 |0 REFM|FBrf0157045 |9 REFM|FBrf0081893 |Davis and Judd |1995 |0 REFM|FBrf0129733 |Biemont et al. |1999 |2 REFM|FBrf0051351 |Zhang et al. |1990 |0 REFM|FBrf0111330 |Biemont and Cizeron |1999 |0 REFM|FBrf0079992 |Ding and Lipshitz |1994 |0 } REFDSR { RDID|FBrf0040134 |Goldberg et al. |1983 PHP|Sequences homologous to @3S18@ are present about 25 times in the Drosophila |genome. SYN|BEL } REFDSR { RDID|FBrf0049635 |Rabinow and Birchler |1989 TE|number of copies in genome: Approximately 25 SYN|BEL } REFDSR { RDID|FBrf0050555 |Georgiev and Gerasimova |1989 SYN|BEL } REFDSR { RDID|FBrf0073744 |Lim and Simmons |1994 WT|Progeny derived from @wa@/@wa4@ heterozygotes demonstrate that |ectopic recombination between paired @3S18@ elements produces duplications and |deficiencies. SYN|BEL } REFDSR { RDID|FBrf0079992 |Ding and Lipshitz |1994 WT|The spatial and temporal expression patterns of fifteen families of |retrotransposons are analyzed during embryogenesis and are found to |be conserved. Results suggest that all families carry cis-acting elements |that control their spatial and temporal expression patterns. } REFDSR { RDID|FBrf0081893 |Davis and Judd |1995 TE|number of copies in genome: Approximately 15-25 |total length in bp: 6126 |terminal repeat length in bp: 361 SYN|BEL } REFDSR { RDID|FBrf0100260 |Sun et al. |1997 SYN|BEL } REFDSR { RDID|FBrf0111510 |Vieira et al. |1999 SYN|BEL } REFDSR { RDID|FBrf0114405 |Davis |1995.3.24 SYN|BEL } REFDSR { RDID|FBrf0129733 |Biemont et al. |1999 SYN|bel } REFDSR { RDID|FBrf0134631 |Frame et al. |2001 SYN|BEL } REFDSR { RDID|FBrf0138423 |Bowen and McDonald |2001 SYN|BEL } REFDSR { RDID|FBrf0144916 |Rizzon et al. |2002 SYN|Bel } REFDSR { RDID|FBrf0149106 |Bartolome et al. |2002 SYN|BEL } REFDSR { RDID|FBrf0155821 |Sun et al. |2003 SYN|Belshazar/3S18 |Bel |Motu 4 } REFDSR { RDID|FBrf0157045 SYN|Bel } } # EOR GENR { RETE|ID 1 FBgn0044337 CLA 1 transposable element gene GSYM 1 3S18\ORF DT 1 14 Aug 03 RESZ 219 DBA 2 ALESR 1 GSYM|3S18\ORF DT|14 Aug 03 ID|FBgn0044337 CLA|transposable_element_gene AM|encoded by: @3S18@ DBA|NA:U23420 |PA:AAB03640 PAC|PIR:T13250 ALESR { ASYM|3S18\ORF+ ID|FBal0122860 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0015580 CLA 1 Gene NAM 1 4.1 GSYM 1 4.1 DT 1 14 Aug 03 RESZ 323 DBA 1 ALESR 1 REF 2 GSYM|4.1 DT|14 Aug 03 ID|FBgn0015580 NAM|4.1 DBA|NA:AC003923 REF { REFM|FBrf0065526 |Parra et al. |1993 |1 REFM|FBrf0105495 |FlyBase |1992- |9 } ALESR { ASYM|4.1+ ID|FBal0075462 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0000001 CLA 1 nuclear untranslated RNA gene NAM 1 4.5SRNA GSYM 1 4.5SRNA DT 1 14 Aug 03 RESZ 826 CLOC 1 65A ALESR 1 REF 2 GSYM|4.5SRNA DT|14 Aug 03 ID|FBgn0000001 CLA|nuclear_untranslated_RNA_gene UAB|Deficiency: Df(3L)v65c (inferred from cytology) |Duplication: Dp(3;3)M67C+1 (inferred from cytology) NAM|4.5SRNA KLOC|83492 GLOC|3-[21] CLOC|65A |Left limit from in situ hybridization (FBrf0042734) |Right limit from in situ hybridization (FBrf0042734) CYC|Experimentally determined: 65A REF { REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0042734 |Steffensen et al. |1985 |1 } REFDSR { RDID|FBrf0042734 |Steffensen et al. |1985 CLOC|65A (determined by in situ hybridization) GPD|RNA-4.5S OTH|A function for the 4.5S RNA is still in the realm of speculation. } ALESR { ASYM|4.5SRNA+ ID|FBal0066319 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0022712 CLA 1 Gene GSYM 1 406 DT 1 14 Aug 03 RESZ 497 WT 1 @406@ is required for continued renewal of the male germ line ALESR 1 REF 2 GSYM|406 DT|14 Aug 03 ID|FBgn0022712 WT|@406@ is required for continued renewal of the male germ line. REF { REFM|FBrf0078655 |Hime et al. |1994 |1 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0078655 |Hime et al. |1994 WT|@406@ is required for continued renewal of the male germ line. } ALESR { ASYM|406+ ID|FBal0081519 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0000006 CLA 1 transposable element NAM 1 412 element GSYM 1 412 DT 1 14 Aug 03 RESZ 21177 PDOM 4 INTERPRO:IPR000477 == RNA-directed DNA polymerase (Reverse transcriptase) DBA 33 REF 146 GSYM|412 DT|14 Aug 03 ID|FBgn0000006 CLA|transposable_element SYN|Dm412 |MDG2 |MDG412 |EG:BACR37P7.4 |Motu 3 |Ubx-t72 |BcDNA:GM07634 ID2|FBgn0062487 NAM|412 element AM|encoded genes: @412\ORF1@, @412\ORF2@, @412\ORF3@, @412\ORF4@, @412\sORF2@ TE|element type: LTR retrotransposon |terminal repeat length in bp: 481 or 571 (FBrf0036946) |total length in bp: 7.6kb (FBrf0041380) |target site duplication length in bp: 4 (FBrf0036946) |number of copies in genome: 40 (FBrf0036946) PDOM|IPR000477 == RNA-directed DNA polymerase (Reverse transcriptase) |IPR001584 == Integrase, catalytic core |IPR001969 == Eukaryotic and viral aspartic protease active site |IPR001995 == Retroviral-type aspartic protease DBA|NA:AA696412 |BDGP-DGC:GM07634 |NA:AL008801 |dbSTS:53384 |NA:AL050231 |NA:AW941290 |BDGP-DGC:GM07634 |NA:AY095181 |BDGP-DGC:GM07634 |NA:AY183920 |EPD:17018 |NA:M30371 |NA:M30372 |NA:M30373 |NA:M54873 |NA:M54874 |NA:V00195 |NA:V00196 |NA:X04132 |NA:X52763 |NA:X52764 |NA:Z31757 |dbSTS:4293 |NA:Z31842 |dbSTS:4382 |NA:Z32198 |dbSTS:4749 |NA:Z70811 |dbSTS:33579 |NA:Z70825 |dbSTS:33682 |NA:Z83387 |dbSTS:47388 PAC|MEROPS:A02.951 REV|FBrf0129733 |FBrf0098575 REF { REFM|FBrf0141542 |Maside et al. |2001 |0 REFM|FBrf0151273 |Stein et al. |2002 |0 REFM|FBrf0129815 |Fortunati and Junakovic |1999 |0 REFM|FBrf0078392 |Finnegan |1992 |0 REFM|FBrf0091382 |Furman and Bukharina |1996 |0 REFM|FBrf0093473 |Graba et al. |1997 |2 REFM|FBrf0105736 |Kanapin and Ivanov |1998 |0 REFM|FBrf0055613 |de Frutos et al. |1992 |0 REFM|FBrf0036946 |Will et al. |1981 |0 REFM|FBrf0049432 |di Franco et al. |1989 |0 REFM|FBrf0080225 |Madueno et al. |1995 |0 REFM|FBrf0149106 |Bartolome et al. |2002 |0 REFM|FBrf0149104 |Vieira et al. |2002 |0 REFM|FBrf0111510 |Vieira et al. |1999 |0 REFM|FBrf0089219 |Zhang et al. |1996 |0 REFM|FBrf0146932 |Carr et al. |2002 |0 REFM|FBrf0083530 |Zabanov et al. |1995 |0 REFM|FBrf0138461 |Costas et al. |2001 |0 REFM|FBrf0056195 |Biemont |1992 |0 REFM|FBrf0056194 |di Franco et al. |1992 |0 REFM|FBrf0052641 |Gould et al. |1990 |0 REFM|FBrf0086648 |Tan et al. |1996 |0 REFM|FBrf0130134 |Vasil'eva et al. |2000 |0 REFM|FBrf0079992 |Ding and Lipshitz |1994 |0 REFM|FBrf0053865 |Arkhipova and Ilyin |1991 |0 REFM|FBrf0085614 |Moriyama et al. |1996 |1 REFM|FBrf0052837 |Harada et al. |1990 |0 REFM|FBrf0155821 |Sun et al. |2003 |0 REFM|FBrf0134868 |Haoudi and Mason |2000 |2 REFM|FBrf0056189 |Purugganan and Wessler |1992 |0 REFM|FBrf0081987 |Feinstein et al. |1995 |0 REFM|FBrf0107409 |Vasil'eva et al. |1998 |0 REFM|FBrf0136953 |Robert et al. |2001 |0 REFM|FBrf0056185 |von Sternberg et al. |1992 |2 REFM|FBrf0102359 |Makarova et al. |1995 |0 REFM|FBrf0052594 |Kim et al. |1990 |0 REFM|FBrf0141114 |Benos |1999.12.13 |9 REFM|FBrf0100260 |Sun et al. |1997 |0 REFM|FBrf0091153 |Ratner and Amikishiev |1996 |0 REFM|FBrf0108981 |Pantazidis et al. |1999 |0 REFM|FBrf0091152 |Ratner and Amikishiev |1996 |0 REFM|FBrf0091151 |Ratner and Vasil'eva |1996 |0 REFM|FBrf0102948 |Junakovic et al. |1998 |0 REFM|FBrf0054124 |Pret and Searles |1991 |0 REFM|FBrf0083473 |Terrinoni et al. |1995 |1 REFM|FBrf0054718 |Kim and Belyaeva |1991 |0 REFM|FBrf0057399 |Cuticchia et al. |1992 |0 REFM|FBrf0129733 |Biemont et al. |1999 |2 REFM|FBrf0068424 |Botas |1993 |2 REFM|FBrf0082240 |Kozhemiakina and Furman |1995 |0 REFM|FBrf0036313 |Baev et al. |1981 |0 REFM|FBrf0158886 |Van Doren et al. |2003 |0 REFM|FBrf0104396 |Akhmanova and Hennig |1998 |0 REFM|FBrf0052022 |Avedisov et al. |1990 |0 REFM|FBrf0045017 |Chang et al. |1986 |0 REFM|FBrf0083460 |Suh et al. |1995 |0 REFM|FBrf0064793 |Bate |1993 |2 REFM|FBrf0056166 |di Franco et al. |1992 |0 REFM|FBrf0141652 |Carr et al. |2001 |0 REFM|FBrf0088079 |Dominguez and Albornoz |1996 |0 REFM|FBrf0057228 |Kulkosky et al. |1992 |0 REFM|FBrf0137200 |Kirby et al. |2001 |0 REFM|FBrf0072501 |Anikeeva et al. |1994 |0 REFM|FBrf0041380 |Shepherd and Finnegan |1984 |0 REFM|FBrf0102924 |Furman et al. |1998 |0 REFM|FBrf0138423 |Bowen and McDonald |2001 |0 REFM|FBrf0134638 |Borie et al. |2000 |0 REFM|FBrf0134799 |van Steensel et al. |2001 |9 REFM|FBrf0127032 |Canizares et al. |2000 |0 REFM|FBrf0053397 |Mahoney et al. |1991 |0 REFM|FBrf0089687 |Hoogland and Biemont |1996 |0 REFM|FBrf0130255 |Nuzhdin |1999 |2 REFM|FBrf0055481 |Arkhipova and Ilyin |1992 |2 REFM|FBrf0125337 |Boeke and Corces |1989 |2 REFM|FBrf0137949 |Alonso-Gonzalez et al. |2001 |1 REFM|FBrf0152038 |Coffman et al. |2002 |0 REFM|FBrf0127224 |Marsano et al. |2000 |0 REFM|FBrf0064615 |Morata |1993 |2 REFM|FBrf0125292 |Xiong and Eickbush |1990 |0 REFM|FBrf0056148 |Charlesworth et al. |1992 |0 REFM|FBrf0053421 |Becker et al. |1991 |0 REFM|FBrf0105793 |Cizeron et al. |1998 |0 REFM|FBrf0056146 |Charlesworth et al. |1992 |0 REFM|FBrf0105435 |Furman and Bukharina |1998 |0 REFM|FBrf0090845 |Vieira and Biemont |1996 |0 REFM|FBrf0098575 |Nikitin and Shmookler Reis |1997 |2 REFM|FBrf0044280 |Yuki et al. |1986 |0 REFM|FBrf0056332 |Jiang and Gibson |1992 |0 REFM|FBrf0054836 |Haynes et al. |1991 |0 REFM|FBrf0100771 |Moore et al. |1998 |0 REFM|FBrf0074490 |Sniegowski and Charlesworth |1994 |0 REFM|FBrf0056294 |Ratner et al. |1992 |0 REFM|FBrf0079937 |Charlesworth et al. |1994 |0 REFM|FBrf0072994 |Driver and Vogrig |1994 |0 REFM|FBrf0123225 |Vasilyeva et al. |1999 |0 REFM|FBrf0051081 |Engels |1989 |0 REFM|FBrf0101991 |Riechmann et al. |1998 |0 REFM|FBrf0054198 |Goryachkovskaya and Vasilyeva |1991 |0 REFM|FBrf0111953 |Losada et al. |1999 |0 REFM|FBrf0099583 |Vasil'eva et al. |1997 |0 REFM|FBrf0100563 |Furman and Bukharina |1997 |0 REFM|FBrf0131051 |Marin and Llorens |2000 |0 REFM|FBrf0083977 |Greig and Akam |1995 |0 REFM|FBrf0134564 |Hayes et al. |2001 |0 REFM|FBrf0058967 |Kimura et al. |1993 |0 REFM|FBrf0098551 |Suh et al. |1994 |1 REFM|FBrf0078101 |Boyle and DiNardo |1995 |0 REFM|FBrf0031217 |Finnegan et al. |1978 |0 REFM|FBrf0135823 |Benos et al. |2001 |0 REFM|FBrf0051664 |Castelli-Gair and Garcia-Bellido |1990 |0 REFM|FBrf0045129 |Yuki et al. |1986 |0 REFM|FBrf0055845 |Brookman et al. |1992 |0 REFM|FBrf0082744 |Vasil'eva et al. |1995 |0 REFM|FBrf0092473 |Boyle et al. |1997 |0 REFM|FBrf0036022 |Rubin et al. |1981 |0 REFM|FBrf0100750 |Broihier et al. |1998 |0 REFM|FBrf0077988 |Arnault and Dufournel |1994 |2 REFM|FBrf0056275 |Ratner and Vasil'eva |1992 |0 REFM|FBrf0145151 |Vasilyeva et al. |2001 |1 REFM|FBrf0098744 |Arnault et al. |1997 |0 REFM|FBrf0057537 |Ratner et al. |1992 |0 REFM|FBrf0083015 |Aulard et al. |1995 |0 REFM|FBrf0083014 |Aulard et al. |1995 |1 REFM|FBrf0099808 |Nuzhdin et al. |1997 |0 REFM|FBrf0144916 |Rizzon et al. |2002 |0 REFM|FBrf0051854 |Fridell et al. |1990 |0 REFM|FBrf0099807 |Biemont et al. |1997 |0 REFM|FBrf0144915 |Bubenshchikova et al. |2002 |0 REFM|FBrf0112805 |Baev |1994.12.13 |9 REFM|FBrf0112804 |Baev |1994.12.13 |9 REFM|FBrf0084234 |Nuzhdin |1995 |0 REFM|FBrf0105955 |Whalen and Grigliatti |1998 |0 REFM|FBrf0105952 |Vasil'eva et al. |1998 |0 REFM|FBrf0052879 |Scheinker et al. |1990 |0 REFM|FBrf0108673 |Cizeron and Biemont |1999 |0 REFM|FBrf0048823 |Micard et al. |1988 |0 REFM|FBrf0128568 |Maside et al. |2000 |0 REFM|FBrf0151719 |Tulin et al. |2002 |0 REFM|FBrf0111330 |Biemont and Cizeron |1999 |0 REFM|FBrf0054206 |Kolesnikova et al. |1991 |0 REFM|FBrf0071734 |EDGP Project Members |1994- |9 REFM|FBrf0054202 |Kim and Belyaeva |1991 |0 REFM|FBrf0079108 |Nuzhdin and Mackay |1995 |9 REFM|FBrf0029352 |Rubin et al. |1976 |0 REFM|FBrf0109131 |Vasil'eva et al. |1998 |0 REFM|FBrf0055781 |Kim et al. |1992 |0 } REFDSR { RDID|FBrf0049432 |di Franco et al. |1989 TE|The genomic distribution of transposable elements in somatic tissues and |during development is homogeneous. } REFDSR { RDID|FBrf0052022 |Avedisov et al. |1990 TE|The @mdg1@ element shows considerable homology with the @412@ element. } REFDSR { RDID|FBrf0052594 |Kim et al. |1990 TE|The distribution of a number of transposable elements, including @412@ |elements, in a D.melanogaster laboratory strain with a high |frequency of spontaneous mutations and its derivatives, has been studied. } REFDSR { RDID|FBrf0052837 |Harada et al. |1990 TE|Transposition rates of mobile elements in lines AW and JH, in which |spontaneous mutations have accumulated for about 400 generations, are |studied. @412@ and @17.6@ elements rate of transposition is very low, |@I-element@ and @hobo@ insertions occur much more frequently. } REFDSR { RDID|FBrf0053397 |Mahoney et al. |1991 TE|The @412@ transposon inserted into @ft@ differs from previously |described @412@ insertions: the 5' LTR contains an additional 33bp of which 29 |are a direct repeat of the LTR sequence, there is a 3bp insertion between |@ft@ and the 5' LTR, 11bp of @ft@ DNA at site of insertion is lost. } REFDSR { RDID|FBrf0054198 |Goryachkovskaya and Vasilyeva |1991 SYN|Dm412 } REFDSR { RDID|FBrf0054206 |Kolesnikova et al. |1991 SYN|Dm412 } REFDSR { RDID|FBrf0055781 |Kim et al. |1992 TE|During the course of experiments with genetically unstable MS strains |gypsy elements were observed to transpose whereas @mdg1@ and @412@ sites in |the X chromosome were unchanged. } REFDSR { RDID|FBrf0055845 |Brookman et al. |1992 MD|Expression of the @412@ element provides a useful early marker for the |development of the gonadal mesoderm. This high level of expression |does not depend on contact with germ cells, but does depend on @abd-A@ |and @Abd-B@. } REFDSR { RDID|FBrf0056146 |Charlesworth et al. |1992 PPC|In a study of the distribution in the genome of 9 families of |transposable element among chromosomes 2 and 3 of a natural population, it |was found that the elements were distributed randomly in the distal section |of chromosome arms, whereas some linkage disequilibrium was detected in |proximal regions. Different elements tend to occupy different sites. The |more proximal the site, the more likely the element was to show a |non-random distribution. } REFDSR { RDID|FBrf0056148 |Charlesworth et al. |1992 PPC|Distribution of 9 families of transposable elements in a natural |population was studied and the hypothesis that transposable element |abundance is regulated primarily by deleterious fitness consequences of |ectopic meiotic exchange was supported. } REFDSR { RDID|FBrf0056166 |di Franco et al. |1992 TE|Stability of 11 transposable element families compared by Southern |blotting among individuals of lines that had been subjected to 30 |generations of sister sib matings. @412@, @roo@, @blood@, @297@, @1731@ |and @G-element@ all appear stable, whereas @copia@, @hobo@, @I-element@, |@gypsy@ and @jockey@ elements show instability. } REFDSR { RDID|FBrf0056275 |Ratner and Vasil'eva |1992 PPC|Mobile genetic elements participate directly in the expression, |variability, selection and evolution of different quantitative characters. } REFDSR { RDID|FBrf0056294 |Ratner et al. |1992 TE|Increase in transposition of @412@ by heavy heat shock treatment is |statistically significant. } REFDSR { RDID|FBrf0057537 |Ratner et al. |1992 TE|Multiple transpositions of @copia@-like @412@ occur in the next generation |after heat shock treatment. } REFDSR { RDID|FBrf0072501 |Anikeeva et al. |1994 SYN|Dm412 } REFDSR { RDID|FBrf0072994 |Driver and Vogrig |1994 TE|The @copia@ and @412@ transposable elements increase in copy number in |aged adult tissue due to the activation of reverse transcriptase. } REFDSR { RDID|FBrf0074490 |Sniegowski and Charlesworth |1994 TE|Element copy numbers on inversion and standard chromosomes has been |determined. The copy number is significantly higher within low frequency |inversions than within the corresponding standard chromosome regions. } REFDSR { RDID|FBrf0079937 |Charlesworth et al. |1994 TE|Estimating the genomic numbers of transposable elements demonstrates |many families of element are over-represented in heterochromatin. } REFDSR { RDID|FBrf0079992 |Ding and Lipshitz |1994 TE|The spatial and temporal expression patterns of fifteen families of |retrotransposons during embryogenesis suggest that all families carry |cis-acting elements that control their spatial and temporal expression |patterns. } REFDSR { RDID|FBrf0082240 |Kozhemiakina and Furman |1995 TE|Spontaneous insertions and excisions of @mdg1@, @copia@, @412@ and |@roo@ have been monitored over 65 generations of mass mating. Excisions |are outnumbered by insertions. Their contribution to variation for |transposable element location is not great. SYN|Dm412 } REFDSR { RDID|FBrf0082744 |Vasil'eva et al. |1995 SYN|Dm412 } REFDSR { RDID|FBrf0084234 |Nuzhdin |1995 TE|The distribution of transposable elements in D.simulans is similar |to that found in D.melanogaster, though total copy number is lower. } REFDSR { RDID|FBrf0086648 |Tan et al. |1996 MD|@412@ is expressed in a cell-specific manner during embryogenesis. |At stage 11 transcripts are present in bilateral clusters of cells |within the mesoderm. The posterior clusters of cells become associated |with the gonads at stage 13. Results demonstrate development of the |visceral muscle or fat body do not affect the expression of @412@ during |embryogenesis. } REFDSR { RDID|FBrf0089687 |Hoogland and Biemont |1996 TE|Study of TE distribution (@P-element@, @hobo@, @I-element@, @copia@, |@mdg1@, @mdg3@, @412@, @297@ and @roo@) along chromosome arms shows |no global tendency for the TE site occupancy frequency to negatively |follow the recombination rate, except for the 3L arm. } REFDSR { RDID|FBrf0090845 |Vieira and Biemont |1996 PPC|Insertion site numbers are determined in various natural populations. |@Dsim\412@ exhibits a lower insertion number than @412@ due to a lower |proportion of insertions on the X chromosome. Results suggest that |selection is a major mechanism explaining @412@ and @Dsim\412@ copy |number (selection being stronger in D.simulans than in D.melanogaster). PPS|sampled from: France |Portugal |Arabia } REFDSR { RDID|FBrf0091151 |Ratner and Vasil'eva |1996 SYN|Dm412 } REFDSR { RDID|FBrf0091152 |Ratner and Amikishiev |1996 TE|Functional site motifs are distributed within the @412@ element. SYN|Dm412 |MDG2 } REFDSR { RDID|FBrf0091153 |Ratner and Amikishiev |1996 TE|Analysis of motifs of functional sites reveals these motifs ensure |the basic molecular functions of @412@, expression of its open reading |frame, transcription, induction of transposition and modification of |adjacent genes and polygenes. SYN|Dm412 |MDG2 } REFDSR { RDID|FBrf0091382 |Furman and Bukharina |1996 SYN|Dm412 } REFDSR { RDID|FBrf0098744 |Arnault et al. |1997 TE|No transposition was detected in progeny after heat shock of parents. } REFDSR { RDID|FBrf0099583 |Vasil'eva et al. |1997 SYN|Dm412 } REFDSR { RDID|FBrf0099807 |Biemont et al. |1997 PPC|A lower proportion of @copia@, @mdg1@ and @412@ element insertion |sites on the X chromosome in comparison with autosomes (in |D.melanogaster and D.simulans populations) suggests that selection |against the detrimental effects of TE insertions in the major force |containing TE copies in populations. } REFDSR { RDID|FBrf0099808 |Nuzhdin et al. |1997 TE|Correlations between the rate of transposition and TE copy number are |determined for @412@ and @roo@ and are found to be zero. } REFDSR { RDID|FBrf0100563 |Furman and Bukharina |1997 SYN|Dm412 } REFDSR { RDID|FBrf0102924 |Furman et al. |1998 SYN|Dm412 } REFDSR { RDID|FBrf0105435 |Furman and Bukharina |1998 OTH|Transposable elements can be used to reveal cross-over events. SYN|Dm412 } REFDSR { RDID|FBrf0105952 |Vasil'eva et al. |1998 SYN|Dm412 } REFDSR { RDID|FBrf0108673 |Cizeron and Biemont |1999 PPC|More rearranged copies of the 412 element are found in D.simulans |(@Dsim\412@) than in D.melanogaster (@412@). } REFDSR { RDID|FBrf0112804 |Baev |1994.12.13 SYN|MDG412 } REFDSR { RDID|FBrf0112805 |Baev |1994.12.13 SYN|MDG412 } REFDSR { RDID|FBrf0134638 |Borie et al. |2000 TE|The expression of @412@ varies greatly between populations. } REFDSR { RDID|FBrf0141114 |Benos |1999.12.13 SYN|EG:BACR37P7.4 } REFDSR { RDID|FBrf0155821 |Sun et al. |2003 SYN|Motu 3 } } # EOR GENR { RETE|ID 1 FBgn0043849 CLA 1 transposable element gene GSYM 1 412\ORF1 DT 1 14 Aug 03 RESZ 300 DBA 2 ALESR 1 REF 1 GSYM|412\ORF1 DT|14 Aug 03 ID|FBgn0043849 CLA|transposable_element_gene AM|encoded by: @412@ DBA|NA:X04132 |PA:CAA27747 PAC|PIR:A29349 REF { REFM|FBrf0138461 |Costas et al. |2001 |0 } ALESR { ASYM|412\ORF1+ ID|FBal0121459 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0043848 CLA 1 transposable element gene GSYM 1 412\ORF2 DT 1 14 Aug 03 RESZ 300 DBA 2 ALESR 1 REF 1 GSYM|412\ORF2 DT|14 Aug 03 ID|FBgn0043848 CLA|transposable_element_gene AM|encoded by: @412@ DBA|NA:X04132 |PA:CAA27749 PAC|PIR:B29349 REF { REFM|FBrf0138461 |Costas et al. |2001 |0 } ALESR { ASYM|412\ORF2+ ID|FBal0121458 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0043847 CLA 1 transposable element gene GSYM 1 412\ORF3 DT 1 14 Aug 03 RESZ 294 DBA 5 ALESR 1 GSYM|412\ORF3 DT|14 Aug 03 ID|FBgn0043847 CLA|transposable_element_gene AM|encoded by: @412@ DBA|NA:AY095181 |PA:AAM12274 |BDGP-DGC:GM07634 |NA:X04132 |PA:CAA27750 PAC|PIR:C29349 |SPTREMBL:Q8T3I3 |SWP:P10394 ALESR { ASYM|412\ORF3+ ID|FBal0121457 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0043846 CLA 1 transposable element gene GSYM 1 412\ORF4 DT 1 14 Aug 03 RESZ 218 DBA 2 ALESR 1 GSYM|412\ORF4 DT|14 Aug 03 ID|FBgn0043846 CLA|transposable_element_gene AM|encoded by: @412@ DBA|NA:X04132 |PA:CAA27748 PAC|PIR:D29349 ALESR { ASYM|412\ORF4+ ID|FBal0121456 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0046319 CLA 1 transposable element gene GSYM 1 412\sORF2 DT 1 14 Aug 03 RESZ 337 ALESR 1 REF 1 GSYM|412\sORF2 DT|14 Aug 03 ID|FBgn0046319 CLA|transposable_element_gene REF { REFM|FBrf0138461 |Costas et al. |2001 |0 } REFDSR { RDID|FBrf0138461 |Costas et al. |2001 AM|encoded by: @412@ } ALESR { ASYM|412\sORF2+ ID|FBal0127164 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0015002 CLA 1 transposable element NAM 1 422 element GSYM 1 422 DT 1 14 Aug 03 RESZ 410 WT 1 A transposable element that remains to be fully characterized REF 1 GSYM|422 DT|14 Aug 03 ID|FBgn0015002 CLA|transposable_element NAM|422 element WT|A transposable element that remains to be fully characterized. REF { REFM|FBrf0067208 |Frolov et al. |1994 |0 } REFDSR { RDID|FBrf0067208 |Frolov et al. |1994 WT|The @422@ element was identified during the molecular analysis of the |@pn@ locus. } } # EOR GENR { RETE|ID 1 FBgn0039258 CLA 1 Gene NAM 1 &bgr;-4-galactosyltransferase 7 GSYM 1 &bgr;4GalT7 DT 1 14 Aug 03 RESZ 11864 PDOM 1 SCOP:53448 == Nucleotide-diphospho-sugar transferases DBA 11 HG 4 Bos taurus 'galactosyltransferase' EMBL:M13214 FNC 1 proteoglycan biosynthesis CEL 1 Golgi apparatus CLOC 1 96B16 ALESR 5 REF 9 GSYM|&bgr;4GalT7 DT|14 Aug 03 ID|FBgn0039258 UAB|Deficiency: Df(3R)XTA1 (inferred from cytology) |Duplication: Dp(3;3)Su8 (inferred from cytology) SYN|CG11780 |CG11780 |CG11780 |CG11780 |D&bgr;4GalT7 |d&bgr;4GalTI |&bgr;-4-galactosyltransferase 7 KLOC|124311 CLOC|96B16 |Limits computationally determined from genome sequence between l(3)01207 and l(3)j2D9 FNC|proteoglycan biosynthesis ; GO:0030166 | inferred from sequence similarity with HUGO:B4GALT7; OMIM:604327 CEL|Golgi apparatus ; GO:0005794 | inferred from direct assay PDOM|SCOP:53448 == Nucleotide-diphospho-sugar transferases; CG11780|FBgn0039258|pp-CT33045|FBan0011780 NAM|&bgr;-4-galactosyltransferase 7 ENZ|galactosyltransferase activity ; GO:0008378 ; EC:2.4.1.- | non-traceable author statement |xylosylprotein 4-beta-galactosyltransferase activity ; GO:0046525 ; EC:2.4.1.133 | inferred from direct assay |xylosylprotein 4-beta-galactosyltransferase activity ; GO:0046525 ; EC:2.4.1.133 | inferred from sequence similarity with HUGO:B4GALT7; OMIM:604327 |xylosylprotein 4-beta-galactosyltransferase activity ; GO:0046525 ; EC:2.4.1.133 | inferred from sequence similarity with WB:sqv-3; WP:CE00306 |xylosylprotein 4-beta-galactosyltransferase activity ; GO:0046525 ; EC:2.4.1.133 | non-traceable author statement |galactosyltransferase activity ; GO:0008378 ; EC:2.4.1.- | inferred from direct assay DBA|NA:AA142310 |BDGP:CK02622 |NA:AB091099 |PA:BAC22695 |NA:AE003750 |PA:AAF56377 |NA:AY094665 |PA:AAM11018 |BDGP-DGC:AT28119 |NA:BF491385 |BDGP-DGC:AT28119 PAC|SPTREMBL:Q8I6J0 |SPTREMBL:Q8T3P3 |SPTREMBL:Q9VBZ9 HG|species == Bos taurus; gene == 'galactosyltransferase'; EMBL:M13214; gi:163074; score == 110; expect == 2.e-23 |species == Caenorhabditis elegans; gene == R10E11.4; WP:CE00306; score == 224; expect == 1.e-57 |species == Homo sapiens; gene == '&bgr;-1,4-galactosyltransferase'; EMBL:D29805; protein_id:BAA06188; gi:705388; score == 111; expect == 7.e-24 |species == Mus musculus; gene == '&bgr;-1,4-galactosyltransferase'; EMBL:M27923; gi:609529; score == 113; expect == 2.e-24 ASQ|FBan0011780 REF { REFM|FBrf0159024 |Takemae et al. |2003 |0 REFM|FBrf0152785 |Furukawa |2002.8.30 |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0126651 |Ashburner |1999.11 |9 REFM|FBrf0152109 |Nakamura et al. |2002 |0 REFM|FBrf0155642 |Wilson |2002 |2 REFM|FBrf0151720 |Vadaie et al. |2002 |0 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: AT28119 (BDGP-DGC) } REFDSR { RDID|FBrf0151720 |Vadaie et al. |2002 ENZ|xylosylprotein 4-beta-galactosyltransferase activity ; GO:0046525 ; EC:2.4.1.133 | inferred from direct assay |xylosylprotein 4-beta-galactosyltransferase activity ; GO:0046525 ; EC:2.4.1.133 | inferred from sequence similarity with HUGO:B4GALT7; OMIM:604327 |xylosylprotein 4-beta-galactosyltransferase activity ; GO:0046525 ; EC:2.4.1.133 | inferred from sequence similarity with WB:sqv-3; WP:CE00306 NAM|&bgr;-4-galactosyltransferase 7 FNC|proteoglycan biosynthesis ; GO:0030166 | inferred from sequence similarity with HUGO:B4GALT7; OMIM:604327 MD|Identified with: CK02622 AM|Source for identity of: &bgr;4GalT7 CG11780 CEL|Golgi apparatus ; GO:0005794 | inferred from direct assay GPD|beta-4-galactosyltransferase VII SYN|CG11780 } REFDSR { RDID|FBrf0152109 |Nakamura et al. |2002 ENZ|galactosyltransferase activity ; GO:0008378 ; EC:2.4.1.- | inferred from direct assay MD|Identified with: CK02622 SYN|D&bgr;4GalT7 } REFDSR { RDID|FBrf0152785 |Furukawa |2002.8.30 ENZ|xylosylprotein 4-beta-galactosyltransferase activity ; GO:0046525 ; EC:2.4.1.133 | non-traceable author statement FNC|glycosaminoglycan biosynthesis ; GO:0006024 | non-traceable author statement } REFDSR { RDID|FBrf0155642 |Wilson |2002 ENZ|galactosyltransferase activity ; GO:0008378 ; EC:2.4.1.- | non-traceable author statement FNC|chondroitin sulfate biosynthesis ; GO:0030206 | non-traceable author statement |heparan sulfate proteoglycan biosynthesis ; GO:0015012 | non-traceable author statement SYN|CG11780 } REFDSR { RDID|FBrf0159024 |Takemae et al. |2003 ENZ|galactosyltransferase activity ; GO:0008378 ; EC:2.4.1.- | inferred from direct assay MD|Identified with: CK02622 SYN|d&bgr;4GalTI |CG11780 } ALESR { ASYM|&bgr;4GalT7Act5C.T:Avic\GFP ID|FBal0138598 PHI|Mode of assay: Drosophila cell culture REF|FBrf0151720 REFDSR { RDID|FBrf0151720 |Vadaie et al. |2002 MD|Construct: An @Act5C@ promoter drives expression of @&bgr;4GalT7@ tagged at the |C-terminal end with @T:Avic\GFP@. OTH|Carried in plasmid pAc5.1DmGalT-VII-GFP and transfected into S2 cells |to study the subcellular localization of the protein produced. MU|in vitro construct | regulatory fusion |in vitro construct | coding region fusion PHI|Mode of assay: Drosophila cell culture } } ALESR { ASYM|&bgr;4GalT7dsRNA.C.Scer\UAS ID|FBal0148522 PHC|lethal with @Scer\GAL4Act5C.PHb@ PHI|Mode of assay: In transgenic Drosophila REF|FBrf0159024 REFDSR { RDID|FBrf0159024 |Takemae et al. |2003 MD|Construct: @Scer\UAS@ regulatory sequences drive expression of an inverted repeat |(in head-to-head orientation) of the C-terminal region of @&bgr;4GalT7@ |(amino acids 209-322). MU|in vitro construct | RNAi CNS|FBtp0017456 == P{UAS-&bgr;4GalT7.dsRNA.C} PHC|lethal with @Scer\GAL4Act5C.PHb@ PHI|Mode of assay: In transgenic Drosophila } } ALESR { ASYM|&bgr;4GalT7dsRNA.N.Scer\UAS ID|FBal0148521 PHC|lethal with @Scer\GAL4Act5C.PHb@ PHI|Mode of assay: In transgenic Drosophila REF|FBrf0159024 REFDSR { RDID|FBrf0159024 |Takemae et al. |2003 MD|Construct: @Scer\UAS@ regulatory sequences drive expression of an inverted repeat |(in head-to-head orientation) of the N-terminal region of @&bgr;4GalT7@ |(amino acids 1-167). MU|in vitro construct | RNAi CNS|FBtp0017455 == P{UAS-&bgr;4GalT7.dsRNA.N} PHC|lethal with @Scer\GAL4Act5C.PHb@ PHI|Mode of assay: In transgenic Drosophila } } ALESR { ASYM|&bgr;4GalT7dsRNA.Scer\UAS ID|FBal0148520 PHC|visible with @Scer\GAL4ptc-559.1@ |visible with @Scer\GAL4sd-SG29.1@ |visible with @Scer\GAL4ap-md544@ |visible with @Scer\GAL4en-e16E@ |visible with @Scer\GAL4Dll-md23@ |visible with @Scer\GAL4da.G32@ PHM|wing with @Scer\GAL4ptc-559.1@ |wing with @Scer\GAL4sd-SG29.1@ |wing | dorsal compartment with @Scer\GAL4ap-md544@ |wing vein L2 with @Scer\GAL4ap-md544@ |wing | posterior compartment with @Scer\GAL4en-e16E@ |leg | distal with @Scer\GAL4Dll-md23@ |leg | distal with @Scer\GAL4da.G32@ PHI|The distance between wing veins 3 and 4 is significantly reduced compared |to wild type in flies expressing @&bgr;4GalT7dsRNA.Scer\UAS@ under |the control of @Scer\GAL4ptc-559.1@. |The distance between wing veins 3 and 4 is weakly reduced compared |to wild type in flies expressing @&bgr;4GalT7dsRNA.Scer\UAS@ under |the control of @Scer\GAL4sd-SG29.1@. |The dorsal compartment of the wing is reduced in size in flies expressing |@&bgr;4GalT7dsRNA.Scer\UAS@ under the control of @Scer\GAL4ap-md544@. |The loss of tissue is more pronounced toward the edges of the wing, |and wing vein 2 is completely lost from the dorsal surface of the wing. |The posterior compartment of the wing is reduced in size in flies expressing |@&bgr;4GalT7dsRNA.Scer\UAS@ under the control of @Scer\GAL4en-e16E@. |The loss of tissue is most pronounced between the posterior edge of |the wing and wing vein 5. |The legs are truncated distally in flies expressing @&bgr;4GalT7dsRNA.Scer\UAS@ |under the control of @Scer\GAL4Dll-md23@. |Distal truncations are seen in about 15% of legs in flies expressing |@&bgr;4GalT7dsRNA.Scer\UAS@ under the control of @Scer\GAL4da.G32@. |Mode of assay: In transgenic Drosophila REF|FBrf0152109 REFDSR { RDID|FBrf0152109 |Nakamura et al. |2002 MD|Construct: @Scer\UAS@ regulatory sequences drive expression of two copies of @&bgr;4GalT7@ |exon 2 in an inverted repeat, separated by @&bgr;4GalT7@ intron 2 and |22bp of vector sequences. MU|in vitro construct | regulatory fusion |in vitro construct | RNAi CNS|FBtp0017454 == P{UAS-&bgr;4GalT7.dsRNA} PHC|visible with @Scer\GAL4ptc-559.1@ |visible with @Scer\GAL4sd-SG29.1@ |visible with @Scer\GAL4ap-md544@ |visible with @Scer\GAL4en-e16E@ |visible with @Scer\GAL4Dll-md23@ |visible with @Scer\GAL4da.G32@ PHM|wing with @Scer\GAL4ptc-559.1@ |wing with @Scer\GAL4sd-SG29.1@ |wing | dorsal compartment with @Scer\GAL4ap-md544@ |wing vein L2 with @Scer\GAL4ap-md544@ |wing | posterior compartment with @Scer\GAL4en-e16E@ |leg | distal with @Scer\GAL4Dll-md23@ |leg | distal with @Scer\GAL4da.G32@ PHI|The distance between wing veins 3 and 4 is significantly reduced compared |to wild type in flies expressing @&bgr;4GalT7dsRNA.Scer\UAS@ under |the control of @Scer\GAL4ptc-559.1@. |The distance between wing veins 3 and 4 is weakly reduced compared |to wild type in flies expressing @&bgr;4GalT7dsRNA.Scer\UAS@ under |the control of @Scer\GAL4sd-SG29.1@. |The dorsal compartment of the wing is reduced in size in flies expressing |@&bgr;4GalT7dsRNA.Scer\UAS@ under the control of @Scer\GAL4ap-md544@. |The loss of tissue is more pronounced toward the edges of the wing, |and wing vein 2 is completely lost from the dorsal surface of the wing. |The posterior compartment of the wing is reduced in size in flies expressing |@&bgr;4GalT7dsRNA.Scer\UAS@ under the control of @Scer\GAL4en-e16E@. |The loss of tissue is most pronounced between the posterior edge of |the wing and wing vein 5. |The legs are truncated distally in flies expressing @&bgr;4GalT7dsRNA.Scer\UAS@ |under the control of @Scer\GAL4Dll-md23@. |Distal truncations are seen in about 15% of legs in flies expressing |@&bgr;4GalT7dsRNA.Scer\UAS@ under the control of @Scer\GAL4da.G32@. |Mode of assay: In transgenic Drosophila } } ALESR { ASYM|&bgr;4GalT7+ ID|FBal0138678 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027538 CLA 1 Gene GSYM 1 &bgr;4GalTA DT 1 14 Aug 03 RESZ 2433 PDOM 1 SCOP:53448 == Nucleotide-diphospho-sugar transferases DBA 13 HG 4 Caenorhabditis elegans 'similar to n-acetyllactosamine synthase EMBL:Z66521 CLOC 1 50E6 ALESR 1 REF 5 GSYM|&bgr;4GalTA DT|14 Aug 03 ID|FBgn0027538 UAB|Deficiency: Df(2R)L7 (inferred from cytology) |Duplication: Dp(2;2)SMG45 (inferred from cytology) SYN|CG8536 |CG8536 |d&bgr;4GalTA |BcDNA:GH13356 KLOC|63300 CLOC|50E6 |Limits computationally determined from genome sequence between l(2)s3475/l(2)k04907 and l(2)06949/l(2)03563 PDOM|SCOP:53448 == Nucleotide-diphospho-sugar transferases; BcDNA:GH13356|FBgn0027538|pp-CT24923|FBan0008536 MD|Identified with: GH13356 (BDGP-DGC) |Identified with: RE56531 (BDGP-DGC) ENZ|beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase activity ; GO:0003831 ; EC:2.4.1.38 | inferred from sequence similarity with EMBL:M27923 DBA|NA:AE003815 |PA:AAF58268 |NA:AF132158 |PA:AAD34746 |NA:AI135553 |BDGP-DGC:GH13356 |NA:AI513247 |BDGP-DGC:GH13356 |NA:AY095531 |PA:AAM12262 |BDGP-DGC:RE56531 |NA:BI370121 |BDGP-DGC:RE56531 PAC|SPTREMBL:Q9XZ05 HG|species == Caenorhabditis elegans; gene == 'similar to n-acetyllactosamine synthase; cDNA EST yk258c9.5 comes'; EMBL:Z66521; protein_id:CAA91401; gi:3880435; score == 160; expect == 3.e-38 |species == Gallus gallus; gene == '&bgr;-1,4-galactosyltransferase'; EMBL:U19890; gi:1469908; score == 212; expect == 5.e-54 |species == Homo sapiens; gene == 'UNKNOWN'; gi:4502347; score == 195; expect == 7.e-49 |species == Mus musculus; gene == '&bgr;-1,4-galactosyltransferase'; EMBL:M27923; gi:609529; score == 204; expect == 2.e-51 ASQ|FBan0008536 REF { REFM|FBrf0126651 |Ashburner |1999.11 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0159024 |Takemae et al. |2003 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase activity ; GO:0003831 ; EC:2.4.1.38 | inferred from sequence similarity with EMBL:M27923 GPD|beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH13356 (BDGP-DGC) |Identified with: RE56531 (BDGP-DGC) } REFDSR { RDID|FBrf0159024 |Takemae et al. |2003 SYN|CG8536 |d&bgr;4GalTA } ALESR { ASYM|&bgr;4GalTA+ ID|FBal0148674 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0039625 CLA 1 Gene GSYM 1 &bgr;4GalTB DT 1 14 Aug 03 RESZ 2231 PDOM 1 SCOP:53448 == Nucleotide-diphospho-sugar transferases DBA 6 HG 4 Caenorhabditis elegans 'N-acetyllactosamine synthase' EMBL:X98132 CLOC 1 98F5 ALESR 1 REF 5 GSYM|&bgr;4GalTB DT|14 Aug 03 ID|FBgn0039625 UAB|Deficiency: Df(3R)3450 (inferred from cytology) |Duplication: Dp(3;3)501 (inferred from cytology) SYN|CG14517 |CG14517 |d&bgr;4GalTB KLOC|127893 CLOC|98F5 |Limits computationally determined from genome sequence between l(3)06487 and EP(3)3390 PDOM|SCOP:53448 == Nucleotide-diphospho-sugar transferases; CG14517|FBgn0039625|pp-CT34244|FBan0014517 MD|Identified with: RE31995 (BDGP-DGC) ENZ|UDP-galactose-glucosylceramide beta-1,4-galactosyltransferase activity ; GO:0008489 | inferred from sequence similarity with EMBL:AF097158; protein_id:AAD41694.1 DBA|NA:AE003768 |PA:AAF56843 |NA:BG635140 |BDGP-DGC:AT31631 |NA:BT003627 |PA:AAO39631 PAC|SPTREMBL:Q9VAQ8 HG|species == Caenorhabditis elegans; gene == 'N-acetyllactosamine synthase'; EMBL:X98132; protein_id:CAA66831; gi:1359573; score == 161; expect == 8.e-39 |species == Gallus gallus; gene == '&bgr;-1,4-galactosyltransferase'; EMBL:U19890; gi:1469908; score == 191; expect == 7.e-48 |species == Homo sapiens; gene == 'UNKNOWN'; gi:4502349; score == 188; expect == 5.e-47 |species == Mus musculus; gene == 'UDP-Gal:glucosylceramide &bgr;-1,4-galactosyltransfera'; EMBL:097158_1 (AF097158; protein_id:AAD41694.1; gi:5305555; score == 189; expect == 3.e-47 ASQ|FBan0014517 REF { REFM|FBrf0126651 |Ashburner |1999.11 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0159024 |Takemae et al. |2003 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|UDP-galactose-glucosylceramide beta-1,4-galactosyltransferase activity ; GO:0008489 | inferred from sequence similarity with EMBL:AF097158; protein_id:AAD41694.1 GPD|UDP-galactose-glucosylceramide beta-1,4-galactosyltransferase } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: RE31995 (BDGP-DGC) } REFDSR { RDID|FBrf0159024 |Takemae et al. |2003 SYN|CG14517 |d&bgr;4GalTB } ALESR { ASYM|&bgr;4GalTB+ ID|FBal0149038 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0028966 CLA 1 Gene NAM 1 5' nucleotidase precursor GSYM 1 5'-nucleotidase-precursor DT 1 14 Aug 03 RESZ 876 ALESR 1 REF 1 GSYM|5'-nucleotidase-precursor DT|14 Aug 03 ID|FBgn0028966 SYN|5' nucleotidase precursor NAM|5' nucleotidase precursor MD|Gene order: In direction of increasing cytology: mthl3? anon-54Ba? robls54B? |Gene order: robl? CG14478? qkr54B? 5'-nucleotidase-precursor? ENZ|5'-nucleotidase activity ; GO:0008253 ; EC:3.1.3.5 | inferred from sequence similarity REF { REFM|FBrf0112176 |Bowman |1999.11.11 |9 } REFDSR { RDID|FBrf0112176 |Bowman |1999.11.11 ENZ|5'-nucleotidase activity ; GO:0008253 ; EC:3.1.3.5 | inferred from sequence similarity NAM|5' nucleotidase precursor MD|Gene order: In direction of increasing cytology: mthl3? anon-54Ba? robls54B? |Gene order: robl? CG14478? qkr54B? 5'-nucleotidase-precursor? } ALESR { ASYM|5'-nucleotidase-precursor+ ID|FBal0102312 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0065041 CLA 1 Gene GSYM 1 5-131 DT 1 14 Aug 03 RESZ 444 ALESR 1 REF 1 GSYM|5-131 DT|14 Aug 03 ID|FBgn0065041 REF { REFM|FBrf0155200 |1 } REFDSR { RDID|FBrf0155200 PHP|Mutants are resistant to the behavioral effects of both nicotine and |ethanol. Mutants show a strongly accentuated and prolonged startle |response, suggesting that they are more sensitive to the sensory input |of the alcohol smell, or more responsive to it. } ALESR { ASYM|5-131+ ID|FBal0143093 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0044336 CLA 1 Gene GSYM 1 5-68 DT 1 14 Aug 03 RESZ 913 ALESR 2 REF 1 GSYM|5-68 DT|14 Aug 03 ID|FBgn0044336 REF { REFM|FBrf0129796 |Eberl et al. |2000 |0 } ALESR { ASYM|5-685-68 ID|FBal0122335 PHC|behavioral | recessive |locomotor behavior defective | recessive |uncoordinated | recessive PHI|Mutants are uncoordinated. Sound-evoked potential recorded from the |antennal nerve are normal. REF|FBrf0129796 REFDSR { RDID|FBrf0129796 |Eberl et al. |2000 PHC|behavioral | recessive |locomotor behavior defective | recessive |uncoordinated | recessive PHI|Mutants are uncoordinated. Sound-evoked potential recorded from the |antennal nerve are normal. SYN|unnamed } } ALESR { ASYM|5-68+ ID|FBal0122859 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0004168 CLA 1 Gene NAM 1 Serotonin receptor 1A GSYM 1 5-HT1A DT 1 14 Aug 03 RESZ 8275 PDOM 2 INTERPRO:IPR000276 == Rhodopsin-like GPCR superfamily PTD 1 DBA 7 HG 4 Caenorhabditis elegans 'serotonin receptor' EMBL:U15167 FNC 3 serotonin receptor signaling pathway CEL 2 integral to membrane WT 2 One of several known Drosophila serotonin receptor encoding genes CLOC 1 56B2--5 ALESR 1 REF 25 GSYM|5-HT1A PTD ARGS DT|14 Aug 03 ID|FBgn0004168 UAB|Duplication: Dp(2;Y)53D;57C (inferred from cytology) SYN|CG16720 |5HT-dro2A |5HT-drp2A |5HT1A |5-HT1ADro |5htdro2a |DRO2A |5-HT-dro2A |5-HT1ADro |Dm5HTdro2A |5HT-R2A: Serotonin receptor 2A |Serotonin receptor 2A |serotonin-receptor-2A NAM|Serotonin receptor 1A KLOC|70413-6094 CLOC|56B2--5 |Limits computationally determined from genome sequence between l(2)k08810 and l(2)02029/l(2)k08713 CYC|Experimentally determined: 56A--B FNC|serotonin receptor signaling pathway ; GO:0007210 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 |serotonin receptor, adenylate cyclase inhibiting pathway ; GO:0007198 | inferred from direct assay |serotonin receptor, phospholipase C activating pathway ; GO:0007208 | inferred from direct assay CEL|integral to membrane ; GO:0016021 | inferred from sequence similarity |plasma membrane ; GO:0005886 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 WT|One of several known Drosophila serotonin receptor encoding genes. |Presumed to be a recent duplication of @5-HT1B@ gene. PDOM|IPR000276 == Rhodopsin-like GPCR superfamily |SCOP:56869 == Membrane all-alpha; 5-HT1A|FBgn0004168|pp-CT34985|FBan0016720 ENZ|amine receptor activity ; GO:0008227 | inferred from sequence similarity |G-protein coupled serotonin receptor activity ; GO:0016609 | non-traceable author statement |G-protein coupled serotonin receptor activity ; GO:0016609 | inferred from sequence similarity |serotonin receptor activity ; GO:0004993 | traceable author statement |serotonin receptor activity ; GO:0004993 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 |5-HT1 receptor activity ; GO:0001586 | non-traceable author statement DBA|NA:AC007839 |BDGP:BACR01N09 |NA:AE003797 |PA:AAF57603 |PA:AAM68432 |NA:Z11489 |PA:CAA77570 PAC|GCR:0254 |PIR:S18153 |PIR:S19155 |SPTREMBL:Q9V8Q9 |SWP:P28285 HG|species == Caenorhabditis elegans; gene == 'serotonin receptor'; EMBL:U15167; gi:2317845; score == 309; expect == 1.e-49 |species == HELVI; gene == '5-HYDROXYTRYPTAMINE RECEPTOR (5-HT RECEPTOR) (SEROTONIN RECEPTOR) >gi'; SWP:Q25190; gi:2494933; score == 485; expect == 2.e-87 |species == Homo sapiens; OMIM:109760; score == 290.6; expect == 1.e-48 |species == Mus musculus; gene == Htr1a; MGI:96273; score == 294.3; expect == 5.e-49 ASQ|FBan0016720 REV|FBrf0138226 REF { REFM|FBrf0138226 |Blenau and Baumann |2001 |2 REFM|FBrf0141499 |Shim et al. |2001 |0 REFM|FBrf0129744 |Brody and Cravchik |2000 |0 REFM|FBrf0128759 |Lai |1999.11 |9 REFM|FBrf0080576 |Maroteaux |1995.5.31 |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126659 |Cravchik |1999.11 |9 REFM|FBrf0154602 |1 REFM|FBrf0123896 |SwissProt Project Members |1992.12.1 |9 REFM|FBrf0058170 |Hen |1993 |0 REFM|FBrf0064857 |Boschert et al. |1991 |1 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0152099 |Radford et al. |2002 |0 REFM|FBrf0108201 |Hita et al. |1999 |9 REFM|FBrf0054500 |Buchner |1991 |2 REFM|FBrf0104704 |Pebusque et al. |1998 |0 REFM|FBrf0088108 |Feng et al. |1996 |0 REFM|FBrf0135704 |Tierney |2001 |2 REFM|FBrf0110590 |Prokop |1999 |2 REFM|FBrf0066373 |Boschert et al. |1991 |1 REFM|FBrf0141689 |Claridge-Chang et al. |2001 |0 REFM|FBrf0102326 |Han et al. |1998 |0 REFM|FBrf0064277 |Witz et al. |1991 |1 REFM|FBrf0055969 |Saudou et al. |1992 |0 } REFDSR { RDID|FBrf0054500 |Buchner |1991 SYN|5HT-dro2A } REFDSR { RDID|FBrf0055969 |Saudou et al. |1992 CLOC|56A--B (determined by in situ hybridization) FNC|serotonin receptor, adenylate cyclase inhibiting pathway ; GO:0007198 | inferred from direct assay |serotonin receptor, phospholipase C activating pathway ; GO:0007208 | inferred from direct assay WT|@5-HT1A@ receptor inhibits adenylate cyclase and activates phospholipase |C. Expression starts in late embryos predominantly in midline motor |neurones, suggesting a role in motor control. @5-HT1A@ and @5-HT1B@ |have a common chromosomal location and high sequence homology suggesting |they are the result of a recent duplication event. } REFDSR { RDID|FBrf0058170 |Hen |1993 SYN|5HT-drp2A } REFDSR { RDID|FBrf0064277 |Witz et al. |1991 SYN|5HT1A } REFDSR { RDID|FBrf0064857 |Boschert et al. |1991 SYN|5HT-dro2A } REFDSR { RDID|FBrf0066373 |Boschert et al. |1991 SYN|5HT-dro2A: serotonin-receptor-2A } REFDSR { RDID|FBrf0080576 |Maroteaux |1995.5.31 SYN|5-HT1ADro } REFDSR { RDID|FBrf0088108 |Feng et al. |1996 SYN|5htdro2a } REFDSR { RDID|FBrf0102326 |Han et al. |1998 SYN|DRO2A } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|serotonin receptor activity ; GO:0004993 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 FNC|serotonin receptor signaling pathway ; GO:0007210 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 MD|Maps to clone: BACR01N09 CEL|plasma membrane ; GO:0005886 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 GPD|serotonin-receptor } REFDSR { RDID|FBrf0108201 |Hita et al. |1999 MD|Maps to clone: DS07626 } REFDSR { RDID|FBrf0123896 |SwissProt Project Members |1992.12.1 ENZ|G-protein coupled serotonin receptor activity ; GO:0016609 | non-traceable author statement FNC|serotonin receptor, adenylate cyclase inhibiting pathway ; GO:0007198 | non-traceable author statement CEL|integral to plasma membrane ; GO:0005887 | non-traceable author statement GPD|5-hydroxytryptamine receptor 2A } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: RE57708 (BDGP-DGC) } REFDSR { RDID|FBrf0128759 |Lai |1999.11 AM|Source for identity of: 5-HT1A CG16720 } REFDSR { RDID|FBrf0129744 |Brody and Cravchik |2000 ENZ|G-protein coupled serotonin receptor activity ; GO:0016609 | inferred from sequence similarity FNC|serotonin receptor signaling pathway ; GO:0007210 | inferred from sequence similarity CEL|integral to membrane ; GO:0016021 | inferred from sequence similarity GPD|serotonin receptor } REFDSR { RDID|FBrf0135704 |Tierney |2001 SYN|5-HT-dro2A |5-HT1ADro |5HT-dro2A ENZ|5-HT1 receptor activity ; GO:0001586 | non-traceable author statement |serotonin receptor activity ; GO:0004993 | traceable author statement FNC|serotonin receptor, adenylate cyclase inhibiting pathway ; GO:0007198 | traceable author statement |serotonin receptor, phospholipase C activating pathway ; GO:0007208 | traceable author statement } REFDSR { RDID|FBrf0138226 |Blenau and Baumann |2001 SYN|Dm5HTdro2A } REFDSR { RDID|FBrf0141689 |Claridge-Chang et al. |2001 MD|Shows particularly robust cycling of transcription in adult heads, |as assessed by expression analysis using high density oligonucleotide |arrays with probe generated during three 12-point time course experiments |over the course of 6 days. } REFDSR { RDID|FBrf0152099 |Radford et al. |2002 ENZ|amine receptor activity ; GO:0008227 | inferred from sequence similarity } ALESR { ASYM|5-HT1A+ ID|FBal0071518 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0004572 CLA 1 Gene NAM 1 Serotonin receptor 1B GSYM 1 5-HT1B DT 1 14 Aug 03 RESZ 7307 PDOM 2 INTERPRO:IPR000276 == Rhodopsin-like GPCR superfamily PTD 1 DBA 4 HG 4 Caenorhabditis elegans 'serotonin receptor' EMBL:U15167 FNC 3 serotonin receptor signaling pathway CEL 2 integral to membrane WT 2 One of several known Drosophila serotonin receptor encoding genes CLOC 1 56B1 ALESR 1 REF 21 GSYM|5-HT1B PTD MMP DT|14 Aug 03 ID|FBgn0004572 UAB|Duplication: Dp(2;Y)53D;57C (inferred from cytology) SYN|CG15113 |5HT-dro2B |5HT-dro2B |5-HT1BDro |5-HTdro2B |5htdro2b |DRO2B |5-HT-dro2B |5-HT1BDro |Dm5HTdro2B |5HT-R2B: Serotonin receptor 2B |Serotonin receptor 2B NAM|Serotonin receptor 1B KLOC|70361 CLOC|56B1 |Limits computationally determined from genome sequence between l(2)k08810 and l(2)02029/l(2)k08713 CYC|Experimentally determined: 56A--B FNC|serotonin receptor signaling pathway ; GO:0007210 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 |serotonin receptor, adenylate cyclase inhibiting pathway ; GO:0007198 | inferred from direct assay |serotonin receptor, phospholipase C activating pathway ; GO:0007208 | inferred from direct assay CEL|integral to membrane ; GO:0016021 | inferred from sequence similarity |plasma membrane ; GO:0005886 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 WT|One of several known Drosophila serotonin receptor encoding genes. |Presumed to be a recent duplication of @5-HT1A@ gene. PDOM|IPR000276 == Rhodopsin-like GPCR superfamily |SCOP:56869 == Membrane all-alpha; 5-HT1B|FBgn0004572|pp-CT34991|FBan0015113 ENZ|amine receptor activity ; GO:0008227 | inferred from sequence similarity |G-protein coupled serotonin receptor activity ; GO:0016609 | non-traceable author statement |G-protein coupled serotonin receptor activity ; GO:0016609 | inferred from sequence similarity |serotonin receptor activity ; GO:0004993 | traceable author statement |serotonin receptor activity ; GO:0004993 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 |5-HT1 receptor activity ; GO:0001586 | non-traceable author statement DBA|NA:AE003797 |PA:AAF57610 |NA:Z11490 |PA:CAA77571 PAC|GCR:0255 |PIR:S18154 |PIR:S19156 |SPTREMBL:Q9V8Q3 |SWP:P28286 HG|species == Caenorhabditis elegans; gene == 'serotonin receptor'; EMBL:U15167; gi:2317845; score == 250.8; expect == 1.e-35 |species == HELVI; gene == '5-HYDROXYTRYPTAMINE RECEPTOR (5-HT RECEPTOR) (SEROTONIN RECEPTOR) >gi'; SWP:Q25190; gi:2494933; score == 341; expect == 1.e-50 |species == Homo sapiens; OMIM:109760; score == 229.7; expect == 1.e-29 |species == Mus musculus; gene == Htr1a; MGI:96273; score == 227.3; expect == 2.e-29 ASQ|FBan0015113 REV|FBrf0138226 REF { REFM|FBrf0138226 |Blenau and Baumann |2001 |2 REFM|FBrf0129744 |Brody and Cravchik |2000 |0 REFM|FBrf0080576 |Maroteaux |1995.5.31 |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0154602 |1 REFM|FBrf0126659 |Cravchik |1999.11 |9 REFM|FBrf0123897 |SwissProt Project Members |1992.12.1 |9 REFM|FBrf0058170 |Hen |1993 |0 REFM|FBrf0064857 |Boschert et al. |1991 |1 REFM|FBrf0152099 |Radford et al. |2002 |0 REFM|FBrf0108201 |Hita et al. |1999 |9 REFM|FBrf0054500 |Buchner |1991 |2 REFM|FBrf0104704 |Pebusque et al. |1998 |0 REFM|FBrf0088108 |Feng et al. |1996 |0 REFM|FBrf0135704 |Tierney |2001 |2 REFM|FBrf0110590 |Prokop |1999 |2 REFM|FBrf0066373 |Boschert et al. |1991 |1 REFM|FBrf0086561 |Obosi et al. |1996 |0 REFM|FBrf0102326 |Han et al. |1998 |0 REFM|FBrf0055969 |Saudou et al. |1992 |0 } REFDSR { RDID|FBrf0054500 |Buchner |1991 SYN|5HT-dro2B } REFDSR { RDID|FBrf0055969 |Saudou et al. |1992 CLOC|56A--B (determined by in situ hybridization) FNC|serotonin receptor, adenylate cyclase inhibiting pathway ; GO:0007198 | inferred from direct assay |serotonin receptor, phospholipase C activating pathway ; GO:0007208 | inferred from direct assay WT|@5-HT1B@ receptor inhibits adenylate cyclase and activates phospholipase |C. Expression starts in late embryos and is restricted to distinct |populations in the CNS. @5-HT1A@ and @5-HT1B@ have a common chromosomal |location and high sequence homology suggesting they are the result |of a recent duplication event. } REFDSR { RDID|FBrf0058170 |Hen |1993 SYN|5HT-dro2B } REFDSR { RDID|FBrf0064857 |Boschert et al. |1991 SYN|5HT-dro2B } REFDSR { RDID|FBrf0066373 |Boschert et al. |1991 SYN|5HT-dro2B } REFDSR { RDID|FBrf0080576 |Maroteaux |1995.5.31 SYN|5-HT1BDro } REFDSR { RDID|FBrf0086561 |Obosi et al. |1996 SYN|5-HTdro2B } REFDSR { RDID|FBrf0088108 |Feng et al. |1996 SYN|5htdro2b } REFDSR { RDID|FBrf0102326 |Han et al. |1998 SYN|DRO2B } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|serotonin receptor activity ; GO:0004993 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 FNC|serotonin receptor signaling pathway ; GO:0007210 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 CEL|plasma membrane ; GO:0005886 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 GPD|serotonin-receptor } REFDSR { RDID|FBrf0123897 |SwissProt Project Members |1992.12.1 ENZ|G-protein coupled serotonin receptor activity ; GO:0016609 | non-traceable author statement FNC|serotonin receptor, adenylate cyclase inhibiting pathway ; GO:0007198 | non-traceable author statement CEL|integral to plasma membrane ; GO:0005887 | non-traceable author statement GPD|5-hydroxytryptamine receptor 2B } REFDSR { RDID|FBrf0129744 |Brody and Cravchik |2000 ENZ|G-protein coupled serotonin receptor activity ; GO:0016609 | inferred from sequence similarity FNC|serotonin receptor signaling pathway ; GO:0007210 | inferred from sequence similarity CEL|integral to membrane ; GO:0016021 | inferred from sequence similarity GPD|serotonin receptor } REFDSR { RDID|FBrf0135704 |Tierney |2001 ENZ|5-HT1 receptor activity ; GO:0001586 | non-traceable author statement |serotonin receptor activity ; GO:0004993 | traceable author statement FNC|serotonin receptor, adenylate cyclase inhibiting pathway ; GO:0007198 | traceable author statement |serotonin receptor, phospholipase C activating pathway ; GO:0007208 | traceable author statement SYN|5-HT-dro2B |5-HT1BDro |5HT-dro2B } REFDSR { RDID|FBrf0138226 |Blenau and Baumann |2001 SYN|Dm5HTdro2B } REFDSR { RDID|FBrf0152099 |Radford et al. |2002 ENZ|amine receptor activity ; GO:0008227 | inferred from sequence similarity } ALESR { ASYM|5-HT1B+ ID|FBal0071519 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0013743 CLA 1 Gene NAM 1 Serotonin receptor 2 GSYM 1 5-HT2 DT 1 14 Aug 03 RESZ 12585 PDOM 2 INTERPRO:IPR000276 == Rhodopsin-like GPCR superfamily PTD 1 DBA 13 HG 4 Caenorhabditis elegans 'serotonin receptor' EMBL:AF031414 FNC 2 serotonin receptor signaling pathway CEL 1 plasma membrane CLOC 1 82C5 ALESR 4 REF 26 GSYM|5-HT2 PTD DT|14 Aug 03 ID|FBgn0013743 UAB|Deficiency: Df(3R)110 |Duplication: Dp(3;3)81-83 (inferred from cytology) SYN|CG1056 |5HT-dro1 |5-HT2Dro |5-HT2 |5HT2Dro |5-ht2Dro |5HT2Dro |5-HT2Dro |5HT2-Dro |Dm5HT2 |5HT-R82A NAM|Serotonin receptor 2 KLOC|103545 GLOC|3- CLOC|82C5 |Limits computationally determined from genome sequence between l(3)01456/l(3)02733 and EP(3)0974 CYC|Experimentally determined: 82C, 82C--D, 82C--E FNC|serotonin receptor signaling pathway ; GO:0007210 | inferred from sequence similarity |serotonin receptor signaling pathway ; GO:0007210 | traceable author statement CEL|plasma membrane ; GO:0005886 | inferred from direct assay PDOM|IPR000276 == Rhodopsin-like GPCR superfamily |SCOP:56869 == Membrane all-alpha; 5-HT2|FBgn0013743|pp-CT1149|FBan0001056 ENZ|amine receptor activity ; GO:0008227 | inferred from sequence similarity |G-protein coupled serotonin receptor activity ; GO:0016609 | inferred from sequence similarity |serotonin receptor activity ; GO:0004993 | traceable author statement |serotonin receptor activity ; GO:0004993 | non-traceable author statement |5-HT2 receptor activity ; GO:0001587 | non-traceable author statement DBA|NA:AA699149 |BDGP-DGC:HL07802 |NA:AE003605 |PA:AAF52113 |PA:AAN13284 |NA:AW942018 |BDGP-DGC:HL07802 |NA:AY061039 |PA:AAL28587 |BDGP-DGC:HL07802 |NA:X81835 |PA:CAA57429 |NA:X85407 PAC|SPTREMBL:Q24511 |SPTREMBL:Q8IPN2 |SPTREMBL:Q95RY6 |SPTREMBL:Q9VN38 HG|species == Caenorhabditis elegans; gene == 'serotonin receptor'; EMBL:AF031414; gi:2642279; score == 276; expect == 1.e-39 |species == Homo sapiens; gene == '5-hydroxytryptamine (serotonin) receptor 2C'; gi:4504541; score == 259.7; expect == 7.e-39 |species == Lymnaea stagnalis; gene == 'serotonin receptor 5-HT2'; EMBL:U50080; gi:3150433; score == 304; expect == 6.e-48 |species == Mus musculus; gene == Htr2c; MGI:96281; score == 252.8; expect == 2.e-37 ASQ|FBan0001056 REV|FBrf0138226 |FBrf0138225 REF { REFM|FBrf0111346 |Colas et al. |1999 |0 REFM|FBrf0101089 |Maroteaux et al. |1998 |1 REFM|FBrf0138226 |Blenau and Baumann |2001 |2 REFM|FBrf0138225 |Vanden Broeck |2001 |2 REFM|FBrf0129744 |Brody and Cravchik |2000 |0 REFM|FBrf0109520 |Colas et al. |1999 |1 REFM|FBrf0080576 |Maroteaux |1995.5.31 |9 REFM|FBrf0117712 |Maroteaux |1995.3.14 |9 REFM|FBrf0117711 |Maroteaux |1994.9.19 |9 REFM|FBrf0083085 |Colas et al. |1995 |1 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0154602 |1 REFM|FBrf0083842 |Colas et al. |1995 |1 REFM|FBrf0058170 |Hen |1993 |0 REFM|FBrf0106916 |Maroteaux et al. |1999 |1 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0092338 |Colas et al. |1997 |1 REFM|FBrf0152099 |Radford et al. |2002 |0 REFM|FBrf0086363 |Colas et al. |1996 |1 REFM|FBrf0135704 |Tierney |2001 |2 REFM|FBrf0104704 |Pebusque et al. |1998 |0 REFM|FBrf0141689 |Claridge-Chang et al. |2001 |0 REFM|FBrf0078230 |Colas et al. |1995 |1 REFM|FBrf0081644 |Colas et al. |1995 |0 REFM|FBrf0111347 |Colas et al. |1999 |0 } REFDSR { RDID|FBrf0058170 |Hen |1993 SYN|5HT-dro1 } REFDSR { RDID|FBrf0078230 |Colas et al. |1995 WT|Identified in a screen for genes encoding G-protein coupled receptors. } REFDSR { RDID|FBrf0080576 |Maroteaux |1995.5.31 SYN|5-HT2Dro CLOC|82C--D (determined by in situ hybridization) WT|This serotonin receptor displays a sequence, gene organization and pharmacology |typical of the mammalian serotonin 5-HT2 receptor type (5-HT2B subtype) |acting on phospholipase C. } REFDSR { RDID|FBrf0081644 |Colas et al. |1995 SYN|5-HT2 CEL|plasma membrane ; GO:0005886 | inferred from direct assay |plasma membrane ; GO:0005886 | inferred from sequence similarity WT|Characterization of @5-HT2@ reveals it is expressed in the central |nervous system during larval and adult stages and the receptor is expressed |at the blastoderm stage in a pattern similar to that of @ftz@. BMD|Df(3R)110 BMDD|Df(3R)6-7 } REFDSR { RDID|FBrf0083085 |Colas et al. |1995 SYN|5-HT2Dro } REFDSR { RDID|FBrf0083842 |Colas et al. |1995 SYN|5-HT2Dro } REFDSR { RDID|FBrf0086363 |Colas et al. |1996 SYN|5-HT2Dro } REFDSR { RDID|FBrf0092338 |Colas et al. |1997 SYN|5HT2Dro } REFDSR { RDID|FBrf0101089 |Maroteaux et al. |1998 SYN|5-HT2Dro } REFDSR { RDID|FBrf0106916 |Maroteaux et al. |1999 SYN|5-ht2Dro } REFDSR { RDID|FBrf0109520 |Colas et al. |1999 SYN|5-ht2Dro } REFDSR { RDID|FBrf0111346 |Colas et al. |1999 SYN|5HT2Dro MD|Peaks of @5-HT2@ expression and serotonin synthesis coincide precisely |with the onset of convergent extension of the ectoderm. |Maps to clone: DS04152 |Maps to clone: 56E12 |Maps to clone: 78C10 BMD|Df(3R)110 BMD|Df(3R)HTRE BMD|Df(3R)HTRI BMDD|Df(3R)HTR6 PHP|Mutants do not extend the germband properly, and ectodermal movements |become asynchronous with the morphogenetic movements in the endoderm |and mesoderm. Adherens junctions in the ectoderm show altered subcellular |distribution at the onset of the asynchronicity. } REFDSR { RDID|FBrf0111347 |Colas et al. |1999 SYN|5HT2Dro CLOC|82C--E WT|Serotinin, acting through the @5-HT2@ gene product, is necessary for |proper gastrulation. BMD|Df(3R)HTRI BMDD|Df(3R)HTR6 PHP|Deletion |of @5-HT2@ is associated with a specific, double-line cuticular |phenotype. } REFDSR { RDID|FBrf0117711 |Maroteaux |1994.9.19 SYN|5-HT2Dro } REFDSR { RDID|FBrf0117712 |Maroteaux |1995.3.14 ENZ|serotonin receptor activity ; GO:0004993 | non-traceable author statement GLOC|3- CLOC|82C FNC|serotonin receptor signaling pathway ; GO:0007210 | non-traceable author statement CEL|plasma membrane ; GO:0005886 | non-traceable author statement GPD|serotonin-receptor } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: HL07802 (BDGP-DGC) } REFDSR { RDID|FBrf0129744 |Brody and Cravchik |2000 ENZ|G-protein coupled serotonin receptor activity ; GO:0016609 | inferred from sequence similarity FNC|serotonin receptor signaling pathway ; GO:0007210 | inferred from sequence similarity CEL|integral to membrane ; GO:0016021 | inferred from sequence similarity GPD|serotonin receptor } REFDSR { RDID|FBrf0135704 |Tierney |2001 SYN|5-HT2Dro ENZ|5-HT2 receptor activity ; GO:0001587 | non-traceable author statement |serotonin receptor activity ; GO:0004993 | traceable author statement FNC|serotonin receptor signaling pathway ; GO:0007210 | traceable author statement } REFDSR { RDID|FBrf0138225 |Vanden Broeck |2001 SYN|5HT2-Dro } REFDSR { RDID|FBrf0138226 |Blenau and Baumann |2001 SYN|Dm5HT2 } REFDSR { RDID|FBrf0141689 |Claridge-Chang et al. |2001 MD|Shows particularly robust cycling of transcription in adult heads, |as assessed by expression analysis using high density oligonucleotide |arrays with probe generated during three 12-point time course experiments |over the course of 6 days. } REFDSR { RDID|FBrf0152099 |Radford et al. |2002 ENZ|amine receptor activity ; GO:0008227 | inferred from sequence similarity } ALESR { ASYM|5-HT2a.Y32.hs ID|FBal0101837 PHC|lethal | conditional ts PHM|extended germ band stage |pole cell |ventral midline PHI|Mutant embryos show abnormal germband extension movements. There is |a desynchronization between germband extension and mesodermal and endodermal |invaginations, and a premature termination of movements. The ventral |midline closure is often incomplete, and pole cells abnormally positioned. |Mode of assay: In transgenic Drosophila REF|FBrf0111346 REFDSR { RDID|FBrf0111346 |Colas et al. |1999 NAM|antisense Y32 heat shock construct MD|Construct: Expression of @5-HT2@ cDNA including the N-terminus, the extracellular |region and the first transmembrane region in the antisense orientation |is driven by a heat shock promoter. MU|in vitro construct | regulatory fusion CNS|FBtp0011635 == P{hs-5-HT2.Y32.a} PHC|lethal | conditional ts PHM|extended germ band stage |pole cell |ventral midline PHI|Mutant embryos show abnormal germband extension movements. There is |a desynchronization between germband extension and mesodermal and endodermal |invaginations, and a premature termination of movements. The ventral |midline closure is often incomplete, and pole cells abnormally positioned. |Mode of assay: In transgenic Drosophila } } ALESR { ASYM|5-HT2hs.PC ID|FBal0101836 PHC|lethal | dominant | conditional ts PHM|epidermis | embryonic PHI|Even after a heat shock of only 8 minutes the ectodermal layer elongation |is disturbed, and lethality results. |Mode of assay: In transgenic Drosophila REF|FBrf0111346 REFDSR { RDID|FBrf0111346 |Colas et al. |1999 NAM|heat shock construct of Colas MD|Construct: Expression of full length @5-HT2@ cDNA is driven by a heat shock promoter. MU|in vitro construct | regulatory fusion CNS|FBtp0011634 == P{hs-5-HT2.C} PHC|lethal | dominant | conditional ts PHM|epidermis | embryonic PHI|Even after a heat shock of only 8 minutes the ectodermal layer elongation |is disturbed, and lethality results. |Mode of assay: In transgenic Drosophila } } ALESR { ASYM|5-HT2Scer\UAS.cCa ID|FBal0101838 PHC|viable with @Scer\GAL4Kr.PM@ |viable | poor | conditional ts with @Scer\GAL4Kr.PM@ PHM|gastrula with @Scer\GAL4Kr.PM@ PHI|When expression is driven by @Scer\GAL4Kr.PM@ there are initially |significant perturbations at the beginning of gastrulation, due to |a mistiming in morphogenetic movements, which is compensated later |in embryogenesis by an increase in rate of cell movement. Heat shocking |increases the lethality. |Mode of assay: In transgenic Drosophila REF|FBrf0111346 REFDSR { RDID|FBrf0111346 |Colas et al. |1999 NAM|Saccharomyces cerevisiae UAS construct a of Colas MD|Construct: Expression of full length @5-HT2@ cDNA is governed by @Scer\UAS@ regulatory |sequences. MU|in vitro construct | regulatory fusion CNS|FBtp0011636 == P{UAS-5-HT2.C} PHC|viable with @Scer\GAL4Kr.PM@ |viable | poor | conditional ts with @Scer\GAL4Kr.PM@ PHM|gastrula with @Scer\GAL4Kr.PM@ PHI|When expression is driven by @Scer\GAL4Kr.PM@ there are initially |significant perturbations at the beginning of gastrulation, due to |a mistiming in morphogenetic movements, which is compensated later |in embryogenesis by an increase in rate of cell movement. Heat shocking |increases the lethality. |Mode of assay: In transgenic Drosophila } } ALESR { ASYM|5-HT2+ ID|FBal0066320 CLA|wild-type generic REF|FBrf0105495 } IFL|../hjmuller/serotr1.htm } # EOR GENR { RETE|ID 1 FBgn0004573 CLA 1 Gene NAM 1 Serotonin receptor 7 GSYM 1 5-HT7 DT 1 14 Aug 03 RESZ 7467 PDOM 2 INTERPRO:IPR000276 == Rhodopsin-like GPCR superfamily PTD 1 DBA 11 HG 4 Bombyx mori 'OCTOPAMINE RECEPTOR' SWP:Q17232 FNC 2 serotonin receptor signaling pathway CEL 2 integral to membrane WT 3 @5-HT7@ receptor stimulates adenylate cyclase CLOC 1 100B1 ALESR 1 REF 21 GSYM|5-HT7 PTD DT|14 Aug 03 ID|FBgn0004573 UAB|Deficiency: Df(3R)tll-e (inferred from cytology) |Duplication: Dp(3;3)516 (inferred from cytology) SYN|CG12073 |5HT-dro |5HT-dro1 |5-HT7Dro |5-HTdro1 |5htdror |DRO1 |5-HT-dro1 |5-HT7Dro |5-HT-dro |5-HTdro1 |5-HT7 |Dm5HTdro1 |5HT-R1: Serotonin receptor 1 |Serotonin receptor 1 NAM|Serotonin receptor 7 KLOC|129663 CLOC|100B1 |Limits computationally determined from genome sequence between l(3)s2500 and l(3)07028/l(3)rK215 CYC|Experimentally determined: 100A, 99F--100A FNC|serotonin receptor signaling pathway ; GO:0007210 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 |serotonin receptor, adenylate cyclase activating pathway ; GO:0007192 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 CEL|integral to membrane ; GO:0016021 | inferred from sequence similarity |plasma membrane ; GO:0005886 | inferred from sequence similarity with MGD:Htr2c; MGI:MGI:96281 PDOM|IPR000276 == Rhodopsin-like GPCR superfamily |SCOP:56869 == Membrane all-alpha; 5-HT7|FBgn0004573|pp-CT4852|FBan0012073 WT|@5-HT7@ receptor stimulates adenylate cyclase. Expression starts in |late embryos and is restricted to distinct cell populations in the |CNS. ENZ|amine receptor activity ; GO:0008227 | inferred from sequence similarity |serotonin receptor activity ; GO:0004993 | inferred from sequence similarity with MGD:Htr2c; MGI:MGI:96281 |G-protein coupled serotonin receptor activity ; GO:0016609 | non-traceable author statement |G-protein coupled serotonin receptor activity ; GO:0016609 | inferred from sequence similarity |serotonin receptor activity ; GO:0004993 | traceable author statement DBA|NA:AA201540 |BDGP-DGC:LD04507 |NA:AE003776 |PA:AAF57104 |NA:AW941548 |BDGP-DGC:LD04507 |NA:AY118491 |PA:AAM49860 |BDGP-DGC:LD04507 |NA:M55533 |PA:AAA28305 PAC|GCR:0023 |PIR:A38271 |SWP:P20905 HG|species == Bombyx mori; gene == 'OCTOPAMINE RECEPTOR'; SWP:Q17232; gi:2495004; score == 254.4; expect == 2.e-38 |species == Caenorhabditis elegans; gene == 'similar to family 1 of G-protein coupled receptors, most similar to serotonin re'; EMBL:U64601; gi:1439648; score == 224.2; expect == 1.e-31 |species == Homo sapiens; gene == '5-hydroxytryptamine7 receptor isoform b'; EMBL:U68487; gi:1857143; score == 245; expect == 5.e-64 |species == Mus musculus; gene == Htr7; MGI:99841; score == 267; expect == 3.e-42 ASQ|FBan0012073 REV|FBrf0138226 REF { REFM|FBrf0075179 |Boschert et al. |1991 |9 REFM|FBrf0138226 |Blenau and Baumann |2001 |2 REFM|FBrf0129744 |Brody and Cravchik |2000 |0 REFM|FBrf0123747 |SwissProt Project Members |1991.2.1 |9 REFM|FBrf0080576 |Maroteaux |1995.5.31 |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126659 |Cravchik |1999.11 |9 REFM|FBrf0052872 |Witz et al. |1990 |0 REFM|FBrf0051655 |Saudou et al. |1990 |0 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0064857 |Boschert et al. |1991 |1 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0152099 |Radford et al. |2002 |0 REFM|FBrf0104704 |Pebusque et al. |1998 |0 REFM|FBrf0088108 |Feng et al. |1996 |0 REFM|FBrf0135704 |Tierney |2001 |2 REFM|FBrf0066373 |Boschert et al. |1991 |1 REFM|FBrf0086561 |Obosi et al. |1996 |0 REFM|FBrf0102326 |Han et al. |1998 |0 REFM|FBrf0055969 |Saudou et al. |1992 |0 } REFDSR { RDID|FBrf0051655 |Saudou et al. |1990 SYN|5HT-dro } REFDSR { RDID|FBrf0052872 |Witz et al. |1990 CLOC|99F--100A (determined by in situ hybridization) } REFDSR { RDID|FBrf0055969 |Saudou et al. |1992 CLOC|100A (determined by in situ hybridization) WT|@5-HT7@ receptor stimulates adenylate cyclase. Expression starts in |late embryos and is restricted to distinct cell populations in the |CNS. } REFDSR { RDID|FBrf0064857 |Boschert et al. |1991 CLOC|100A (determined by in situ hybridization) SYN|5HT-dro1 } REFDSR { RDID|FBrf0066373 |Boschert et al. |1991 SYN|5HT-dro1 } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 MD|Identified with: D1183 } REFDSR { RDID|FBrf0075179 |Boschert et al. |1991 CLOC|100A (determined by in situ hybridization) } REFDSR { RDID|FBrf0080576 |Maroteaux |1995.5.31 SYN|5-HT7Dro } REFDSR { RDID|FBrf0086561 |Obosi et al. |1996 SYN|5-HTdro1 } REFDSR { RDID|FBrf0088108 |Feng et al. |1996 SYN|5htdror } REFDSR { RDID|FBrf0102326 |Han et al. |1998 SYN|DRO1 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|serotonin receptor activity ; GO:0004993 | inferred from sequence similarity with MGD:Htr2c; MGI:MGI:96281 FNC|serotonin receptor signaling pathway ; GO:0007210 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 |serotonin receptor, adenylate cyclase activating pathway ; GO:0007192 | inferred from sequence similarity with MGD:Htr1a; MGI:MGI:96273 CEL|plasma membrane ; GO:0005886 | inferred from sequence similarity with MGD:Htr2c; MGI:MGI:96281 GPD|serotonin-receptor } REFDSR { RDID|FBrf0123747 |SwissProt Project Members |1991.2.1 ENZ|G-protein coupled serotonin receptor activity ; GO:0016609 | non-traceable author statement FNC|serotonin receptor, adenylate cyclase activating pathway ; GO:0007192 | non-traceable author statement CEL|integral to plasma membrane ; GO:0005887 | non-traceable author statement GPD|5-hydroxytryptamine receptor 1 } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD04507 (BDGP-DGC) } REFDSR { RDID|FBrf0129744 |Brody and Cravchik |2000 ENZ|G-protein coupled serotonin receptor activity ; GO:0016609 | inferred from sequence similarity FNC|serotonin receptor signaling pathway ; GO:0007210 | inferred from sequence similarity CEL|integral to membrane ; GO:0016021 | inferred from sequence similarity GPD|serotonin receptor } REFDSR { RDID|FBrf0135704 |Tierney |2001 ENZ|serotonin receptor activity ; GO:0004993 | traceable author statement FNC|serotonin receptor, adenylate cyclase activating pathway ; GO:0007192 | traceable author statement SYN|5-HT-dro1 |5-HT7Dro |5-HT-dro |5-HTdro1 |5HT-dro1 |5-HT7 } REFDSR { RDID|FBrf0138226 |Blenau and Baumann |2001 SYN|Dm5HTdro1 } REFDSR { RDID|FBrf0152099 |Radford et al. |2002 ENZ|amine receptor activity ; GO:0008227 | inferred from sequence similarity } ALESR { ASYM|5-HT7+ ID|FBal0071517 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0025466 CLA 1 existence-uncertain gene NAM 1 5-Hydroxy Tryptophan decarboxylase GSYM 1 5-HTdc DT 1 14 Aug 03 RESZ 752 ALESR 1 REF 2 GSYM|5-HTdc DT|14 Aug 03 ID|FBgn0025466 CLA|existence-uncertain gene SYN|5-Hydroxy Tryptophan decarboxylase NAM|5-Hydroxy Tryptophan decarboxylase ENZ|aromatic-L-amino acid decarboxylase activity ; GO:0004058 ; EC:4.1.1.28 | inferred from direct assay REF { REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0040032 |Livingstone and Tempel |1983 |0 } REFDSR { RDID|FBrf0040032 |Livingstone and Tempel |1983 ENZ|aromatic-L-amino acid decarboxylase activity ; GO:0004058 ; EC:4.1.1.28 | inferred from direct assay NAM|5-Hydroxy Tryptophan decarboxylase GPD|aromatic-L-amino-acid decarboxylase } ALESR { ASYM|5-HTdc+ ID|FBal0092394 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0061471 CLA 1 multicopy cytosolic ribosomal RNA gene GSYM 1 5.8SrRNA DT 1 14 Aug 03 RESZ 1073 DBA 6 ALESR 1 REF 5 GSYM|5.8SrRNA DT|14 Aug 03 ID|FBgn0061471 CLA|multicopy_cytosolic_ribosomal_RNA_gene SYN|5.8S and 2S ribosomal rRNA |5.8S DNA and IGS |5.8S rRNA |5.8SRNA AM|encoded by: @bb@, @Ybb@ |component genes: @5.8SrRNA:CR40454@, @5.8SrRNA:CR40457@ DBA|NA:AF083522 |NA:M21017 |NA:U20145 |NA:V00236 |NA:X15707 |NA:X68958 REF { REFM|FBrf0117968 |McKee |1993.7.12 |9 REFM|FBrf0154285 |Ashburner |2003.2.5 |9 REFM|FBrf0127122 |Hori et al. |2000 |0 REFM|FBrf0115021 |Fox |1995.1.20 |9 REFM|FBrf0121292 |Tautz |1990.3.15 |9 } REFDSR { RDID|FBrf0115021 |Fox |1995.1.20 SYN|5.8S and 2S ribosomal rRNA } REFDSR { RDID|FBrf0117968 |McKee |1993.7.12 SYN|5.8S DNA and IGS } REFDSR { RDID|FBrf0121292 |Tautz |1990.3.15 SYN|5.8S rRNA } REFDSR { RDID|FBrf0127122 |Hori et al. |2000 SYN|5.8S rRNA } ALESR { ASYM|5.8SrRNA+ ID|FBal0142208 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0058454 CLA 1 existence-uncertain gene GSYM 1 5.8SrRNA:CR40454 DT 1 14 Aug 03 RESZ 262 ALESR 1 GSYM|5.8SrRNA:CR40454 DT|14 Aug 03 ID|FBgn0058454 CLA|existence-uncertain gene SYN|CR40454 AM|member gene of: @5.8SrRNA@ ASQ|FBan0040454 ALESR { ASYM|5.8SrRNA:CR40454+ ID|FBal0143092 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0058457 CLA 1 existence-uncertain gene GSYM 1 5.8SrRNA:CR40457 DT 1 14 Aug 03 RESZ 262 ALESR 1 GSYM|5.8SrRNA:CR40457 DT|14 Aug 03 ID|FBgn0058457 CLA|existence-uncertain gene SYN|CR40457 AM|member gene of: @5.8SrRNA@ ASQ|FBan0040457 ALESR { ASYM|5.8SrRNA:CR40457+ ID|FBal0143091 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0000002 CLA 1 multicopy cytosolic ribosomal RNA gene NAM 1 5S ribosomal RNA GSYM 1 5SrRNA DT 1 14 Aug 03 RESZ 10970 DBA 11 CEL 1 cytosolic large ribosomal subunit (sensu Eukarya) WT 2 The locus encoding the genes for 5S RNA CLOC 1 56F1--2 ALESR 5 SK 1 REF 44 GSYM|5SrRNA DT|14 Aug 03 ID|FBgn0000002 CLA|multicopy_cytosolic_ribosomal_RNA_gene UAB|Duplication: Dp(2;Y)53D;57C (inferred from cytology) SYN|5SRNA |5S |l(2)03068 |Dm5S |RNA X |PZ03068 |5S rRNA |2S rRNA ID2|FBgn0010528 NAM|5S ribosomal RNA KLOC|71381-2605 GLOC|2-[90] CLOC|56F1--2 |Left limit from in situ hybridization (FBrf0067338) |Right limit from in situ hybridization (FBrf0067338) CYC|Experimentally determined: 56E--F, 56F, 56F1--2, 56F1--7 CEL|cytosolic large ribosomal subunit (sensu Eukarya) ; GO:0005842 | non-traceable author statement WT|The locus encoding the genes for 5S RNA. Ordinarily, the haploid |complement carries approximately 165 copies of 5S genes. DBA|NA:AQ025605 |BDGP:l(2)03068 |NA:J01122 |NA:J01854 |NA:M11034 |NA:M25016 |NA:M25181 |NA:X01082 |NA:X06937 |NA:X06938 |NA:X87880 PHP|Heterozygous deficiency for the region is normal in phenotype. REF { REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0134799 |van Steensel et al. |2001 |9 REFM|FBrf0021974 |Wimber and Steffensen |1970 |0 REFM|FBrf0098238 |Fox |1997 |0 REFM|FBrf0063901 |Szabo |1974 |1 REFM|FBrf0084251 |Paques et al. |1995 |0 REFM|FBrf0128662 |Takada et al. |2000 |0 REFM|FBrf0054341 |Preiser and Levinger |1991 |0 REFM|FBrf0063869 |Shimada |1992 |0 REFM|FBrf0086568 |Paques et al. |1996 |0 REFM|FBrf0037913 |Tschudi et al. |1982 |0 REFM|FBrf0048240 |Samson and Wegnez |1988 |0 REFM|FBrf0058810 |Matunis et al. |1993 |0 REFM|FBrf0027507 |Procunier and Tartof |1975 |0 REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0041596 |Sharp et al. |1984 |0 REFM|FBrf0122003 |Wegnez |1995.6.6 |9 REFM|FBrf0098998 |Hansen et al. |1997 |0 REFM|FBrf0035460 |Tschudi and Pirrotta |1980 |0 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0083714 |Meister and Braun |1995.10 |9 REFM|FBrf0083745 |Arkhipova |1995 |0 REFM|FBrf0152006 |Ishizuka et al. |2002 |0 REFM|FBrf0051101 |Sandmeyer et al. |1990 |2 REFM|FBrf0100595 |Liu and Restifo |1998 |0 REFM|FBrf0056422 |Levinger et al. |1992 |0 REFM|FBrf0029713 |Hershey et al. |1977 |0 REFM|FBrf0028698 |Benhamou and Jordan |1976 |0 REFM|FBrf0035459 |Junakovic |1980 |0 REFM|FBrf0127122 |Hori et al. |2000 |0 REFM|FBrf0058769 |Preiser et al. |1993 |0 REFM|FBrf0027234 |Rubin and Hogness |1975 |0 REFM|FBrf0074691 |Vasisht et al. |1994 |0 REFM|FBrf0048648 |Sharp and Garcia |1988 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0089555 |Deshpande et al. |1996 |0 REFM|FBrf0054354 |Preiser and Levinger |1991 |0 REFM|FBrf0036942 |Thompson et al. |1981 |0 REFM|FBrf0104768 |McKim and Hayashi-Hagihara |1998 |0 REFM|FBrf0131150 |Berk |2000 |2 REFM|FBrf0038450 |DeLotto et al. |1982 |0 REFM|FBrf0129876 |Jones and Kadonaga |2000 |0 REFM|FBrf0029697 |Artavanis-Tsakonas et al. |1977 |0 REFM|FBrf0031166 |Procunier and Dunn |1978 |0 } REFDSR { RDID|FBrf0021974 |Wimber and Steffensen |1970 CLOC|56E--F (determined by in situ hybridization) SYN|5SRNA } REFDSR { RDID|FBrf0035460 |Tschudi and Pirrotta |1980 CLOC|56F (determined by in situ hybridization) } REFDSR { RDID|FBrf0037913 |Tschudi et al. |1982 WT|The Oregon R Yale stock contains various arrangements of the 5SrRNA |cluster, one variant is due to the insertion of a @roo@ element. Others, |that lack the @roo@ insertion, have a variety of deletions removing 0--60% |of the genes at the insertion site. The Oregon R Heidelberg stock |studied has no @roo@ element so has no heterogeneity in cluster arrangement. |D.melanogaster shows a large redundancy of 5SrRNA genes as there is |no visible phenotype when homozygous or heterozygous against a total |deletion of the cluster. } REFDSR { RDID|FBrf0038450 |DeLotto et al. |1982 CLOC|56F (determined by in situ hybridization) SYN|5SRNA } REFDSR { RDID|FBrf0048240 |Samson and Wegnez |1988 CLOC|56F (determined by in situ hybridization) } REFDSR { RDID|FBrf0051101 |Sandmeyer et al. |1990 SYN|5SRNA } REFDSR { RDID|FBrf0054341 |Preiser and Levinger |1991 SYN|5SRNA } REFDSR { RDID|FBrf0054354 |Preiser and Levinger |1991 SYN|5SRNA } REFDSR { RDID|FBrf0056422 |Levinger et al. |1992 OTH|The effects of stem I and loop A transversions, transitions, selected |additions and deletions on @5SrRNA@ processing are studied. SYN|5SRNA } REFDSR { RDID|FBrf0058769 |Preiser et al. |1993 PHP|@La@ binds to the 3' terminus of the @5SrRNA@ primary transcript, inhibiting |a 3' exonuclease activity. SYN|5SRNA } REFDSR { RDID|FBrf0058810 |Matunis et al. |1993 SYN|5S } REFDSR { RDID|FBrf0063869 |Shimada |1992 PHP|The distribution of split 5.8S rRNA was studied in Diptera and Siphonaptera |to learn the origin of 5.8S rRNA. Four species of mosquitoes and a |flea have a single 5.8S rRNA. A crane fly, a midge, a robber fly, |a house fly and D.melanogaster have split 5.8S rRNA. SYN|5SRNA } REFDSR { RDID|FBrf0063901 |Szabo |1974 CLOC|56F1--7 (determined by in situ hybridization) SYN|5SRNA } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|56F1--2 LOI|5SrRNA03068 BMDD|Df(2R)017 SYN|l(2)03068 } REFDSR { RDID|FBrf0074691 |Vasisht et al. |1994 PHP|Point mutations introduced in vitro into pre-@5SrRNA@ have been used |to determine which regions of the pre-RNA are required for processing. SYN|5SRNA } REFDSR { RDID|FBrf0083714 |Meister and Braun |1995.10 SYN|l(2)03068 } REFDSR { RDID|FBrf0083745 |Arkhipova |1995 SYN|Dm5S } REFDSR { RDID|FBrf0086568 |Paques et al. |1996 SYN|5SRNA } REFDSR { RDID|FBrf0089555 |Deshpande et al. |1996 SYN|5S } REFDSR { RDID|FBrf0098238 |Fox |1997 OTH|@5SrRNA@ was discovered while studying heat-induced alterations of the |ribosome. SYN|RNA X } REFDSR { RDID|FBrf0098998 |Hansen et al. |1997 SYN|5SRNA } REFDSR { RDID|FBrf0100595 |Liu and Restifo |1998 SYN|PZ03068 } REFDSR { RDID|FBrf0104768 |McKim and Hayashi-Hagihara |1998 SYN|l(2)03068 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 CLOC|56F1--2 (determined by in situ hybridization) LOI|5SrRNA03068 AM|Source for merge of: 5SRNA l(2)03068 CEL|cytosolic large ribosomal subunit (sensu Eukarya) ; GO:0005842 | non-traceable author statement GPD|ribosomal-RNA-5S BMDD|Df(2R)017 } REFDSR { RDID|FBrf0122003 |Wegnez |1995.6.6 SYN|5S rRNA } REFDSR { RDID|FBrf0127122 |Hori et al. |2000 SYN|2S rRNA } REFDSR { RDID|FBrf0128662 |Takada et al. |2000 SYN|5SRNA } REFDSR { RDID|FBrf0129876 |Jones and Kadonaga |2000 SYN|5S } REFDSR { RDID|FBrf0131150 |Berk |2000 SYN|5SRNA } REFDSR { RDID|FBrf0134799 |van Steensel et al. |2001 SYN|5S } ALESR { ASYM|5SrRNA03068 SYN|l(2)0306803068 |PZ03068 |l(2)03068 |5SRNA03068 ID|FBal0008014 DIS|A. Spradling. TRN|FBti0004438 == P{PZ}5SrRNA03068 |BDGP:l(2)03068 MU|P-element activity PHC|semi-lethal REF|FBrf0067338 |FBrf0100595 |FBrf0083714 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 OTH|Complements: @18w00053@. |Complements: @mus20902448@. |Complements: @mus20902697@. |Complements: @mus20906652@. |Complements: @l(2)k08002k08002@. |Complements: @RpL30k09918@. |Complements: @htsk14523@. |Complements: @l(2)k16210k16210@. |Complements: @mus209s1534@. TRN|FBti0004438 == P{PZ}5SrRNA03068 |BDGP:l(2)03068 SYN|l(2)0306803068 } REFDSR { RDID|FBrf0083714 |Meister and Braun |1995.10 SYN|l(2)0306803068 } REFDSR { RDID|FBrf0100595 |Liu and Restifo |1998 OTH|@H217H217@ complements @5SrRNA03068@. TRN|FBti0004438 == P{PZ}5SrRNA03068 |BDGP:l(2)03068 PHC|semi-lethal | recessive SYN|PZ03068 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0004438 == P{PZ}5SrRNA03068 |BDGP:l(2)03068 PHC|lethal | recessive SYN|l(2)03068 } SK|FBstBL-11265 |cn[1] P{ry[+t7.2]=PZ}5SrRNA[03068]/CyO; ry[506] } ALESR { ASYM|5SrRNAL62 SYN|5SRNAL62 ID|FBal0027937 DIS|L. Sandler. OTH|@T(Y;2)L62@ breakpoint splits the 5SrRNA gene cluster. MU|X ray ABA|FBab0008617 == T(Y;2)L62 } ALESR { ASYM|5SrRNA216 SYN|5SRNA216 ID|FBal0047967 PHI|Mode of assay: In transgenic Drosophila REF|FBrf0086568 REFDSR { RDID|FBrf0086568 |Paques et al. |1996 MD|Construct: Truncated @5SrRNA@ unit, 216bp. MU|in vitro construct | other CNS|FBtp0005757 == P{CAR1} |FBtp0011305 == P{CAR2} |FBtp0011306 == P{CAR3} |FBtp0011307 == P{E22} PHI|Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|5SrRNA376 SYN|5SRNA376 ID|FBal0047968 PHI|Mode of assay: In transgenic Drosophila REF|FBrf0086568 REFDSR { RDID|FBrf0086568 |Paques et al. |1996 MD|Construct: Complete @5SrRNA@ unit, 376bp. MU|in vitro construct | other CNS|FBtp0005757 == P{CAR1} |FBtp0011305 == P{CAR2} |FBtp0011306 == P{CAR3} |FBtp0011307 == P{E22} PHI|Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|5SrRNA+ ID|FBal0141974 CLA|wild-type generic } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0022711 CLA 1 Gene GSYM 1 61bis DT 1 14 Aug 03 RESZ 698 CLOC 1 68C ALESR 1 REF 2 GSYM|61bis DT|14 Aug 03 ID|FBgn0022711 UAB|Deficiency: Df(3L)vin66 (inferred from cytology) |Duplication: Dp(3;3)M67C+4 (inferred from cytology) KLOC|88382 CLOC|68C |Left limit from in situ hybridization (FBrf0098649) |Right limit from in situ hybridization (FBrf0098649) CYC|Experimentally determined: 68C REF { REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0098649 |Aragnol et al. |1997 |1 } REFDSR { RDID|FBrf0098649 |Aragnol et al. |1997 CLOC|68C (determined by in situ hybridization) } ALESR { ASYM|61bis+ ID|FBal0081518 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0012033 CLA 1 Gene GSYM 1 65F DT 1 14 Aug 03 RESZ 762 ALESR 1 REF 6 GSYM|65F DT|14 Aug 03 ID|FBgn0012033 DIS|H. Ruohola-Baker and T.A. Jongens. REF { REFM|FBrf0076114 |Mahajan-Miklos and Cooley |1994 |0 REFM|FBrf0065590 |Theurkauf et al. |1993 |1 REFM|FBrf0065589 |Theurkauf et al. |1993 |0 REFM|FBrf0075028 |Knowles and Cooley |1994 |2 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0076115 |Theurkauf |1994 |0 } REFDSR { RDID|FBrf0065589 |Theurkauf et al. |1993 PHP|Encodes an oocyte-specific mRNA. } ALESR { ASYM|65F+ ID|FBal0066322 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0008639 CLA 1 Gene NAM 1 66Dem GSYM 1 66Dem DT 1 14 Aug 03 RESZ 775 WT 1 An incompletely characterized homeodomain sequence CLOC 1 66B ALESR 1 REF 2 GSYM|66Dem DT|14 Aug 03 ID|FBgn0008639 UAB|Deficiency: Df(3L)Mg27 (inferred from cytology) |Duplication: Dp(3;3)M67C+2 (inferred from cytology) NAM|66Dem KLOC|85456 GLOC|3-[25] CLOC|66B |Left limit from in situ hybridization (FBrf0065373) |Right limit from in situ hybridization (FBrf0065373) CYC|Experimentally determined: 66B WT|An incompletely characterized homeodomain sequence. REF { REFM|FBrf0065373 |Dessain and McGinnis |1993 |2 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0065373 |Dessain and McGinnis |1993 CLOC|66B (determined by in situ hybridization) } ALESR { ASYM|66Dem+ ID|FBal0071521 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0044335 CLA 1 Gene GSYM 1 674 DT 1 14 Aug 03 RESZ 340 ALESR 1 REF 1 GSYM|674 DT|14 Aug 03 ID|FBgn0044335 REF { REFM|FBrf0133992 |Myat and Andrew |2001 |1 } REFDSR { RDID|FBrf0133992 |Myat and Andrew |2001 PHP|In mutants the salivary gland is branched rather than a linear tube. } ALESR { ASYM|674+ ID|FBal0122858 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0044334 CLA 1 Gene GSYM 1 682 DT 1 14 Aug 03 RESZ 544 ALESR 1 REF 1 GSYM|682 DT|14 Aug 03 ID|FBgn0044334 SYN|Line 682 REF { REFM|FBrf0134185 |Guo and Zinsmaier |2001 |1 } REFDSR { RDID|FBrf0134185 |Guo and Zinsmaier |2001 PHP|Mutants show normal EJP amplitudes at low stimulation frequency, |while at a high stimulation frequency EJPs completely fail within 20 |seconds. Simultaneously, the frequency of spontaneously occurring |mEJPs increases dramatically. SYN|Line 682 } ALESR { ASYM|682+ ID|FBal0122857 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0065040 CLA 1 Gene GSYM 1 6BP DT 1 14 Aug 03 RESZ 485 ALESR 1 REF 1 GSYM|6BP DT|14 Aug 03 ID|FBgn0065040 SYN|D6BP |Drosophila INT6 binding protein REF { REFM|FBrf0145005 |Traicoff and Callahan |2000 |1 } REFDSR { RDID|FBrf0145005 |Traicoff and Callahan |2000 OTH|Identification: as a protein that specifically binds @Int6@ protein |in a yeast two hybrid assay. SYN|D6BP: Drosophila INT6 binding protein } ALESR { ASYM|6BP+ ID|FBal0143090 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0062518 CLA 1 Gene GSYM 1 752 DT 1 14 Aug 03 RESZ 560 FNC 1 TGFbeta receptor signaling pathway WT 1 Involved in @dpp@ signaling in the developing wing ALESR 1 REF 1 GSYM|752 DT|14 Aug 03 ID|FBgn0062518 SYN|#752 FNC|TGFbeta receptor signaling pathway ; GO:0007179 | inferred from mutant phenotype WT|Involved in @dpp@ signaling in the developing wing. REF { REFM|FBrf0146151 |Jung et al. |2002 |1 } REFDSR { RDID|FBrf0146151 |Jung et al. |2002 FNC|TGFbeta receptor signaling pathway ; GO:0007179 | inferred from mutant phenotype WT|Involved in @dpp@ signaling in the developing wing. SYN|#752 } ALESR { ASYM|752+ ID|FBal0135552 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0041707 CLA 1 Gene GSYM 1 7B2 DT 1 14 Aug 03 RESZ 3074 DBA 11 HG 2 Caenorhabditis elegans 'cDNA EST comes from this gene' EMBL:T00659 FNC 1 peptide hormone processing CLOC 1 83A1 ALESR 2 REF 9 GSYM|7B2 DT|14 Aug 03 ID|FBgn0041707 UAB|Duplication: Dp(3;3)Tpl-T34 (inferred from cytology) SYN|CG1168 |CG1168 |d7B2 |FBgn0040073 ID2|FBgn0037318 KLOC|104169 CLOC|83A1 |Limits computationally determined from genome sequence between l(3)01456/l(3)02733 and EP(3)0974 FNC|peptide hormone processing ; GO:0016486 | inferred from sequence similarity with EMBL:U72709 ENZ|proprotein convertase 2 activator activity ; GO:0016484 | inferred from sequence similarity with EMBL:U72709 DBA|NA:AE003603 |PA:AAF52036 |NA:AI062015 |BDGP-DGC:GH01053.5prime |NA:AJ271974 |PA:CAB72934 |NA:AW941705 |BDGP-DGC:GH01053 |NA:AY119453 |PA:AAM50107 |BDGP-DGC:GH01053 PAC|SPTREMBL:Q9N9Z7 |SPTREMBL:Q9VNB0 HG|species == Caenorhabditis elegans; gene == 'cDNA EST EMBL:T00659 comes from this gene'; EMBL:Z92838; protein_id:CAB07408; gi:3879379; score == 106; expect == 2.e-22 |species == Lymnaea stagnalis; gene == '7B2'; EMBL:U72709; gi:1813565; score == 113; expect == 2.e-24 ASQ|FBan0001168 REF { REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0130241 |Tellam et al. |2000 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0126678 |Kodira |1999.11 |9 REFM|FBrf0125653 |Hwang |2000.2.8 |9 REFM|FBrf0123056 |Hwang et al. |1999 |1 REFM|FBrf0128499 |Hwang et al. |2000 |0 REFM|FBrf0129037 |Taghert |2000.5.2 |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|proprotein convertase 2 activator activity ; GO:0016484 | inferred from sequence similarity with EMBL:U72709 FNC|peptide hormone processing ; GO:0016486 | inferred from sequence similarity with EMBL:U72709 } REFDSR { RDID|FBrf0123056 |Hwang et al. |1999 SYN|d7B2 } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH01053 (BDGP-DGC) } REFDSR { RDID|FBrf0125653 |Hwang |2000.2.8 GPD|secretory granule neuroendocrine protein } REFDSR { RDID|FBrf0129037 |Taghert |2000.5.2 MD|Identified with: GH01053.5prime AM|Source for merge of: 7B2 CG1168 SYN|CG1168 |d7B2 } REFDSR { RDID|FBrf0130241 |Tellam et al. |2000 MD|Gene order: Overall orientation not stated: tRNA:R:83AB- kkv+ 7B2- SYN|unnamed } ALESR { ASYM|7B2cHa ID|FBal0117934 PHI|Mode of assay: Drosophila cell culture REF|FBrf0128499 REFDSR { RDID|FBrf0128499 |Hwang et al. |2000 NAM|construct a of Hwang MD|Construct: Contains @7B2@ coding sequences. OTH|Carried in a plasmid, transfected into S2 cells and used to study the |activation of @amon@ by @7B2@. MU|in vitro construct | other PHI|Mode of assay: Drosophila cell culture } } ALESR { ASYM|7B2+ ID|FBal0116908 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0000003 CLA 1 nuclear untranslated RNA gene NAM 1 RNA 7SL GSYM 1 7SLRNA DT 1 14 Aug 03 RESZ 1371 DBA 3 FNC 1 SRP-dependent cotranslational membrane targeting CEL 1 signal recognition particle CLOC 1 84A5 ALESR 1 REF 4 GSYM|7SLRNA DT|14 Aug 03 ID|FBgn0000003 CLA|nuclear_untranslated_RNA_gene UAB|Deficiency: Df(3R)BD5 (inferred from cytology) |Duplication: Dp(3;Y)77ab (inferred from cytology) SYN|CR32864 NAM|RNA 7SL KLOC|105438 CLOC|84A5 |Limits computationally determined from genome sequence between l(3)04498 and l(3)L2100 FNC|SRP-dependent cotranslational membrane targeting ; GO:0006614 | inferred from sequence similarity CEL|signal recognition particle ; GO:0005786 | inferred from sequence similarity DBA|NA:AE003673 |NA:X00952 |NA:X01056 ASQ|FBan0032864 REF { REFM|FBrf0040773 |Gundelfinger et al. |1984 |0 REFM|FBrf0148886 |FlyBase Genome Annotators |2002- |9 REFM|FBrf0155827 |Misra et al. |2002 |0 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0040773 |Gundelfinger et al. |1984 FNC|SRP-dependent cotranslational membrane targeting ; GO:0006614 | inferred from sequence similarity CEL|signal recognition particle ; GO:0005786 | inferred from sequence similarity GPD|RNA-7SL } REFDSR { RDID|FBrf0148886 |FlyBase Genome Annotators |2002- OTH|New annotation (CR32864) in release 3 of the genome annotation. } ALESR { ASYM|7SLRNA+ ID|FBal0066323 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0052208 CLA 1 Gene GSYM 1 825-Oak DT 1 14 Aug 03 RESZ 1437 DBA 2 FNC 1 biological_process unknown CEL 1 cellular_component unknown CLOC 1 76B3 ALESR 1 REF 3 GSYM|825-Oak DT|14 Aug 03 ID|FBgn0052208 SYN|CG32208 KLOC|96785 CLOC|76B3 |Limits computationally determined from genome sequence between EP(3)3142 and l(3)L3809 FNC|biological_process unknown ; GO:0000004 | no biological data available CEL|cellular_component unknown ; GO:0008372 | no biological data available ENZ|molecular_function unknown ; GO:0005554 | no biological data available DBA|NA:AE003516 |PA:AAN11647 PAC|SPTREMBL:Q8IQU7 ASQ|FBan0032208 REF { REFM|FBrf0148886 |FlyBase Genome Annotators |2002- |9 REFM|FBrf0151675 |Prochnik |2002.10.14 |9 REFM|FBrf0159398 |FlyBase Curators |2002- |9 } REFDSR { RDID|FBrf0148886 |FlyBase Genome Annotators |2002- OTH|New annotation (CG32208) in release 3 of the genome annotation. } REFDSR { RDID|FBrf0151675 |Prochnik |2002.10.14 AM|Source for identity of: 825-Oak CG32208 OTH|Etymology: unrevealed! |Name "825-Oak" chosen by Simon Prochnik to mark his contribution to |the FlyBase Release 3 annotation project. } REFDSR { RDID|FBrf0159398 |FlyBase Curators |2002- ENZ|molecular_function unknown ; GO:0005554 | no biological data available FNC|biological_process unknown ; GO:0000004 | no biological data available CEL|cellular_component unknown ; GO:0008372 | no biological data available } ALESR { ASYM|825-Oak+ ID|FBal0140827 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0023418 CLA 1 Gene GSYM 1 8H11 DT 1 14 Aug 03 RESZ 941 WT 2 @8H11@ has an important role in the process by which axons navigate ALESR 1 REF 3 GSYM|8H11 DT|14 Aug 03 ID|FBgn0023418 WT|@8H11@ has an important role in the process by which axons navigate |across the ventral midline. REF { REFM|FBrf0101103 |Noordermeer et al. |1998 |1 REFM|FBrf0099424 |Noordermeer et al. |1997 |1 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0099424 |Noordermeer et al. |1997 WT|@8H11@ has an important role in the process by which axons navigate |across the ventral midline. OTH|Defined by a reverse genetic approach designed to identify novel |extracellular molecules that are involved in axon guidance. PHP|Loss of function and ectopic expression experiments indicate a |significant role for @8H11@ in the establishment of the anterior and |posterior commissures. } ALESR { ASYM|8H11+ ID|FBal0087454 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0044332 CLA 1 Gene GSYM 1 9.35 DT 1 14 Aug 03 RESZ 911 FNC 1 germ-cell migration GLOC 1 2L ALESR 1 REF 2 GSYM|9.35 DT|14 Aug 03 ID|FBgn0044332 FNC|germ-cell migration ; GO:0008354 | inferred from genetic interaction with FLYBASE:Hmgcr; FB:FBgn0001205 KLOC|29816 GLOC|2L |Maps to the right of dp |Maps to the left of b REF { REFM|FBrf0135351 |Lehmann |2001.3.15 |9 REFM|FBrf0133952 |Stein et al. |2001 |1 } REFDSR { RDID|FBrf0133952 |Stein et al. |2001 FNC|germ-cell migration ; GO:0008354 | inferred from genetic interaction with FLYBASE:Hmgcr; FB:FBgn0001205 WTI|Hmgcr PHP|Mutants disrupt germ cell migration - germ cells are lost in the |posterior of the embryo and on top of the midgut. } REFDSR { RDID|FBrf0135351 |Lehmann |2001.3.15 GLOC|2L |Maps to the right of dp |Maps to the left of b } ALESR { ASYM|9.35+ ID|FBal0122855 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0043016 CLA 1 Gene GSYM 1 91R DT 1 14 Aug 03 RESZ 1226 GLOC 1 3- ALESR 2 REF 2 GSYM|91R DT|14 Aug 03 ID|FBgn0043016 KLOC|79136 GLOC|3- REF { REFM|FBrf0127214 |Maitra et al. |2000 |0 REFM|FBrf0151345 |Maitra et al. |2002 |0 } REFDSR { RDID|FBrf0127214 |Maitra et al. |2000 GLOC|3- } ALESR { ASYM|91R91R SYN|91R ID|FBal0118615 REF|FBrf0127214 |FBrf0151345 REFDSR { RDID|FBrf0127214 |Maitra et al. |2000 OTH|A factor (or factors) on the third chromosome of D.melanogaster (@91R@) |affects the levels of @Cyp6a2@ and @Cyp6a8@ RNA expression. It is |suggested that in the "91-R" strain there is a mutation in this 3rd |chromosome factor (@91R91R@) allowing high levels of @Cyp6a2@ and |@Cyp6a8@ expression. It is not clear whether or not the @Cyp6a2@ and |@Cyp6a8@ genes are also mutated in this strain or whether the high |level of expression is due solely to the mutation in the @91R@ factor. SYN|91R } REFDSR { RDID|FBrf0151345 |Maitra et al. |2002 SYN|91R } } ALESR { ASYM|91R+ ID|FBal0119080 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0044331 CLA 1 Gene GSYM 1 936 DT 1 14 Aug 03 RESZ 519 ALESR 1 REF 1 GSYM|936 DT|14 Aug 03 ID|FBgn0044331 REF { REFM|FBrf0134185 |Guo and Zinsmaier |2001 |1 } REFDSR { RDID|FBrf0134185 |Guo and Zinsmaier |2001 PHP|EJP amplitudes are reduced by about 60% in mutants. During high |frequency stimulation at 10 Hz, EJP amplitudes significantly |facilitate to 135% of the original response in mutants, while EJPs |in controls become depressed to 80%. } ALESR { ASYM|936+ ID|FBal0122854 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0008641 CLA 1 Gene NAM 1 94Che GSYM 1 94Che DT 1 14 Aug 03 RESZ 774 WT 1 An incompletely characterized homeodomain sequence CLOC 1 94B ALESR 1 REF 2 GSYM|94Che DT|14 Aug 03 ID|FBgn0008641 UAB|Deficiency: Df(3R)hh (inferred from cytology) |Duplication: Dp(3;3)M95A+13 (inferred from cytology) NAM|94Che KLOC|120840 GLOC|3-[76] CLOC|94B |Left limit from in situ hybridization (FBrf0065373) |Right limit from in situ hybridization (FBrf0065373) CYC|Experimentally determined: 94B WT|An incompletely characterized homeodomain sequence. REF { REFM|FBrf0065373 |Dessain and McGinnis |1993 |2 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0065373 |Dessain and McGinnis |1993 CLOC|94B (determined by in situ hybridization) } ALESR { ASYM|94Che+ ID|FBal0071522 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0000009 CLA 1 Gene NAM 1 Abnormal abdomen GSYM 1 A DT 1 14 Aug 03 RESZ 4533 WT 4 Defined by incompletely characterized mutations that show an 'abnormal CLOC 1 3A5 ALESR 4 REF 14 GSYM|A DT|14 Aug 03 ID|FBgn0000009 UAB|Deficiency: Df(1)TEM7 (inferred from cytology) |Duplication: Dp(1;Y)w+303 (inferred from cytology) SYN|Abnormal NAM|Abnormal abdomen KLOC|2770 GLOC|1-4.5 CLOC|3A5 DIS|Morgan, July 1911. GLC|1-[1.0] CYC|Cytology from deficiency analysis of @A53g@ (Hillman, in |FBrf0066905); however this is at variance with the genetic position of @A1@. WT|Defined by incompletely characterized mutations that show an 'abnormal |abdomen' phenotype. Expressivity and penetrance very sensitive to |environmental conditions. Stocks accumulate modifiers, resulting in |apparent reversion (FBrf0006100). PHP|Very variable mutant phenotype affecting abdominal tergites and sternites. REF { REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0025024 |Hillman |1973 |0 REFM|FBrf0025023 |Rose and Hillman |1973 |0 REFM|FBrf0025022 |Hillman et al. |1973 |0 REFM|FBrf0000823 |Morgan and Bridges |1916 |0 REFM|FBrf0026596 |Shafer and Hillman |1974 |0 REFM|FBrf0015469 |Hillman and Barbour |1963 |1 REFM|FBrf0063471 |Gooskov |1971 |0 REFM|FBrf0065663 |Hillman |1953 |0 REFM|FBrf0000764 |Morgan |1915 |0 REFM|FBrf0063908 |Thalmann |1974 |0 REFM|FBrf0029533 |Hillman |1977 |0 REFM|FBrf0020251 |Rose and Hillman |1969 |0 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0063908 |Thalmann |1974 WTI|E(A53g) (data from @A53g@) } ALESR { ASYM|A1 ID|FBal0000037 OTH|Highly variable, wild phenotype in old dry cultures. Heterozygotes less |extreme than homozygotes or hemizygous and males. |Lost by reversion to wild type. PHC|visible | semidominant |viable | female |female fertile PHM|abdominal tergite |abdominal sternite |cuticle |microchaeta |abdomen |macrochaeta |abdomen PHI|Tergites and sternites raggedly incomplete, exposing a thin crinkled |cuticle; bristles and hairs on abdomen correspondingly eliminated. |RK2 in well-fed cultures. REF|FBrf0000823 } ALESR { ASYM|A70 ID|FBal0000038 AMSO|Allelism conjectural. REF|FBrf0063471 } ALESR { ASYM|A53g SYN|A53g ID|FBal0000039 AMSO|May not be allelic to @A1@. DIS|Hillman, July 1953. OTH|Supernatents from homogenates of @A53g@-bearing adults stimulate amino |acid incorporation and aminoacylation of tRNA more than those from wild |type (FBrf0020251). Mutant late pupae and adults show increased |concentrations of soluble protein. |Expression in @A53g@/@A53g@ females > @A53g@/Y males > |@A53g@/+ females. |Expression maternally influenced (FBrf0026596). Highly variable; |sensitive to modifiers on X, 2 and 3, including @E(A53g)@ on 2L. Sensitive |to culture conditions; expression reduced in old cultures and under |conditions of crowding, low temperature (TSP in late second and early third |instar) and low humidity. Also reduced by agents that inhibit RNA or |protein synthesis or oxidative phosphorylation (FBrf0025022). |Expression of biochemical phenotype correlated with that of visible |phenotype (FBrf0025023). MU|spontaneous PHC|visible | semidominant PHM|abdominal tergite PHI|Epidermal foldings of abdomen abnormal. Tergite formation incomplete, |ranging from loss of tergites 2-8 in extreme cases to loss of lateral part |of tergite in one or more segments. |RK2 in young cultures. REF|FBrf0015469 |FBrf0065663 |FBrf0025024 |FBrf0029533 |FBrf0063908 REFDSR { RDID|FBrf0063908 |Thalmann |1974 GIC2|enhanceable by @E(A53g)1@ } } ALESR { ASYM|A+ ID|FBal0071523 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0000008 CLA 1 Gene NAM 1 arc GSYM 1 a DT 1 14 Aug 03 RESZ 26523 PDOM 2 INTERPRO:IPR001478 == PDZ domain (also known as DHR or GLGF) PTD 1 DBA 16 HG 4 Caenorhabditis elegans C52A11.4 WP:CE01530 FNC 1 eye morphogenesis (sensu Drosophila) CEL 2 adherens junction WT 2 @a@ may affect eye development by modulating adherens junctions of CLOC 1 58C4--5 ALESR 27 SK 6 REF 29 GSYM|a PTD DT|14 Aug 03 ID|FBgn0000008 UAB|Deficiency: Df(2R)Egfr5 (inferred from cytology) |Duplication: Dp(2;2)l-32 (inferred from cytology) SYN|CG6741 |CG13505 |CG6741 |CG13505 |CG13505 |CG6741 |bran: broad angular |Arc |broad angular |bran ID2|FBgn0034701 |FBgn0034702 NAM|arc KLOC|74176-6336 GLOC|2-99.2 CLOC|58C4--5 |Limits computationally determined from genome sequence between EP(2)2457 and l(2)07768 DIS|Bridges, 24th May 1912. CYC|Experimentally determined: 58C--D FNC|eye morphogenesis (sensu Drosophila) ; GO:0007456 | inferred from mutant phenotype CEL|adherens junction ; GO:0005912 | inferred from direct assay |apical plasma membrane ; GO:0016324 | inferred from direct assay PDOM|IPR001478 == PDZ domain (also known as DHR or GLGF) |SCOP:50156 == PDZ domain-like; a|FBgn0000008|pp-CT20921|FBan0006741 WT|@a@ may affect eye development by modulating adherens junctions of |the developing ommatidia. DBA|NA:AE003456 |PA:AAF46809 |PA:AAF46810 |NA:AF188473 |PA:AAF37816 |NA:AF188474 |PA:AAF37817 |NA:AF188475 |PA:AAF37818 |NA:AI389852 |BDGP-DGC:GH21134 |NA:AW940815 |BDGP-DGC:GH21134 |NA:AY058433 |PA:AAL13662 |BDGP-DGC:GH21134 PAC|SPTREMBL:Q9W283 WTI|svr HG|species == Caenorhabditis elegans; gene == C52A11.4; WP:CE01530; score == 110.5; expect == 2.e-07 |species == Homo sapiens; gene == 'UNKNOWN'; gi:4505231; score == 169.8; expect == 3.e-10 |species == Mus musculus; gene == 'multiple PDZ domain protein'; EMBL:AJ131869; protein_id:CAA10523; gi:4150878; score == 201; expect == 3.e-14 |species == Rattus norvegicus; gene == 'multi PDZ domain protein 1'; EMBL:AJ001320; protein_id:CAA04681; gi:2959979; score == 119.9; expect == 8.e-10 ASQ|FBan0006741 REV|FBrf0141282 REF { REFM|FBrf0094738 |Fradkin |1957 |0 REFM|-2114620305 |Lewis |Cited in Lindsley and Grell |-1 |1968 REFM|FBrf0003308 |Goldschmidt |1935 |0 REFM|FBrf0139846 |Lengyel |2001.1.4 |9 REFM|FBrf0001379 |Morgan et al. |1925 |2 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0094793 |Goldschmidt |1944 |0 REFM|FBrf0131066 |Lengyel |2000.8.1 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0003816 |Bridges |1937 |0 REFM|FBrf0003920 |Dunn and Mossige |1937 |0 REFM|FBrf0006430 |Goldschmidt |1945 |0 REFM|FBrf0101731 |Liu et al. |1998 |1 REFM|FBrf0000979 |Bridges and Morgan |1919 |0 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0006895 |Goldschmidt |1947 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|-2114621701 |Lewis |Cited in Lindsley and Grell |0 |1968 REFM|FBrf0127206 |Liu and Lengyel |2000 |0 REFM|FBrf0003299 |Goldschmidt |1935 |0 REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0063692 |Meyer |1963 |0 REFM|FBrf0020044 |Lindsley and Grell |1968 |2 REFM|FBrf0141282 |Tepass et al. |2001 |2 REFM|FBrf0129141 |Millburn |2000.5.31 |9 REFM|FBrf0127946 |Liu |1999.9.21 |9 REFM|FBrf0129140 |Lengyel |2000.3.26 |9 REFM|FBrf0100133 |Liu and Lengyel |1997 |1 REFM|FBrf0138539 |Bilder |2001 |2 } REFDSR { RDID|FBrf0003816 |Bridges |1937 BMD|Df(2R)M58F BMDD|Df(2R)P } REFDSR { RDID|FBrf0003920 |Dunn and Mossige |1937 BMD|Df(2R)M58F } REFDSR { RDID|FBrf0006430 |Goldschmidt |1945 BMD|Df(2R)a-ba2 } REFDSR { RDID|FBrf0020044 |Lindsley and Grell |1968 PHP|Defined by recessive mutations that result in a broad, often bent, wing. } REFDSR { RDID|FBrf0063692 |Meyer |1963 GLOC|2-99.2 BMD|In(2LR)aM60 } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 BMDD|Df(2R)E3578 BMDD|Df(2R)ST1 BMDD|Df(2R)XE-916 BMDD|Df(2R)nap16 } REFDSR { RDID|FBrf0094793 |Goldschmidt |1944 GLOC|2- BMD|Df(2R)a-ba2 SYN|bran: broad angular } REFDSR { RDID|FBrf0100133 |Liu and Lengyel |1997 NAM|arc SYN|Arc } REFDSR { RDID|FBrf0101731 |Liu et al. |1998 NAM|arc } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH21134 (BDGP-DGC) } REFDSR { RDID|FBrf0127206 |Liu and Lengyel |2000 FNC|eye morphogenesis (sensu Drosophila) ; GO:0007456 | inferred from mutant phenotype MD|Gene order: In direction of increasing cytology: mei-S332+ a+ ari-2+ dve+ CEL|adherens junction ; GO:0005912 | inferred from direct assay |apical plasma membrane ; GO:0016324 | inferred from direct assay WT|@a@ may affect eye development by modulating adherens junctions of |the developing ommatidia. BMD|Df(2R)a7 BMD|Df(2R)aEX1 BMD|Df(2R)aEX2 } REFDSR { RDID|FBrf0127946 |Liu |1999.9.21 CLOC|58C--D CEL|adherens junction ; GO:0005912 | non-traceable author statement } REFDSR { RDID|FBrf0129140 |Lengyel |2000.3.26 AM|Source for merge of: a CG6741 SYN|CG6741 } REFDSR { RDID|FBrf0129141 |Millburn |2000.5.31 AM|Source for merge of: a CG13505 SYN|CG13505 } REFDSR { RDID|FBrf0131066 |Lengyel |2000.8.1 AM|Source for merge of: a CG13505 CG6741 SYN|CG13505 |CG6741 } ALESR { ASYM|a1 ID|FBal0000040 MU|spontaneous PHC|visible | recessive PHM|wing |crossvein PHI|Wings broader; bent downward in slight, even arc; |edges drawn down to diamond shape. Sometimes in stock, |wings are bent upward instead of downward. Crossveins |closer together. |RK2. REF|FBrf0006430 |FBrf0020044 |FBrf0127206 |-2114620305 REFDSR { RDID|-2114620305 |Lewis |Cited in Lindsley and Grell GIC2|non-suppressible by @su(Hw)2@ } REFDSR { RDID|FBrf0127206 |Liu and Lengyel |2000 OTH|Allelic series of mutations: @Df(2R)aEX1@ = @Df(2R)aEX2@ > aEM50 |>= @ak11011b@ > @aEM1@ >= @aEM27@ > @a1@ > @aEM15@. } SK|FBstBL-1554 |a[1] px[1] or[1] |FBstBL-312 |hy[1] a[1] px[1] sp[1]/SM1 |FBstBL-3301 |al[1] dp[ov1] b[1] pr[1] cn[1] vg[1] c[1] a[1] px[1] bw[1] mi[1] sp[1]/SM1 |FBstBL-6525 |dp[ov1] cn[1] l(2)57Da[1] a[1] px[1] sp[1]/SM1 } ALESR { ASYM|a7 ID|FBal0117621 ABA|FBab0029357 == Df(2R)a7 PHM|(with Df(2R)aEX1) eye |(with Df(2R)aEX1) ommatidium PHI|@a7@/@Df(2R)aEX1@ flies have eyes that are significantly smaller |than wild-type, and those eyes have rhomboidal ommatidia. The arrangement |of photoreceptors within each ommatidium appears wild-type. @a7@/@Df(2R)aEX1@ |have no detectable phenotype in epithelial development. REF|FBrf0127206 REFDSR { RDID|FBrf0127206 |Liu and Lengyel |2000 MD|Breakpoint is just before exon 4. PRG|ak11011b MU|X ray ABA|FBab0029357 == Df(2R)a7 GIA2|(with Df(2R)aEX1) eye, non-enhanceable by @nmoP1@/@nmoP1@ GIC2|(with Df(2R)aEX1) non-enhanceable by @Df(3L)MY10@/+ |(with Df(2R)aEX1) non-enhanceable by @arm1@/+ |(with Df(2R)aEX1) non-enhanceable by @cnomis1@/@cnomis1@ |(with Df(2R)aEX1) non-suppressible by @Df(3L)MY10@/+ |(with Df(2R)aEX1) non-suppressible by @arm1@/+ |(with Df(2R)aEX1) non-suppressible by @cnomis1@/@cnomis1@ GIC|(with Df(2R)aEX1) non-enhancer of @pydtam@ GIA|(with Df(2R)aEX1) non-enhancer of eye phenotype of @nmoP1@ GIC|(with Df(2R)aEX1) non-suppressor of @pydtam@ GIA|(with Df(2R)aEX1) non-suppressor of eye phenotype of @nmoP1@ GIC|(with Df(2R)aEX1) non-enhancer of @cnomis1@ |(with Df(2R)aEX1) non-suppressor of @cnomis1@ GIA2|(with Df(2R)aEX1) eye, non-suppressible by @nmoP1@/@nmoP1@ GII|The addition of @pydtam@/+, @nmoP1@/@nmoP1@, @cnomis1@/@cnomis1@ |or @arm1@/+ has no effect on @a7@/@Df(2R)aEX1@ flies. PHM|(with Df(2R)aEX1) eye |(with Df(2R)aEX1) ommatidium PHI|@a7@/@Df(2R)aEX1@ flies have eyes that are significantly smaller |than wild-type, and those eyes have rhomboidal ommatidia. The arrangement |of photoreceptors within each ommatidium appears wild-type. @a7@/@Df(2R)aEX1@ |have no detectable phenotype in epithelial development. } } ALESR { ASYM|a57e14 ID|FBal0063000 REF|FBrf0094738 REFDSR { RDID|FBrf0094738 |Fradkin |1957 DIS|Fradkin, 1957. MU|spontaneous } } ALESR { ASYM|aBa SYN|Bran ID|FBal0000048 NAM|Broad angular Dominant DIS|Goldschmidt. PRG|aba MU|spontaneous PHC|visible | dominant PHM|wing |posterior scutellar bristle |macrochaeta PHI|Wings broader and shorter than wild type, blunt at the |tip; frequently shows upturned posterior scutellar bristles. |@aBa@/@aba@ shows Minute-like bristles. |RK2. REF|FBrf0006430 |FBrf0020044 } ALESR { ASYM|aba SYN|bran ID|FBal0000055 NAM|broad angular DIS|Goldschmidt, 1934. OTH|Claimed to recur repeatedly in certain lines (FBrf0006430). CYA|Polytene chromosomes normal (Kodani). MU|spontaneous GIA2|wing with @svrpoi@ PHC|visible | recessive PHM|wing |posterior scutellar bristle PHI|Wings broader and shorter than wild type, blunt at the |tip. Frequently shows upturned posterior scutellar |bristles. In combination with @svrpoi@, produces soft |blistered wing. Other interactions described by |Goldschmidt (FBrf0006430: table 74). Wing grows in pupal stage |to full length and then retracts, possibly with |histolysis (FBrf0003308). |RK2. REF|FBrf0003308 |FBrf0094793 |FBrf0006430 REFDSR { RDID|FBrf0094793 |Goldschmidt |1944 DIS|R.B. Goldschmidt. CYA|Polytene chromosomes normal. PHC|visible PHM|wing PHI|RK2. |Wings are broad and short or broad and blunt at the tip. SYN|bran } } ALESR { ASYM|aba1 SYN|bran1 ID|FBal0000041 DIS|Goldschmidt. CYA|Polytene chromosomes normal (Kodani). MU|spontaneous PHI|Nearly normal; distinguished by its interaction with certain |@svr@ alleles (see FBrf0006430: table 74). |RK3. REF|FBrf0094793 |FBrf0006430 |FBrf0020044 REFDSR { RDID|FBrf0094793 |Goldschmidt |1944 DIS|R.B. Goldschmidt. CYA|Polytene chromosomes normal. PHC|visible PHM|wing PHI|RK3 |Almost normal wings. SYN|bran1 } } ALESR { ASYM|aba2 SYN|bran2 ID|FBal0000042 DIS|Goldschmidt. CYA|Polytene chromosomes normal (Kodani). MU|spontaneous ABA|FBab0002062 == Df(2R)a-ba2 PHC|wild-type PHI|Normal; distinguished by its interaction with certain |@svr@ alleles (see FBrf0006430: table 74). |RK3. REF|FBrf0094793 |FBrf0006430 |FBrf0020044 REFDSR { RDID|FBrf0094793 |Goldschmidt |1944 DIS|R.B. Goldschmidt. ABA|FBab0002062 == Df(2R)a-ba2 PHC|visible PHM|wing PHI|RK2. |Wings are broad and short or broad and blunt at the tip. Small basal |blisters appear. SYN|bran2 } } ALESR { ASYM|aba3 SYN|bran3 ID|FBal0000043 DIS|Goldschmidt. CYA|Polytene chromosomes normal (Kodani). MU|spontaneous PHC|wild-type PHI|Normal; distinguished by its interaction with certain |@svr@ alleles (see FBrf0006430: table 74). |RK3. REF|FBrf0006430 |FBrf0020044 } ALESR { ASYM|aba4 SYN|bran4 ID|FBal0000044 DIS|Goldschmidt. CYA|Polytene chromosomes normal (Kodani). PRG|aba3 \? MU|spontaneous PHC|visible | recessive PHM|wing |posterior scutellar bristle PHI|Wings broader and shorter than wild type, blunt at the |tip. Frequently shows upturned posterior scutellar |bristles. |Distinguished from @aba@ by its interaction with |certain @svr@ alleles (see FBrf0006430: table 74). |RK2. REF|FBrf0094793 |FBrf0006430 |FBrf0020044 REFDSR { RDID|FBrf0094793 |Goldschmidt |1944 DIS|R.B. Goldschmidt. PHC|visible PHM|wing PHI|RK5 |Wings are broad and short or broad and blunt at the tip. SYN|bran4 } } ALESR { ASYM|aBaC SYN|BranCa ID|FBal0000049 NAM|Broad angular in Canton-S DIS|Goldschmidt. CYA|Polytene chromosomes normal (Hannah-Alava). MU|spontaneous GIA2|wing with @svrunspecified@ GIC2|visible | dominant with @svrunspecified@ PHC|visible | recessive PHM|wing PHI|@aBaC@/+ is normal; @aBaC@/@aba@ has broad |angular wing, but overlaps wild type. @aBaC@ is dominant |in its interaction with certain @svr@ alleles. |RK3. REF|FBrf0006430 |FBrf0006895 |FBrf0020044 } ALESR { ASYM|abadb ID|FBal0027938 NAM|broad angular dumpy blistered DIS|Goldschmidt. CYA|Polytene chromosomes normal (Kodani). MU|spontaneous PHC|visible | recessive PHM|wing |posterior scutellar bristle PHI|Wings broader and shorter than wild type, blunt at the |tip. Frequently shows upturned posterior scutellar |bristles. |Distinguished from @aba@ by its interaction with |certain @svr@ alleles (see FBrf0006430: table 74). |RK2. REF|FBrf0094793 |FBrf0006430 |FBrf0020044 REFDSR { RDID|FBrf0094793 |Goldschmidt |1944 DIS|R.B. Goldschmidt. CYA|Polytene chromosomes normal. PHC|visible PHM|wing PHI|RK3 |Wings are broad and short or broad and blunt at the tip. SYN|brandb } } ALESR { ASYM|abadp SYN|brandp ID|FBal0000046 NAM|broad angular dumpy DIS|Goldschmidt. OTH|Claimed by Goldschmidt to recur repeatedly in certain lines. CYA|Polytene chromosomes normal (Kodani). MU|spontaneous PHC|wild-type PHI|Normal; distinguished by its interaction with certain |@svr@ alleles (see FBrf0006430: table 74). |RK3. REF|FBrf0094793 |FBrf0006430 |FBrf0020044 REFDSR { RDID|FBrf0094793 |Goldschmidt |1944 DIS|R.B. Goldschmidt. CYA|Polytene chromosomes normal. PHI|RK4. SYN|brandp } } ALESR { ASYM|aBap1 ID|FBal0000050 NAM|Broad angular in silver-pointed MU|spontaneous REF|FBrf0006430 |FBrf0020044 } ALESR { ASYM|aBap2 SYN|Branpoi47-2 ID|FBal0000051 DIS|Goldschmidt, 1947. CYA|Polytene chromosomes normal (Hannah-Alava). MU|spontaneous GIC2|visible | dominant with @svrunspecified@ PHC|lethal | recessive PHI|Phenotype normal in combination with @aba@ and @a@+. |RK2 as lethal. REF|FBrf0006430 |FBrf0006895 |FBrf0020044 } ALESR { ASYM|aBapl SYN|Branpoi47-1 ID|FBal0039120 DIS|Goldschmidt, 1947. CYA|Polytene chromosomes normal (Hannah-Alava). MU|spontaneous PHC|visible | dominant PHM|wing |posterior scutellar bristle PHI|Wings broader and shorter than wild type, blunt at the |tip; frequently shows upturned posterior scutellar bristles. |RK2. REF|FBrf0006895 } ALESR { ASYM|abar SYN|branr ID|FBal0000047 NAM|broad angular rudimentary DIS|Goldschmidt. PRG|abadp MU|spontaneous PHC|visible | recessive PHM|wing PHI|Wings broad, round and @dp@-like. Interacts with certain |@svr@ alleles (see FBrf0006430: table 74). |RK2. REF|FBrf0094793 |FBrf0006430 |FBrf0020044 REFDSR { RDID|FBrf0094793 |Goldschmidt |1944 DIS|R.B. Goldschmidt. CYA|Polytene chromosomes normal. PHC|visible PHM|wing PHI|RK4 |Broad and truncated wings. SYN|branr } } ALESR { ASYM|aBaX SYN|branX |Branx |abaX ID|FBal0000052 NAM|Broad angular from X irradiation DIS|Goldschmidt. MU|X ray NAF|Discarded. PHC|visible | dominant |lethal | recessive \? PHM|wing PHI|Resembles @aba2@ and @abadb@ but more or |less dominant. Homozygote never obtained. Interactions |listed by Goldschmidt (FBrf0006430: table 153). |RK2. REF|FBrf0094793 |FBrf0006430 |FBrf0020044 REFDSR { RDID|FBrf0094793 |Goldschmidt |1944 DIS|R.B. Goldschmidt. MU|X ray NAF|Discarded. SYN|branX } } ALESR { ASYM|aBay SYN|Brany px b1 ID|FBal0000053 DIS|Goldschmidt. CYA|Polytene chromosomes normal (Hannah-Alava). MU|spontaneous GIA2|wing with @svrpoi@ PHC|visible | dominant |lethal | recessive |sterile | recessive PHM|wing PHI|Heterozygote shows broad-angular phenotype with occasional truncate-like |wings. In combination with @svrpoi@, resembles @r@ and @bs@. |RK2 as lethal. REF|FBrf0006430 |FBrf0006895 |FBrf0020044 } ALESR { ASYM|aEM1 ID|FBal0117619 PHC|viable REF|FBrf0127206 REFDSR { RDID|FBrf0127206 |Liu and Lengyel |2000 OTH|Allelic series of mutations: @Df(2R)aEX1@ = @Df(2R)aEX2@ > aEM50 |>= @ak11011b@ > @aEM1@ >= @aEM27@ > @a1@ > @aEM15@. MU|ethyl methanesulfonate PHC|viable } } ALESR { ASYM|aEM15 ID|FBal0117620 PHC|viable REF|FBrf0127206 REFDSR { RDID|FBrf0127206 |Liu and Lengyel |2000 OTH|Allelic series of mutations: @Df(2R)aEX1@ = @Df(2R)aEX2@ > aEM50 |>= @ak11011b@ > @aEM1@ >= @aEM27@ > @a1@ > @aEM15@. MU|ethyl methanesulfonate PHC|viable } } ALESR { ASYM|aEM27 ID|FBal0117618 PHC|viable REF|FBrf0127206 REFDSR { RDID|FBrf0127206 |Liu and Lengyel |2000 OTH|Allelic series of mutations: @Df(2R)aEX1@ = @Df(2R)aEX2@ > aEM50 |>= @ak11011b@ > @aEM1@ >= @aEM27@ > @a1@ > @aEM15@. MU|ethyl methanesulfonate PHC|viable } } ALESR { ASYM|aEM50 ID|FBal0117617 PHC|viable REF|FBrf0127206 REFDSR { RDID|FBrf0127206 |Liu and Lengyel |2000 MU|ethyl methanesulfonate PHC|viable } } ALESR { ASYM|aEX3 ID|FBal0117616 PHC|lethal | recessive REF|FBrf0127206 REFDSR { RDID|FBrf0127206 |Liu and Lengyel |2000 PRG|ak11011b MU|P-element activity PHC|lethal | recessive } } ALESR { ASYM|ak11011b SYN|aP ID|FBal0117614 ALC|hypomorph PHM|wing |eye PHI|Homozygotes develop broad and downwardly bent wings. The also have |slightly smaller, but otherwise normal looking eyes. REF|FBrf0127206 REFDSR { RDID|FBrf0127206 |Liu and Lengyel |2000 MD|The insertion is 11bp after the transcription start. OTH|Allelic series of mutations: @Df(2R)aEX1@ = @Df(2R)aEX2@ > aEM50 |>= @ak11011b@ > @aEM1@ >= @aEM27@ > @a1@ > @aEM15@. TRN|FBti0012078 == P{lacW}ak11011b ALC|hypomorph PHM|wing |eye PHI|Homozygotes develop broad and downwardly bent wings. The also have |slightly smaller, but otherwise normal looking eyes. SYN|aP } SK|FBstBL-7075 |w[*]; P{w[+mc]=lacW}a[k11011b] } ALESR { ASYM|aM60 ID|FBal0000054 NAM|of Meyer DIS|Meyer, June 1960. MU|X ray ABA|FBab0004848 == In(2LR)aM60 PHC|visible | dominant |lethal | recessive PHI|RK3A. REF|FBrf0063692 REFDSR { RDID|FBrf0063692 |Meyer |1963 DIS|Meyer. MU|X ray ABA|FBab0004848 == In(2LR)aM60 PHC|lethal | recessive } } ALESR { ASYM|ayUAS SYN|aUAS |aScer\UAS.cLa ID|FBal0117615 PHC|lethal with @Scer\GAL4Act5C.PI@ PHM|eye with @Scer\GAL4Act5C.PI@ |ommatidium with @Scer\GAL4Act5C.PI@ |eye with @Scer\GAL4GMR.PF@ PHI|@ayUAS@ homozygotes develop normal wings and eyes. |@ayUAS@ driven by @Scer\GAL4en-e16E@ produces no phenotype. |@ayUAS@ driven by @Scer\GAL4Act5C.PI@ leads to pupal lethality, |these pupae have rough eye with fused ommatidia, but otherwise appear |morphologically normal. @ayUAS@ driven by @Scer\GAL4GMR.PF@ |produces flies with a rough eye phenotype with eyes larger than seen |in wild-type or with @Scer\GAL4GMR.PF@ alone. REF|FBrf0139846 |FBrf0127206 REFDSR { RDID|FBrf0127206 |Liu and Lengyel |2000 MD|A @P{yUAS}@ element (containing five copies of the @Scer\UAS@ |regulatory sequence fused upstream of a basal Hsp70 promoter) is |inserted upstream of @a@ by @P-element@ replacement. TRN|FBti0020936 == P{Mae-UAS.6.11}ayUAS PHC|lethal with @Scer\GAL4Act5C.PI@ PHM|eye with @Scer\GAL4Act5C.PI@ |ommatidium with @Scer\GAL4Act5C.PI@ |eye with @Scer\GAL4GMR.PF@ PHI|@ayUAS@ homozygotes develop normal wings and eyes. |@ayUAS@ driven by @Scer\GAL4en-e16E@ produces no phenotype. |@ayUAS@ driven by @Scer\GAL4Act5C.PI@ leads to pupal lethality, |these pupae have rough eye with fused ommatidia, but otherwise appear |morphologically normal. @ayUAS@ driven by @Scer\GAL4GMR.PF@ |produces flies with a rough eye phenotype with eyes larger than seen |in wild-type or with @Scer\GAL4GMR.PF@ alone. SYN|aUAS } REFDSR { RDID|FBrf0139846 |Lengyel |2001.1.4 MD|Replacement of the @P{lacW}@ element in @ak11011b@ with a @P{yUAS}@ |element. PRG|P{lacW}ak11011b TRN|FBti0020936 == P{Mae-UAS.6.11}ayUAS MU|gene conversion |P-element activity SYN|aUAS } SK|FBstBL-7071 |y[1] w[*]; P{y[+t7.7]=Mae-UAS.6.11}a[yUAS] } ALESR { ASYM|a+ ID|FBal0068527 CLA|wild-type generic REF|FBrf0105495 } IFL|../dbzhnsky/arc1.htm SKC|6 } # EOR GENR { RETE|ID 1 FBgn0004930 CLA 1 Gene NAM 1 abnormal abdomen (1) 48 GSYM 1 a(1)48 DT 1 14 Aug 03 RESZ 4070 WT 1 Defined by incompletely characterized mutations that show an 'abnormal abdomen' phenotype GLOC 1 1- ALESR 4 REF 5 GSYM|a(1)48 DT|14 Aug 03 ID|FBgn0004930 NAM|abnormal abdomen (1) 48 KLOC|853 GLOC|1- DIS|Zimmermann, 1948. AM|Genetic relations not worked out. WT|Defined by incompletely characterized mutations that show an 'abnormal abdomen' phenotype. WTI|a(2)48 |a(3)48 PHP|Used to describe three X chromosomes with little or no |effect of their own but which increase the incidence |of abdominal malformations in crosses with a(2) and |a(3). REF { REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0009915 |Zimmermann |1954 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0020044 |Lindsley and Grell |1968 |2 REFM|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 |0 } REFDSR { RDID|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 WTI|a(2)48 (data from @a(1)4848@, @a(1)4850@) |a(3)48 (data from @a(1)4848@, @a(1)4850@) } ALESR { ASYM|a(1)4848 SYN|a(1)48 ID|FBal0000056 MU|spontaneous PHC|visible | recessive |viable | good |fertile | good PHM|abdomen PHI|RK3. REF|FBrf0020044 |FBrf0063299 REFDSR { RDID|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 MU|spontaneous GII|Increases the penetrance of @a(2)4848@ and @a(3)481@. GIC|enhancer of @a(2)4848@ |enhancer of @a(3)481@ PHC|viable |fertile SYN|a(1)48 } } ALESR { ASYM|a(1)4850 SYN|a(1)50 ID|FBal0000057 DIS|Zimmerman, 1950. MU|spontaneous GIC|enhancer of @a(2)4850@ |enhancer of @a(3)481@ PHC|visible | recessive |viable | good |fertile | good PHM|abdomen | adult PHI|RK3. |Irregularities in abdomen most frequently involving the |anterior segments. Penetrance 1%. Enhances maternal |effects of @a(2)4850@ and @a(3)481@. REF|FBrf0020044 |FBrf0009915 |FBrf0063299 REFDSR { RDID|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 MU|spontaneous GII|Increases the penetrance of @a(2)4848@ and @a(3)481@. GIC|enhancer of @a(2)4848@ |enhancer of @a(3)481@ PHC|viable |fertile SYN|a(1)50 } } ALESR { ASYM|a(1)4851 SYN|a(1)51 ID|FBal0000058 DIS|Zimmerman, 1951. MU|spontaneous PHC|visible | recessive | maternal effect |viable | good |fertile | good PHM|abdomen | adult PHI|RK3. |Shows maternal effect only, with 2% of progeny |affected. Abnormalities more anterior than those of |@a(2)4850@ and @a(1)4850@. REF|FBrf0020044 |FBrf0009915 |FBrf0063299 REFDSR { RDID|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 MU|spontaneous PHC|viable |fertile SYN|a(1)51 } } ALESR { ASYM|a(1)48+ ID|FBal0071524 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0004931 CLA 1 Gene NAM 1 abnormal abdomen HM26 GSYM 1 a(1)HM26 DT 1 14 Aug 03 RESZ 1532 WT 1 Defined by incompletely characterized mutations that show an 'abnormal abdomen' phenotype CLOC 1 [1B1--5C2] ALESR 2 REF 3 GSYM|a(1)HM26 DT|14 Aug 03 ID|FBgn0004931 SYN|l(1)HM26 NAM|abnormal abdomen HM26 GLOC|Maps to the right of y |Maps to the left of cv CLOC|[1B1--5C2] |Left limit from recombination mapping relative to y (FBrf0024658) |Right limit from recombination mapping relative to cv (FBrf0024658) WT|Defined by incompletely characterized mutations that show an 'abnormal abdomen' phenotype. REF { REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0024658 |Mayoh and Suzuki |1973 |0 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0024658 |Mayoh and Suzuki |1973 GLOC|Maps to the right of y |Maps to the left of cv } ALESR { ASYM|a(1)HM261 ID|FBal0000059 MU|ethyl methanesulfonate PHC|visible | recessive | conditional cs PHM|abdominal tergite |abdominal sternite PHI|Missing or reduced sternites; missing or angled |tergites; black specks on ventral surface of abdomen |in about one-third of males at 22oC and more than |half of males at 17oC. Viability reduced at 17oC |relative to that at 22oC. REF|FBrf0066905 |FBrf0024658 } ALESR { ASYM|a(1)HM26+ ID|FBal0068528 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0004932 CLA 1 existence-uncertain gene NAM 1 abnormal abdomen HM27 GSYM 1 a(1)HM27 DT 1 14 Aug 03 RESZ 1197 WT 1 Defined by incompletely characterized mutations that show an 'abnormal abdomen' phenotype GLOC 1 1- ALESR 2 REF 3 GSYM|a(1)HM27 DT|14 Aug 03 ID|FBgn0004932 CLA|existence-uncertain gene SYN|l(1)HM27 NAM|abnormal abdomen HM27 KLOC|853 GLOC|1- GLC|Maps near @y@. WT|Defined by incompletely characterized mutations that show an 'abnormal abdomen' phenotype. REF { REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0024658 |Mayoh and Suzuki |1973 |0 REFM|FBrf0105495 |FlyBase |1992- |9 } ALESR { ASYM|a(1)HM271 ID|FBal0000060 MU|ethyl methanesulfonate PHC|visible | recessive | conditional cs PHM|abdominal tergite |abdominal sternite PHI|Missing or reduced sternites; missing or angled |tergites; black specks on ventral surface of abdomen; more severe at |17oC than at 22oC. Viability slightly reduced at |17oC relative to that at 22oC. REF|FBrf0066905 |FBrf0024658 } ALESR { ASYM|a(1)HM27+ ID|FBal0068529 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0004933 CLA 1 Gene NAM 1 abnormal abdomen (2) 48 GSYM 1 a(2)48 DT 1 14 Aug 03 RESZ 4094 WT 1 Defined by incompletely characterized mutations that show an 'abnormal abdomen' phenotype GLOC 1 2- ALESR 5 REF 5 GSYM|a(2)48 DT|14 Aug 03 ID|FBgn0004933 NAM|abnormal abdomen (2) 48 KLOC|29816 GLOC|2- DIS|Zimmermann, 1948. AM|Genetic relations not worked out. PEVR|T(1;2)N264-9 WT|Defined by incompletely characterized mutations that show an 'abnormal abdomen' phenotype. WTI|a(1)48 |a(3)48 REF { REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0009915 |Zimmermann |1954 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0020044 |Lindsley and Grell |1968 |2 REFM|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 |0 } REFDSR { RDID|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 WTI|a(1)48 (data from @a(2)4848@) |a(3)48 (data from @a(2)48A51@) } ALESR { ASYM|a(2)4848 SYN|a(2)48 ID|FBal0057944 OTH|Penetrance 7%. Also shows maternal effect. PHC|visible | recessive |viable | good |fertile | good PHM|abdominal tergite |abdominal sternite PHI|Abdominal irregularities most frequently involve |anterior segments. |RK3. REF|FBrf0020044 |FBrf0066905 |FBrf0063299 REFDSR { RDID|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 AFC|a(2)48A51 MU|spontaneous GIC2|enhanceable by @a(1)4848@ |enhanceable by @a(1)4850@ PHC|viable |fertile SYN|a(2)48 } } ALESR { ASYM|a(2)4850 SYN|a(2)50 ID|FBal0000061 DIS|Zimmerman, 1950. OTH|Penetrance 7%. MU|spontaneous GIC2|enhanceable by @a(1)4850@ NAF|Stated to be lost. PHC|viable | good |fertile | good |visible | recessive |visible | recessive | maternal effect PHM|abdomen | adult PHI|Abdominal irregularities most frequently involve |anterior segments. |RK3. REF|FBrf0009915 |FBrf0063299 REFDSR { RDID|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 MU|spontaneous NAF|Stated to be lost. SYN|a(2)50 } } ALESR { ASYM|a(2)4851 SYN|a(2)51 ID|FBal0000062 DIS|Zimmerman, 1951. MU|spontaneous NAF|Stated to be lost. PHC|visible | recessive | maternal effect PHI|Penetrance 50%. |RK3. REF|FBrf0009915 |FBrf0063299 REFDSR { RDID|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 MU|spontaneous NAF|Stated to be lost. SYN|a(2)51 } } ALESR { ASYM|a(2)48A51 SYN|A(2)51 |A(2)4851 ID|FBal0000063 DIS|Zimmerman, 1951. MU|spontaneous GIC|enhancer | dominant of @a(3)481@ PHC|wild-type PHI|RK3. REF|FBrf0009915 |FBrf0063299 REFDSR { RDID|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 AFC|a(2)4848 MU|spontaneous GIC|enhancer of @a(3)481@ GII|Increases the penetrance of @a(2)4848@ and @a(3)481@. SYN|A(2)51 } } ALESR { ASYM|a(2)48+ ID|FBal0071525 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0004934 CLA 1 Gene NAM 1 abnormal abdomen (3) 48 GSYM 1 a(3)48 DT 1 14 Aug 03 RESZ 2174 WT 1 Defined by incompletely characterized mutations that show an 'abnormal abdomen' phenotype GLOC 1 3- ALESR 2 REF 4 GSYM|a(3)48 DT|14 Aug 03 ID|FBgn0004934 NAM|abnormal abdomen (3) 48 KLOC|79136 GLOC|3- DIS|Zimmermann, 1948. WT|Defined by incompletely characterized mutations that show an 'abnormal abdomen' phenotype. WTI|a(1)48 |a(2)48 REF { REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0009915 |Zimmermann |1954 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 |0 } REFDSR { RDID|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 WTI|a(1)48 (data from @a(3)481@) |a(2)48 (data from @a(3)481@) } ALESR { ASYM|a(3)481 SYN|a(3)48 ID|FBal0000064 MU|spontaneous GIC2|enhanceable by @a(1)4850@ |enhanceable by @a(2)48A51@ PHC|visible | recessive | maternal effect |viable | good |fertile | good PHM|abdominal tergite |abdominal sternite PHI|Incompletely penetrant. Affects only 2.5% of progeny. |Irregularities most frequently involve posterior |segments of abdomen. |RK3. REF|FBrf0066905 |FBrf0009915 |FBrf0063299 REFDSR { RDID|FBrf0063299 |Zoologisches Institut der Universitat Gottingen |1952 MU|spontaneous GIC2|enhanceable by @a(1)4848@ |enhanceable by @a(1)4850@ |enhanceable by @a(2)48A51@ PHC|viable |fertile SYN|a(3)48 } } ALESR { ASYM|a(3)48+ ID|FBal0068530 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0004929 CLA 1 existence-uncertain gene NAM 1 Abnormal abdomen polygenic GSYM 1 A-p DT 1 14 Aug 03 RESZ 1133 ALESR 1 REF 7 GSYM|A-p DT|14 Aug 03 ID|FBgn0004929 CLA|existence-uncertain gene SYN|AA |Asy: Asymmetric |Asymmetric NAM|Abnormal abdomen polygenic DIS|Sobels, Sep. 1949. GLC|Polygenic. PHP|Incomplete mediodorsal fusion and onesided reduction |of tergites. When more than one tergite is abnormal, |spiral segmentation types are most frequent. |Expression strongly dependent on environment. |Penetrance and expressivity correlated (Bezem and |Sobels, 1953). In strains selected for penetrance |of A-p, mediodorsal fusion or asymmetrical reduction |of head and thorax also occur. REF { REFM|FBrf0008552 |Sobels |1952 |0 REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0008585 |Sobels |1952 |0 REFM|FBrf0063879 |Sobels et al. |1951 |0 REFM|FBrf0063880 |Sobels |1950 |0 REFM|FBrf0009221 |Bezem and Sobels |1953 |0 REFM|FBrf0105495 |FlyBase |1992- |9 } ALESR { ASYM|A-p+ ID|FBal0071526 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0011293 CLA 1 Gene NAM 1 antennal protein 10 GSYM 1 a10 DT 1 14 Aug 03 RESZ 3194 PTD 1 DBA 6 HG 1 Schistocerca gregaria 'chemosensory protein CSP-sg1' EMBL:AF070961 FNC 1 chemosensory perception CLOC 1 73E4 ALESR 1 REF 10 GSYM|a10 PTD DT|14 Aug 03 ID|FBgn0011293 UAB|Deficiency: Df(3L)st7 (inferred from cytology) |Duplication: Dp(3;3)st+g18 (inferred from cytology) SYN|CG6642 |OS-D |A10 |Os-D ID2|FBgn0010402 NAM|antennal protein 10 KLOC|94208 CLOC|73E4 |Limits computationally determined from genome sequence between l(3)02281 and l(3)01658 CYC|Experimentally determined: 73F, 83C--D FNC|chemosensory perception ; GO:0007606 | inferred from sequence similarity with EMBL:AF070961 ENZ|odorant binding ; GO:0005549 | non-traceable author statement |pheromone binding ; GO:0005550 | non-traceable author statement DBA|NA:AE003525 |PA:AAF49381 |NA:U02546 |PA:AAA21358 |NA:U05244 |PA:AAC46473 PAC|SWP:Q27377 HG|species == Schistocerca gregaria; gene == 'chemosensory protein CSP-sg1'; EMBL:AF070961; gi:3283932; score == 118; expect == 4.e-26 ASQ|FBan0006642 REF { REFM|FBrf0075175 |Hekmat-Scafe |1995 |9 REFM|FBrf0117975 |McKenna |1993.10.15 |9 REFM|FBrf0126686 |Milshina |1999.11 |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0073868 |McKenna et al. |1994 |0 REFM|FBrf0124368 |SwissProt Project Members |1997.2.1 |9 REFM|FBrf0127265 |Park et al. |2000 |0 REFM|FBrf0118974 |Pikielny |1994.1.18 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0066935 |Pikielny et al. |1994 |0 } REFDSR { RDID|FBrf0066935 |Pikielny et al. |1994 WT|@a10@ is one of seven clones that have been identified from subtracted |cDNA libraries, containing antennal cDNA from which head cDNAs have |been subtracted. The protein is expressed in |subsets of olfactory hairs and have a putative signal peptide at the |amino terminus. } REFDSR { RDID|FBrf0073868 |McKenna et al. |1994 CLOC|73F (determined by in situ hybridization) OTH|Isolated from a subtracted antennal cDNA library enriched for cDNAs |expressed in the antennae but not the rest of the head or body of adult |flies. PHP|An @a10@ cDNA has been cloned and sequenced. SYN|OS-D } REFDSR { RDID|FBrf0075175 |Hekmat-Scafe |1995 CLOC|73F (stated as revision) WT|Encodes a putative olfactant binding protein. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- FNC|chemosensory perception ; GO:0007606 | inferred from sequence similarity with EMBL:AF070961 } REFDSR { RDID|FBrf0117975 |McKenna |1993.10.15 ENZ|pheromone binding ; GO:0005550 | non-traceable author statement CLOC|83C--D SYN|OS-D } REFDSR { RDID|FBrf0118974 |Pikielny |1994.1.18 CLOC|73F } REFDSR { RDID|FBrf0124368 |SwissProt Project Members |1997.2.1 ENZ|odorant binding ; GO:0005549 | non-traceable author statement GPD|odorant binding protein A10 } REFDSR { RDID|FBrf0127265 |Park et al. |2000 SYN|A10 } ALESR { ASYM|a10+ ID|FBal0071527 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0025723 CLA 1 Gene GSYM 1 A122 DT 1 14 Aug 03 RESZ 2070 CLOC 1 [38E3--43E14] ALESR 2 REF 2 GSYM|A122 DT|14 Aug 03 ID|FBgn0025723 CLOC|[38E3--43E14] |Left limit from recombination mapping relative to Bl (FBrf0104442) |Right limit from recombination mapping relative to cn (FBrf0104442) KLOC|29816 GLOC|2-? |Maps to the right of b |Maps to the right of Bl |Maps to the left of cn |Maps to the left of L GLC|Maps close to @cn@, and closer to @Bl@ than to @L@. REF { REFM|FBrf0104442 |Go and Artavanis-Tsakonas |1998 |0 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0104442 |Go and Artavanis-Tsakonas |1998 GLOC|2-? |Maps to the right of b |Maps to the right of Bl |Maps to the left of cn |Maps to the left of L GLC|Maps close to @cn@, and closer to @Bl@ than to @L@. OTH|Identification: Screen for genetic modifiers of @NAx-16@. WTI|N (data from @A122A122@) } ALESR { ASYM|A122A122 SYN|A122 ID|FBal0093527 PHC|lethal | larval | recessive REF|FBrf0104442 REFDSR { RDID|FBrf0104442 |Go and Artavanis-Tsakonas |1998 MU|ethyl methanesulfonate GIC|suppressor of visible phenotype of @NAx-16@ |suppressor of visible phenotype of @NAx-9@ GIA|suppressor of wing vein phenotype of @NAx-16@ |suppressor of macrochaeta phenotype of @NAx-16@ |suppressor of microchaeta phenotype of @NAx-16@ |suppressor of macrochaeta phenotype of @NAx-9@ GII|Suppresses the bristle and wing vein phenotypes of @NAx-16@ and the |'fewer bristle' phenotype of @NAx-9@. PHC|lethal | larval | recessive SYN|A122 } } ALESR { ASYM|A122+ ID|FBal0093737 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0028965 CLA 1 Gene GSYM 1 A16 DT 1 14 Aug 03 RESZ 1438 PDOM 3 INTERPRO:IPR000953 == Chromo domain DBA 15 CLOC 1 34A4 ALESR 1 REF 2 GSYM|A16 DT|14 Aug 03 ID|FBgn0028965 UAB|Duplication: Dp(2;2)GYL (inferred from cytology) SYN|CG9933 ID2|FBgn0032468 KLOC|42743 CLOC|34A4 |Limits computationally determined from genome sequence between l(2)rK639/l(2)k07015 and l(2)k11328/l(2)k10105 CYC|Experimentally determined: 34A PDOM|IPR000953 == Chromo domain |SCOP:50156 == PDZ domain-like; CG9933|FBgn0032468|pp-CT27954|FBan0009933 |SCOP:54160 == Chromo domain-like; CG9933|FBgn0032468|pp-CT27954|FBan0009933 DBA|NA:AA391464 |BDGP-DGC:LD10135 |NA:AA941120 |BDGP:LD25087.5prime |NA:AC010214 |BDGP:BACR27F17 |NA:AE003638 |PA:AAF53239 |NA:AI109007 |BDGP:GH07495.3prime |NA:AI109028 |BDGP:GH07525.3prime |NA:AY122156 |PA:AAM52668 |BDGP-DGC:LD10135 PAC|SPTREMBL:Q9VK43 ASQ|FBan0009933 REF { REFM|FBrf0112243 |Greig and O'Kane |1999.10.21 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 } REFDSR { RDID|FBrf0112243 |Greig and O'Kane |1999.10.21 CLOC|34A (determined by in situ hybridization) MD|Maps to clone: BACR27F17 |Identified with: GH07495.3prime |Identified with: GH07525.3prime |Identified with: LD25087.5prime OTH|Identification: interacts with @G-i&agr;65A@ in a yeast two hybrid |screen. } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD10135 (BDGP-DGC) } ALESR { ASYM|A16+ ID|FBal0102311 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0067327 CLA 1 Gene GSYM 1 A23 DT 1 14 Aug 03 RESZ 1387 ALESR 2 REF 1 GSYM|A23 DT|14 Aug 03 ID|FBgn0067327 REF { REFM|FBrf0150728 |Akieda and Merriam |2001 |0 } ALESR { ASYM|A23A23 SYN|A23 ID|FBal0148509 PHC|lethal with @Scer\GAL4Act5C.PI@ |eye color defective with @Scer\GAL4GMR.PF@ PHM|pigment cell with @Scer\GAL4GMR.PF@ PHI|Postmitotic adult bristles are normal in animals expressing @A23A23@ |under the control of @Scer\GAL4B11@. |Eyes show partial pigment loss in animals expressing @A23A23@ under |the control of @Scer\GAL4GMR.PF@. REF|FBrf0150728 REFDSR { RDID|FBrf0150728 |Akieda and Merriam |2001 TRN|FBti0027613 == P{Mae-UAS.6.11}A23A23 MU|P-element activity PHC|lethal with @Scer\GAL4Act5C.PI@ |eye color defective with @Scer\GAL4GMR.PF@ PHM|pigment cell with @Scer\GAL4GMR.PF@ PHI|Postmitotic adult bristles are normal in animals expressing @A23A23@ |under the control of @Scer\GAL4B11@. |Eyes show partial pigment loss in animals expressing @A23A23@ under |the control of @Scer\GAL4GMR.PF@. SYN|A23 } } ALESR { ASYM|A23+ ID|FBal0150107 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0020515 CLA 1 Gene GSYM 1 A3 DT 1 14 Aug 03 RESZ 1369 WT 3 The expression pattern CLOC 1 92B2--C3 ALESR 1 REF 4 GSYM|A3 DT|14 Aug 03 ID|FBgn0020515 UAB|Deficiency: Df(3R)I9 |Deficiency: Df(3R)Dl-BX12 (inferred from cytology) |Duplication: Dp(3;3)C123.3 (inferred from cytology) KLOC|117956-118211 CLOC|92B2--C3 |Left limit from inclusion within Df(3R)oraI9 (FBrf0093828) |Right limit from inclusion within Df(3R)oraI9 (FBrf0093828) WT|The expression pattern, cellular localization and loss of function |phenotype of @A3@ strongly suggests @A3@ plays an important role in the |asymmetric localization of @pros@ during mitosis. REF { REFM|FBrf0093828 |Shen |1997.4.19 |9 REFM|FBrf0100478 |Jan |1997 |1 REFM|FBrf0091690 |Shen et al. |1997 |1 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0091690 |Shen et al. |1997 WT|The expression pattern, cellular localization and loss of function |phenotype of @A3@ strongly suggests @A3@ plays an important role in the |asymmetric localization of @pros@ during mitosis. OTH|Identification: Yeast two hybrid screen for proteins that interact |directly with @numb@ and @pros@. } REFDSR { RDID|FBrf0093828 |Shen |1997.4.19 BMD|Df(3R)I9 } ALESR { ASYM|A3+ ID|FBal0079507 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0028550 CLA 1 Gene GSYM 1 A3-3 DT 1 14 Aug 03 RESZ 3951 PDOM 3 INTERPRO:IPR000837 == Fos transforming protein DBA 13 HG 3 Homo sapiens 'activating transcription factor 3 long isoform' gi:4502263 CLOC 1 1E5 ALESR 2 REF 8 GSYM|A3-3 DT|14 Aug 03 ID|FBgn0028550 UAB|Deficiency: Df(1)S39 (inferred from cytology) |Duplication: Dp(1;3)sta (inferred from cytology) SYN|CG11405 |CG11405 |EG:33C11.1 ID2|FBgn0026877 KLOC|1068 CLOC|1E5 |Limits computationally determined from genome sequence between EP(X)1594/EP(X)0964 and EP(X)1542/EP(X)1336 CYC|Experimentally determined: 1F PDOM|IPR000837 == Fos transforming protein |IPR001871 == bZIP (Basic-leucine zipper) transcription factor family |SCOP:47454 == Binding domain of Skn-1; A3-3|FBgn0028550|pp-CT31841|FBan0011405 ENZ|protein dimerization activity ; GO:0046983 | inferred from sequence similarity DBA|NA:AE003420 |PA:AAF45599 |NA:AI404815 |BDGP-DGC:GH24653 |NA:AL035331 |PA:CAA22962 |NA:AL121806 |PA:CAB65887 |NA:AW940950 |BDGP-DGC:GH24653 |NA:AY121628 |PA:AAM51955 |BDGP-DGC:GH24653 PAC|SPTREMBL:Q8MRE5 |SPTREMBL:Q9XZS8 HG|species == Homo sapiens; gene == 'activating transcription factor 3 long isoform'; gi:4502263; score == 62.5; expect == 1.e-08 |species == Mus musculus; gene == Atf3; MGI:109384; score == 62.5; expect == 1.e-08 |species == Rattus norvegicus; gene == 'jun dimerization protein 2'; EMBL:U53449; gi:2853265; score == 62.8; expect == 8.e-09 ASQ|FBan0011405 REF { REFM|FBrf0111592 |Heitzeberg |1999.9.15 |9 REFM|FBrf0141117 |Benos |1999.12.28 |9 REFM|FBrf0133222 |Benos |2000.12.13 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0109889 |Heitzeberg et al. |1999 |1 REFM|FBrf0125090 |Gatt and Ashburner |2000.2.3 |9 REFM|FBrf0135823 |Benos et al. |2001 |0 REFM|FBrf0152056 |Fassler et al. |2002 |0 } REFDSR { RDID|FBrf0109889 |Heitzeberg et al. |1999 } REFDSR { RDID|FBrf0111592 |Heitzeberg |1999.9.15 CLOC|1F } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH24653 (BDGP-DGC) } REFDSR { RDID|FBrf0125090 |Gatt and Ashburner |2000.2.3 AM|Source for merge of: A3-3 EG:33C11.1 } REFDSR { RDID|FBrf0133222 |Benos |2000.12.13 SYN|CG11405 |EG:33C11.1 } REFDSR { RDID|FBrf0135823 |Benos et al. |2001 MD|Identified with: GH24653 SYN|EG:33C11.1 } REFDSR { RDID|FBrf0141117 |Benos |1999.12.28 MD|Gene order: In direction of increasing cytology: CG14628+ CG32859- CG11378+ CG11384- |Gene order: CG11379+ CG14627+ CG14626+ CG11380+ |Gene order: CG14625+ CG14624+ CG11382+ CG11398- |Gene order: CG3638- CG11403- A3-3- SYN|EG:33C11.1 } REFDSR { RDID|FBrf0152056 |Fassler et al. |2002 ENZ|protein dimerization activity ; GO:0046983 | inferred from sequence similarity } ALESR { ASYM|A3-31 ID|FBal0100468 PHC|lethal | larval | partially | recessive |female fertile | reduced PHI|Homozygotes show reduced viability during larval development. |Mutant females mated to wild-type males lay eggs, but most of them |do not show any development. The percentage of defective eggs |increases with the age of the female flies. REF|FBrf0109889 REFDSR { RDID|FBrf0109889 |Heitzeberg et al. |1999 MD|@P{lArB}@ insertion in an intron. TRN|FBti0013984 == P{lArB}A3-31 PHC|lethal | larval | partially | recessive |female fertile | reduced PHI|Homozygotes show reduced viability during larval development. |Mutant females mated to wild-type males lay eggs, but most of them |do not show any development. The percentage of defective eggs |increases with the age of the female flies. SYN|unnamed } } ALESR { ASYM|A3-3+ ID|FBal0101097 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0020514 CLA 1 Gene GSYM 1 A35 DT 1 14 Aug 03 RESZ 786 CLOC 1 54D4--E7 ALESR 1 REF 3 GSYM|A35 DT|14 Aug 03 ID|FBgn0020514 UAB|Duplication: Dp(2;Y)53D;57C (inferred from cytology) KLOC|68366-68600 CLOC|54D4--E7 |Left limit from in situ hybridization (FBrf0093842) |Right limit from in situ hybridization (FBrf0093842) CYC|Experimentally determined: 54D4--E7 REF { REFM|FBrf0093842 |Foss |1997.4.18 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0091815 |Foss et al. |1997 |1 } REFDSR { RDID|FBrf0091815 |Foss et al. |1997 SYN|unnamed } REFDSR { RDID|FBrf0093842 |Foss |1997.4.18 CLOC|54D4--E7 (determined by in situ hybridization) } ALESR { ASYM|A35+ ID|FBal0079506 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0024506 CLA 1 Gene GSYM 1 A359 DT 1 14 Aug 03 RESZ 768 ALESR 1 REF 5 GSYM|A359 DT|14 Aug 03 ID|FBgn0024506 REV|FBrf0128450 REF { REFM|FBrf0101072 |Dobens and Raftery |1998 |1 REFM|FBrf0106423 |Dobens et al. |1999 |1 REFM|FBrf0102087 |Dobens |1998.3.17 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0128450 |Dobens and Raftery |2000 |2 } REFDSR { RDID|FBrf0101072 |Dobens and Raftery |1998 OTH|@dpp@ target gene. } REFDSR { RDID|FBrf0102087 |Dobens |1998.3.17 LOI|P{lArB}A359.1M3 } ALESR { ASYM|A359+ ID|FBal0088440 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0067326 CLA 1 Gene GSYM 1 A43 DT 1 14 Aug 03 RESZ 1785 ALESR 2 REF 1 GSYM|A43 DT|14 Aug 03 ID|FBgn0067326 REF { REFM|FBrf0150728 |Akieda and Merriam |2001 |0 } ALESR { ASYM|A43A43 SYN|A43 ID|FBal0148508 PHC|lethal with @Scer\GAL4Act5C.PI@ |viable with @Scer\GAL4byn-Gal4@ |visible with @Scer\GAL4GMR.PF@ |eye color defective with @Scer\GAL4GMR.PF@ PHM|eye with @Scer\GAL4GMR.PF@ |pigment cell with @Scer\GAL4GMR.PF@ PHI|Postmitotic adult bristles are normal in animals expressing @A43A43@ |under the control of @Scer\GAL4B11@. |Eyes are small and show partial pigment loss in animals expressing |@A43A43@ under the control of @Scer\GAL4GMR.PF@. REF|FBrf0150728 REFDSR { RDID|FBrf0150728 |Akieda and Merriam |2001 TRN|FBti0027612 == P{Mae-UAS.6.11}A43A43 MU|P-element activity PHC|lethal with @Scer\GAL4Act5C.PI@ |viable with @Scer\GAL4byn-Gal4@ |visible with @Scer\GAL4GMR.PF@ |eye color defective with @Scer\GAL4GMR.PF@ PHM|eye with @Scer\GAL4GMR.PF@ |pigment cell with @Scer\GAL4GMR.PF@ PHI|Postmitotic adult bristles are normal in animals expressing @A43A43@ |under the control of @Scer\GAL4B11@. |Eyes are small and show partial pigment loss in animals expressing |@A43A43@ under the control of @Scer\GAL4GMR.PF@. SYN|A43 } } ALESR { ASYM|A43+ ID|FBal0150106 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027096 CLA 1 Gene GSYM 1 A45 DT 1 14 Aug 03 RESZ 195 ALESR 1 REF 1 GSYM|A45 DT|14 Aug 03 ID|FBgn0027096 REF { REFM|FBrf0108059 |Vosshall et al. |1999 |0 } ALESR { ASYM|A45+ ID|FBal0097824 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0011294 CLA 1 Gene NAM 1 antennal protein 5 GSYM 1 a5 DT 1 14 Aug 03 RESZ 3510 PDOM 1 SCOP:49777 == Phosphatidylethanolamine binding protein PTD 1 DBA 8 HG 5 Caenorhabditis elegans 'Similar to phosphatidylethanolamine binding protein EMBL:AF016423 CLOC 1 22A1 ALESR 1 REF 8 GSYM|a5 PTD ARGS DT|14 Aug 03 ID|FBgn0011294 UAB|Deficiency: Df(2L)frtz17 (inferred from cytology) |Duplication: Dp(2;2)M+Su24+-1 (inferred from cytology) SYN|CG5430 |A5 NAM|antennal protein 5 KLOC|30914 CLOC|22A1 |Limits computationally determined from genome sequence between EP(2)0434/l(2)k00619 and EP(2)2582 CYC|Experimentally determined: 22A--B PDOM|SCOP:49777 == Phosphatidylethanolamine binding protein; a5|FBgn0011294|pp-CT17230|FBan0005430 MD|Maps to clone: DS08613 |Maps to clone: BACR16D07 ENZ|phosphatidylethanolamine binding ; GO:0008429 | non-traceable author statement |phosphatidylethanolamine binding ; GO:0008429 | inferred from sequence similarity with Swiss-Prot:P31044 DBA|NA:AC004439 |BDGP:DS08613 |NA:AC092221 |BDGP:BACR16D07 |NA:AE003586 |PA:AAF51385 |NA:U05243 |PA:AAC46472 PAC|SWP:P54185 HG|species == Caenorhabditis elegans; gene == 'Similar to phosphatidylethanolamine binding protein; coded for by C. elegans c'; EMBL:AF016423; gi:2291199; score == 161; expect == 4.e-39 |species == Homo sapiens; gene == 'prostatic binding protein'; gi:4505621; score == 143; expect == 9.e-34 |species == Mus musculus; gene == 'PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN'; SWP:P70296; gi:2499440; score == 147; expect == 8.e-35 |species == Rattus; gene == 'PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN (23 KD MORPHINE-BINDING PROTEIN'; SWP:P31044; gi:400734; score == 153; expect == 1.e-36 |species == Saccharomyces cerevisiae; gene == 'hypothetical protein YDR322w'; PIR:S59788; gi:2131429; score == 59.7; expect == 2.e-08 ASQ|FBan0005430 REF { REFM|FBrf0118975 |Pikielny |1994.1.18 |9 REFM|FBrf0127265 |Park et al. |2000 |0 REFM|FBrf0141153 |SWISS-PROT Project Members |1996.10.1 |9 REFM|FBrf0126686 |Milshina |1999.11 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0126682 |Li |1999.11 |9 REFM|FBrf0066935 |Pikielny et al. |1994 |0 } REFDSR { RDID|FBrf0066935 |Pikielny et al. |1994 PHP|@a5@ is one of seven clones that have been identified from subtracted |cDNA libraries, containing antennal cDNA from which head cDNAs have |been subtracted. The protein is expressed in |subsets of olfactory hairs and have a putative signal peptide at the |amino terminus. @a5@ protein is highly similar both to vertebrate |brain proteins that bind hydrophobic ligands and to yeast and nematode |proteins. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|phosphatidylethanolamine binding ; GO:0008429 | inferred from sequence similarity with Swiss-Prot:P31044 MD|Maps to clone: DS08613 |Maps to clone: BACR16D07 } REFDSR { RDID|FBrf0118975 |Pikielny |1994.1.18 CLOC|22A--B } REFDSR { RDID|FBrf0126682 |Li |1999.11 AM|Source for identity of: a5 CG5430 } REFDSR { RDID|FBrf0127265 |Park et al. |2000 SYN|A5 } REFDSR { RDID|FBrf0141153 |SWISS-PROT Project Members |1996.10.1 ENZ|phosphatidylethanolamine binding ; GO:0008429 | non-traceable author statement GPD|odorant binding protein A5 } ALESR { ASYM|a5+ ID|FBal0068531 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0023130 CLA 1 Gene GSYM 1 a6 DT 1 14 Aug 03 RESZ 2618 PTD 1 DBA 16 FNC 1 embryonic development (sensu Insecta) CEL 1 cellular_component unknown CLOC 1 2B7 ALESR 1 REF 10 GSYM|a6 PTD ARGS DT|14 Aug 03 ID|FBgn0023130 UAB|Deficiency: Df(1)A94 (inferred from cytology) |Duplication: Dp(1;Y)2E (inferred from cytology) SYN|CG3771 |CG3771 |EG:9D2.3 KLOC|1539 CLOC|2B7 |Limits computationally determined from genome sequence between EP(X)1515 and EP(X)1444/EP(X)1190 CYC|Experimentally determined: 2B6--8 FNC|embryonic development (sensu Insecta) ; GO:0001700 | inferred from expression pattern CEL|cellular_component unknown ; GO:0008372 | no biological data available ENZ|odorant binding ; GO:0005549 | non-traceable author statement DBA|NA:AA439160 |BDGP-DGC:LD13641 |NA:AE003421 |PA:AAF45661 |NA:AL031025 |PA:CAA19836 |EDGP:9D2 |NA:AW942280 |BDGP-DGC:LD13641 |NA:AY069426 |PA:AAL39571 |BDGP-DGC:LD13641 |NA:Y16065 |PA:CAA76017 |NA:Y16066 |PA:CAA76018 PAC|SWP:O46341 ASQ|FBan0003771 REF { REFM|FBrf0135823 |Benos et al. |2001 |0 REFM|FBrf0126686 |Milshina |1999.11 |9 REFM|FBrf0123119 |Makunin et al. |1999 |0 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0133223 |Benos |2000.12.13 |9 REFM|FBrf0133222 |Benos |2000.12.13 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0127005 |Benos et al. |2000 |2 REFM|FBrf0117663 |Makunin |1997.12.30 |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|-1826174152 CEL|cellular_component unknown ; GO:0008372 | no biological data available } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|odorant binding ; GO:0005549 | non-traceable author statement MD|Maps to clone: 9D2 } REFDSR { RDID|FBrf0117663 |Makunin |1997.12.30 CLOC|2B6--8 } REFDSR { RDID|FBrf0123119 |Makunin et al. |1999 FNC|embryonic development (sensu Insecta) ; GO:0001700 | inferred from expression pattern } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD13641 (BDGP-DGC) } REFDSR { RDID|FBrf0133222 |Benos |2000.12.13 SYN|CG3771 |EG:9D2.3 } REFDSR { RDID|FBrf0133223 |Benos |2000.12.13 SYN|EG:9D2.3 } REFDSR { RDID|FBrf0135823 |Benos et al. |2001 MD|Identified with: LD13641 SYN|EG:9D2.3 } ALESR { ASYM|a6+ ID|FBal0087232 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0026612 CLA 1 Gene GSYM 1 A69 DT 1 14 Aug 03 RESZ 356 ALESR 1 REF 1 GSYM|A69 DT|14 Aug 03 ID|FBgn0026612 REF { REFM|FBrf0106341 |Chou et al. |1999 |1 } REFDSR { RDID|FBrf0106341 |Chou et al. |1999 OTH|Identification: Mutation that disrupts the expression |pattern of opsins in the eye. } ALESR { ASYM|A69+ ID|FBal0096583 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0004935 CLA 1 Gene NAM 1 Altered abdomen GSYM 1 Aa DT 1 14 Aug 03 RESZ 1757 GLOC 1 1- ALESR 2 REF 3 GSYM|Aa DT|14 Aug 03 ID|FBgn0004935 NAM|Altered abdomen KLOC|853 GLOC|1- DIS|Cicak, June 1956. PHP|Known from a poorly characterized mutation with melanin deposition in the abdominal tergites. REF { REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0063371 |Cicak and Oster |1957 |0 } REFDSR { RDID|FBrf0063371 |Cicak and Oster |1957 GLOC|1- } ALESR { ASYM|Aa1 ID|FBal0000065 AMIS|Induced on: @In(1)dl-49@, @y@ @w@ @f@ arm of @C(1)DX@. OTH|@Aa1@ detachment-bearing males sterile. CYA|Possibly associated with a rearrangement in addition to @In(1)dl-49@. MU|X ray PHC|visible | dominant PHM|abdominal tergite PHI|Heavy deposition of melanin in tergites of females and males. |RK2A. REF|FBrf0063371 |FBrf0066905 REFDSR { RDID|FBrf0063371 |Cicak and Oster |1957 AMIS|Induced on: @In(1)dl-49@, @y@ @w@ @f@ of a "doubly-attached" X chromosome. MU|X ray PHC|visible | dominant PHM|abdominal tergite PHI|Heavy deposition of melanin is seen in the tergites of males and females |approximately 12 hours after eclosion, this darkens intensely as the |flies age. Heterozygous females are fully viable and fertile. Hemizygous |males are viable and probably sterile (the sterility of the males may |be due to hyperploidy resulting from unequal breakage of the attached |X chromosome on which @Aa1@ was induced). SYN|Aa } } ALESR { ASYM|Aa+ ID|FBal0066328 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0000010 CLA 1 Gene NAM 1 anarista GSYM 1 aa DT 1 14 Aug 03 RESZ 1062 CLOC 1 61E2--62A6 ALESR 2 SK 2 REF 3 GSYM|aa DT|14 Aug 03 ID|FBgn0000010 UAB|Deficiency: Df(3L)Ar14-8 (inferred from cytology) SYN|al-b: aristaless-b |aristaless-b NAM|anarista KLOC|79084-79521 GLOC|3-0.0 CLOC|61E2--62A6 |Left limit from complementation mapping against T(Y;2;3)D (citation unavailable) |Right limit from complementation mapping against T(Y;2;3)D (citation unavailable) DIS|Bridges, 10th April 1923. PHP|Known only from a single allele with bare or tufted aristae and somewhat broad wings. REF { REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0001379 |Morgan et al. |1925 |2 REFM|FBrf0105495 |FlyBase |1992- |9 } ALESR { ASYM|aa1 ID|FBal0000066 PHC|visible | recessive PHM|arista |wing PHI|Aristae bare or tufted. Wings somewhat broader than |wild type. Expression variable, overlaps wild type |often in female and sometimes in male. |RK3. SK|FBstBL-444 |aa[1] h[1] |FBstBL-445 |aa[1] tu-36e[1] } ALESR { ASYM|aa+ ID|FBal0071528 CLA|wild-type generic REF|FBrf0105495 } SKC|2 } # EOR GENR { RETE|ID 1 FBgn0027885 CLA 1 Gene GSYM 1 Aac11 DT 1 14 Aug 03 RESZ 5118 PDOM 1 SCOP:48371 == ARM repeat PTD 1 DBA 10 HG 3 Arabidopsis thaliana 'unknown protein' EMBL:AC002341 FNC 2 anti-apoptosis CLOC 1 36C9 ALESR 3 SK 1 REF 8 GSYM|Aac11 PTD ARGS DT|14 Aug 03 ID|FBgn0027885 UAB|Deficiency: Df(2L)net-PM47C |Duplication: Dp(2;Y)G (inferred from cytology) SYN|CG6582 |BcDNA.LD09852 |l(2)k06710 |BcDNA:LD09852 ID2|FBgn0022116 KLOC|45701 CLOC|36C9 |Limits computationally determined from genome sequence between l(2)k10423/l(2)k03902 and l(2)k06710 CYC|Experimentally determined: 36C8--11, 36D1--3 FNC|anti-apoptosis ; GO:0006916 | inferred from sequence similarity |anti-apoptosis ; GO:0006916 | inferred from sequence similarity with TrEMBL:O15441 PDOM|SCOP:48371 == ARM repeat; Aac11|FBgn0027885|pp-CT20430|FBan0006582 ENZ|apoptosis inhibitor activity ; GO:0008189 | inferred from sequence similarity |apoptosis inhibitor activity ; GO:0008189 | inferred from sequence similarity with TrEMBL:O15441 DBA|NA:AA391324 |BDGP-DGC:LD09852 |NA:AC010121 |BDGP:BACR07M13 |NA:AE003655 |PA:AAF53618 |NA:AF160921 |PA:AAD46861 |NA:AQ025805 |BDGP:l(2)k06710 PAC|SPTREMBL:Q9V431 HG|species == Arabidopsis thaliana; gene == 'unknown protein'; EMBL:AC002341; gi:2342724; score == 151; expect == 1.e-35 |species == Homo sapiens; gene == 'Aac11'; EMBL:U83857; gi:2623761; score == 384; expect == 1.e-106 |species == Mus musculus; gene == 'unknown'; EMBL:U35846; gi:2623755; score == 400; expect == 1.e-110 ASQ|FBan0006582 REF { REFM|FBrf0126832 |Beaton |2000.1.31 |9 REFM|FBrf0125032 |Beaton |1999.12.12 |9 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0121508 |Tsang |1999.6.19 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0111489 |Spradling et al. |1999 |0 } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|36C8--11 |36D1--3 CYC|Location 36C8--11 inferred from insertion in: Aac11k06710 |Location 36D1--3 inferred from insertion in: Aac11k07112 BMD|Df(2L)H20 BMD|Df(2L)net-PM47C BMD|Df(2L)net-PMF BMDD|Df(2L)VA18 BMDD|Df(2L)net62 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|apoptosis inhibitor activity ; GO:0008189 | inferred from sequence similarity with TrEMBL:O15441 FNC|anti-apoptosis ; GO:0006916 | inferred from sequence similarity with TrEMBL:O15441 MD|Maps to clone: BACR07M13 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 ENZ|apoptosis inhibitor activity ; GO:0008189 | inferred from sequence similarity CLOC|36C8--11 (determined by in situ hybridization) FNC|anti-apoptosis ; GO:0006916 | inferred from sequence similarity MD|Identified with: LD09852 BMD|Df(2L)H20 BMDD|Df(2L)VA18 } REFDSR { RDID|FBrf0121508 |Tsang |1999.6.19 SYN|BcDNA.LD09852 } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD09852 (BDGP-DGC) } REFDSR { RDID|FBrf0126832 |Beaton |2000.1.31 SYN|l(2)k06710 } ALESR { ASYM|Aac11k06710 SYN|l(2)k06710 |l(2)k06710k06710 ID|FBal0064421 REF|FBrf0067338 |FBrf0125032 |FBrf0126832 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 AFC|Aac11k07112 DIS|I. Kiss. TRN|FBti0006726 == P{lacW}Aac11k06710 |BDGP:l(2)k06710 MU|P-element activity PHC|lethal | recessive } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0006726 == P{lacW}Aac11k06710 |BDGP:l(2)k06710 PHC|lethal | recessive SYN|l(2)k06710 } REFDSR { RDID|FBrf0126832 |Beaton |2000.1.31 OTH|After six generations of outcrossing the lethality continued to segragate |with the @P{lacW}@ insertion. TRN|FBti0006726 == P{lacW}Aac11k06710 |BDGP:l(2)k06710 PHC|lethal | recessive } SK|FBstBL-10645 |y[1] w[67c23]; P{w[+mC]=lacW}Aac11[k06710]/CyO } ALESR { ASYM|Aac11k07112 SYN|l(2)k07112 |l(2)k06710k07112 ID|FBal0064420 REF|FBrf0067338 |FBrf0125032 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 AFC|Aac11k06710 DIS|I. Kiss. TRN|FBti0006725 == P{lacW}Aac11k07112 |BDGP:l(2)k07112 MU|P-element activity PHC|lethal | recessive } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0006725 == P{lacW}Aac11k07112 |BDGP:l(2)k07112 PHC|lethal | recessive SYN|l(2)k07112 } } ALESR { ASYM|Aac11+ ID|FBal0101915 CLA|wild-type generic } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0026153 CLA 1 foreign gene GSYM 1 Aaeg\Apy DT 1 14 Aug 03 RESZ 220 FSQ 1 Aedes aegypti 'Apy, Apyrase'. REF 1 GSYM|Aaeg\Apy DT|14 Aug 03 ID|FBgn0026153 CLA|foreign_gene FSQ|species == Aedes aegypti; gene == 'Apy, Apyrase'. REF { REFM|FBrf0106352 |Coates et al. |1999 |0 } } # EOR GENR { RETE|ID 1 FBgn0024504 CLA 1 foreign gene GSYM 1 Aaeg\DefA-la DT 1 14 Aug 03 RESZ 581 FSQ 1 Aedes aegypti 'DefA-la, Defensin-A-large'. REF 1 GSYM|Aaeg\DefA-la DT|14 Aug 03 ID|FBgn0024504 CLA|foreign_gene SYN|AaDef Ala FSQ|species == Aedes aegypti; gene == 'DefA-la, Defensin-A-large'. REF { REFM|FBrf0099991 |Cho and Chiou |1998 |1 } REFDSR { RDID|FBrf0099991 |Cho and Chiou |1998 OTH|The upstream region of @Aaeg\DefA-la@ drives nuclear expression of |@Ecol\lacZ@ in Malpighian tubules and guts of D.melanogaster after bacterial |challenge. SYN|AaDef Ala } } # EOR GENR { RETE|ID 1 FBgn0042096 CLA 1 foreign gene NAM 1 Ecdysone receptor GSYM 1 Aaeg\ECR DT 1 14 Aug 03 RESZ 790 FSQ 1 Aedes aegypti 'ECR_AEDAE' SWP:P49880 ALESR 1 REF 1 GSYM|Aaeg\ECR DT|14 Aug 03 ID|FBgn0042096 CLA|foreign_gene NAM|Ecdysone receptor FSQ|species == Aedes aegypti; gene == 'ECR_AEDAE'; SWP:P49880. REF { REFM|FBrf0127381 |Wang et al. |2000 |0 } ALESR { ASYM|Aaeg\ECRAct5C.PW ID|FBal0117933 PHI|Mode of assay: Drosophila cell culture REF|FBrf0127381 REFDSR { RDID|FBrf0127381 |Wang et al. |2000 NAM|Actin 5C promoter construct of Wang MD|The entire @Aaeg\ECR@ cDNA is expressed under the control of the @Act5C@ |promoter. OTH|Carried in a plasmid pAc5-AaEcR and transfected into S2 cells. MU|in vitro construct | regulatory fusion PHI|Mode of assay: Drosophila cell culture } } } # EOR GENR { RETE|ID 1 FBgn0024151 CLA 1 foreign gene GSYM 1 Aaeg\KH DT 1 14 Aug 03 RESZ 1085 FSQ 1 Aedes aegypti 'KH, kynurenine hydroxylase'. REF 2 GSYM|Aaeg\KH DT|14 Aug 03 ID|FBgn0024151 CLA|foreign_gene SYN|kh FSQ|species == Aedes aegypti; gene == 'KH, kynurenine hydroxylase'. REF { REFM|FBrf0100770 |Cornel et al. |1997 |0 REFM|FBrf0102507 |Jasinskiene et al. |1998 |0 } REFDSR { RDID|FBrf0100770 |Cornel et al. |1997 AM|Partially functionally complemented by: cn |The white eye color of the WE strain is caused by a mutation in its |kynurenine hydroxylase gene, the wild type @cn@ gene is capable of |complementing this mutation. The @cn@ promoter is recognized and the two |introns are apparently correctly spliced. } REFDSR { RDID|FBrf0102507 |Jasinskiene et al. |1998 AM|Partially functionally complemented by: cn |The white eye color of the A.aegypti khw mutant (caused by a |mutation in @Aaeg\KH@) is partially complemented by D.melanogaster @cn@. |The @cn@ gene acts in a semi-dominant manner. SYN|kh } } # EOR GENR { RETE|ID 1 FBgn0026152 CLA 1 foreign gene GSYM 1 Aaeg\Mal1 DT 1 14 Aug 03 RESZ 229 FSQ 1 Aedes aegypti 'Mal1, Maltase-like 1'. REF 1 GSYM|Aaeg\Mal1 DT|14 Aug 03 ID|FBgn0026152 CLA|foreign_gene FSQ|species == Aedes aegypti; gene == 'Mal1, Maltase-like 1'. REF { REFM|FBrf0106352 |Coates et al. |1999 |0 } } # EOR GENR { RETE|ID 1 FBgn0042095 CLA 1 foreign gene NAM 1 ultraspiracle GSYM 1 Aaeg\usp DT 1 14 Aug 03 RESZ 825 FSQ 1 Aedes aegypti 'usp'. ALESR 1 REF 2 GSYM|Aaeg\usp DT|14 Aug 03 ID|FBgn0042095 CLA|foreign_gene NAM|ultraspiracle FSQ|species == Aedes aegypti; gene == 'usp'. REF { REFM|FBrf0127381 |Wang et al. |2000 |0 REFM|-357473823 |Kapitskaya et al. |1996 |0 |Mol. Cell. Endocrinol. 121: 119--132 } ALESR { ASYM|Aaeg\uspAct5C.PW ID|FBal0117932 PHI|Mode of assay: Drosophila cell culture REF|FBrf0127381 REFDSR { RDID|FBrf0127381 |Wang et al. |2000 NAM|Actin 5C promoter construct of Wang MD|The @Aaeg\usp@ cDNA is expressed under the control of the @Act5C@ promoter. OTH|Carried in a plasmid pAc5-AaUSP-B and transfected into S2 cells. MU|in vitro construct | regulatory fusion PHI|Mode of assay: Drosophila cell culture } } } # EOR GENR { RETE|ID 1 FBgn0013379 CLA 1 Gene NAM 1 armadillo-associated glycoprotein GSYM 1 aagp DT 1 14 Aug 03 RESZ 680 WT 1 The @aagp@ protein forms part of a membrane-associated complex that includes the @arm@ and @&agr;-Cat@ proteins ALESR 1 REF 2 GSYM|aagp DT|14 Aug 03 ID|FBgn0013379 NAM|armadillo-associated glycoprotein WT|The @aagp@ protein forms part of a membrane-associated complex that includes the @arm@ and @&agr;-Cat@ proteins. REF { REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0058828 |Peifer |1993 |0 } REFDSR { RDID|FBrf0058828 |Peifer |1993 NAM|armadillo-associated glycoprotein WT|The @aagp@ product forms part of a membrane-associated complex that includes |the @arm@ and @&agr;-Cat@ gene products. } ALESR { ASYM|aagp+ ID|FBal0068532 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0027094 CLA 1 Gene NAM 1 Alanyl-tRNA synthetase GSYM 1 Aats-ala DT 1 14 Aug 03 RESZ 3782 PDOM 3 INTERPRO:IPR002318 == Alanyl-tRNA synthetase PTD 1 DBA 18 HG 4 Bombyx mori 'ALANYL-TRNA SYNTHETASE (ALANINE--TRNA LIGASE) (ALARS)' SWP:P21894 FNC 1 alanyl-tRNA aminoacylation CLOC 1 29B3 ALESR 2 REF 9 GSYM|Aats-ala PTD DT|14 Aug 03 ID|FBgn0027094 UAB|Deficiency: Df(2L)TE29Aa-36 (inferred from cytology) |Duplication: Dp(2;3)dph27 (inferred from cytology) SYN|CG13391 |ARS |AlaRS |alaS |Alanyl-tRNA synthetase KLOC|38056 CLOC|29B3 |Limits computationally determined from genome sequence between EP(2)0646/l(2)k09614 and l(2)k12914/l(2)k07118 FNC|alanyl-tRNA aminoacylation ; GO:0006419 | inferred from sequence similarity with SGD_LOCUS:ALA1; SGD:S0005862 PDOM|IPR002318 == Alanyl-tRNA synthetase |IPR003156 == DHHA1 domain |SCOP:55186 == Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Aats-ala|FBgn0027094|pp-CT32737|FBan0013391 NAM|Alanyl-tRNA synthetase ENZ|alanine-tRNA ligase activity ; GO:0004813 ; EC:6.1.1.7 | inferred from sequence similarity with SGD_LOCUS:ALA1; SGD:S0005862 |alanine-tRNA ligase activity ; GO:0004813 ; EC:6.1.1.7 | non-traceable author statement DBA|NA:AA263914 |BDGP:LD07142 |NA:AE003621 |PA:AAF52657 |NA:AF188718 |PA:AAF05593 |NA:AI239138 |BDGP-DGC:GM03058 |NA:AI530798 |BDGP-DGC:SD01519 |NA:AW944184 |BDGP-DGC:SD01519 |NA:AY069255 |PA:AAL39400 |BDGP-DGC:GM03058 |NA:AY069773 |PA:AAL39918 |BDGP-DGC:SD01519 PAC|SPTREMBL:Q8T9G8 |SPTREMBL:Q8T9K4 |SPTREMBL:Q9U6B4 |SPTREMBL:Q9VLM8 HG|species == Bombyx mori; gene == 'ALANYL-TRNA SYNTHETASE (ALANINE--TRNA LIGASE) (ALARS)'; SWP:P21894; gi:135089; score == 1307; expect == 0 |species == Caenorhabditis elegans; gene == 'Similar to aminoacyl-tRNA synthetase; coded for by C. elegans cDNA yk126g5.3; co'; EMBL:U97013; gi:1938531; score == 1101; expect == 0 |species == Homo sapiens; gene == 'alanyl-tRNA synthetase'; gi:4501841; score == 1157; expect == 0 |species == Saccharomyces cerevisiae; gene == ALA1; SGDID:L0002757; score == 910; expect == 0 ASQ|FBan0013391 REF { REFM|FBrf0138382 |Lovato et al. |2001 |0 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0132177 |Gene Disruption Project members |2001- |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0126678 |Kodira |1999.11 |9 REFM|FBrf0113830 |Chihade |1999.9.22 |9 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|alanine-tRNA ligase activity ; GO:0004813 ; EC:6.1.1.7 | inferred from sequence similarity with SGD_LOCUS:ALA1; SGD:S0005862 FNC|alanyl-tRNA aminoacylation ; GO:0006419 | inferred from sequence similarity with SGD_LOCUS:ALA1; SGD:S0005862 GPD|alanyl-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Alanyl-tRNA synthetase SYN|ARS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: LD07142 SYN|AlaRS } REFDSR { RDID|FBrf0113830 |Chihade |1999.9.22 ENZ|alanine-tRNA ligase activity ; GO:0004813 ; EC:6.1.1.7 | non-traceable author statement SYN|alaS } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GM03058 (BDGP-DGC) |Identified with: SD01519 (BDGP-DGC) } REFDSR { RDID|FBrf0138382 |Lovato et al. |2001 SYN|AlaRS } ALESR { ASYM|Aats-alaEY01137b ID|FBal0148506 REF|FBrf0132177 REFDSR { RDID|FBrf0132177 |Gene Disruption Project members |2001- TRN|FBti0024896 == P{EPgy2}Aats-alaEY01137b |BDGP:EY01137 } } ALESR { ASYM|Aats-ala+ ID|FBal0097822 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0028962 CLA 1 Gene NAM 1 mitochondrial alanyl-tRNA synthetase GSYM 1 Aats-ala-m DT 1 14 Aug 03 RESZ 3294 PDOM 2 INTERPRO:IPR002318 == Alanyl-tRNA synthetase DBA 16 HG 4 Bombyx mori 'ALANYL-TRNA SYNTHETASE (ALANINE--TRNA LIGASE) (ALARS)' SWP:P21894 FNC 1 alanyl-tRNA aminoacylation CEL 1 mitochondrion CLOC 1 64C9 ALESR 1 REF 7 GSYM|Aats-ala-m DT|14 Aug 03 ID|FBgn0028962 UAB|Deficiency: Df(3L)GN24 (inferred from cytology) |Duplication: Dp(3;3)M34 (inferred from cytology) SYN|CG4633 |AlaS |Dm mt AlaRS NAM|mitochondrial alanyl-tRNA synthetase KLOC|82829 CLOC|64C9 |Limits computationally determined from genome sequence between l(3)rG166 and l(3)01418 FNC|alanyl-tRNA aminoacylation ; GO:0006419 | inferred from sequence similarity with SGD_LOCUS:ALA1; SGD:S0005862 CEL|mitochondrion ; GO:0005739 | inferred from sequence similarity with SGD_LOCUS:ALA1; SGD:S0005862 PDOM|IPR002318 == Alanyl-tRNA synthetase |SCOP:55186 == Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Aats-ala-m|FBgn0028962|pp-CT14952|FBan0004633 ENZ|alanine-tRNA ligase activity ; GO:0004813 ; EC:6.1.1.7 | inferred from sequence similarity with SGD_LOCUS:ALA1; SGD:S0005862 |alanine-tRNA ligase activity ; GO:0004813 ; EC:6.1.1.7 | non-traceable author statement DBA|NA:AA392398 |BDGP-DGC:LD11251 |NA:AE003567 |PA:AAF50804 |NA:AF188716 |PA:AAF05591 |NA:AW942182 |BDGP-DGC:LD11251 |NA:AY128439 |PA:AAM75032 |BDGP-DGC:LD11251 |NA:BI579932 |BDGP-DGC:RE74040 |NA:BT001744 |PA:AAN71499 |BDGP-DGC:RE74040 PAC|SPTREMBL:Q9U6B6 |SPTREMBL:Q9VRJ1 HG|species == Bombyx mori; gene == 'ALANYL-TRNA SYNTHETASE (ALANINE--TRNA LIGASE) (ALARS)'; SWP:P21894; gi:135089; score == 477; expect == 1.e-133 |species == Caenorhabditis elegans; gene == 'Similar to aminoacyl-tRNA synthetase; coded for by C. elegans cDNA yk126g5.3; co'; EMBL:U97013; gi:1938531; score == 451; expect == 1.e-126 |species == Homo sapiens; gene == 'alanyl-tRNA synthetase'; gi:4501841; score == 485; expect == 1.e-136 |species == Saccharomyces cerevisiae; gene == ALA1; SGDID:L0002757; score == 434; expect == 1.e-120 ASQ|FBan0004633 REF { REFM|FBrf0126665 |Gabrielian |1999.11 |9 REFM|FBrf0126664 |Find Enzymes |1999.11 |9 REFM|FBrf0113831 |Chihade |1999.9.22 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0138382 |Lovato et al. |2001 |0 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|alanine-tRNA ligase activity ; GO:0004813 ; EC:6.1.1.7 | inferred from sequence similarity with SGD_LOCUS:ALA1; SGD:S0005862 FNC|alanyl-tRNA aminoacylation ; GO:0006419 | inferred from sequence similarity with SGD_LOCUS:ALA1; SGD:S0005862 CEL|mitochondrion ; GO:0005739 | inferred from sequence similarity with SGD_LOCUS:ALA1; SGD:S0005862 GPD|mitochondrial alanyl-tRNA ligase } REFDSR { RDID|FBrf0113831 |Chihade |1999.9.22 ENZ|alanine-tRNA ligase activity ; GO:0004813 ; EC:6.1.1.7 | non-traceable author statement SYN|AlaS } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD11251 (BDGP-DGC) |Identified with: RE74040 (BDGP-DGC) } REFDSR { RDID|FBrf0126665 |Gabrielian |1999.11 AM|Source for identity of: Aats-ala-m CG4633 } REFDSR { RDID|FBrf0138382 |Lovato et al. |2001 MD|Identified with: LD11251 SYN|Dm mt AlaRS } ALESR { ASYM|Aats-ala-m+ ID|FBal0102309 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027093 CLA 1 Gene NAM 1 Arginyl-tRNA synthetase GSYM 1 Aats-arg DT 1 14 Aug 03 RESZ 3493 PDOM 5 INTERPRO:IPR001278 == Arginyl-tRNA synthetase PTD 1 DBA 9 HG 4 CRILO 'ARGINYL-TRNA SYNTHETASE (ARGININE--TRNA LIGASE) (ARGRS)' SWP:P37880 FNC 1 arginyl-tRNA aminoacylation CEL 1 cytoplasm CLOC 1 13F10 ALESR 1 REF 7 GSYM|Aats-arg PTD DT|14 Aug 03 ID|FBgn0027093 UAB|Deficiency: Df(1)sd72b (inferred from cytology) |Duplication: Dp(1;1)M48.6 (inferred from cytology) SYN|CG9020 |RRS |ArgRS |Arginyl-tRNA synthetase ID2|FBgn0030698 KLOC|18848 CLOC|13F10 |Limits computationally determined from genome sequence between EP(X)1581/EP(X)1088 and EP(X)1071 FNC|arginyl-tRNA aminoacylation ; GO:0006420 | non-traceable author statement CEL|cytoplasm ; GO:0005737 | non-traceable author statement PDOM|IPR001278 == Arginyl-tRNA synthetase |IPR001412 == Aminoacyl-transfer RNA synthetases class-I |SCOP:47323 == Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; CG9020|FBgn0030698|pp-CT25916|FBan0009020 |SCOP:52374 == Nucleotidylyl transferase; CG9020|FBgn0030698|pp-CT25916|FBan0009020 |SCOP:55190 == Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain; CG9020|FBgn0030698|pp-CT25916|FBan0009020 NAM|Arginyl-tRNA synthetase ENZ|arginine-tRNA ligase activity ; GO:0004814 ; EC:6.1.1.19 | inferred from sequence similarity with NCBI_gi:4506429 |arginine-tRNA ligase activity ; GO:0004814 ; EC:6.1.1.19 | non-traceable author statement DBA|NA:AA696998 |BDGP:GM08880 |NA:AE003500 |PA:AAF48524 |NA:AY070924 |PA:AAL48546 |BDGP-DGC:RE02962 |NA:BI163540 |BDGP-DGC:RE02962 PAC|SWP:Q9VXN4 HG|species == CRILO; gene == 'ARGINYL-TRNA SYNTHETASE (ARGININE--TRNA LIGASE) (ARGRS)'; SWP:P37880; gi:586063; score == 658; expect == 0 |species == Caenorhabditis elegans; gene == F26F4.10; WP:CE01258; score == 566; expect == 1.e-160 |species == Homo sapiens; gene == 'arginyl-tRNA synthetase; ArgRS'; gi:4506429; score == 628; expect == 1.e-179 |species == Saccharomyces cerevisiae; gene == 'PROBABLE ARGINYL-TRNA SYNTHETASE, CYTOPLASMIC (ARGININE--TRNA LIGASE'; SWP:Q05506; gi:2501051; score == 171; expect == 1.e-41 ASQ|FBan0009020 REF { REFM|FBrf0104946 |FlyBase |1996- |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0126664 |Find Enzymes |1999.11 |9 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0151119 |SWISS-PROT Project Members |2002.3.1 |9 } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AM|Source for merge of: Aats-arg CG9020 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|arginine-tRNA ligase activity ; GO:0004814 ; EC:6.1.1.19 | inferred from sequence similarity with NCBI_gi:4506429 |arginine-tRNA ligase activity ; GO:0004814 ; EC:6.1.1.19 | non-traceable author statement FNC|arginyl-tRNA aminoacylation ; GO:0006420 | non-traceable author statement GPD|arginyl-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Arginyl-tRNA synthetase SYN|RRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: GM08880 SYN|ArgRS } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: RE02962 (BDGP-DGC) } REFDSR { RDID|FBrf0151119 |SWISS-PROT Project Members |2002.3.1 ENZ|arginine-tRNA ligase activity ; GO:0004814 ; EC:6.1.1.19 | non-traceable author statement CEL|cytoplasm ; GO:0005737 | non-traceable author statement } ALESR { ASYM|Aats-arg+ ID|FBal0097821 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027092 CLA 1 Gene NAM 1 Asparaginyl-tRNA synthetase GSYM 1 Aats-asn DT 1 14 Aug 03 RESZ 3331 PDOM 4 INTERPRO:IPR002309 == tRNA synthetases, class II (D, K and N) PTD 1 DBA 10 HG 4 BRUMA 'ASPARAGINYL-TRNA SYNTHETASE, CYTOPLASMIC (ASPARAGINE--TRNA LIGASE) (AS' SWP:P10723 FNC 1 asparaginyl-tRNA aminoacylation CLOC 1 37C1 ALESR 1 REF 8 GSYM|Aats-asn PTD DT|14 Aug 03 ID|FBgn0027092 UAB|Deficiency: Df(2L)hk-UC2 (inferred from cytology) |Duplication: Dp(2;1)C239 (inferred from cytology) SYN|CG10687 |NRS |AsnRS |BcDNA:GH06451 |Asparaginyl-tRNA synthetase ID2|FBgn0028492 KLOC|46694 CLOC|37C1 |Limits computationally determined from genome sequence between l(2)k02104 and l(2)k06028/l(2)k09613 FNC|asparaginyl-tRNA aminoacylation ; GO:0006421 | non-traceable author statement PDOM|IPR002309 == tRNA synthetases, class II (D, K and N) |IPR002312 == Aspartyl-tRNA synthetase |SCOP:50249 == Nucleic acid-binding proteins; BcDNA:GH06451|FBgn0028492|pp-CT29946|FBan0010687 |SCOP:55681 == Class II aaRS and biotin synthetases; BcDNA:GH06451|FBgn0028492|pp-CT29946|FBan0010687 NAM|Asparaginyl-tRNA synthetase ENZ|asparagine-tRNA ligase activity ; GO:0004816 ; EC:6.1.1.22 | inferred from sequence similarity with EMBL:D84273; protein_id:AJ000334.1 |asparagine-tRNA ligase activity ; GO:0004816 ; EC:6.1.1.22 | non-traceable author statement DBA|NA:AA695878 |BDGP:GM04706 |NA:AE003661 |PA:AAF53768 |NA:AF181634 |PA:AAD55420 |NA:AI107139 |BDGP-DGC:GH06451 |NA:AI402048 |BDGP-DGC:GH06451 PAC|SPTREMBL:Q9V434 HG|species == BRUMA; gene == 'ASPARAGINYL-TRNA SYNTHETASE, CYTOPLASMIC (ASPARAGINE--TRNA LIGASE) (AS'; SWP:P10723; gi:112832; score == 603; expect == 1.e-171 |species == Caenorhabditis elegans; gene == F22D6.3; WP:CE05684; score == 644; expect == 0 |species == Homo sapiens; gene == 'asparaginyl-tRNA synthetase'; gi:4758762; score == 816; expect == 0 |species == Saccharomyces cerevisiae; gene == DED81; SGDID:L0002734; score == 570; expect == 1.e-161 ASQ|FBan0010687 REF { REFM|FBrf0104946 |FlyBase |1996- |9 REFM|FBrf0131436 |Zou et al. |2000 |0 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0126651 |Ashburner |1999.11 |9 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AM|Source for merge of: Aats-asn CG10687 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|asparagine-tRNA ligase activity ; GO:0004816 ; EC:6.1.1.22 | inferred from sequence similarity with EMBL:D84273; protein_id:AJ000334.1 |asparagine-tRNA ligase activity ; GO:0004816 ; EC:6.1.1.22 | non-traceable author statement FNC|asparaginyl-tRNA aminoacylation ; GO:0006421 | non-traceable author statement GPD|asparaginyl-tRNA ligase |asparagine-tRNA ligase-like } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Asparaginyl-tRNA synthetase SYN|NRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: GM04706 SYN|AsnRS } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH06451 (BDGP-DGC) } REFDSR { RDID|FBrf0131436 |Zou et al. |2000 MD|Identified with: GH06451 } ALESR { ASYM|Aats-asn+ ID|FBal0097820 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0002069 CLA 1 Gene NAM 1 Aspartyl-tRNA synthetase GSYM 1 Aats-asp DT 1 14 Aug 03 RESZ 20908 PDOM 5 INTERPRO:IPR002106 == Aminoacyl-transfer RNA synthetases class-II PTD 1 DBA 20 HG 4 Caenorhabditis elegans B0464.1 WP:CE00015 FNC 1 aspartyl-tRNA aminoacylation CLOC 1 49D7 ALESR 17 SK 3 REF 21 GSYM|Aats-asp PTD ARGS DT|14 Aug 03 ID|FBgn0002069 UAB|Deficiency: Df(2R)vg-D |Duplication: Dp(2;2)Y3b (inferred from cytology) SYN|CG3821 |l(2)vr1 |vr1 |cDNA1 |DRS |poney |AspRS |l(2)k04508 |l(2)49Db: lethal(2)49Db |aats-asp |l(2)v27 |l(2)49Db |lethal(2)49Db ID2|FBgn0022204 NAM|Aspartyl-tRNA synthetase KLOC|61701 CLOC|49D7 |Limits computationally determined from genome sequence between l(2)k10712 and l(2)01424 CYC|Experimentally determined: 49E1--2 FNC|aspartyl-tRNA aminoacylation ; GO:0006422 | inferred from sequence similarity with SGD_LOCUS:DPS1; SGD:S0003941 PDOM|IPR002106 == Aminoacyl-transfer RNA synthetases class-II |IPR002309 == tRNA synthetases, class II (D, K and N) |IPR002312 == Aspartyl-tRNA synthetase |SCOP:50249 == Nucleic acid-binding proteins; Aats-asp|FBgn0002069|pp-CT12785|FBan0003821 |SCOP:55681 == Class II aaRS and biotin synthetases; Aats-asp|FBgn0002069|pp-CT12785|FBan0003821 ENZ|aspartate-tRNA ligase activity ; GO:0004815 ; EC:6.1.1.12 | inferred from sequence similarity with SGD_LOCUS:DPS1; SGD:S0003941 DBA|NA:AA803810 |BDGP-DGC:GM14334 |NA:AA820943 |BDGP:LD24891 |NA:AC091499 |BDGP:BACR33L22 |NA:AE003820 |PA:AAF58445 |NA:AF113612 |PA:AAD21582 |NA:AI519001 |BDGP-DGC:GM14334 |NA:AQ254787 |BDGP:l(2)k05408 |NA:AX093985 |NA:AY070532 |PA:AAL48003 |BDGP-DGC:GM14334 |NA:BH614995 |BDGP:KG03912 PAC|SPTREMBL:Q9V6H8 |SPTREMBL:Q9XYM1 HG|species == Caenorhabditis elegans; gene == B0464.1; WP:CE00015; score == 627; expect == 1.e-179 |species == Homo sapiens; gene == 'aspartyl-tRNA synthetase'; gi:4557513; score == 672; expect == 0 |species == Rattus; gene == 'ASPARTYL-TRNA SYNTHETASE (ASPARTATE--TRNA LIGASE) (ASPRS)'; SWP:P15178; gi:135099; score == 672; expect == 0 |species == Saccharomyces cerevisiae; gene == DPS1; SGDID:L0002834; score == 511; expect == 1.e-144 ASQ|FBan0003821 REV|FBrf0123106 REF { REFM|-1505380982 |0 |Patent: WO 0118547-A 15-MAR-2001; REFM|FBrf0121071 |Stitzinger |1998.12.14 |9 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0123122 |Markesich et al. |2000 |0 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0132177 |Gene Disruption Project members |2001- |9 REFM|FBrf0082794 |Wu and Howe |1995 |0 REFM|FBrf0125032 |Beaton |1999.12.12 |9 REFM|FBrf0107310 |Stitzinger et al. |1999 |0 REFM|FBrf0123106 |Lehner |1999 |2 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0068169 |Albrecht and Salz |1994 |1 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0108515 |Galloni and Edgar |1999 |0 REFM|FBrf0138402 |Lee et al. |2001 |0 REFM|FBrf0048224 |Lasko and Pardue |1988 |0 REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0151899 |Jasper et al. |2002 |0 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 } REFDSR { RDID|FBrf0048224 |Lasko and Pardue |1988 BMD|Df(2R)R7 BMD|Df(2R)vg-B BMD|Df(2R)vg-C BMD|Df(2R)vg-D BMD|Df(2R)vg-P2 BMD|Df(2R)vg104 BMD|Df(2R)vg106 BMD|Df(2R)vg107 BMD|Df(2R)vg120 BMD|Df(2R)vg124 BMD|Df(2R)vg133 BMD|Df(2R)vg135 BMD|Df(2R)vg33 BMD|Df(2R)vg62 BMD|Df(2R)vg79b3 BMD|Df(2R)vg79d8 BMD|Df(2R)vg81 BMD|Df(2R)vg83f15 BMD|In(2LR)vg79a BMDD|Df(2R)vg136 BMDD|Df(2R)vg56 SYN|l(2)vr1 } REFDSR { RDID|995280948 |Davies |2001.3.30 OTH|Area matching Drosophila gene for Aspartate ligase, Acc. No. AF113612. } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|49E1--2 (determined by in situ hybridization) BMD|Df(2R)CX1 BMD|Df(2R)vg-B BMD|Df(2R)vg135 } REFDSR { RDID|FBrf0068169 |Albrecht and Salz |1994 PHP|@Aats-asp@ is involved in sex determination and a mutant has been isolated |that rescues the male lethality of @snf1@ @SxlM1@ individuals. } REFDSR { RDID|FBrf0082794 |Wu and Howe |1995 BMD|Df(2R)Su(z)3-1.iy BMD|Df(2R)vg-B BMD|Df(2R)vg-C BMD|Df(2R)vg-D BMD|Df(2R)vg62 BMDD|Df(2R)Su(z)2-1.a6 BMDD|Df(2R)Su(z)2-1.b8 BMDD|Df(2R)Su(z)3-1.jtg SYN|vr1 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|aspartate-tRNA ligase activity ; GO:0004815 ; EC:6.1.1.12 | inferred from sequence similarity with SGD_LOCUS:DPS1; SGD:S0003941 FNC|aspartyl-tRNA aminoacylation ; GO:0006422 | inferred from sequence similarity with SGD_LOCUS:DPS1; SGD:S0003941 MD|Maps to clone: BACR33L22 GPD|aspartyl-tRNA ligase } REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 MD|Gene order: In direction of increasing cytology: anon-49Da- Nmda1- Aats-asp+ vg+ BMD|Df(2R)Su(z)3-1.iy WTI|Sxl (data from @Aats-asp12-21R@, @Aats-asp1@, @Aats-asp25-1R@, @Aats-aspTW3@, @Aats-aspTW6@) |snf (data from @Aats-asp12-21R@, @Aats-asp1@, @Aats-asp25-1R@, @Aats-aspTW3@, @Aats-aspTW6@) SYN|cDNA1 } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 SYN|DRS } REFDSR { RDID|FBrf0108515 |Galloni and Edgar |1999 MD|Gene order: Overall orientation not stated: Nmda1- Aats-asp+ AM|Source for merge of: Aats-asp l(2)k04508 OTH|Identification: One of a collection of genes identified with defective |larval growth that extend larval life. WTI|Dp (data from @Aats-aspunspecified@) |E2f (data from @Aats-aspunspecified@) SYN|poney } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: LD24891 SYN|AspRS } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 CLOC|49E1--2 (determined by in situ hybridization) SYN|l(2)k04508 } REFDSR { RDID|FBrf0121071 |Stitzinger |1998.12.14 SYN|l(2)49Db } REFDSR { RDID|FBrf0123106 |Lehner |1999 SYN|poney } REFDSR { RDID|FBrf0123122 |Markesich et al. |2000 SYN|l(2)49Db } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GM14334 (BDGP-DGC) } REFDSR { RDID|FBrf0138402 |Lee et al. |2001 SYN|poney } REFDSR { RDID|FBrf0151899 |Jasper et al. |2002 SYN|aats-asp } ALESR { ASYM|Aats-asp1 SYN|vr120 |l(2)20 |l(2)49Db1 ID|FBal0009040 DIS|Lasko. MU|ethyl methanesulfonate PHC|lethal | recessive REF|FBrf0048224 |FBrf0107310 |FBrf0082794 REFDSR { RDID|FBrf0048224 |Lasko and Pardue |1988 MU|ethyl methanesulfonate PHC|lethal | recessive } REFDSR { RDID|FBrf0082794 |Wu and Howe |1995 SYN|vr120 } REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 GIC|enhancer of @SxlfP7B0@, @snfJ210@ GIC2|viable | reduced | female with @snfJ210@, @SxlfP7B0@ GII|The weak interaction between @SxlfP7B0@ and @snfJ210@ is enhanced |by @Aats-asp1@; the viability of female @SxlfP7B0@/+ embryos derived |from mothers heterozygous for @snfJ210@ and @Aats-asp1@ is reduced. SYN|vr120 } SK|FBstBL-5552 |al[1] b[1] Aats-asp[1] c[1] sp[1]/SM5 } ALESR { ASYM|Aats-asp2 SYN|l(2)27 |l(2)49Db2 ID|FBal0009041 DIS|Lasko. MU|ethyl methanesulfonate PHC|lethal | recessive REF|FBrf0048224 REFDSR { RDID|FBrf0048224 |Lasko and Pardue |1988 MU|ethyl methanesulfonate PHC|lethal | recessive } } ALESR { ASYM|Aats-asp12-21R SYN|l(2)49Db12-21 |l(2)49Db12-21R ID|FBal0095908 REF|FBrf0123122 |FBrf0107310 REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 MU|ethyl methanesulfonate GIC|enhancer of @SxlfP7B0@, @snfJ210@ GII|The weak interaction between @SxlfP7B0@ and @snfJ210@ is enhanced |by @Aats-asp12-21R@; the viability of female @SxlfP7B0@/+ embryos |derived from mothers heterozygous for @snfJ210@ and @Aats-asp12-21R@ |is reduced. GIC2|viable | reduced | female with @snfJ210@, @SxlfP7B0@ } REFDSR { RDID|FBrf0123122 |Markesich et al. |2000 OTH|Not rescued by: @P{cosG1.8}@. SYN|l(2)49Db12-21 } } ALESR { ASYM|Aats-asp14-25R SYN|l(2)49Db14-25 |l(2)49Db14-25R ID|FBal0095907 REF|FBrf0123122 |FBrf0107310 REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 MU|ethyl methanesulfonate } REFDSR { RDID|FBrf0123122 |Markesich et al. |2000 OTH|Not rescued by: @P{cosG1.8}@. SYN|l(2)49Db14-25 } } ALESR { ASYM|Aats-asp25-1R SYN|l(2)49Db25-1R ID|FBal0095906 REF|FBrf0107310 REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 MU|ethyl methanesulfonate GIC|enhancer of @SxlfP7B0@, @snfJ210@ GII|The weak interaction between @SxlfP7B0@ and @snfJ210@ is enhanced |by @Aats-asp25-1R@; the viability of female @SxlfP7B0@/+ embryos |derived from mothers heterozygous for @snfJ210@ and @Aats-asp25-1R@ |is reduced. GIC2|viable | reduced | female with @snfJ210@, @SxlfP7B0@ } } ALESR { ASYM|Aats-asp27-8R SYN|l(2)49Db27-8R ID|FBal0095905 REF|FBrf0107310 REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 MU|ethyl methanesulfonate } } ALESR { ASYM|Aats-aspk04508 SYN|l(2)k04508 |l(2)k04508k04508 ID|FBal0064537 REF|FBrf0067338 |FBrf0125032 |FBrf0138402 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 AFC|Aats-aspk05408 |Aats-aspk16309 DIS|I. Kiss. OTH|Complements: @l(2)0142401424@. |Complements: @l(2)k05722k05722@. |Complements: @bick10712@. TRN|FBti0006842 == P{lacW}Aats-aspk04508 |BDGP:l(2)k04508 MU|P-element activity PHC|lethal | recessive } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0006842 == P{lacW}Aats-aspk04508 |BDGP:l(2)k04508 PHC|lethal | recessive SYN|l(2)k04508 } REFDSR { RDID|FBrf0138402 |Lee et al. |2001 GIC|non-enhancer of mitotic | maternal effect phenotype of @png2@/@png5@ |non-suppressor of mitotic | maternal effect phenotype of @png2@/@png5@ SYN|l(2)k04508 } SK|FBstBL-10543 |y[1] w[67c23]; P{w[+mC]=lacW}Aats-asp[k04508]/CyO } ALESR { ASYM|Aats-aspk05408 SYN|l(2)k05408 |l(2)k04508k05408 ID|FBal0064536 REF|FBrf0067338 |FBrf0125032 |FBrf0108515 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 AFC|Aats-aspk04508 |Aats-aspk05411 DIS|I. Kiss. OTH|Complements: @l(2)0142401424@. TRN|FBti0006841 == P{lacW}Aats-aspk05408 |BDGP:l(2)k05408 MU|P-element activity } REFDSR { RDID|FBrf0108515 |Galloni and Edgar |1999 OTH|Excision of the @P-element@ is accompanied by reversion of the mutant |phenotype. TRN|FBti0006841 == P{lacW}Aats-aspk05408 |BDGP:l(2)k05408 PHC|mitotic | recessive | cell autonomous |reduced cell size | somatic clone | cell autonomous |lethal | larval | recessive |mitotic | recessive PHM|dorsal mesothoracic disc | somatic clone | cell autonomous PHI|Larval growth arrest, L2 and L3 are the same size. 60% survive until |4 days after hatching. 25% survive until 11 days after hatching. |DNA replication continues at a reduced level compared to wild type. |Mutant phenotype is cell autonomous. Mutant clones in the wing disc |show a severe size reduction. Mosaic adults look normal. Mutant clones |in the eye survive well. SYN|l(2)k05408 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0006841 == P{lacW}Aats-aspk05408 |BDGP:l(2)k05408 PHC|lethal | recessive SYN|l(2)k05408 } } ALESR { ASYM|Aats-aspk05411 SYN|l(2)k05411 |l(2)k04508k05411 ID|FBal0064535 OTH|This allele was listed in the BDGP database as a lethal or sterile line |during the period 1994-1999, but was discarded from the gene disruption |project prior to the summary publication (FBrf0111489). Reasons for |excluding lines from the collection described in FBrf0111489 include |presence of more than one P insertion on the mutant chromosome, |separation of lethality (or sterility) from the location of the |insertion, and loss of lethality (or sterility) from the stock. |Further information is available from http://www.fruitfly.org/bfd/ and |from Dr. Spradling (spradling@mail1.ciwemb.edu). PHC|lethal | larval | recessive |mitotic | recessive PHI|Larval growth arrest, L2 and L3 are the same size. 60% survive until |4 days after hatching. 25% survive until 11 days after hatching. |DNA replication continues at a reduced level compared to wild type. |Mutant phenotype is cell autonomous. REF|FBrf0067338 |FBrf0108515 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 AFC|Aats-aspk05408 |Aats-aspk16309 DIS|I. Kiss. OTH|Complements: @l(2)0142401424@. TRN|FBti0006840 == P{lacW}Aats-aspk05411 |BDGP:l(2)k05411 MU|P-element activity } REFDSR { RDID|FBrf0108515 |Galloni and Edgar |1999 MD|Insertion 5' to the @Aats-asp@ transcription unit, between @Aats-asp@ |and @Nmda1@. OTH|Excision of the @P-element@ is accompanied by reversion of the mutant |phenotype. TRN|FBti0006840 == P{lacW}Aats-aspk05411 |BDGP:l(2)k05411 PHC|lethal | larval | recessive |mitotic | recessive PHI|Larval growth arrest, L2 and L3 are the same size. 60% survive until |4 days after hatching. 25% survive until 11 days after hatching. |DNA replication continues at a reduced level compared to wild type. |Mutant phenotype is cell autonomous. SYN|l(2)k05411 } } ALESR { ASYM|Aats-aspk16309 SYN|l(2)k04508k16309 ID|FBal0064534 PHC|lethal | recessive REF|FBrf0067338 |FBrf0125032 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 AFC|Aats-aspk04508 |Aats-aspk05411 DIS|I. Kiss. OTH|Complements: @l(2)0142401424@. TRN|FBti0006839 == P{lacW}Aats-aspk16309 |BDGP:l(2)k16309 MU|P-element activity PHC|lethal | recessive } } ALESR { ASYM|Aats-aspKG03912 ID|FBal0131818 REF|FBrf0132177 REFDSR { RDID|FBrf0132177 |Gene Disruption Project members |2001- TRN|FBti0021290 == P{SUPor-P}Aats-aspKG03912 |BDGP:KG03912 } SK|FBstBL-13265 |y[1]; P{y[+mDint2] w[BR.E.BR]=SUPor-P}Aats-asp[KG03912]/CyO; ry[506] } ALESR { ASYM|Aats-aspTW3 SYN|934.3bs |l(2)49DbTW3 ID|FBal0095904 REF|FBrf0107310 REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 DIS|T. Wu MU|ethyl methanesulfonate GIC|enhancer of @SxlfP7B0@, @snfJ210@ GII|The weak interaction between @SxlfP7B0@ and @snfJ210@ is enhanced |by @Aats-aspTW3@; the viability of female @SxlfP7B0@/+ embryos |derived from mothers heterozygous for @snfJ210@ and @Aats-aspTW3@ |is reduced. GIC2|viable | reduced | female with @snfJ210@, @SxlfP7B0@ SYN|934.3bs } } ALESR { ASYM|Aats-aspTW6 SYN|934.6as |l(2)49DbTW6 ID|FBal0095903 REF|FBrf0107310 REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 DIS|T. Wu MU|ethyl methanesulfonate GIC|enhancer of @SxlfP7B0@, @snfJ210@ GII|The weak interaction between @SxlfP7B0@ and @snfJ210@ is enhanced |by @Aats-aspTW6@; the viability of female @SxlfP7B0@/+ embryos |derived from mothers heterozygous for @snfJ210@ and @Aats-aspTW6@ |is reduced. GIC2|viable | reduced | female with @snfJ210@, @SxlfP7B0@ SYN|934.6as } } ALESR { ASYM|Aats-aspunspecified ID|FBal0095902 REF|FBrf0108515 |FBrf0107310 REFDSR { RDID|FBrf0108515 |Galloni and Edgar |1999 GIC2|suppressible by @Dphs.PD@ |suppressible by @E2fhs.PD@ } } ALESR { ASYM|Aats-asp&Dgr;Xba SYN|l(2)49Db&Dgr;Xba ID|FBal0095910 PHI|Mode of assay: In transgenic Drosophila REF|FBrf0107310 REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 AFS|Aats-aspunspecified AMSO|Fails to rescue the recessive zygotic lethality of @Aats-aspunspecified@. MD|Construct: 2.5kb deletion which removes the @Aats-asp@ gene. PRG|Aats-asp+t5.5 MU|in vitro construct | deletion CNS|FBtp0010646 == P{Aats-asp&Dgr;Xba} GII|Fails to rescue the lethality of female @SxlfP7B0@/+ embryos derived |from mothers heterozygous for @snfJ210@ and @Df(2R)Su(z)3-1.iy@. PHI|Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|Aats-asp+t5.5 SYN|l(2)49Db+t5.5 ID|FBal0095909 PHC|wild-type PHI|Mode of assay: In transgenic Drosophila REF|FBrf0107310 REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 ARS|Aats-aspunspecified AMSO|Rescues the recessive zygotic lethality of @Aats-aspunspecified@. ARG2|FBgn0002069. MD|Construct: 5.5kb genomic fragment containing @Aats-asp@. MU|in vitro construct | rescue fragment CNS|FBtp0010645 == P{Aats-asp+t5.5} GII|Rescues the lethality of female @SxlfP7B0@/+ embryos derived from |mothers heterozygous for @snfJ210@ and @Df(2R)Su(z)3-1.iy@. PHC|wild-type PHI|Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|Aats-asp+ ID|FBal0095935 CLA|wild-type generic } SKC|3 } # EOR GENR { RETE|ID 1 FBgn0027091 CLA 1 Gene NAM 1 Cysteinyl-tRNA synthetase GSYM 1 Aats-cys DT 1 14 Aug 03 RESZ 3145 PDOM 2 INTERPRO:IPR002308 == Cysteinyl-tRNA synthetase PTD 1 DBA 10 HG 5 Caenorhabditis elegans 'contains similarity to class-I aminoacyl-tRNA synthetases' EMBL:AF077541 FNC 1 cysteinyl-tRNA aminoacylation CLOC 1 52E10--11 ALESR 1 REF 7 GSYM|Aats-cys PTD DT|14 Aug 03 ID|FBgn0027091 UAB|Deficiency: Df(2R)vg89e88 (inferred from cytology) |Duplication: Dp(2;2)SMG45 (inferred from cytology) SYN|CG8431 |CRS |CysRS |BcDNA:LD21177 |Cysteinyl-tRNA synthetase ID2|FBgn0027536 KLOC|65785-16021 CLOC|52E10--11 |Limits computationally determined from genome sequence between EP(2)0645/EP(2)0631 and l(2)k11702/EP(2)0969 FNC|cysteinyl-tRNA aminoacylation ; GO:0006423 | non-traceable author statement PDOM|IPR002308 == Cysteinyl-tRNA synthetase |SCOP:52374 == Nucleotidylyl transferase; BcDNA:LD21177|FBgn0027536|pp-CT18980|FBan0008431 NAM|Cysteinyl-tRNA synthetase ENZ|cysteine-tRNA ligase activity ; GO:0004817 ; EC:6.1.1.16 | inferred from sequence similarity with EMBL:AB015589 |cysteine-tRNA ligase activity ; GO:0004817 ; EC:6.1.1.16 | non-traceable author statement DBA|NA:AA264510 |BDGP:LD07625 |NA:AA735359 |BDGP-DGC:LD21177 |NA:AE003808 |PA:AAF58057 |NA:AF132160 |PA:AAD34748 |NA:AI455104 |BDGP-DGC:LD21177 PAC|SPTREMBL:Q9XZ07 HG|species == Caenorhabditis elegans; gene == 'contains similarity to class-I aminoacyl-tRNA synthetases'; EMBL:AF077541; gi:3319446; score == 664; expect == 0 |species == Homo sapiens; OMIM:123859; score == 726; expect == 0 |species == Mus musculus; gene == 'cysteinyl-tRNA synthetase'; EMBL:AB015589; protein_id:BAA29032; gi:3242657; score == 649; expect == 0 |species == Saccharomyces cerevisiae; gene == 'PUTATIVE CYSTEINYL-TRNA SYNTHETASE C29E6.06C (CYSTEINE--TRNA LIGASE)'; SWP:P53852; gi:1730840; score == 552; expect == 1.e-156 |species == Schizosaccharomyces pombe; gene == 'PUTATIVE CYSTEINYL-TRNA SYNTHETASE C29E6.06C (CYSTEINE--TRNA LIGASE)'; SWP:Q09860; gi:1351621; score == 510; expect == 1.e-143 ASQ|FBan0008431 REF { REFM|FBrf0104946 |FlyBase |1996- |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0126704 |Zhu |1999.11 |9 } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AM|Source for merge of: Aats-cys CG8431 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|cysteine-tRNA ligase activity ; GO:0004817 ; EC:6.1.1.16 | inferred from sequence similarity with EMBL:AB015589 |cysteine-tRNA ligase activity ; GO:0004817 ; EC:6.1.1.16 | non-traceable author statement FNC|cysteinyl-tRNA aminoacylation ; GO:0006423 | non-traceable author statement GPD|cysteine-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Cysteinyl-tRNA synthetase SYN|CRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: LD07625 SYN|CysRS } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD21177 (BDGP-DGC) } ALESR { ASYM|Aats-cys+ ID|FBal0097819 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027090 CLA 1 Gene NAM 1 Glutaminyl-tRNA synthetase GSYM 1 Aats-gln DT 1 14 Aug 03 RESZ 6649 PDOM 4 INTERPRO:IPR000924 == Glutamyl-tRNA synthetase PTD 1 DBA 15 HG 4 Caenorhabditis elegans 'predicted using Genefinder EMBL:Z95559 FNC 1 glutaminyl-tRNA aminoacylation CLOC 1 96C8 ALESR 3 SK 1 REF 12 GSYM|Aats-gln PTD DT|14 Aug 03 ID|FBgn0027090 UAB|Deficiency: Df(3R)slo8 (inferred from cytology) |Duplication: Dp(3;3)Su8 (inferred from cytology) SYN|CG10506 |l(3)05461 |QRS |GlnRS |Aast-g1n |BcDNA:GH11673 |Glutaminyl-tRNA synthetase ID2|FBgn0010867 |FBgn0027545 KLOC|124576 CLOC|96C8 |Limits computationally determined from genome sequence between l(3)j2D9 and l(3)05461 CYC|Experimentally determined: 96C8--9 FNC|glutaminyl-tRNA aminoacylation ; GO:0006425 | inferred from sequence similarity with SGD_LOCUS:GLN4; SGD:S0005694 PDOM|IPR000924 == Glutamyl-tRNA synthetase |IPR001412 == Aminoacyl-transfer RNA synthetases class-I |SCOP:50715 == Ribosomal protein L25-like; Aats-gln|FBgn0027090|pp-CT29352|FBan0010506 |SCOP:52374 == Nucleotidylyl transferase; Aats-gln|FBgn0027090|pp-CT29352|FBan0010506 NAM|Glutaminyl-tRNA synthetase ENZ|ATP binding ; GO:0005524 | non-traceable author statement |glutamine-tRNA ligase activity ; GO:0004819 ; EC:6.1.1.18 | inferred from sequence similarity |glutamine-tRNA ligase activity ; GO:0004819 ; EC:6.1.1.18 | inferred from sequence similarity with SGD_LOCUS:GLN4; SGD:S0005694 |glutamine-tRNA ligase activity ; GO:0004819 ; EC:6.1.1.18 | non-traceable author statement DBA|NA:AA803519 |BDGP:GM13383 |NA:AA941321 |BDGP:LD25392 |NA:AE003751 |PA:AAF56434 |NA:AF145668 |PA:AAD38643 |NA:AI134263 |BDGP-DGC:GH11673 |NA:AI402269 |BDGP-DGC:GH11673 |NA:AQ034065 |BDGP:Dm4027 |BDGP:l(3)05461 PAC|SWP:Q9Y105 HG|species == Caenorhabditis elegans; gene == 'predicted using Genefinder; similar to tRNA synthetases class I (E'; EMBL:Z95559; protein_id:CAB08998; gi:3880882; score == 876; expect == 0 |species == Homo sapiens; gene == 'glutamine-tRNA synthetase'; gi:4826960; score == 899; expect == 0 |species == LUPLU; gene == 'GLUTAMINYL-TRNA SYNTHETASE (GLUTAMINE--TRNA LIGASE) (GLNRS)'; SWP:P52780; gi:3915866; score == 610; expect == 1.e-173 |species == Saccharomyces cerevisiae; gene == GLN4; SGDID:L0000711; score == 511; expect == 1.e-143 ASQ|FBan0010506 REF { REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0125032 |Beaton |1999.12.12 |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0131734 |SwissProt Project Members |1999.11.1 |9 REFM|FBrf0158942 |Orian et al. |2003 |0 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0129569 |Misra |2000.8.9 |9 REFM|FBrf0083714 |Meister and Braun |1995.10 |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|96C8--9 LOI|Aats-gln05461 BMDD|Df(3R)XTA1 SYN|l(3)05461 } REFDSR { RDID|FBrf0083714 |Meister and Braun |1995.10 SYN|l(3)05461 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|glutamine-tRNA ligase activity ; GO:0004819 ; EC:6.1.1.18 | inferred from sequence similarity with SGD_LOCUS:GLN4; SGD:S0005694 FNC|glutaminyl-tRNA aminoacylation ; GO:0006425 | inferred from sequence similarity with SGD_LOCUS:GLN4; SGD:S0005694 GPD|glutamine-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Glutaminyl-tRNA synthetase SYN|QRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: LD25392 SYN|GlnRS } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 ENZ|glutamine-tRNA ligase activity ; GO:0004819 ; EC:6.1.1.18 | inferred from sequence similarity CLOC|96C8--9 (determined by in situ hybridization) MD|Identified with: Dm4027 |Identified with: GM13383 AM|Source for merge of: Aats-gln l(3)05461 GPD|glutamine-tRNA ligase BMDD|Df(3R)XTA1 } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH11673 (BDGP-DGC) } REFDSR { RDID|FBrf0129569 |Misra |2000.8.9 AM|Source for merge of: Aats-gln BcDNA:GH11673 } REFDSR { RDID|FBrf0131734 |SwissProt Project Members |1999.11.1 ENZ|ATP binding ; GO:0005524 | non-traceable author statement |glutamine-tRNA ligase activity ; GO:0004819 ; EC:6.1.1.18 | non-traceable author statement } REFDSR { RDID|FBrf0158942 |Orian et al. |2003 SYN|Aast-g1n } ALESR { ASYM|Aats-gln05461 SYN|l(3)0546105461 |l(3)05461 ID|FBal0009538 DIS|A. Spradling. TRN|FBti0005535 == P{PZ}Aats-gln05461 |BDGP:l(3)05461 MU|P-element activity REF|FBrf0067338 |FBrf0125032 |FBrf0083714 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 AFC|Aats-glns1926b OTH|Complements: @l(3)0196901969@. |Complements: @l(3)j12B4j12B4@. |Complements: @Fur1rL205@. TRN|FBti0005535 == P{PZ}Aats-gln05461 |BDGP:l(3)05461 PHC|lethal | recessive SYN|l(3)0546105461 } REFDSR { RDID|FBrf0083714 |Meister and Braun |1995.10 SYN|l(3)0546105461 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0005535 == P{PZ}Aats-gln05461 |BDGP:l(3)05461 PHC|lethal | recessive SYN|l(3)05461 } SK|FBstBL-11660 |ry[506] P{ry[+t7.2]=PZ}Aats-gln[05461]/TM3, ry[RK] Sb[1] Ser[1] } ALESR { ASYM|Aats-glns1926b SYN|l(3)1926 |l(3)s1926 ID|FBal0103105 PHC|lethal | recessive REF|FBrf0067338 |FBrf0125032 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 AFC|Aats-gln05461 OTH|Complements: @l(3)j12B4j12B4@. } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0015565 == P{lacW}Aats-glns1926b PHC|lethal | recessive SYN|l(3)1926 } REFDSR { RDID|FBrf0125032 |Beaton |1999.12.12 SYN|l(3)s1926 } } ALESR { ASYM|Aats-gln+ ID|FBal0097818 CLA|wild-type generic } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0005674 CLA 1 Gene NAM 1 Glutamyl-prolyl-tRNA synthetase GSYM 1 Aats-glupro DT 1 14 Aug 03 RESZ 12006 PDOM 11 INTERPRO:IPR000738 == WHEP-TRS domain PTD 1 DBA 27 HG 5 Caenorhabditis elegans 'similar to glutamyl-trna synthetase EMBL:D65878 FNC 2 glutamyl-tRNA aminoacylation CEL 1 aminoacyl-tRNA synthetase multienzyme complex CLOC 1 95D1 ALESR 5 SK 1 REF 21 GSYM|Aats-glupro PTD DT|14 Aug 03 ID|FBgn0005674 UAB|Deficiency: Df(3R)mbc-R.1 (inferred from cytology) |Duplication: Dp(3;3)M95A+13 (inferred from cytology) SYN|CG5394 |aminoacyl-tRNA synthetase |GluPro-RS |GluProRS |ERS |GluRS |glutamyl-prolyl-tRNA synthetase |AATs-GluPro |AATS |Aa-tRNA-syn-glupro |Aats-glu |Glutamyl-tRNA synthetase |glutamyl-prolyl-tRA synthetase ID2|FBgn0027089 NAM|Glutamyl-prolyl-tRNA synthetase KLOC|122702 CLOC|95D1 |Limits computationally determined from genome sequence between l(3)04684 and l(3)00096 CYC|Experimentally determined: 95C--D, 95C1--D11 FNC|glutamyl-tRNA aminoacylation ; GO:0006424 | inferred from sequence similarity with EMBL:X54326; protein_id:CAA38224.1 |prolyl-tRNA aminoacylation ; GO:0006433 | inferred from sequence similarity with EMBL:X54326; protein_id:CAA38224.1 CEL|aminoacyl-tRNA synthetase multienzyme complex ; GO:0017101 | non-traceable author statement PDOM|IPR000738 == WHEP-TRS domain |IPR000924 == Glutamyl-tRNA synthetase |IPR001412 == Aminoacyl-transfer RNA synthetases class-I |IPR002314 == tRNA synthetases, class-II (G, H, P and S) |IPR002316 == Prolyl-tRNA synthetase |SCOP:47060 == S15/NS1 RNA-binding domain; Aats-glupro|FBgn0005674|pp-CT17114|FBan0005394 |SCOP:47616 == Glutathione S-transferases, C-terminal domain; Aats-glupro|FBgn0005674|pp-CT17114|FBan0005394 |SCOP:50715 == Ribosomal protein L25-like; Aats-glupro|FBgn0005674|pp-CT17114|FBan0005394 |SCOP:52374 == Nucleotidylyl transferase; Aats-glupro|FBgn0005674|pp-CT17114|FBan0005394 |SCOP:52954 == Anticodon-binding domain of Class II aaRS; Aats-glupro|FBgn0005674|pp-CT17114|FBan0005394 |SCOP:55681 == Class II aaRS and biotin synthetases; Aats-glupro|FBgn0005674|pp-CT17114|FBan0005394 ENZ|proline-tRNA ligase activity ; GO:0004827 ; EC:6.1.1.15 | non-traceable author statement |glutamate-tRNA ligase activity ; GO:0004818 ; EC:6.1.1.17 | inferred from sequence similarity with NCBI_gi:4758294 |proline-tRNA ligase activity ; GO:0004827 ; EC:6.1.1.15 | inferred from sequence similarity with NCBI_gi:4758294 |glutamate-tRNA ligase activity ; GO:0004818 ; EC:6.1.1.17 | non-traceable author statement DBA|NA:AA439518 |BDGP:LD14109 |NA:AE003745 |PA:AAF56211 |PA:AAN13964 |NA:AI516730 |BDGP-DGC:LD42739 |NA:AW942301 |BDGP:LD14109 |NA:AX093922 |NA:AY058703 |PA:AAL13932 |BDGP-DGC:LD42739 |NA:AY061172 |PA:AAL28720 |BDGP:LD14109 |NA:BH809524 |BDGP:KG06229 |NA:BI243807 |BDGP-DGC:RE41560 |NA:BT001645 |PA:AAN71400 |BDGP-DGC:RE41560 |NA:M74104 |PA:AAA28594 |NA:U59923 |PA:AAC47469 PAC|PIR:S18644 |SPTREMBL:Q8IGR4 |SPTREMBL:Q8IMX9 |SPTREMBL:Q95TL3 |SWP:P28668 HG|species == Caenorhabditis elegans; gene == 'similar to glutamyl-trna synthetase; cDNA EST EMBL:D65878 comes fr'; EMBL:Z75714; protein_id:CAB00060; gi:3925372; score == 997; expect == 0 |species == Homo sapiens; gene == 'glutamyl-prolyl-tRNA synthetase'; gi:4758294; score == 1768; expect == 0 |species == Mus musculus; gene == Wars; MGI:104630; score == 57; expect == 1.e-06 |species == Saccharomyces cerevisiae; gene == 'PUTATIVE PROLYL-TRNA SYNTHETASE YHR020W (PROLINE--TRNA LIGASE) (PRORS'; SWP:P38708; gi:731640; score == 594; expect == 1.e-168 |species == unknown; gene == 'SPBC19C7.06, putative prolyl-trna synthetase, len:71 6aa, simi'; EMBL:AL023859; protein_id:CAA19574.1; gi:3218410; score == 592; expect == 1.e-168 ASQ|FBan0005394 REF { REFM|FBrf0126678 |Kodira |1999.11 |9 REFM|FBrf0073545 |Kerjan et al. |1994 |0 REFM|-1505380982 |0 |Patent: WO 0118547-A 15-MAR-2001; REFM|FBrf0053898 |Cerini et al. |1991 |0 REFM|FBrf0137035 |Begun |2001 |0 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0132177 |Gene Disruption Project members |2001- |9 REFM|FBrf0132349 |Ranz et al. |2001 |0 REFM|FBrf0092490 |Cerini et al. |1997 |0 REFM|FBrf0137433 |Ranz et al. |2001 |9 REFM|FBrf0128393 |Begun and Whitley |2000 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0115420 |Gratecos |1996.6.4 |9 REFM|FBrf0108260 |Ranz et al. |1999 |0 REFM|FBrf0126809 |Berthonneau and Mirande |2000 |0 REFM|FBrf0083078 |Cerini et al. |1995 |1 REFM|FBrf0107136 |Quevillon et al. |1999 |0 REFM|FBrf0123906 |SwissProt Project Members |1992.12.1 |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 } REFDSR { RDID|FBrf0053898 |Cerini et al. |1991 CLOC|95C1--D11 (determined by in situ hybridization) } REFDSR { RDID|995280759 |Davies |2001.3.30 OTH|Area matching Drosophila glutamyl-prolyl-tRNA synthetase gene, Acc. No. U59923. } REFDSR { RDID|FBrf0073545 |Kerjan et al. |1994 PHP|The aminoacyl-tRNA synthetase complex in Drosophila is essentially |similar to those isolated from various mammalian origins. SYN|aminoacyl-tRNA synthetase } REFDSR { RDID|FBrf0092490 |Cerini et al. |1997 OTH|Intron exon organization of @Aats-glupro@ is determined and transcript |analysis reveals two transcripts encode different proteins that are |controlled by independent promoters. Transgenic lines overexpressing |@Aats-glupro@ show a dominant negative behavior, competing in vivo |with the endogenous partners of the complex, due to the central region |containing the repeated motifs. SYN|GluPro-RS: glutamyl-prolyl-tRA synthetase } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|glutamate-tRNA ligase activity ; GO:0004818 ; EC:6.1.1.17 | inferred from sequence similarity with NCBI_gi:4758294 |proline-tRNA ligase activity ; GO:0004827 ; EC:6.1.1.15 | inferred from sequence similarity with NCBI_gi:4758294 FNC|glutamyl-tRNA aminoacylation ; GO:0006424 | inferred from sequence similarity with EMBL:X54326; protein_id:CAA38224.1 |prolyl-tRNA aminoacylation ; GO:0006433 | inferred from sequence similarity with EMBL:X54326; protein_id:CAA38224.1 GPD|glutamate/proline-tRNA ligase } REFDSR { RDID|FBrf0107136 |Quevillon et al. |1999 SYN|GluProRS } REFDSR { RDID|FBrf0108260 |Ranz et al. |1999 CLOC|95C--D (determined by in situ hybridization) PPC|The organization of the D.melanogaster 95A-96A region has been studied |in D.repleta, D.buzzatii amd D.virilis. The data indicates significant |statistical differences in the evolution rate of Muller's element E |among lineages. } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 SYN|ERS: Glutamyl-tRNA synthetase } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: LD14109 SYN|GluRS } REFDSR { RDID|FBrf0115420 |Gratecos |1996.6.4 SYN|glutamyl-prolyl-tRNA synthetase } REFDSR { RDID|FBrf0123906 |SwissProt Project Members |1992.12.1 ENZ|glutamate-tRNA ligase activity ; GO:0004818 ; EC:6.1.1.17 | non-traceable author statement |proline-tRNA ligase activity ; GO:0004827 ; EC:6.1.1.15 | non-traceable author statement CEL|aminoacyl-tRNA synthetase multienzyme complex ; GO:0017101 | non-traceable author statement } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD42739 (BDGP-DGC) |Identified with: RE41560 (BDGP-DGC) } REFDSR { RDID|FBrf0126678 |Kodira |1999.11 AM|Source for identity of: Aats-glupro CG5394 } REFDSR { RDID|FBrf0126809 |Berthonneau and Mirande |2000 SYN|GluProRS } REFDSR { RDID|FBrf0128393 |Begun and Whitley |2000 PPC|Polymorphism data from 40 genes, including this one, distributed across |arms X and 3R of D. simulans (a sibling species of D. melanogaster) |shows that significantly less silent polymorphism is seen in D. simulans |on the X chromosome than on 3R, but no difference is seen between arms |for silent divergence between species. SYN|AATs-GluPro } REFDSR { RDID|FBrf0137035 |Begun |2001 SYN|AATS } ALESR { ASYM|Aats-gluproKG06229 ID|FBal0134433 REF|FBrf0132177 REFDSR { RDID|FBrf0132177 |Gene Disruption Project members |2001- TRN|FBti0023203 == P{SUPor-P}Aats-gluproKG06229 |BDGP:KG06229 } SK|FBstBL-14031 |y[1]; ry[506] P{y[+mDint2] w[BR.E.BR]=SUPor-P}Aats-glupro[KG06229] } ALESR { ASYM|Aats-glupro&Dgr;RM.hs.T:Hsap\MYC SYN|Aats-glupro&Dgr;RM.hs.T:Myc ID|FBal0065465 PHI|Continuous expression at 29oC in adults causes no significant reduction |in fertility. Overexpression has no deleterious effects and does not |produce a visible phenotype. |Mode of assay: In transgenic Drosophila REF|FBrf0092490 REFDSR { RDID|FBrf0092490 |Cerini et al. |1997 MD|Construct: Deletion of the repeat motifs and flanking sequences, amino acids 688 |to 1240. PRG|Aats-gluproGP.hs.T:Hsap\MYC MU|in vitro construct | deletion CNS|FBtp0008623 == P{hsp70-Aats-glupro.&Dgr;RM} PHI|Continuous expression at 29oC in adults causes no significant reduction |in fertility. Overexpression has no deleterious effects and does not |produce a visible phenotype. |Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|Aats-gluproGP.hs.T:Hsap\MYC SYN|Aats-gluproGP.hs.T:Myc ID|FBal0065464 PHC|female fertile | reduced PHI|Continuous expression at 29oC in adults causes a significantly reduced |fertility. Eggs laid in these conditions produce viable adults. |Mode of assay: In transgenic Drosophila REF|FBrf0092490 REFDSR { RDID|FBrf0092490 |Cerini et al. |1997 MD|Construct: Full length protein (amino acids 1 to 1714) is tagged with nine amino |acids of the cellular protooncogene c-myc and expressed from an Hsp70 |promoter. MU|in vitro construct | regulatory fusion |in vitro construct | coding region fusion CNS|FBtp0008622 == P{hsp70-Aats-glupro.GP} PHC|female fertile | reduced PHI|Continuous expression at 29oC in adults causes a significantly reduced |fertility. Eggs laid in these conditions produce viable adults. |Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|Aats-gluproRM.hs.T:Hsap\MYC SYN|Aats-gluproRM.hs.T:Myc ID|FBal0065463 PHC|female fertile | reduced PHI|Continuous expression at 29oC in adults causes a significantly reduced |fertility. Eggs laid in these conditions produce viable adults. |Mode of assay: In transgenic Drosophila REF|FBrf0092490 REFDSR { RDID|FBrf0092490 |Cerini et al. |1997 MD|Construct: Repeat motifs of the @Aats-glupro@ protein (amino acids 745 to 1184) |are tagged with nine amino acids of the cellular protooncogene c-myc |and expressed from an Hsp70 promoter. MU|in vitro construct | regulatory fusion |in vitro construct | coding region fusion CNS|FBtp0008621 == P{hsp70-Aats-glupro.RM} PHC|female fertile | reduced PHI|Continuous expression at 29oC in adults causes a significantly reduced |fertility. Eggs laid in these conditions produce viable adults. |Mode of assay: In transgenic Drosophila SYN|unnamed } } ALESR { ASYM|Aats-glupro+ ID|FBal0066329 CLA|wild-type generic REF|FBrf0105495 } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0027088 CLA 1 Gene NAM 1 Glycyl-tRNA synthetase GSYM 1 Aats-gly DT 1 14 Aug 03 RESZ 3162 PDOM 7 INTERPRO:IPR000738 == WHEP-TRS domain PTD 1 DBA 12 HG 4 Bombyx mori 'GLYCYL-TRNA SYNTHETASE (GLYCINE--TRNA LIGASE) (GLYRS)' SWP:Q04451 FNC 1 glycyl-tRNA aminoacylation CLOC 1 71B4 ALESR 1 REF 6 GSYM|Aats-gly PTD DT|14 Aug 03 ID|FBgn0027088 UAB|Deficiency: Df(3L)Brd15 (inferred from cytology) |Duplication: Dp(3;3)M71 (inferred from cytology) SYN|CG6778 |GRS |GlyRS |Glycyl-tRNA synthetase ID2|FBgn0036477 KLOC|91861 CLOC|71B4 |Limits computationally determined from genome sequence between l(3)s2172/l(3)j2A2 and EP(3)0572 FNC|glycyl-tRNA aminoacylation ; GO:0006426 | non-traceable author statement PDOM|IPR000738 == WHEP-TRS domain |IPR002106 == Aminoacyl-transfer RNA synthetases class-II |IPR002314 == tRNA synthetases, class-II (G, H, P and S) |IPR002315 == Homodimeric glycyl-tRNA synthetase |SCOP:47060 == S15/NS1 RNA-binding domain; CG6778|FBgn0036477|pp-CT21033|FBan0006778 |SCOP:52954 == Anticodon-binding domain of Class II aaRS; CG6778|FBgn0036477|pp-CT21033|FBan0006778 |SCOP:55681 == Class II aaRS and biotin synthetases; CG6778|FBgn0036477|pp-CT21033|FBan0006778 NAM|Glycyl-tRNA synthetase ENZ|glycine-tRNA ligase activity ; GO:0004820 ; EC:6.1.1.14 | inferred from sequence similarity with PIR:A55314 |glycine-tRNA ligase activity ; GO:0004820 ; EC:6.1.1.14 | non-traceable author statement DBA|NA:AA567149 |BDGP:GM01134 |NA:AE003532 |PA:AAF49668 |PA:AAN11786 |NA:AI109879 |BDGP-DGC:GH09263 |NA:AI402167 |BDGP-DGC:GH09263 |NA:AY051413 |PA:AAK92837 |BDGP-DGC:GH09263 PAC|SPTREMBL:Q961R8 |SPTREMBL:Q9VUK8 HG|species == Bombyx mori; gene == 'GLYCYL-TRNA SYNTHETASE (GLYCINE--TRNA LIGASE) (GLYRS)'; SWP:Q04451; gi:1351153; score == 939; expect == 0 |species == Caenorhabditis elegans; gene == T10F2.1; WP:CE02040; score == 860; expect == 0 |species == Homo sapiens; gene == 'glycine--tRNA ligase (EC 6.1.1.14) precursor'; PIR:A55314; gi:1082407; score == 838; expect == 0 |species == Saccharomyces cerevisiae; gene == GRS1; SGDID:L0000731; score == 601; expect == 1.e-171 ASQ|FBan0006778 REF { REFM|FBrf0104946 |FlyBase |1996- |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0126664 |Find Enzymes |1999.11 |9 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AM|Source for merge of: Aats-gly CG6778 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|glycine-tRNA ligase activity ; GO:0004820 ; EC:6.1.1.14 | inferred from sequence similarity with PIR:A55314 |glycine-tRNA ligase activity ; GO:0004820 ; EC:6.1.1.14 | non-traceable author statement FNC|glycyl-tRNA aminoacylation ; GO:0006426 | non-traceable author statement GPD|glycyl-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Glycyl-tRNA synthetase SYN|GRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: GM01134 SYN|GlyRS } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH09263 (BDGP-DGC) } ALESR { ASYM|Aats-gly+ ID|FBal0097816 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027087 CLA 1 Gene NAM 1 Histidyl-tRNA synthetase GSYM 1 Aats-his DT 1 14 Aug 03 RESZ 3396 PDOM 6 INTERPRO:IPR000738 == WHEP-TRS domain PTD 1 DBA 12 HG 5 Caenorhabditis elegans 'predicted using Genefinder EMBL:Z69384 FNC 1 histidyl-tRNA aminoacylation CLOC 1 17C1 ALESR 1 REF 7 GSYM|Aats-his PTD DT|14 Aug 03 ID|FBgn0027087 UAB|Deficiency: Df(1)E128 (inferred from cytology) |Duplication: Dp(1;1)BSTAG (inferred from cytology) SYN|CG6335 |HRS |HisRS |Histidyl-tRNA synthetase ID2|FBgn0030934 KLOC|22728 CLOC|17C1 |Limits computationally determined from genome sequence between EP(X)1317 and EP(X)1306/EP(X)1383 FNC|histidyl-tRNA aminoacylation ; GO:0006427 | non-traceable author statement PDOM|IPR000738 == WHEP-TRS domain |IPR002106 == Aminoacyl-transfer RNA synthetases class-II |IPR002314 == tRNA synthetases, class-II (G, H, P and S) |SCOP:47060 == S15/NS1 RNA-binding domain; CG6335|FBgn0030934|pp-CT19788|FBan0006335 |SCOP:52954 == Anticodon-binding domain of Class II aaRS; CG6335|FBgn0030934|pp-CT19788|FBan0006335 |SCOP:55681 == Class II aaRS and biotin synthetases; CG6335|FBgn0030934|pp-CT19788|FBan0006335 NAM|Histidyl-tRNA synthetase ENZ|histidine-tRNA ligase activity ; GO:0004821 ; EC:6.1.1.21 | inferred from sequence similarity with MGD:Hars; MGI:MGI:108087 |histidine-tRNA ligase activity ; GO:0004821 ; EC:6.1.1.21 | non-traceable author statement DBA|NA:AA696161 |BDGP:GM05203 |NA:AE003509 |PA:AAF48856 |PA:AAN09471 |NA:AI403106 |BDGP-DGC:GH22474 |NA:AY102665 |PA:AAM27494 |BDGP-DGC:GH22474 |NA:BG633221 |BDGP-DGC:GH22474 PAC|SPTREMBL:Q8IQX8 |SPTREMBL:Q9VWT1 HG|species == Caenorhabditis elegans; gene == 'predicted using Genefinder; Similarity to C.elegans Histidyl-tRNA'; EMBL:Z69384; protein_id:CAA93416; gi:3879781; score == 510; expect == 1.e-143 |species == Fugu rubripes; gene == 'HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)'; SWP:P70076; gi:2501006; score == 628; expect == 1.e-179 |species == Homo sapiens; OMIM:142810; score == 650; expect == 0 |species == Mus musculus; gene == Hars; MGI:108087; score == 648; expect == 0 |species == Saccharomyces cerevisiae; gene == HTS1; SGDID:L0000832; score == 450; expect == 1.e-125 ASQ|FBan0006335 REF { REFM|FBrf0104946 |FlyBase |1996- |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0126651 |Ashburner |1999.11 |9 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AM|Source for merge of: Aats-his CG6335 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|histidine-tRNA ligase activity ; GO:0004821 ; EC:6.1.1.21 | inferred from sequence similarity with MGD:Hars; MGI:MGI:108087 |histidine-tRNA ligase activity ; GO:0004821 ; EC:6.1.1.21 | non-traceable author statement FNC|histidyl-tRNA aminoacylation ; GO:0006427 | non-traceable author statement GPD|histidyl-tRNA ligase |histidine-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Histidyl-tRNA synthetase SYN|HRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: GM05203 SYN|HisRS } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH22474 (BDGP-DGC) } ALESR { ASYM|Aats-his+ ID|FBal0097815 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027086 CLA 1 Gene NAM 1 Isoleucyl-tRNA synthetase GSYM 1 Aats-ile DT 1 14 Aug 03 RESZ 6543 PDOM 11 INTERPRO:IPR002300 == t-RNA synthetase, class Ia PTD 1 DBA 17 HG 5 Caenorhabditis elegans R11A8.6 WP:CE06304 FNC 1 isoleucyl-tRNA aminoacylation CLOC 1 79D4--E1 ALESR 2 SK 1 REF 12 GSYM|Aats-ile PTD DT|14 Aug 03 ID|FBgn0027086 UAB|Deficiency: Df(3L)Ten-m-AL29 (inferred from cytology) SYN|CG11471 |l(3)00827 |IRS |IleRS |Isoleucyl-tRNA synthetase ID2|FBgn0010728 |FBgn0037159 KLOC|100251-100323 CLOC|79D4--E1 |Limits computationally determined from genome sequence between l(3)j1B10 and l(3)j2C4 CYC|Experimentally determined: 79E1--2 FNC|isoleucyl-tRNA aminoacylation ; GO:0006428 | inferred from sequence similarity with SGD_LOCUS:ILS1; SGD:S0000172 PDOM|IPR002300 == t-RNA synthetase, class Ia |IPR002301 == Isoleucyl-tRNA synthetase |SCOP:47323 == Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; Aats-ile|FBgn0027086|pp-CT36257|FBan0011471 |SCOP:47323 == Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; Aats-ile|FBgn0027086|pp-CT36261|FBan0011471 |SCOP:47323 == Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; Aats-ile|FBgn0027086|pp-CT36277|FBan0011471 |SCOP:50677 == ValRS/IleRS editing domain; Aats-ile|FBgn0027086|pp-CT36257|FBan0011471 |SCOP:50677 == ValRS/IleRS editing domain; Aats-ile|FBgn0027086|pp-CT36261|FBan0011471 |SCOP:50677 == ValRS/IleRS editing domain; Aats-ile|FBgn0027086|pp-CT36277|FBan0011471 |SCOP:52374 == Nucleotidylyl transferase; Aats-ile|FBgn0027086|pp-CT36257|FBan0011471 |SCOP:52374 == Nucleotidylyl transferase; Aats-ile|FBgn0027086|pp-CT36261|FBan0011471 |SCOP:52374 == Nucleotidylyl transferase; Aats-ile|FBgn0027086|pp-CT36277|FBan0011471 NAM|Isoleucyl-tRNA synthetase ENZ|isoleucine-tRNA ligase activity ; GO:0004822 ; EC:6.1.1.5 | inferred from sequence similarity |isoleucine-tRNA ligase activity ; GO:0004822 ; EC:6.1.1.5 | inferred from sequence similarity with SGD_LOCUS:ILS1; SGD:S0000172 DBA|NA:AA392674 |BDGP:LD11930 |NA:AA695742 |BDGP:GM04407 |NA:AA941855 |BDGP-DGC:LD27166 |NA:AE003597 |PA:AAF51822 |PA:AAF51823 |PA:AAO41285 |NA:AQ026160 |BDGP:l(3)00827 |NA:AW942740 |BDGP-DGC:LD27166 |NA:AY118538 |PA:AAM49907 |BDGP-DGC:LD27166 PAC|SPTREMBL:Q8MSW0 HG|species == Caenorhabditis elegans; gene == R11A8.6; WP:CE06304; score == 1234; expect == 0 |species == Homo sapiens; OMIM:600709; score == 1342; expect == 0 |species == Mus musculus; gene == 'valyl-tRNA synthetase'; EMBL:087141_1 (AF087141; protein_id:AAD26531.1; gi:4590328; score == 153; expect == 9.e-36 |species == Saccharomyces cerevisiae; gene == ILS1; SGDID:L0000856; score == 1088; expect == 0 |species == Schizosaccharomyces pombe; gene == 'ISOLEUCYL-TRNA SYNTHETASE, CYTOPLASMIC (ISOLEUCINE--TRNA LIGASE) (IL'; SWP:O13651; gi:3122901; score == 1092; expect == 0 ASQ|FBan0011471 REF { REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0125024 |Spradling |1999.12.9 |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0138231 |Anholt and Mackay |2001 |0 REFM|FBrf0129569 |Misra |2000.8.9 |9 REFM|FBrf0083028 |Baumgartner et al. |1995 |0 REFM|FBrf0083714 |Meister and Braun |1995.10 |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|79E1--2 (determined by in situ hybridization) BMDD|Df(3L)Pc-MK SYN|l(3)00827 } REFDSR { RDID|FBrf0083028 |Baumgartner et al. |1995 SYN|l(3)00827 } REFDSR { RDID|FBrf0083714 |Meister and Braun |1995.10 SYN|l(3)00827 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|isoleucine-tRNA ligase activity ; GO:0004822 ; EC:6.1.1.5 | inferred from sequence similarity with SGD_LOCUS:ILS1; SGD:S0000172 FNC|isoleucyl-tRNA aminoacylation ; GO:0006428 | inferred from sequence similarity with SGD_LOCUS:ILS1; SGD:S0000172 GPD|isoleucyl-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Isoleucyl-tRNA synthetase SYN|IRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: LD11930 SYN|IleRS } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 ENZ|isoleucine-tRNA ligase activity ; GO:0004822 ; EC:6.1.1.5 | inferred from sequence similarity CLOC|79E1--2 (determined by in situ hybridization) LOI|Aats-ile00827 MD|Identified with: GM04407 AM|Source for merge of: Aats-ile l(3)00827 BMDD|Df(3L)Pc-MK } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD27166 (BDGP-DGC) } REFDSR { RDID|FBrf0129569 |Misra |2000.8.9 AM|Source for merge of: Aats-ile CG11471 } ALESR { ASYM|Aats-ile00827 SYN|l(3)00827 |l(3)0082700827 ID|FBal0009389 DIS|A. Spradling. TRN|FBti0005412 == P{PZ}Aats-ile00827 |BDGP:l(3)00827 MU|P-element activity REF|FBrf0083028 |FBrf0067338 |FBrf0083714 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 OTH|Complements: @RpP001544@. |Complements: @Ten-m02017@. |Complements: @Ten-m02218@. |Complements: @Hem03335@. |Complements: @Csp03988@. |Complements: @l(3)0405304053@. |Complements: @Ten-m05309@. |Complements: @l(3)0907009070@. |Complements: @TyrRneo30@. TRN|FBti0005412 == P{PZ}Aats-ile00827 |BDGP:l(3)00827 } REFDSR { RDID|FBrf0083028 |Baumgartner et al. |1995 OTH|Complements @Hem03335@. TRN|FBti0005412 == P{PZ}Aats-ile00827 |BDGP:l(3)00827 MU|P-element activity PHC|lethal | recessive SYN|l(3)00827 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0005412 == P{PZ}Aats-ile00827 |BDGP:l(3)00827 PHC|lethal | recessive SYN|l(3)00827 } SK|FBstBL-11510 |P{ry[+t7.2]=PZ}Aats-ile[00827] ry[506]/TM3, ry[RK] Sb[1] Ser[1] } ALESR { ASYM|Aats-ile+ ID|FBal0097814 CLA|wild-type generic } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0027085 CLA 1 Gene NAM 1 Leucyl-tRNA synthetase GSYM 1 Aats-leu DT 1 14 Aug 03 RESZ 4465 PDOM 6 INTERPRO:IPR001412 == Aminoacyl-transfer RNA synthetases class-I PTD 1 DBA 11 HG 5 Caenorhabditis elegans 'predicted using Genefinder EMBL:Z81038 FNC 2 leucyl-tRNA aminoacylation CEL 2 mitochondrial matrix CLOC 1 64C2 ALESR 1 REF 8 GSYM|Aats-leu PTD DT|14 Aug 03 ID|FBgn0027085 UAB|Deficiency: Df(3L)GN24 (inferred from cytology) |Duplication: Dp(3;3)M34 (inferred from cytology) SYN|CG7479 |LRS |LeuRS |Leucyl-tRNA synthetase ID2|FBgn0035576 KLOC|82627 CLOC|64C2 |Limits computationally determined from genome sequence between l(3)rG166 and l(3)01418 FNC|leucyl-tRNA aminoacylation ; GO:0006429 | inferred from sequence similarity with Swiss-Prot:Q15031 |leucyl-tRNA aminoacylation ; GO:0006429 | non-traceable author statement CEL|mitochondrial matrix ; GO:0005759 | inferred from sequence similarity with Swiss-Prot:Q15031 |mitochondrion ; GO:0005739 | inferred from sequence similarity with SGD_LOCUS:NAM2; SGD:S0004374 PDOM|IPR001412 == Aminoacyl-transfer RNA synthetases class-I |IPR002300 == t-RNA synthetase, class Ia |IPR002302 == Leucyl-tRNA synthetase |SCOP:47323 == Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; CG7479|FBgn0035576|pp-CT1866|FBan0007479 |SCOP:50677 == ValRS/IleRS editing domain; CG7479|FBgn0035576|pp-CT1866|FBan0007479 |SCOP:52374 == Nucleotidylyl transferase; CG7479|FBgn0035576|pp-CT1866|FBan0007479 NAM|Leucyl-tRNA synthetase ENZ|leucine-tRNA ligase activity ; GO:0004823 ; EC:6.1.1.4 | inferred from sequence similarity with SGD_LOCUS:NAM2; SGD:S0004374 |leucine-tRNA ligase activity ; GO:0004823 ; EC:6.1.1.4 | inferred from sequence similarity with Swiss-Prot:Q15031 |leucine-tRNA ligase activity ; GO:0004823 ; EC:6.1.1.4 | non-traceable author statement DBA|NA:AA803053 |BDGP:GM06905 |NA:AE003482 |PA:AAF47943 |NA:AI512488 |BDGP-DGC:LD44376 |NA:AW943719 |BDGP-DGC:LD44376 |NA:AY089557 |PA:AAL90295 |BDGP-DGC:LD44376 PAC|MITODROME:MTDROME07479 |SPTREMBL:Q9VZ82 HG|species == Caenorhabditis elegans; gene == 'predicted using Genefinder; Similarity to Yeast isoleucyl-tRNA syn'; EMBL:Z81038; protein_id:CAB02766; gi:3874441; score == 62.8; expect == 1.e-08 |species == Homo sapiens; gene == 'PROBABLE LEUCYL-TRNA SYNTHETASE, MITOCHONDRIAL PRECURSOR (LEUCINE--T'; SWP:Q15031; gi:2501029; score == 658; expect == 0 |species == Mus musculus; gene == 'G7A'; EMBL:AF109905; gi:3986754; score == 80; expect == 7.e-14 |species == SYNY3; gene == 'LEUCYL-TRNA SYNTHETASE (LEUCINE--TRNA LIGASE) (LEURS)'; SWP:P73274; gi:2501028; score == 530; expect == 1.e-149 |species == Saccharomyces cerevisiae; gene == NAM2; SGDID:L0001229; score == 476; expect == 1.e-133 ASQ|FBan0007479 REF { REFM|FBrf0159903 |Sardiello et al. |2003.6.11 |9 REFM|FBrf0104946 |FlyBase |1996- |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0126704 |Zhu |1999.11 |9 } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AM|Source for merge of: Aats-leu CG7479 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|leucine-tRNA ligase activity ; GO:0004823 ; EC:6.1.1.4 | inferred from sequence similarity with SGD_LOCUS:NAM2; SGD:S0004374 |leucine-tRNA ligase activity ; GO:0004823 ; EC:6.1.1.4 | non-traceable author statement FNC|leucyl-tRNA aminoacylation ; GO:0006429 | non-traceable author statement CEL|mitochondrion ; GO:0005739 | inferred from sequence similarity with SGD_LOCUS:NAM2; SGD:S0004374 GPD|leucyl-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Leucyl-tRNA synthetase SYN|LRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: GM06905 SYN|LeuRS } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD44376 (BDGP-DGC) } REFDSR { RDID|FBrf0159903 |Sardiello et al. |2003.6.11 ENZ|leucine-tRNA ligase activity ; GO:0004823 ; EC:6.1.1.4 | inferred from sequence similarity with Swiss-Prot:Q15031 FNC|leucyl-tRNA aminoacylation ; GO:0006429 | inferred from sequence similarity with Swiss-Prot:Q15031 CEL|mitochondrial matrix ; GO:0005759 | inferred from sequence similarity with Swiss-Prot:Q15031 GPD|mitochondrial leucyl-tRNA ligase } ALESR { ASYM|Aats-leu+ ID|FBal0097813 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027084 CLA 1 Gene NAM 1 Lysyl-tRNA synthetase GSYM 1 Aats-lys DT 1 14 Aug 03 RESZ 3584 PDOM 6 INTERPRO:IPR002106 == Aminoacyl-transfer RNA synthetases class-II PTD 1 DBA 14 HG 4 CRILO 'LYSYL-TRNA SYNTHETASE (LYSINE--TRNA LIGASE) (LYSRS)' SWP:P37879 FNC 2 lysyl-tRNA aminoacylation CLOC 1 8F1 ALESR 1 REF 8 GSYM|Aats-lys PTD DT|14 Aug 03 ID|FBgn0027084 UAB|Deficiency: Df(1)C52 (inferred from cytology) |Duplication: Dp(1;1)J37.6 (inferred from cytology) SYN|CG12141 |KRS |LysRS |Lysyl-tRNA synthetase ID2|FBgn0030143 KLOC|11249 CLOC|8F1 |Limits computationally determined from genome sequence between EP(X)0912 and EP(X)0950/EP(X)1179 FNC|lysyl-tRNA aminoacylation ; GO:0006430 | inferred from sequence similarity with SGD_LOCUS:KRS1; SGD:S0002444 |lysyl-tRNA aminoacylation ; GO:0006430 | non-traceable author statement PDOM|IPR002106 == Aminoacyl-transfer RNA synthetases class-II |IPR002309 == tRNA synthetases, class II (D, K and N) |IPR002312 == Aspartyl-tRNA synthetase |IPR002313 == Lysyl-tRNA synthetase, class-2 |SCOP:50249 == Nucleic acid-binding proteins; CG12141|FBgn0030143|pp-CT7914|FBan0012141 |SCOP:55681 == Class II aaRS and biotin synthetases; CG12141|FBgn0030143|pp-CT7914|FBan0012141 NAM|Lysyl-tRNA synthetase ENZ|lysine-tRNA ligase activity ; GO:0004824 ; EC:6.1.1.6 | inferred from sequence similarity with SGD_LOCUS:KRS1; SGD:S0002444 |lysine-tRNA ligase activity ; GO:0004824 ; EC:6.1.1.6 | non-traceable author statement DBA|NA:AA439197 |BDGP:LD13687 |NA:AA817561 |BDGP-DGC:LD23509 |NA:AE003447 |PA:AAF46510 |PA:AAN09255 |NA:AI516192 |BDGP:LD41976.5prime |NA:AY089547 |PA:AAL90285 |BDGP-DGC:LD23509 |NA:BG638364 |BDGP-DGC:LD23509 PAC|SPTREMBL:Q8SXM8 |SPTREMBL:Q9W327 HG|species == CRILO; gene == 'LYSYL-TRNA SYNTHETASE (LYSINE--TRNA LIGASE) (LYSRS)'; SWP:P37879; gi:586059; score == 758; expect == 0 |species == Caenorhabditis elegans; gene == T02G5.9; WP:CE04861; score == 669; expect == 0 |species == Homo sapiens; OMIM:601421; score == 758; expect == 0 |species == Saccharomyces cerevisiae; gene == KRS1; SGDID:L0000919; score == 646; expect == 0 ASQ|FBan0012141 REF { REFM|FBrf0104946 |FlyBase |1996- |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0126651 |Ashburner |1999.11 |9 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0135180 |Tolkunova et al. |2000 |0 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AM|Source for merge of: Aats-lys CG12141 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|lysine-tRNA ligase activity ; GO:0004824 ; EC:6.1.1.6 | inferred from sequence similarity with SGD_LOCUS:KRS1; SGD:S0002444 |lysine-tRNA ligase activity ; GO:0004824 ; EC:6.1.1.6 | non-traceable author statement FNC|lysyl-tRNA aminoacylation ; GO:0006430 | inferred from sequence similarity with SGD_LOCUS:KRS1; SGD:S0002444 |lysyl-tRNA aminoacylation ; GO:0006430 | non-traceable author statement GPD|lysyl-tRNA ligase |leucine-tRNA ligase-like |lysine-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Lysyl-tRNA synthetase SYN|KRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: LD13687 SYN|LysRS } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD23509 (BDGP-DGC) } REFDSR { RDID|FBrf0135180 |Tolkunova et al. |2000 MD|Identified with: LD41976.5prime } ALESR { ASYM|Aats-lys+ ID|FBal0097812 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027083 CLA 1 Gene NAM 1 Methionyl-tRNA synthetase GSYM 1 Aats-met DT 1 14 Aug 03 RESZ 3477 PDOM 3 INTERPRO:IPR002300 == t-RNA synthetase, class Ia PTD 1 DBA 11 HG 4 Homo sapiens 'methionine-tRNA synthetase' gi:4826826 FNC 1 methionyl-tRNA aminoacylation CEL 1 mitochondrion CLOC 1 88B1 ALESR 1 REF 8 GSYM|Aats-met PTD DT|14 Aug 03 ID|FBgn0027083 UAB|Deficiency: Df(3R)red3l (inferred from cytology) |Duplication: Dp(3;2)ry+ (inferred from cytology) SYN|CG31322 |CG8684 |CG9612 |MRS |MetRS |Methionyl-tRNA synthetase ID2|FBgn0038215 |FBgn0038216 |FBgn0051322 KLOC|112556 CLOC|88B1 |Limits computationally determined from genome sequence between l(3)01949 and l(3)j14A6/l(3)00347 FNC|methionyl-tRNA aminoacylation ; GO:0006431 | non-traceable author statement CEL|mitochondrion ; GO:0005739 | inferred from sequence similarity with SGD_LOCUS:MSM1; SGD:S0003403 PDOM|IPR002300 == t-RNA synthetase, class Ia |IPR002304 == Methionyl-tRNA synthetase |SCOP:52374 == Nucleotidylyl transferase; CG8684|FBgn0038216|pp-CT25078|FBan0008684 NAM|Methionyl-tRNA synthetase ENZ|methionine-tRNA ligase activity ; GO:0004825 ; EC:6.1.1.10 | inferred from sequence similarity with SGD_LOCUS:MSM1; SGD:S0003403 |methionine-tRNA ligase activity ; GO:0004825 ; EC:6.1.1.10 | non-traceable author statement DBA|NA:AA264047 |BDGP:LD07463 |NA:AE003703 |PA:AAF55037 |NA:AI135893 |BDGP-DGC:GH13807 |NA:AI513270 |BDGP-DGC:GH13807 |NA:AY069128 |PA:AAL39273 |BDGP-DGC:GH13807 PAC|SPTREMBL:Q9VFL5 HG|species == Homo sapiens; gene == 'methionine-tRNA synthetase'; gi:4826826; score == 75.7; expect == 6.e-13 |species == Mycobacterium tuberculosis; TUBERCULIST:Rv1007c; score == 65.2; expect == 6.e-10 |species == Saccharomyces cerevisiae; gene == MSM1; SGDID:L0001196; score == 256; expect == 2.e-67 |species == unknown; gene == 'SPAC27E2.06c, putative methionyl-trna synthetase, le n:539aa, si'; EMBL:Z98978; protein_id:CAB11680.1; gi:2388946; score == 324; expect == 7.e-88 ASQ|FBan0031322 REF { REFM|FBrf0104946 |FlyBase |1996- |9 REFM|FBrf0126677 |Ketchum |1999.11 |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0148886 |FlyBase Genome Annotators |2002- |9 REFM|FBrf0126664 |Find Enzymes |1999.11 |9 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AM|Source for merge of: Aats-met CG31322 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|methionine-tRNA ligase activity ; GO:0004825 ; EC:6.1.1.10 | inferred from sequence similarity with SGD_LOCUS:MSM1; SGD:S0003403 |methionine-tRNA ligase activity ; GO:0004825 ; EC:6.1.1.10 | non-traceable author statement FNC|methionyl-tRNA aminoacylation ; GO:0006431 | non-traceable author statement CEL|mitochondrion ; GO:0005739 | inferred from sequence similarity with SGD_LOCUS:MSM1; SGD:S0003403 GPD|methionyl-tRNA ligase |methionyl-tRNA ligase, mitochondrial } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Methionyl-tRNA synthetase SYN|MRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: LD07463 SYN|MetRS } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH13807 (BDGP-DGC) } REFDSR { RDID|FBrf0148886 |FlyBase Genome Annotators |2002- AM|Annotations CG8684, CG9612 merged as CG31322 in release 3 of the genome annotation. } ALESR { ASYM|Aats-met+ ID|FBal0097811 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0020766 CLA 1 Gene NAM 1 Phenylalanyl-tRNA synthetase GSYM 1 Aats-phe DT 1 14 Aug 03 RESZ 3495 PDOM 4 INTERPRO:IPR002106 == Aminoacyl-transfer RNA synthetases class-II PTD 1 DBA 15 HG 2 Homo sapiens 'phenylalanine-tRNA synthetase' EMBL:AF097441 FNC 1 phenylalanyl-tRNA aminoacylation CLOC 1 50C20 ALESR 1 REF 9 GSYM|Aats-phe PTD ARGS DT|14 Aug 03 ID|FBgn0020766 UAB|Deficiency: Df(2R)CX1 (inferred from cytology) |Duplication: Dp(2;2)SMG45 (inferred from cytology) SYN|CG13348 |Pts |FRS |PheRS |Phenylalanyl-tRNA synthetase KLOC|62995 CLOC|50C20 |Limits computationally determined from genome sequence between l(2)k15819/l(2)04615 and l(2)k05821 FNC|phenylalanyl-tRNA aminoacylation ; GO:0006432 | inferred from sequence similarity with EMBL:J02691 PDOM|IPR002106 == Aminoacyl-transfer RNA synthetases class-II |IPR002319 == Phenylalanyl-tRNA synthetase |SCOP:54991 == Anticodon-binding domain of PheRS; Aats-phe|FBgn0020766|pp-CT32669|FBan0013348 |SCOP:55681 == Class II aaRS and biotin synthetases; Aats-phe|FBgn0020766|pp-CT32669|FBan0013348 NAM|Phenylalanyl-tRNA synthetase ENZ|phenylalanine-tRNA ligase activity ; GO:0004826 ; EC:6.1.1.20 | non-traceable author statement |phenylalanine-tRNA ligase activity ; GO:0004826 ; EC:6.1.1.20 | inferred from sequence similarity with EMBL:J02691 DBA|NA:AA246340 |BDGP:LD05193 |NA:AA942007 |BDGP-DGC:LD27389 |NA:AC007851 |BDGP:BACR06M19 |NA:AE003816 |PA:AAF58310 |NA:AF012089 |PA:AAB65750 |NA:AW942755 |BDGP-DGC:LD27389 |NA:AY058580 |PA:AAL13809 |BDGP-DGC:LD27389 PAC|SPTREMBL:O16129 HG|species == Homo sapiens; gene == 'phenylalanine-tRNA synthetase'; EMBL:AF097441; gi:3983103; score == 450; expect == 1.e-125 |species == Saccharomyces cerevisiae; gene == 'mitochondrial phenylalanyl-tRNA synthetase &agr; subunit precursor'; EMBL:J02691; gi:171998; score == 311; expect == 8.e-84 ASQ|FBan0013348 REF { REFM|FBrf0102931 |Gray et al. |1998 |0 REFM|FBrf0091064 |Gray et al. |1996 |0 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0115421 |Gray |1997.6.30 |9 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0126695 |Wang |1999.11 |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0102931 |Gray et al. |1998 NAM|Phenylalanyl-tRNA synthetase MD|Gene order: In direction of increasing cytology: Cp1+ Aats-phe+ SYN|Pts } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|phenylalanine-tRNA ligase activity ; GO:0004826 ; EC:6.1.1.20 | inferred from sequence similarity with EMBL:J02691 FNC|phenylalanyl-tRNA aminoacylation ; GO:0006432 | inferred from sequence similarity with EMBL:J02691 MD|Maps to clone: BACR06M19 GPD|phenylalanyl-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 SYN|FRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: LD05193 SYN|PheRS } REFDSR { RDID|FBrf0115421 |Gray |1997.6.30 ENZ|phenylalanine-tRNA ligase activity ; GO:0004826 ; EC:6.1.1.20 | non-traceable author statement MD|Gene order: Overall orientation not stated: Cp1+ Aats-phe+ SYN|unnamed } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD27389 (BDGP-DGC) } ALESR { ASYM|Aats-phe+ ID|FBal0079719 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0028548 CLA 1 Gene NAM 1 mitochondrial phenylalanyl-tRNA synthetase GSYM 1 Aats-phe-m DT 1 14 Aug 03 RESZ 1101 FNC 1 phenylalanyl-tRNA aminoacylation CEL 1 mitochondrion ALESR 1 REF 2 GSYM|Aats-phe-m DT|14 Aug 03 ID|FBgn0028548 SYN|mtPheRS |mitochondrial phenylalanyl-tRNA synthetase ID2|FBgn0027628 FNC|phenylalanyl-tRNA aminoacylation ; GO:0006432 | non-traceable author statement CEL|mitochondrion ; GO:0005739 | non-traceable author statement NAM|mitochondrial phenylalanyl-tRNA synthetase ENZ|phenylalanine-tRNA ligase activity ; GO:0004826 ; EC:6.1.1.20 | non-traceable author statement REF { REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0108640 |Bullard et al. |1999 |0 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|phenylalanine-tRNA ligase activity ; GO:0004826 ; EC:6.1.1.20 | non-traceable author statement FNC|phenylalanyl-tRNA aminoacylation ; GO:0006432 | non-traceable author statement CEL|mitochondrion ; GO:0005739 | non-traceable author statement GPD|mitochondrial phenylalanyl-tRNA ligase } REFDSR { RDID|FBrf0108640 |Bullard et al. |1999 NAM|mitochondrial phenylalanyl-tRNA synthetase SYN|mtPheRS } ALESR { ASYM|Aats-phe-m+ ID|FBal0101095 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027082 CLA 1 Gene NAM 1 Prolyl-tRNA synthetase GSYM 1 Aats-pro DT 1 14 Aug 03 RESZ 3174 PDOM 4 INTERPRO:IPR002106 == Aminoacyl-transfer RNA synthetases class-II PTD 1 DBA 8 HG 3 Aquifex aeolicus 'proline-tRNA synthetase' EMBL:AE000686 FNC 2 prolyl-tRNA aminoacylation CLOC 1 62E8 ALESR 1 REF 6 GSYM|Aats-pro PTD DT|14 Aug 03 ID|FBgn0027082 UAB|Deficiency: Df(3L)Mg27 (inferred from cytology) |Duplication: Dp(3;3)SMG38 (inferred from cytology) SYN|CG12186 |PRS |ProRS |Prolyl-tRNA synthetase ID2|FBgn0035361 KLOC|80524 CLOC|62E8 |Limits computationally determined from genome sequence between l(3)06911/l(3)03349 and l(3)06803 FNC|prolyl-tRNA aminoacylation ; GO:0006433 | inferred from sequence similarity with Swiss-Prot:P39965 |prolyl-tRNA aminoacylation ; GO:0006433 | non-traceable author statement PDOM|IPR002106 == Aminoacyl-transfer RNA synthetases class-II |IPR002316 == Prolyl-tRNA synthetase |SCOP:52954 == Anticodon-binding domain of Class II aaRS; CG12186|FBgn0035361|pp-CT9455|FBan0012186 |SCOP:55681 == Class II aaRS and biotin synthetases; CG12186|FBgn0035361|pp-CT9455|FBan0012186 NAM|Prolyl-tRNA synthetase ENZ|proline-tRNA ligase activity ; GO:0004827 ; EC:6.1.1.15 | inferred from sequence similarity with Swiss-Prot:P39965 |proline-tRNA ligase activity ; GO:0004827 ; EC:6.1.1.15 | non-traceable author statement DBA|NA:AA801905 |BDGP-DGC:GM03563 |NA:AE003475 |PA:AAF47674 |NA:BG633610 |BDGP-DGC:GM03563 |NA:BT003289 |PA:AAO25049 PAC|SPTREMBL:Q9VZY9 HG|species == Aquifex aeolicus; gene == 'proline-tRNA synthetase'; EMBL:AE000686; gi:2983039; score == 290; expect == 6.e-46 |species == Caenorhabditis elegans; gene == 'similar to tRNA synthetases class II (Gly, His, Pro and Ser); cDNA'; EMBL:Z82060; protein_id:CAB04884; gi:3880329; score == 265; expect == 6.e-70 |species == Saccharomyces cerevisiae; gene == 'PROBABLE PROLYL-TRNA SYNTHETASE, CYTOPLASMIC (PROLINE--TRNA LIGASE) ('; SWP:P39965; gi:731489; score == 256; expect == 1.e-36 ASQ|FBan0012186 REF { REFM|FBrf0104946 |FlyBase |1996- |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0126704 |Zhu |1999.11 |9 } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AM|Source for merge of: Aats-pro CG12186 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|proline-tRNA ligase activity ; GO:0004827 ; EC:6.1.1.15 | inferred from sequence similarity with Swiss-Prot:P39965 |proline-tRNA ligase activity ; GO:0004827 ; EC:6.1.1.15 | non-traceable author statement FNC|prolyl-tRNA aminoacylation ; GO:0006433 | inferred from sequence similarity with Swiss-Prot:P39965 |prolyl-tRNA aminoacylation ; GO:0006433 | non-traceable author statement GPD|prolyl-tRNA ligase-like } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Prolyl-tRNA synthetase SYN|PRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: GM03563 SYN|ProRS } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GM03563 (BDGP-DGC) |Identified with: AT04665 (BDGP-DGC) } ALESR { ASYM|Aats-pro+ ID|FBal0097810 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0021750 CLA 1 Gene NAM 1 Seryl-tRNA synthetase GSYM 1 Aats-ser DT 1 14 Aug 03 RESZ 3433 PDOM 3 INTERPRO:IPR002314 == tRNA synthetases, class-II (G, H, P and S) PTD 1 DBA 11 HG 4 Caenorhabditis elegans 'Seryl-tRNA synthetase' EMBL:AB016796 FNC 1 seryl-tRNA aminoacylation CLOC 1 88F1 ALESR 1 REF 9 GSYM|Aats-ser PTD DT|14 Aug 03 ID|FBgn0021750 UAB|Duplication: Dp(3;3)C123.3 (inferred from cytology) SYN|CG4938 |SRS |seryl-tRNA synthetase |SerRS |Aat-Ser |Seryl-tRNA synthetase KLOC|113583 CLOC|88F1 |Limits computationally determined from genome sequence between l(3)j6A3 and l(3)06536 FNC|seryl-tRNA aminoacylation ; GO:0006434 | inferred from sequence similarity with Swiss-Prot:P38705 PDOM|IPR002314 == tRNA synthetases, class-II (G, H, P and S) |IPR002317 == Seryl-tRNA synthetase |SCOP:55681 == Class II aaRS and biotin synthetases; Aats-ser|FBgn0021750|pp-CT15862|FBan0004938 NAM|Seryl-tRNA synthetase ENZ|serine-tRNA ligase activity ; GO:0004828 ; EC:6.1.1.11 | inferred from sequence similarity with Swiss-Prot:P38705 DBA|NA:AA697311 |BDGP:HL02233 |NA:AE003708 |PA:AAF55175 |NA:AY119252 |PA:AAM51112 |BDGP-DGC:SD21818 |NA:BI639269 |BDGP-DGC:SD21818 |NA:Y14823 |PA:CAA75101 PAC|SPTREMBL:O18406 |SPTREMBL:Q9VF85 HG|species == Caenorhabditis elegans; gene == 'Seryl-tRNA synthetase'; EMBL:AB016796; protein_id:BAA74732; gi:4239885; score == 224; expect == 1.e-57 |species == Homo sapiens; gene == 'SERYL-TRNA SYNTHETASE (SERINE--TRNA LIGASE) (SERRS)'; SWP:P49591; gi:1351173; score == 150; expect == 2.e-35 |species == Saccharomyces cerevisiae; gene == 'PUTATIVE SERYL-TRNA SYNTHETASE YHR011W (SERINE--TRNA LIGASE) (SERRS)'; SWP:P38705; gi:731635; score == 220; expect == 1.e-56 |species == Zea mays; gene == 'seryl-tRNA synthetase'; EMBL:Y13053; protein_id:CAA73496; gi:3355717; score == 263; expect == 2.e-69 ASQ|FBan0004938 REF { REFM|FBrf0090406 |Armes and Fried |1996 |0 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0147056 |Zraly et al. |2002 |0 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0109182 |Zhou et al. |1999 |0 REFM|FBrf0115072 |Fried |1997.9.15 |9 REFM|FBrf0105495 |FlyBase |1992- |9 } REFDSR { RDID|FBrf0090406 |Armes and Fried |1996 NAM|Seryl-tRNA synthetase MD|Gene order: Overall orientation not stated: Surf4+ Aats-ser- } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|serine-tRNA ligase activity ; GO:0004828 ; EC:6.1.1.11 | inferred from sequence similarity with Swiss-Prot:P38705 FNC|seryl-tRNA aminoacylation ; GO:0006434 | inferred from sequence similarity with Swiss-Prot:P38705 GPD|seryl-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 SYN|SRS } REFDSR { RDID|FBrf0109182 |Zhou et al. |1999 SYN|seryl-tRNA synthetase } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: HL02233 SYN|SerRS } REFDSR { RDID|FBrf0115072 |Fried |1997.9.15 SYN|unnamed } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: SD21818 (BDGP-DGC) } REFDSR { RDID|FBrf0147056 |Zraly et al. |2002 SYN|Aat-Ser } ALESR { ASYM|Aats-ser+ ID|FBal0080602 CLA|wild-type generic REF|FBrf0105495 } } # EOR GENR { RETE|ID 1 FBgn0027081 CLA 1 Gene NAM 1 Threonyl-tRNA synthetase GSYM 1 Aats-thr DT 1 14 Aug 03 RESZ 8151 PDOM 11 INTERPRO:IPR002106 == Aminoacyl-transfer RNA synthetases class-II PTD 1 DBA 26 HG 4 Caenorhabditis elegans C47D12.6 WP:CE05434 FNC 1 threonyl-tRNA aminoacylation CLOC 1 33C4 ALESR 3 SK 1 REF 12 GSYM|Aats-thr PTD DT|14 Aug 03 ID|FBgn0027081 UAB|Deficiency: Df(2L)prd1.7 |Deficiency: Df(2L)esc-P3-0 (inferred from cytology) |Duplication: Dp(2;2)GYL (inferred from cytology) SYN|CG5353 |l(2)k04203 |42/3 |TRS |ThrRS |threonyl-tRNA synthetase |P539 |Threonyl-tRNA synthetase ID2|FBgn0022209 |FBgn0032411 KLOC|42055 CLOC|33C4 |Limits computationally determined from genome sequence between EP(2)1187 and l(2)k04203 CYC|Experimentally determined: 33C--D, 33C1--2, 33C4--5 FNC|threonyl-tRNA aminoacylation ; GO:0006435 | inferred from sequence similarity with SGD_LOCUS:THS1; SGD:S0001340 PDOM|IPR002106 == Aminoacyl-transfer RNA synthetases class-II |IPR002314 == tRNA synthetases, class-II (G, H, P and S) |IPR002320 == Threonyl-tRNA synthetase |SCOP:52954 == Anticodon-binding domain of Class II aaRS; Aats-thr|FBgn0027081|pp-CT16980|FBan0005353 |SCOP:52954 == Anticodon-binding domain of Class II aaRS; Aats-thr|FBgn0027081|pp-CT37701|FBan0005353 |SCOP:55174 == Alpha-L RNA-binding motif; Aats-thr|FBgn0027081|pp-CT16980|FBan0005353 |SCOP:55174 == Alpha-L RNA-binding motif; Aats-thr|FBgn0027081|pp-CT37701|FBan0005353 |SCOP:55186 == Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Aats-thr|FBgn0027081|pp-CT16980|FBan0005353 |SCOP:55186 == Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Aats-thr|FBgn0027081|pp-CT37701|FBan0005353 |SCOP:55681 == Class II aaRS and biotin synthetases; Aats-thr|FBgn0027081|pp-CT16980|FBan0005353 |SCOP:55681 == Class II aaRS and biotin synthetases; Aats-thr|FBgn0027081|pp-CT37701|FBan0005353 NAM|Threonyl-tRNA synthetase ENZ|threonine-tRNA ligase activity ; GO:0004829 ; EC:6.1.1.3 | inferred from sequence similarity |threonine-tRNA ligase activity ; GO:0004829 ; EC:6.1.1.3 | inferred from sequence similarity with SGD_LOCUS:THS1; SGD:S0001340 DBA|NA:AA247052 |BDGP:LD06190 |NA:AA803371 |BDGP:GM10740 |NA:AE003635 |PA:AAF53166 |PA:AAF53167 |PA:AAN10805 |NA:AF163012 |NA:AF163013 |NA:AF163014 |NA:AI388958 |BDGP-DGC:GH20022 |NA:AQ034143 |BDGP:Dm4251 |BDGP:l(2)k04203 |NA:AW940761 |BDGP-DGC:GH20022 |NA:AY119534 |PA:AAM50188 |BDGP-DGC:GH20022 |NA:BI624036 |BDGP-DGC:RH56418 |NA:BT001848 |PA:AAN71609 |BDGP-DGC:RH56418 PAC|SPTREMBL:Q8IGC5 |SPTREMBL:Q8IP94 |SPTREMBL:Q8MRL7 |SPTREMBL:Q9VKB0 HG|species == Caenorhabditis elegans; gene == C47D12.6; WP:CE05434; score == 902; expect == 0 |species == Homo sapiens; gene == 'threonyl-tRNA synthetase'; gi:4507367; score == 1011; expect == 0 |species == Saccharomyces cerevisiae; gene == THS1; SGDID:L0002301; score == 786; expect == 0 |species == Schizosaccharomyces pombe; gene == 'THREONYL-TRNA SYNTHETASE, CYTOPLASMIC (THREONINE--TRNA LIGASE) (THRR'; SWP:P87144; gi:3183175; score == 784; expect == 0 ASQ|FBan0005353 REF { REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0125032 |Beaton |1999.12.12 |9 REFM|FBrf0100624 |Roch et al. |1998 |0 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0111948 |Liebl |1999 |0 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0129569 |Misra |2000.8.9 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0111465 |Purcell and Artavanis-Tsakonas |1999 |0 REFM|FBrf0126664 |Find Enzymes |1999.11 |9 } REFDSR { RDID|1569194864 |Purcell |1999.10.6 CLOC|33C--D MD|Maps to clone: DS00299 CLOC|33C--D |33C--D } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|33C1--2 |33C4--5 CYC|Location 33C1--2 inferred from insertion in: Aats-thrk04910 |Location 33C4--5 inferred from insertion in: Aats-thrk04203 BMD|Df(2L)Prl BMD|Df(2L)prd1.7 BMDD|Df(2L)prd1.7 SYN|l(2)k04203 } REFDSR { RDID|FBrf0100624 |Roch et al. |1998 PHP|Mutants isolated in a screen of the second chromosome identifying genes |affecting disc morphology. SYN|42/3 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|threonine-tRNA ligase activity ; GO:0004829 ; EC:6.1.1.3 | inferred from sequence similarity with SGD_LOCUS:THS1; SGD:S0001340 FNC|threonyl-tRNA aminoacylation ; GO:0006435 | inferred from sequence similarity with SGD_LOCUS:THS1; SGD:S0001340 GPD|threonine-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Threonyl-tRNA synthetase SYN|TRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: LD06190 SYN|ThrRS } REFDSR { RDID|FBrf0111465 |Purcell and Artavanis-Tsakonas |1999 MD|Gene order: In direction of increasing cytology: Patsas- Aats-thr+ Rab6- Phae1+ Phae2+ SYN|threonyl-tRNA synthetase } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 ENZ|threonine-tRNA ligase activity ; GO:0004829 ; EC:6.1.1.3 | inferred from sequence similarity CLOC|33C4--5 (determined by in situ hybridization) MD|Identified with: Dm4251 |Identified with: GM10740 AM|Source for merge of: Aats-thr l(2)k04203 GPD|threonyl-tRNA ligase BMD|Df(2L)Prl BMD|Df(2L)prd1.7 } REFDSR { RDID|FBrf0111948 |Liebl |1999 MD|Identified with: GH20022 SYN|P539 |l(2)k04203 } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: GH20022 (BDGP-DGC) |Identified with: RH56418 (BDGP-DGC) } REFDSR { RDID|FBrf0129569 |Misra |2000.8.9 AM|Source for merge of: Aats-thr CG5353 } ALESR { ASYM|Aats-thrk04203 SYN|l(2)k04203k04203 |42/3 |l(2)k04203 ID|FBal0064544 REF|FBrf0067338 |FBrf0125032 |FBrf0111948 |FBrf0100624 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 AFC|Aats-thrk04910 DIS|I. Kiss. OTH|Complements: @Rab608323@. |Complements: @Rab6k13606@. TRN|FBti0006849 == P{lacW}Aats-thrk04203 |BDGP:l(2)k04203 MU|P-element activity SYN|l(2)k04203k04203 } REFDSR { RDID|FBrf0100624 |Roch et al. |1998 TRN|FBti0006849 == P{lacW}Aats-thrk04203 |BDGP:l(2)k04203 MU|P-element activity PHC|lethal | recessive PHI|Lethality occurs during third instar larval or pupal stages. Mutants |do not show any visible disc abnormalities. SYN|42/3 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0006849 == P{lacW}Aats-thrk04203 |BDGP:l(2)k04203 PHC|lethal | recessive SYN|l(2)k04203 } REFDSR { RDID|FBrf0111948 |Liebl |1999 TRN|FBti0006849 == P{lacW}Aats-thrk04203 |BDGP:l(2)k04203 SYN|l(2)k04203 } SK|FBstBL-10539 |y[1] w[67c23]; P{w[+mC]=lacW}Aats-thr[k04203]/CyO } ALESR { ASYM|Aats-thrk04910 SYN|l(2)k04203k04910 |l(2)k04910 ID|FBal0064543 REF|FBrf0067338 |FBrf0125032 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 AFC|Aats-thrk04203 DIS|I. Kiss. OTH|Complements: @l(2)0181001810@. |Complements: @bunrI043@. TRN|FBti0006848 == P{lacW}Aats-thrk04910 |BDGP:l(2)k04910 MU|P-element activity PHC|lethal | recessive SYN|l(2)k04203k04910 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0006848 == P{lacW}Aats-thrk04910 |BDGP:l(2)k04910 PHC|lethal | recessive SYN|l(2)k04910 } } ALESR { ASYM|Aats-thr+ ID|FBal0097809 CLA|wild-type generic } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0010803 CLA 1 Gene NAM 1 Tryptophanyl-tRNA synthetase GSYM 1 Aats-trp DT 1 14 Aug 03 RESZ 19214 PDOM 7 INTERPRO:IPR001412 == Aminoacyl-transfer RNA synthetases class-I PTD 1 DBA 25 HG 4 Homo sapiens species == Homo sapiens; ; score == 514.6; expect == 1.e-138 OMIM:191050 FNC 1 tryptophanyl-tRNA aminoacylation CLOC 1 85D7 ALESR 16 SK 1 REF 19 GSYM|Aats-trp PTD DT|14 Aug 03 ID|FBgn0010803 UAB|Deficiency: Df(3R)by10 |Duplication: Dp(3;3)M86D+2 (inferred from cytology) SYN|CG9735 |l(3)3559 |85D-WRS |TrpRS |WRS-85D |WRS |l(3)03559 |l(3)03560 ID2|FBgn0037673 NAM|Tryptophanyl-tRNA synthetase KLOC|107709 CLOC|85D7 |Limits computationally determined from genome sequence between EP(3)0473 and l(3)03559 CYC|Experimentally determined: 85D, 85D7--8 FNC|tryptophanyl-tRNA aminoacylation ; GO:0006436 | inferred from sequence similarity with SGD_LOCUS:WRS1; SGD:S0005457 PDOM|IPR001412 == Aminoacyl-transfer RNA synthetases class-I |IPR002305 == t-RNA synthetase, class Ib |IPR002306 == Tryptophanyl-tRNA synthetase |SCOP:51735 == NAD(P)-binding Rossmann-fold domains; Aats-trp|FBgn0010803|pp-CT27510|FBan0009735 |SCOP:51735 == NAD(P)-binding Rossmann-fold domains; Aats-trp|FBgn0010803|pp-CT42817|FBan0009735 |SCOP:52374 == Nucleotidylyl transferase; Aats-trp|FBgn0010803|pp-CT27510|FBan0009735 |SCOP:52374 == Nucleotidylyl transferase; Aats-trp|FBgn0010803|pp-CT42817|FBan0009735 ENZ|tryptophan-tRNA ligase activity ; GO:0004830 ; EC:6.1.1.2 | inferred from sequence similarity with SGD_LOCUS:WRS1; SGD:S0005457 DBA|NA:AA820699 |BDGP:LD24552 |NA:AE003682 |PA:AAF54352 |PA:AAG22136 |NA:AF125156 |PA:AAF20166 |NA:AF125157 |PA:AAF20167 |NA:AI106951 |BDGP:GH06221 |NA:AI455498 |BDGP:LD24552 |NA:AI543251 |BDGP:SD09954.5prime |NA:AI946287 |NEST:bs23a12.y1 |NA:AY075249 |PA:AAL68116 |BDGP-DGC:AT21437 |NA:BF486891 |BDGP-DGC:AT21437 |NA:G00589 |BDGP:Dm0314 |BDGP:l(3)03559 PAC|SPTREMBL:Q9U4Y0 |SPTREMBL:Q9U4Y1 |SPTREMBL:Q9VHG2 HG|species == Homo sapiens; OMIM:191050; score == 514.6; expect == 1.e-138 |species == Mus musculus; gene == Wars; MGI:104630; score == 470; expect == 1.e-131 |species == Oryctolagus cuniculus; gene == 'TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS)'; SWP:P23612; gi:2851538; score == 510.8; expect == 1.e-137 |species == Saccharomyces cerevisiae; gene == WRS1; SGDID:L0003253; score == 401; expect == 1.e-111 ASQ|FBan0009735 REF { REFM|FBrf0126988 |Andrew et al. |2000 |2 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0101707 |Seshaiah and Andrew |1998 |1 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0125032 |Beaton |1999.12.12 |9 REFM|FBrf0124915 |Seshaiah |1999.1.29 |9 REFM|FBrf0107310 |Stitzinger et al. |1999 |0 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0137492 |Oliver |2001.8.16 |9 REFM|FBrf0092242 |Seshaiah et al. |1997 |1 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0129568 |Bayraktaroglu |2000.8.7 |9 REFM|FBrf0085920 |Seshaiah et al. |1996 |1 REFM|FBrf0083714 |Meister and Braun |1995.10 |9 REFM|FBrf0126664 |Find Enzymes |1999.11 |9 REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0126862 |Kramer |2000.3.5 |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|85D7--8 LOI|Aats-trp03559 |Aats-trp04410 MD|Identified with: Dm0314 BMD|Df(3R)by10 BMDD|Df(3R)by10 BMDD|Df(3R)by62 BMDD|Tp(3;2)by62 } REFDSR { RDID|FBrf0085920 |Seshaiah et al. |1996 CLOC|85D OTH|"l(3)N33" (FBrf0079029) may be an allele. SYN|l(3)3559 } REFDSR { RDID|FBrf0092242 |Seshaiah et al. |1997 SYN|85D-WRS } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|tryptophan-tRNA ligase activity ; GO:0004830 ; EC:6.1.1.2 | inferred from sequence similarity with SGD_LOCUS:WRS1; SGD:S0005457 FNC|tryptophanyl-tRNA aminoacylation ; GO:0006436 | inferred from sequence similarity with SGD_LOCUS:WRS1; SGD:S0005457 GPD|tryptophanyl-tRNA ligase } REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 WTI|Sxl (data from @Aats-trp03559@, @Aats-trp4420@, @Aats-trpP-28B@, @Aats-trpP-74@) |snf (data from @Aats-trp03559@, @Aats-trp4420@, @Aats-trpP-28B@, @Aats-trpP-74@) SYN|TrpRS } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 CLOC|85D7--8 (determined by in situ hybridization) MD|Identified with: LD24552 |Identified with: GH06221 SYN|WRS-85D } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: GH06221 |Identified with: LD24552 SYN|TrpRS } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 CLOC|85D7--8 (determined by in situ hybridization) MD|Identified with: Dm0314 |Identified with: LD24552 BMD|Df(3R)by10 BMDD|Df(3R)by62 } REFDSR { RDID|FBrf0124915 |Seshaiah |1999.1.29 CLOC|85D7--8 } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: AT21437 (BDGP-DGC) } REFDSR { RDID|FBrf0126862 |Kramer |2000.3.5 MD|Gene order: Overall orientation not stated: Aats-trp? Vps16? } REFDSR { RDID|FBrf0126988 |Andrew et al. |2000 SYN|WRS-85D } REFDSR { RDID|FBrf0129568 |Bayraktaroglu |2000.8.7 AM|Source for merge of: Aats-trp CG9735 } REFDSR { RDID|FBrf0137492 |Oliver |2001.8.16 MD|Identified with: bs23a12.y1 |Identified with: SD09954.5prime } ALESR { ASYM|Aats-trp3 SYN|WRS-85D3559exc35 ID|FBal0097441 PHC|lethal | recessive REF|FBrf0108275 REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 AMIS|Selected as: a fly that has lost the @ry@+ marker of the @P{PZ}@ |element present in @Aats-trp03559@. OTH|Excision of the @P{PZ}@ element. PRG|Aats-trp03559 PHC|lethal | recessive SYN|WRS-85D3559exc35 } } ALESR { ASYM|Aats-trp4 SYN|WRS-85D3559exc50 ID|FBal0097439 PHC|lethal | recessive REF|FBrf0108275 REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 AMIS|Selected as: a fly that has lost the @ry@+ marker of the @P{PZ}@ |element present in @Aats-trp03559@. OTH|Excision of the @P{PZ}@ element. PRG|Aats-trp03559 PHC|lethal | recessive SYN|WRS-85D3559exc50 } } ALESR { ASYM|Aats-trp5 SYN|WRS-85D3559exc74 ID|FBal0097438 PHC|lethal | recessive REF|FBrf0108275 REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 AMIS|Selected as: a fly that has lost the @ry@+ marker of the @P{PZ}@ |element present in @Aats-trp03559@. OTH|Excision of the @P{PZ}@ element. PRG|Aats-trp03559 PHC|lethal | recessive SYN|WRS-85D3559exc74 } } ALESR { ASYM|Aats-trp6 SYN|WRS-85D4410exc14 ID|FBal0097437 PHC|lethal | recessive REF|FBrf0108275 REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 AMIS|Selected as: a fly that has lost the @ry@+ marker of the @P{PZ}@ |element present in @Aats-trp04410@. OTH|Excision of the @P{PZ}@ element. PRG|Aats-trp04410 PHC|lethal | recessive SYN|WRS-85D4410exc14 } } ALESR { ASYM|Aats-trp7 SYN|WRS-85D4410exc18 ID|FBal0097436 PHC|lethal | recessive REF|FBrf0108275 REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 AMIS|Selected as: a fly that has lost the @ry@+ marker of the @P{PZ}@ |element present in @Aats-trp04410@. OTH|Excision of the @P{PZ}@ element. PRG|Aats-trp04410 PHC|lethal | recessive SYN|WRS-85D4410exc18 } } ALESR { ASYM|Aats-trp8 SYN|WRS-85D4410exc28B ID|FBal0097435 PHC|lethal | recessive REF|FBrf0108275 REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 AMIS|Selected as: a fly that has lost the @ry@+ marker of the @P{PZ}@ |element present in @Aats-trp04410@. OTH|Excision of the @P{PZ}@ element. PRG|Aats-trp04410 PHC|lethal | recessive SYN|WRS-85D4410exc28B } } ALESR { ASYM|Aats-trp9 SYN|WRS-85D4410exc41 ID|FBal0097434 PHC|lethal | recessive REF|FBrf0108275 REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 AMIS|Selected as: a fly that has lost the @ry@+ marker of the @P{PZ}@ |element present in @Aats-trp04410@. OTH|Excision of the @P{PZ}@ element. PRG|Aats-trp04410 PHC|lethal | recessive SYN|WRS-85D4410exc41 } } ALESR { ASYM|Aats-trp03559 SYN|l(3)3559 |l(3)0355903559 |l(3)3559P |WRS-85D1 |l(3)03559 ID|FBal0009473 DIS|A. Spradling. TRN|FBti0005478 == P{PZ}Aats-trp03559 |BDGP:l(3)03559 MU|P-element activity REF|FBrf0067338 |FBrf0125032 |FBrf0083714 |FBrf0101707 |FBrf0108275 |FBrf0092242 |FBrf0111489 |FBrf0107310 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 AFC|Aats-trp04410 OTH|Complements: @pum01688@. |Complements: @l(3)0172801728@. |Complements: @pum03203@. |Complements: @pum04338@. |Complements: @l(3)0483704837@. |Complements: @cpo05124@. |Complements: @l(3)0543005430@. |Complements: @Ras85D06677@. |Complements: @pum10625@. |Complements: @neurneo37@. TRN|FBti0005478 == P{PZ}Aats-trp03559 |BDGP:l(3)03559 } REFDSR { RDID|FBrf0092242 |Seshaiah et al. |1997 TRN|FBti0005478 == P{PZ}Aats-trp03559 |BDGP:l(3)03559 SYN|l(3)3559 } REFDSR { RDID|FBrf0101707 |Seshaiah and Andrew |1998 SYN|l(3)0355903559 |l(3)3559 } REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 TRN|FBti0005478 == P{PZ}Aats-trp03559 |BDGP:l(3)03559 GIC2|viable | reduced | female with @snfJ210@, @SxlfP7B0@ GIC|enhancer of @SxlfP7B0@, @snfJ210@ GII|The weak interaction between @SxlfP7B0@ and @snfJ210@ is enhanced |by @Aats-trp03559@; the viability of female @SxlfP7B0@/+ embryos |derived from mothers heterozygous for @snfJ210@ and @Aats-trp03559@ |is reduced. SYN|l(3)3559P } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 MD|Insertion of a @P{PZ}@ element 103bp upstream of the @Aats-trp@ open |reading frame. OTH|Loss of the @P{PZ}@ element can result in reversion of the lethality |of @Aats-trp03559@. TRN|FBti0005478 == P{PZ}Aats-trp03559 |BDGP:l(3)03559 PHC|lethal | recessive SYN|WRS-85D1 |l(3)03559 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0005478 == P{PZ}Aats-trp03559 |BDGP:l(3)03559 PHC|lethal | recessive SYN|l(3)03559 } SK|FBstBL-11595 |P{ry[+t7.2]=PZ}Aats-trp[03559] ry[506]/TM3, ry[RK] Sb[1] Ser[1] } ALESR { ASYM|Aats-trp04410 SYN|l(3)4410 |l(3)0355904410 |WRS-85D2 |l(3)04410 ID|FBal0043663 DIS|A. Spradling. TRN|FBti0006093 == P{PZ}Aats-trp04410 |BDGP:l(3)04410 MU|P-element activity REF|FBrf0067338 |FBrf0125032 |FBrf0101707 |FBrf0108275 |FBrf0085920 |FBrf0092242 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 AFC|Aats-trp03559 OTH|Complements: @pum01688@. |Complements: @Ras85D06677@. |Complements: @pum10625@. TRN|FBti0006093 == P{PZ}Aats-trp04410 |BDGP:l(3)04410 } REFDSR { RDID|FBrf0085920 |Seshaiah et al. |1996 SYN|l(3)4410 } REFDSR { RDID|FBrf0092242 |Seshaiah et al. |1997 TRN|FBti0006093 == P{PZ}Aats-trp04410 |BDGP:l(3)04410 SYN|l(3)4410 } REFDSR { RDID|FBrf0101707 |Seshaiah and Andrew |1998 SYN|l(3)0355904410 |l(3)4410 } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 MD|Insertion of a @P{PZ}@ element 103bp upstream of the @Aats-trp@ open |reading frame. OTH|Loss of the @P{PZ}@ element can result in reversion of the lethality |of @Aats-trp04410@. TRN|FBti0006093 == P{PZ}Aats-trp04410 |BDGP:l(3)04410 PHC|lethal | recessive SYN|WRS-85D2 |l(3)04410 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0006093 == P{PZ}Aats-trp04410 |BDGP:l(3)04410 PHC|lethal | recessive SYN|l(3)04410 } } ALESR { ASYM|Aats-trp4420 SYN|l(2)4420P ID|FBal0095901 REF|FBrf0107310 REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 TRN|FBti0015266 == P{}Aats-trp4420 GIC|enhancer of @SxlfP7B0@, @snfJ210@ GII|The weak interaction between @SxlfP7B0@ and @snfJ210@ is enhanced |by @Aats-trp4420@; the viability of female @SxlfP7B0@/+ embryos |derived from mothers heterozygous for @snfJ210@ and @Aats-trp4420@ |is reduced. GIC2|viable | reduced | female with @snfJ210@, @SxlfP7B0@ SYN|l(2)4420P } } ALESR { ASYM|Aats-trp3559exc25 SYN|WRS-85D3559exc25 ID|FBal0097442 PHC|viable REF|FBrf0108275 REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 AMIS|Selected as: a fly that has lost the @ry@+ marker of the @P{PZ}@ |element present in @Aats-trp03559@. OTH|Excision of the @P{PZ}@ element. PRG|Aats-trp03559 PHC|viable SYN|WRS-85D3559exc25 } } ALESR { ASYM|Aats-trp4410exc30 SYN|WRS-85D4410exc30 ID|FBal0097440 PHC|viable REF|FBrf0108275 REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 AMIS|Selected as: a fly that has lost the @ry@+ marker of the @P{PZ}@ |element present in @Aats-trp04410@. OTH|Excision of the @P{PZ}@ element. PRG|Aats-trp04410 PHC|viable SYN|WRS-85D4410exc30 } } ALESR { ASYM|Aats-trpP-74 SYN|l(3)3559P-74 ID|FBal0095899 REF|FBrf0107310 REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 MD|Imprecise excision of the @P{PZ}@ element. PRG|Aats-trp03559 GIC|enhancer of @SxlfP7B0@, @snfJ210@ GIC2|viable | reduced | female with @snfJ210@, @SxlfP7B0@ GII|The weak interaction between @SxlfP7B0@ and @snfJ210@ is enhanced |by @Aats-trpP-74@; the viability of female @SxlfP7B0@/+ embryos |derived from mothers heterozygous for @snfJ210@ and @Aats-trpP-74@ |is reduced. SYN|l(3)3559P-74 } } ALESR { ASYM|Aats-trpP-28B SYN|l(3)4420P-28B ID|FBal0095900 REF|FBrf0107310 REFDSR { RDID|FBrf0107310 |Stitzinger et al. |1999 MD|Imprecise excision of the @P-element@. PRG|Aats-trp4420 GIC|enhancer of @SxlfP7B0@, @snfJ210@ GIC2|viable | reduced | female with @snfJ210@, @SxlfP7B0@ GII|The weak interaction between @SxlfP7B0@ and @snfJ210@ is enhanced |by @Aats-trpP-28B@; the viability of female @SxlfP7B0@/+ embryos |derived from mothers heterozygous for @snfJ210@ and @Aats-trpP-28B@ |is reduced. SYN|l(3)4420P-28B } } ALESR { ASYM|Aats-trpunspecified ID|FBal0097433 PHC|lethal | recessive PHI|Phenotypic manifest in: egg | germ-line clone |Homozygous embryos show no overt defects in the salivary gland. Homozygous |larvae show no overt cuticle defects. The lethal phase of @Aats-trp@ |homozygotes is either during the larval stage or the larval-pupal transition, |depending on the mutant allele used. |Females carrying homozygous germline clones do not produce any eggs, |indicating that @Aats-trp@ is required during oogenesis. REF|FBrf0108275 REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 PHC|lethal | recessive PHI|Phenotypic manifest in: egg | germ-line clone |Homozygous embryos show no overt defects in the salivary gland. Homozygous |larvae show no overt cuticle defects. The lethal phase of @Aats-trp@ |homozygotes is either during the larval stage or the larval-pupal transition, |depending on the mutant allele used. |Females carrying homozygous germline clones do not produce any eggs, |indicating that @Aats-trp@ is required during oogenesis. } } ALESR { ASYM|Aats-trp+ ID|FBal0073277 CLA|wild-type generic REF|FBrf0105495 } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0027080 CLA 1 Gene NAM 1 Tyrosyl-tRNA synthetase GSYM 1 Aats-tyr DT 1 14 Aug 03 RESZ 3438 PDOM 5 INTERPRO:IPR002305 == t-RNA synthetase, class Ib PTD 1 DBA 12 HG 5 Bos taurus 'tyrosyl-tRNA synthetase EMBL:AF087021 FNC 1 tyrosyl-tRNA aminoacylation CLOC 1 72F1 ALESR 1 REF 8 GSYM|Aats-tyr PTD DT|14 Aug 03 ID|FBgn0027080 UAB|Deficiency: Df(3L)st-e4 (inferred from cytology) |Duplication: Dp(3;3)st+g18 (inferred from cytology) SYN|CG4561 |YRS |TyrRS |anon-EST:Posey261 |Tyrosyl-tRNA synthetase ID2|FBgn0025537 |FBgn0036630 KLOC|93316 CLOC|72F1 |Limits computationally determined from genome sequence between l(3)s3123 and l(3)j10E8/l(3)10532 FNC|tyrosyl-tRNA aminoacylation ; GO:0006437 | non-traceable author statement PDOM|IPR002305 == t-RNA synthetase, class Ib |IPR002307 == Tyrosyl-tRNA synthetase |IPR002547 == Putative tRNA binding domain |SCOP:50249 == Nucleic acid-binding proteins; CG4561|FBgn0036630|pp-CT14730|FBan0004561 |SCOP:52374 == Nucleotidylyl transferase; CG4561|FBgn0036630|pp-CT14730|FBan0004561 NAM|Tyrosyl-tRNA synthetase ENZ|tyrosine-tRNA ligase activity ; GO:0004831 ; EC:6.1.1.1 | inferred from sequence similarity with NCBI_gi:4507947 |tyrosine-tRNA ligase activity ; GO:0004831 ; EC:6.1.1.1 | non-traceable author statement DBA|NA:AA697091 |BDGP:GM09071 |NA:AA735326 |BDGP-DGC:LD21116 |NA:AE003527 |PA:AAF49462 |NA:AF083316 |NA:AI455095 |BDGP-DGC:LD21116 |NA:AY051662 |PA:AAK93086 |BDGP-DGC:LD21116 PAC|SPTREMBL:Q9VV60 HG|species == Bos taurus; gene == 'tyrosyl-tRNA synthetase; tyrosine--tRNA ligase'; EMBL:AF087021; gi:3941720; score == 652; expect == 0 |species == Caenorhabditis elegans; gene == F58B3.5; WP:CE06007; score == 151; expect == 1.e-35 |species == Homo sapiens; gene == 'tyrosyl-tRNA synthetase; tyrosyl tRNA ligase'; gi:4507947; score == 646; expect == 0 |species == Mus musculus; gene == 'endothelial monocyte-activating protein II precursor'; PIR:A55053; gi:1083307; score == 153; expect == 2.e-36 |species == Saccharomyces cerevisiae; gene == TYS1; SGDID:L0001105; score == 375; expect == 1.e-103 ASQ|FBan0004561 REF { REFM|FBrf0104946 |FlyBase |1996- |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0126664 |Find Enzymes |1999.11 |9 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0127491 |Grossman et al. |2000 |0 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0131225 |Bayraktaroglu |2000.11.2 |9 } REFDSR { RDID|FBrf0104946 |FlyBase |1996- AM|Source for merge of: Aats-tyr CG4561 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|tyrosine-tRNA ligase activity ; GO:0004831 ; EC:6.1.1.1 | inferred from sequence similarity with NCBI_gi:4507947 |tyrosine-tRNA ligase activity ; GO:0004831 ; EC:6.1.1.1 | non-traceable author statement FNC|tyrosyl-tRNA aminoacylation ; GO:0006437 | non-traceable author statement GPD|tyrosyl-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Tyrosyl-tRNA synthetase SYN|YRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: GM09071 SYN|TyrRS } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD21116 (BDGP-DGC) } REFDSR { RDID|FBrf0131225 |Bayraktaroglu |2000.11.2 AM|Source for merge of: CG4561 anon-EST:Posey261 } ALESR { ASYM|Aats-tyr+ ID|FBal0097808 CLA|wild-type generic } } # EOR GENR { RETE|ID 1 FBgn0027079 CLA 1 Gene NAM 1 Valyl-tRNA synthetase GSYM 1 Aats-val DT 1 14 Aug 03 RESZ 9629 PDOM 6 INTERPRO:IPR001412 == Aminoacyl-transfer RNA synthetases class-I PTD 1 DBA 21 HG 5 Caenorhabditis elegans 'strong similarity to the carboxyl two-thirds of valyl-tRNA synthetases' EMBL:U53155 FNC 1 valyl-tRNA aminoacylation CLOC 1 49F7 ALESR 6 SK 2 REF 10 GSYM|Aats-val PTD DT|14 Aug 03 ID|FBgn0027079 UAB|Deficiency: Df(2R)vg-B |Duplication: Dp(2;2)M14 (inferred from cytology) SYN|CG4062 |l(2)03531 |l(2)rI255 |VRS |ValRS |Valyl-tRNA synthetase ID2|FBgn0010542 |FBgn0010671 |FBgn0033805 KLOC|61990 CLOC|49F7 |Limits computationally determined from genome sequence between EP(2)0728/l(2)k14804 and EP(2)0358 CYC|Experimentally determined: 49F7--8 FNC|valyl-tRNA aminoacylation ; GO:0006438 | inferred from sequence similarity with SGD_LOCUS:VAS1; SGD:S0003326 PDOM|IPR001412 == Aminoacyl-transfer RNA synthetases class-I |IPR002300 == t-RNA synthetase, class Ia |IPR002303 == Valyl-tRNA synthetase |SCOP:47323 == Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; Aats-val|FBgn0027079|pp-CT13504|FBan0004062 |SCOP:50677 == ValRS/IleRS editing domain; Aats-val|FBgn0027079|pp-CT13504|FBan0004062 |SCOP:52374 == Nucleotidylyl transferase; Aats-val|FBgn0027079|pp-CT13504|FBan0004062 NAM|Valyl-tRNA synthetase ENZ|glutamate-tRNA ligase activity ; GO:0004818 ; EC:6.1.1.17 | inferred from sequence similarity |valine-tRNA ligase activity ; GO:0004832 ; EC:6.1.1.9 | inferred from sequence similarity with SGD_LOCUS:VAS1; SGD:S0003326 DBA|NA:AA263922 |BDGP:LD07176 |NA:AA735811 |BDGP:GM09906 |NA:AE003819 |PA:AAF58412 |PA:AAM68598 |NA:AI533059 |BDGP-DGC:SD04748 |NA:AQ026081 |BDGP:l(2)k14804 |NA:AQ026133 |BDGP:l(2)rI255 |NA:AW944384 |BDGP-DGC:SD04748 |NA:AY052099 |PA:AAK93523 |BDGP-DGC:SD04748 |NA:G00583 |BDGP:Dm0304 |BDGP:l(2)03531 PAC|SPTREMBL:Q960E6 |SPTREMBL:Q9V6L1 HG|species == Caenorhabditis elegans; gene == 'strong similarity to the carboxyl two-thirds of valyl-tRNA synthetases'; EMBL:U53155; gi:1255429; score == 536; expect == 1.e-151 |species == Fugu rubripes; gene == 'VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS)'; SWP:P49696; gi:1351179; score == 1257; expect == 0 |species == Homo sapiens; gene == 'G7A'; EMBL:AF134726; protein_id:AAD21819.1; gi:4529896; score == 1257; expect == 0 |species == Mus musculus; gene == 'G7A'; EMBL:AF109905; gi:3986754; score == 1261; expect == 0 |species == Saccharomyces cerevisiae; gene == VAS1; SGDID:L0002457; score == 1000; expect == 0 ASQ|FBan0004062 REF { REFM|FBrf0111489 |Spradling et al. |1999 |0 REFM|FBrf0125032 |Beaton |1999.12.12 |9 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0108275 |Seshaiah and Andrew |1999 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0110770 |Seshaiah and Andrew |1999.7.29 |9 REFM|FBrf0129569 |Misra |2000.8.9 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0083714 |Meister and Braun |1995.10 |9 REFM|FBrf0126664 |Find Enzymes |1999.11 |9 } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|49F7--8 (determined by in situ hybridization) MD|Identified with: Dm0304 BMD|Df(2R)CX1 BMD|Df(2R)vg-B BMDD|Df(2R)vg135 SYN|l(2)03531 |l(2)rI255 } REFDSR { RDID|FBrf0083714 |Meister and Braun |1995.10 SYN|l(2)03531 } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|valine-tRNA ligase activity ; GO:0004832 ; EC:6.1.1.9 | inferred from sequence similarity with SGD_LOCUS:VAS1; SGD:S0003326 FNC|valyl-tRNA aminoacylation ; GO:0006438 | inferred from sequence similarity with SGD_LOCUS:VAS1; SGD:S0003326 GPD|valyl-tRNA ligase } REFDSR { RDID|FBrf0108275 |Seshaiah and Andrew |1999 NAM|Valyl-tRNA synthetase SYN|VRS } REFDSR { RDID|FBrf0110770 |Seshaiah and Andrew |1999.7.29 MD|Identified with: GM09906 SYN|ValRS } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 ENZ|glutamate-tRNA ligase activity ; GO:0004818 ; EC:6.1.1.17 | inferred from sequence similarity CLOC|49F7--8 (determined by in situ hybridization) MD|Identified with: Dm0304 |Identified with: LD07176 |Identified with: GM09906 AM|Source for merge of: Aats-val l(2)03531 GPD|glutamyl-tRNA ligase BMD|Df(2R)vg-B BMDD|Df(2R)vg135 SYN|l(2)03531 } REFDSR { RDID|FBrf0125032 |Beaton |1999.12.12 AM|Source for merge of: Aats-val l(2)rI255 } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: SD04748 (BDGP-DGC) } REFDSR { RDID|FBrf0129569 |Misra |2000.8.9 AM|Source for merge of: Aats-val CG4062 } ALESR { ASYM|Aats-val03531 SYN|l(2)0353103531 |l(2)03531 ID|FBal0008028 DIS|A. Spradling. TRN|FBti0005240 == P{PZ}Aats-val03531 |BDGP:l(2)03531 MU|P-element activity REF|FBrf0067338 |FBrf0083714 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 ACM|Aats-valk14312 |Aats-valrI255 |Aats-valrQ802 AFC|Aats-valk14804 OTH|Complements: @l(2)00434a00434a@. |Complements: @drk10626@. |Complements the @P{lacW}Nrkk14301@ insertion line ("l(2)k14301"). TRN|FBti0005240 == P{PZ}Aats-val03531 |BDGP:l(2)03531 PHC|lethal | recessive SYN|l(2)0353103531 } REFDSR { RDID|FBrf0083714 |Meister and Braun |1995.10 SYN|l(2)0353103531 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0005240 == P{PZ}Aats-val03531 |BDGP:l(2)03531 PHC|lethal | recessive SYN|l(2)03531 } SK|FBstBL-11336 |cn[1] P{ry[+t7.2]=PZ}Aats-val[03531]/CyO; ry[506] } ALESR { ASYM|Aats-valk14312 SYN|l(2)03531k14312 ID|FBal0064744 PHC|lethal | recessive REF|FBrf0067338 |FBrf0125032 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 ACM|Aats-val03531 |Aats-valrI255 |Aats-valrQ802 AFC|Aats-valk14804 |Aats-valrI255 DIS|I. Kiss. OTH|Complements the @P{lacW}Nrkk14301@ insertion line ("l(2)k14301"). TRN|FBti0007025 == P{lacW}Aats-valk14312 |BDGP:l(2)k14312 MU|P-element activity PHC|lethal | recessive SYN|l(2)03531k14312 } } ALESR { ASYM|Aats-valk14804 SYN|l(2)03531k14804 |l(2)k14804 ID|FBal0064743 REF|FBrf0067338 |FBrf0125032 |FBrf0111489 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 ACM|Aats-valrI255 |Aats-valrQ802 AFC|Aats-val03531 |Aats-valk14312 |Aats-valrI255 DIS|I. Kiss. OTH|Complements: @Nrkk14301@. TRN|FBti0007024 == P{lacW}Aats-valk14804 |BDGP:l(2)k14804 MU|P-element activity PHC|lethal | recessive SYN|l(2)03531k14804 } REFDSR { RDID|FBrf0111489 |Spradling et al. |1999 TRN|FBti0007024 == P{lacW}Aats-valk14804 |BDGP:l(2)k14804 PHC|lethal | recessive SYN|l(2)k14804 } SK|FBstBL-10452 |y[1] w[67c23]; P{w[+mC]=lacW}Aats-val[k14804]/CyO } ALESR { ASYM|Aats-valrI255 SYN|l(2)rI255rI255 |l(2)rI255 ID|FBal0009293 DIS|G. Rubin. TRN|FBti0005363 == P{PZ}Aats-valrI255 |BDGP:l(2)rI255 MU|P-element activity PHC|lethal | recessive REF|FBrf0067338 |FBrf0125032 |FBrf0083714 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 ACM|Aats-val03531 |Aats-valk14312 |Aats-valk14804 AFC|Aats-valk14312 |Aats-valk14804 |Aats-valrQ802 OTH|Complements the @P{lacW}Nrkk14301@ insertion line ("l(2)k14301"). TRN|FBti0005363 == P{PZ}Aats-valrI255 |BDGP:l(2)rI255 PHC|lethal | recessive SYN|l(2)rI255rI255 } REFDSR { RDID|FBrf0125032 |Beaton |1999.12.12 SYN|l(2)rI255 } } ALESR { ASYM|Aats-valrQ802 SYN|l(2)rI255rQ802 |l(2)rQ802 ID|FBal0043608 DIS|G. Rubin. TRN|FBti0006039 == P{PZ}Aats-valrQ802 |BDGP:l(2)rQ802 MU|P-element activity PHC|lethal | recessive REF|FBrf0067338 |FBrf0125032 REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 ACM|Aats-val03531 |Aats-valk14312 |Aats-valk14804 AFC|Aats-valrI255 OTH|Complements the @P{lacW}Nrkk14301@ insertion line ("l(2)k14301"). TRN|FBti0006039 == P{PZ}Aats-valrQ802 |BDGP:l(2)rQ802 PHC|lethal | recessive SYN|l(2)rI255rQ802 } REFDSR { RDID|FBrf0125032 |Beaton |1999.12.12 SYN|l(2)rQ802 } } ALESR { ASYM|Aats-val+ ID|FBal0097807 CLA|wild-type generic } SKC|2 } # EOR GENR { RETE|ID 1 FBgn0023129 CLA 1 Gene NAM 1 astray GSYM 1 aay DT 1 14 Aug 03 RESZ 7228 PDOM 3 INTERPRO:IPR001454 == Haloacid dehalogenase/epoxide hydrolase family DBA 15 HG 2 Arabidopsis thaliana '3-phosphoserine phosphatase' EMBL:AB018408 FNC 2 axon guidance CLOC 1 67B4 ALESR 2 SK 1 REF 23 GSYM|aay DT|14 Aug 03 ID|FBgn0023129 UAB|Deficiency: Df(3L)AC1 |Duplication: Dp(3;3)M67C+2 (inferred from cytology) SYN|CG3705 |0423/14 |astray KLOC|86962 CLOC|67B4 |Limits computationally determined from genome sequence between EP(3)3336/l(3)07238 and l(3)02240 CYC|Experimentally determined: 67B1--10 FNC|axon guidance ; GO:0007411 | inferred from mutant phenotype |peripheral nervous system development ; GO:0007422 | traceable author statement PDOM|IPR001454 == Haloacid dehalogenase/epoxide hydrolase family |SCOP:56784 == HAD-like; aay|FBgn0023129|pp-CT12429|FBan0003705 |SCOP:56869 == Membrane all-alpha; aay|FBgn0023129|pp-CT12429|FBan0003705 NAM|astray ENZ|phosphoserine phosphatase activity ; GO:0004647 ; EC:3.1.3.3 | inferred from sequence similarity |phosphoserine phosphatase activity ; GO:0004647 ; EC:3.1.3.3 | inferred from sequence similarity with EMBL:Y10275; protein_id:CAA71318.1 |phosphoserine phosphatase activity ; GO:0004647 ; EC:3.1.3.3 | non-traceable author statement DBA|NA:AA820172 |BDGP-DGC:LD23646 |NA:AE003552 |PA:AAF50274 |NA:AF174664 |NA:AF174665 |NA:AF191498 |PA:AAF14696 |NA:AI455353 |BDGP-DGC:LD23646 |NA:AJ271817 |PA:CAB72249 |NA:AY051689 |PA:AAK93113 |BDGP-DGC:LD23646 PAC|SPTREMBL:Q9NFS2 |SPTREMBL:Q9U4B0 |SPTREMBL:Q9VSY6 HG|species == Arabidopsis thaliana; gene == '3-phosphoserine phosphatase'; EMBL:AB018408; protein_id:BAA33806.1; gi:3759177; score == 194; expect == 1.e-48 |species == Homo sapiens; gene == 'phosphoserine phosphatase'; gi:4758972; score == 216; expect == 2.e-55 ASQ|FBan0003705 REF { REFM|FBrf0137039 |Zhang et al. |2001 |0 REFM|FBrf0111993 |Nuzhdin et al. |1999 |0 REFM|FBrf0151258 |Egger et al. |2002 |0 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0125652 |Georgiev |2000.2.3 |9 REFM|FBrf0126656 |Butler |1999.11 |9 REFM|FBrf0124808 |Prokopenko |1999.8.3 |9 REFM|FBrf0119292 |Prokopenko |1999.10.2 |9 REFM|FBrf0159286 |van Steensel et al. |2003 |0 REFM|FBrf0159873 |Andrade and Cook |2003.6.2 |9 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0111308 |Szeged Stock Center |1998- |9 REFM|FBrf0151960 |Zinke et al. |2002 |0 REFM|FBrf0102826 |Bloomington Drosophila Stock Center |1998.6.3 |9 REFM|FBrf0155477 |Dilda and Mackay |2002 |0 REFM|FBrf0131381 |Prokopenko et al. |2000 |0 REFM|FBrf0155813 |Asha et al. |2003 |0 REFM|FBrf0158942 |Orian et al. |2003 |0 REFM|FBrf0159291 |Beltran et al. |2003 |0 REFM|FBrf0099763 |Salzberg et al. |1997 |0 REFM|FBrf0099762 |Deak et al. |1997 |0 REFM|FBrf0125877 |Prokopenko and Bellen |2000 |1 } REFDSR { RDID|FBrf0099762 |Deak et al. |1997 CLOC|67B1--10 (determined by in situ hybridization) LOI|aayS042314 SYN|0423/14 } REFDSR { RDID|FBrf0099763 |Salzberg et al. |1997 NAM|astray CLOC|67B1--10 (determined by in situ hybridization) LOI|aayS042314 BMD|Df(3L)AC1 OTH|Gene identified during a @P{lacW}@ screen shown to exhibit aberrant |neuronal connections. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|phosphoserine phosphatase activity ; GO:0004647 ; EC:3.1.3.3 | inferred from sequence similarity with EMBL:Y10275; protein_id:CAA71318.1 } REFDSR { RDID|FBrf0111308 |Szeged Stock Center |1998- CLOC|67B1--10 (determined by in situ hybridization) LOI|aayS042314 BMD|Df(3L)AC1 } REFDSR { RDID|FBrf0111993 |Nuzhdin et al. |1999 OTH|Candidate gene for quantitative trait (QTL) locus determining bristle |number. } REFDSR { RDID|FBrf0119292 |Prokopenko |1999.10.2 ENZ|phosphoserine phosphatase activity ; GO:0004647 ; EC:3.1.3.3 | inferred from sequence similarity CLOC|67B1--10 GPD|phosphoserine phosphatase-like } REFDSR { RDID|FBrf0124808 |Prokopenko |1999.8.3 CLOC|67B1--10 } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: LD23646 (BDGP-DGC) } REFDSR { RDID|FBrf0125652 |Georgiev |2000.2.3 MD|Gene order: Overall orientation not stated: aay+ Shc+ RpS17- MTF-1+ } REFDSR { RDID|FBrf0131381 |Prokopenko et al. |2000 ENZ|phosphoserine phosphatase activity ; GO:0004647 ; EC:3.1.3.3 | non-traceable author statement FNC|axon guidance ; GO:0007411 | inferred from mutant phenotype |peripheral nervous system development ; GO:0007422 | traceable author statement |serine biosynthesis ; GO:0006564 | non-traceable author statement } REFDSR { RDID|FBrf0159873 |Andrade and Cook |2003.6.2 BMD|Df(3L)BSC35 } ALESR { ASYM|aayS042314 SYN|0423/14 |423/14 |l(3)S042314 ID|FBal0083142 DBA|NA:AF174664 |NA:AF174665 REF|FBrf0159873 |FBrf0102826 |FBrf0099762 |FBrf0131381 |FBrf0099763 |FBrf0111308 REFDSR { RDID|FBrf0099762 |Deak et al. |1997 TRN|FBti0009720 == P{lacW}aayS042314 MU|&Dgr;2-3 PHC|lethal | pharate adult | recessive SYN|0423/14 } REFDSR { RDID|FBrf0099763 |Salzberg et al. |1997 OTH|&Dgr;2-3 induced reversion demonstrates the insertion is responsible |for the lethal phenotype. TRN|FBti0009720 == P{lacW}aayS042314 MU|P-element activity PHC|lethal | pharate adult | recessive PHM|anterior fascicle | embryonic PHI|Embryos exhibit axonal misrouting, the ISN crosses segment boundaries. SYN|423/14 } REFDSR { RDID|FBrf0102826 |Bloomington Drosophila Stock Center |1998.6.3 SYN|l(3)S042314 } REFDSR { RDID|FBrf0111308 |Szeged Stock Center |1998- TRN|FBti0009720 == P{lacW}aayS042314 MU|P-element activity PHC|lethal | recessive } REFDSR { RDID|FBrf0131381 |Prokopenko et al. |2000 MD|@P{lacW}@ insertion in the 5' UTR, 61bp upstream of the @aay@ AUG codon. TRN|FBti0009720 == P{lacW}aayS042314 SYN|l(3)S042314 } REFDSR { RDID|FBrf0159873 |Andrade and Cook |2003.6.2 TRN|FBti0009720 == P{lacW}aayS042314 } SK|FBstBL-4548 |y[1] w[67c23]; P{w[+mC]=lacW}aay[S042314]/TM3, Sb[1] Ser[1] } ALESR { ASYM|aay+ ID|FBal0087231 CLA|wild-type generic REF|FBrf0105495 } SKC|1 } # EOR GENR { RETE|ID 1 FBgn0000011 CLA 1 Gene NAM 1 abrupt GSYM 1 ab DT 1 14 Aug 03 RESZ 50080 PDOM 4 INTERPRO:IPR000210 == BTB/POZ domain PTD 1 DBA 14 HG 4 Caenorhabditis elegans 'contains similarity to the kelch/MIPP family' EMBL:AF067219 FNC 1 axon choice point recognition CEL 1 nucleus WT 2 @ab@ encodes a BTB-zinc finger regulatory protein that controls the CLOC 1 32E2 ALESR 17 SK 7 REF 47 GSYM|ab PTD MMP ARGS DT|14 Aug 03 ID|FBgn0000011 UAB|Deficiency: Df(2L)FCK-20 (inferred from cytology) |Duplication: Dp(2;2)Mdh3 (inferred from cytology) SYN|CG4807 |CG4807 |clu: clueless |clueless |l(2)k02807 |ptd |clu |parted ID2|FBgn0013436 |FBgn0022233 NAM|abrupt KLOC|41262 GLOC|2-44.0 CLOC|32E2 |Limits computationally determined from genome sequence between l(2)04008/l(2)04431 and l(2)03602 DIS|Bridges, 16th Oct. 1916. CYC|Experimentally determined: 32E1--2 FNC|axon choice point recognition ; GO:0016198 | traceable author statement CEL|nucleus ; GO:0005634 | inferred from sequence similarity with EMBL:AF032676 PDOM|IPR000210 == BTB/POZ domain |IPR000822 == Zinc finger, C2H2 type |SCOP:54695 == POZ domain; ab|FBgn0000011|pp-CT15423|FBan0004807 |SCOP:57667 == C2H2 and C2HC zinc fingers; ab|FBgn0000011|pp-CT15423|FBan0004807 WT|@ab@ encodes a BTB-zinc finger regulatory protein that controls the |specificity of neuromuscular connections. ENZ|specific RNA polymerase II transcription factor activity ; GO:0003704 | inferred from sequence similarity with EMBL:AF032676 DBA|NA:AC092241 |BDGP:BACR09F02 |NA:AE003631 |PA:AAF53087 |PA:AAN10774 |NA:AQ025716 |BDGP:l(2)k02807 |NA:BI228386 |BDGP-DGC:RE25924 |NA:BT001583 |PA:AAN71338 |BDGP-DGC:RE25924 |NA:U43733 |PA:AAA86639 PAC|SWP:Q24174 PHP|Loss of function is lethal, with effects on connectivity of segmental |nerves; hypomorphic alleles affect the development of wing veins, |especially wing vein L5, with effects in coxa, male genitalia and |bristles. HG|species == Caenorhabditis elegans; gene == 'contains similarity to the kelch/MIPP family'; EMBL:AF067219; gi:3150513; score == 64.4; expect == 2.e-09 |species == Homo sapiens; gene == 'KIAA0469 protein'; EMBL:AB007938; protein_id:BAA32314; gi:3413900; score == 62.5; expect == 9.e-09 |species == Manduca sexta; gene == 'broad-complex Z4-isoform'; EMBL:AF032676; gi:3820480; score == 145; expect == 7.e-34 |species == Mus musculus; gene == 'zinc finger 5 protein'; PIR:S41647; gi:543344; score == 61.7; expect == 1.e-08 ASQ|FBan0004807 REV|FBrf0158727 REF { REFM|FBrf0102700 |de Celis |1998 |2 REFM|FBrf0083754 |Atashi et al. |1995 |1 REFM|FBrf0126705 |FamiliarityBreedsContempt |1999.11 |9 REFM|FBrf0126703 |Zhong |1999.11 |9 REFM|FBrf0128693 |Yucel et al. |2000 |0 REFM|FBrf0057894 |van Vactor et al. |1993 |0 REFM|FBrf0050002 |Diaz-Benjumea et al. |1989 |0 REFM|FBrf0125078 |BDGP Project Members |2000- |9 REFM|FBrf0084187 |Meyer |1960 |0 REFM|FBrf0114231 |Crews |1995.12.20 |9 REFM|FBrf0001379 |Morgan et al. |1925 |2 REFM|FBrf0134248 |de Celis and Sotillos |2001 |1 REFM|FBrf0066905 |Lindsley and Zimm |1992 |2 REFM|FBrf0074804 |Wilson |1993 |2 REFM|FBrf0128401 |Bier |2000 |2 REFM|FBrf0063411 |Edmondson |1952 |0 REFM|FBrf0067338 |BDGP Project Members |1994-1999 |9 REFM|FBrf0127098 |Granderath et al. |2000 |0 REFM|FBrf0150842 |Bier et al. |2002 |1 REFM|FBrf0158727 |de Celis |2003 |2 REFM|FBrf0148954 |Siegmund and Lehmann |2002 |0 REFM|FBrf0052918 |Diaz-Benjumea and Garcia-Bellido |1990 |0 REFM|FBrf0108154 |Chiba |1999 |0 REFM|FBrf0078684 |Hu and Crews |1993 |1 REFM|FBrf0047791 |Thompson et al. |1988 |0 REFM|FBrf0078683 |Hu et al. |1995 |1 REFM|FBrf0106224 |Biehs et al. |1999 |1 REFM|FBrf0076146 |Sturtevant and Bier |1995 |0 REFM|FBrf0020044 |Lindsley and Grell |1968 |2 REFM|FBrf0105495 |FlyBase |1992- |9 REFM|FBrf0090624 |Ito et al. |1996 |0 REFM|FBrf0149093 |Johannes and Preiss |2002 |0 REFM|FBrf0064795 |Goodman and Doe |1993 |2 REFM|FBrf0083766 |Bate and Broadie |1995 |2 REFM|FBrf0145810 |Cox and Spradling |2002 |1 REFM|FBrf0100811 |Philp |1998.2.3 |9 REFM|FBrf0072691 |Broadie et al. |1993 |2 REFM|FBrf0102038 |Crews |1998 |2 REFM|FBrf0085244 |Hu et al. |1995 |0 REFM|FBrf0090871 |Yamamoto et al. |1996 |2 REFM|FBrf0092806 |Mohler |1997 |9 REFM|FBrf0074397 |Seeger |1994 |2 REFM|FBrf0108338 |Krempler and Brenig |1999 |2 REFM|FBrf0135681 |Baker et al. |2001 |2 REFM|FBrf0139866 |Whitfield |2001.10.8 |9 REFM|FBrf0055233 |Garcia-Bellido and de Celis |1992 |2 REFM|FBrf0104921 |Biehs et al. |1998 |0 } REFDSR { RDID|FBrf0047791 |Thompson et al. |1988 WTI|N (data from @ab1@) } REFDSR { RDID|FBrf0050002 |Diaz-Benjumea et al. |1989 PHP|@kni@, @tg@, @tt@, @ab@, @cv@, @cv-2@, @cv-c@ and @cv-d@ belong to the radius incompletus |phenotypic group within the 'lack-of-vein' mutant class. Loss-of-function |alleles at these loci remove stretches of veins in two or more longitudinal |veins. Double mutants of this group have additive phenotypes suggesting |the genes are vein-specific, and small lanceolate wings. |Therefore involved in whole vein-region specification rather than vein |differentiation. ab alleles may have pleiotropic effects on leg development |or be embryonic lethal. } REFDSR { RDID|FBrf0052918 |Diaz-Benjumea and Garcia-Bellido |1990 PHP|Mutations in @ab@ affect individual longitudinal veins: vein specific |effects. } REFDSR { RDID|FBrf0057894 |van Vactor et al. |1993 OTH|Identification: Mutations affecting neuromuscular connectivity, |using an antibody to @Fas2@. SYN|clu } REFDSR { RDID|FBrf0063411 |Edmondson |1952 GLOC|2-44.0 } REFDSR { RDID|FBrf0064795 |Goodman and Doe |1993 SYN|clueless } REFDSR { RDID|FBrf0067338 |BDGP Project Members |1994-1999 CLOC|32E1--2 LOI|abk02807 BMDD|Df(2L)Prl } REFDSR { RDID|FBrf0072691 |Broadie et al. |1993 SYN|clueless } REFDSR { RDID|FBrf0074397 |Seeger |1994 SYN|clu } REFDSR { RDID|FBrf0074804 |Wilson |1993 SYN|clueless } REFDSR { RDID|FBrf0076146 |Sturtevant and Bier |1995 WTI|rho PHP|Loss of vein mutations cause suppression of @rhohs.PSt@ ectopic vein |phenotype and enhancement of the @rhove-1@ loss of vein phenotype. } REFDSR { RDID|FBrf0078683 |Hu et al. |1995 PHP|@P-element@ excision and &ggr; ray induced lethal mutations of the enhancer |trap BL97 fail to complement @ab@. } REFDSR { RDID|FBrf0083766 |Bate and Broadie |1995 SYN|clu } REFDSR { RDID|FBrf0085244 |Hu et al. |1995 WT|@ab@ encodes a BTB-zinc finger regulatory protein that controls the |specificity of neuromuscular connections. } REFDSR { RDID|FBrf0105495 |FlyBase |1992- ENZ|specific RNA polymerase II transcription factor activity ; GO:0003704 | inferred from sequence similarity with EMBL:AF032676 MD|Maps to clone: BACR09F02 |Maps to clone: DS05055 CEL|nucleus ; GO:0005634 | inferred from sequence similarity with EMBL:AF032676 } REFDSR { RDID|FBrf0108154 |Chiba |1999 FNC|axon choice point recognition ; GO:0016198 | traceable author statement } REFDSR { RDID|FBrf0114231 |Crews |1995.12.20 CLOC|32E1--2 } REFDSR { RDID|FBrf0125078 |BDGP Project Members |2000- MD|Identified with: RE25924 (BDGP-DGC) |Identified with: AT11330 (BDGP-DGC) } REFDSR { RDID|FBrf0126703 |Zhong |1999.11 AM|Source for identity of: ab CG4807 } REFDSR { RDID|FBrf0128693 |Yucel et al. |2000 MD|Gene order: In direction of increasing cytology: ab+ cmet- ab+ cmet- cana+ CG4851+ mre11+ } REFDSR { RDID|FBrf0139866 |Whitfield |2001.10.8 SYN|CG4807 } REFDSR { RDID|FBrf0145810 |Cox and Spradling |2002 SYN|clueless } ALESR { ASYM|ab1 ID|FBal0000067 MU|spontaneous PHC|visible | recessive | conditional cs PHM|wing vein L5 |posterior scutellar bristle PHI|Vein L5 usually stops after posterior crossvein. |Scutellar bristles usually fewer. Wing effect probably acts during |contraction period (Waddington, cited in FBrf0020044). |Overlaps wild type. |RK2. REF|FBrf0104921 |FBrf0052918 |FBrf0085244 |FBrf0047791 REFDSR { RDID|FBrf0047791 |Thompson et al. |1988 GIC|enhancer of visible phenotype of @NAx-1@ GIA|enhancer of wing vein L5 phenotype of @NAx-1@ GII|The L5 wing vein phenotype is more extreme in @NAx-1@ @ab1@ |double mutants, and there is a deep middorsal furrowing of the thorax |(a trait characteristic of some Abruptex alleles), suggesting that |@ab1@ acts as an enhancer of the @NAx-1@ phenotype. PHC|visible | recessive | conditional cs PHM|wing vein L5 | conditional cs PHI|The L5 wing vein phenotype is more severe at 20oC than 25oC, the |temperature-sensitive period is between 10 and 15% of pupal development |time. } REFDSR { RDID|FBrf0052918 |Diaz-Benjumea and Garcia-Bellido |1990 PHM|wing vein L5 |posterior crossvein |sensillum campaniformium of anterior crossvein |sensillum campaniformium of dorsal radius PHI|Removes all or some of L5, with absence of the posterior crossvein; |the sensilla campaniformia of the anterior crossvein and some of the |L3 are usually absent. } REFDSR { RDID|FBrf0085244 |Hu et al. |1995 OTH|Alleles fall into an allelic series with respect to wing venation and |bristle defects: @ab1@/@ab1@ = @ab94@/@ab94@ < @ab1@/@ab60M@ |= @ab1@/@abG9@ < @ab1@/@ab1D@ = @ab1@/@abG5@. PHC|male sterile | recessive PHM|wing vein L5 |(with ab1D) wing vein |(with abclu-1) wing vein L5 |leg |medial triple row |dorsal double row |mechanosensory ventral triple row |ventral double row |macrochaeta |wing |male genitalia |sensillum campaniformium of dorsal radius PHI|phenotype of other strong alleles is not evident in @abclu-1@. @ab1@/@abclu-1@ |heterozygotes show wing vein L5 failing to reach the margin of the |wing. |Wing vein L5 fails to reach the margin of the wing; wing veins of |@ab1@/@ab1D@ heterozygous adults are absent between the margin |and the posterior crossvein. Thoracic and wing mechanosensory bristles |are missing; occasionally one of the campaniform sense organs on wing |vein L3 is absent; legs are gnarled and the more distal segments are |reduced in length or absent; male genitalia rotated. } SK|FBstBL-203 |ab[1] } ALESR { ASYM|ab2 SYN|pt ID|FBal0000068 DIS|Bridges, 6th July 1923. MU|spontaneous PHC|visible | recessive |male sterile | recessive PHM|wing vein L5 |scutellar bristle |microchaeta |thorax |microchaeta |abdomen |supraalar bristle |coxa |male genitalia PHI|Wing vein L5 does not reach margin. Scutellar bristles |always fewer than wild type; hairs parted down midline |of thorax and abdomen; supraalar bristles sometimes |absent; coxae tend to be thickened; male genitalia rotated. |Stronger bristle phenotype than @ab1@. |RK2. REF|FBrf0052918 |FBrf0149093 |FBrf0001379 REFDSR { RDID|FBrf0052918 |Diaz-Benjumea and Garcia-Bellido |1990 PHM|coxa |male genitalia } SK|FBstBL-1555 |In(2LR)bw[V1], ds[33k] ab[2] cn[4] bw[V1]/Cy[1] pr[1] Bl[1] cn[2] L[4] sp[2] |FBstBL-204 |ab[2]/T(Y;2)E |FBstBL-205 |ab[2] ix[2] bw[1] sp[2]/In(2L)Cy, In(2R)Cy, Cy[1] dp[lv1] Bl[1] L[4] sp[2] |FBstBL-389 |S[1] wg[Sp-1] ab[2] ltd[1]/SM5 |FBstBL-4204 |In(2L)Cy, In(2R)Cy, Cy[1] pr[1] Bl[1] cn[2] L[4] sp[2]/In(2LR)bw[V1], ds[33k] ab[2] cn[4] bw[V1] } ALESR { ASYM|ab94 ID|FBal0049275 PHM|(with ab1D) wing vein |wing vein L5 PHI|Severe wing venation defect when transheterozygous with @ab1D@. |Wing vein L5 fails to reach the margin of the wing. REF|FBrf0085244 REFDSR { RDID|FBrf0085244 |Hu et al. |1995 OTH|Transposase induced revertants have undergone excision of the @P-element@. |Alleles fall into an allelic series with respect to wing venation |and bristle defects: @ab1@/@ab1@ = @ab94@/@ab94@ < @ab1@/@ab60M@ |= @ab1@/@abG9@ < @ab1@/@ab1D@ = @ab1@/@abG5@. TRN|FBti0003948 == P{lwB}ab94 PHM|(with ab1D) wing vein |wing vein L5 PHI|Severe wing venation defect when transheterozygous with @ab1D@. |Wing vein L5 fails to reach the margin of the wing. } } ALESR { ASYM|ab1D ID|FBal0049273 PHC|male sterile | recessive PHM|abdominal posterior fascicle |abdominal transverse nerve |abdominal 2 dorsal acute muscle 3 |abdominal 3 dorsal acute muscle 3 |abdominal 4 dorsal acute muscle 3 |abdominal 5 dorsal acute muscle 3 |abdominal 6 dorsal acute muscle 3 |abdominal 7 dorsal acute muscle 3 |abdominal 2 dorsal oblique muscle 3 |abdominal 3 dorsal oblique muscle 3 |abdominal 4 dorsal oblique muscle 3 |abdominal 5 dorsal oblique muscle 3 |abdominal 6 dorsal oblique muscle 3 |abdominal 7 dorsal oblique muscle 3 |abdominal 2 dorsal oblique muscle 5 |abdominal 3 dorsal oblique muscle 5 |abdominal 4 dorsal oblique muscle 5 |abdominal 5 dorsal oblique muscle 5 |abdominal 6 dorsal oblique muscle 5 |abdominal 7 dorsal oblique muscle 5 |abdominal 2 lateral oblique muscle 1 |abdominal 3 lateral oblique muscle 1 |abdominal 4 lateral oblique muscle 1 |abdominal 5 lateral oblique muscle 1 |abdominal 6 lateral oblique muscle 1 |abdominal 7 lateral oblique muscle 1 |(with ab94) wing vein |(with ab1) wing vein |(with ab1) leg |(with ab1) macrochaeta |(with ab1) wing |(with ab1) male genitalia |(with ab1) sensillum campaniformium of dorsal radius ALC|amorph PHI|During embryogenesis the SNb axons pause at the edge of muscle 13 |and form abnormal branches, instead of forming their wild type |axonal extensions onto the muscle fibers. These aberrant branches |wander over the prospective target muscles and occasionally form |connections at ectopic sites. Mutants do not establish the three |branched terminal arbor on muscles 7, 6, 13 and 12. The transverse |nerve is often incomplete and invades the ventral muscle field. A |few muscles (3, 5, 11, 20) show variably penetrant defects in their |attachment to the epidermis, and variable defects in the location of |their attachments. |Severe wing venation defect when transheterozygous with @ab94@. |Wing veins of @ab1@/@ab1D@ heterozygous adults are absent |between the margin and the posterior crossvein. Thoracic and wing |mechanosensory bristles are missing. Occasionally one of the |campaniform sense organs on wing vein L3 is absent. Legs are gnarled |and the more distal segments are reduced in length or absent; male |genitalia rotated. REF|FBrf0085244 REFDSR { RDID|FBrf0085244 |Hu et al. |1995 MD|0.7kb deletion removing exon 1 of @ab@. The @P{lwB}@ of @ab94@ has |reinserted in the same position but opposite orientation. OTH|Alleles fall into an allelic series with respect to wing venation and |bristle defects: @ab1@/@ab1@ = @ab94@/@ab94@ < @ab1@/@ab60M@ |= @ab1@/@abG9@ < @ab1@/@ab1D@ = @ab1@/@abG5@. PRG|ab94 TRN|FBti0003947 == P{lwB}ab1D MU|&Dgr;2-3 PHC|male sterile | recessive PHM|abdominal posterior fascicle |abdominal transverse nerve |abdominal 2 dorsal acute muscle 3 |abdominal 3 dorsal acute muscle 3 |abdominal 4 dorsal acute muscle 3 |abdominal 5 dorsal acute muscle 3 |abdominal 6 dorsal acute muscle 3 |abdominal 7 dorsal acute muscle 3 |abdominal 2 dorsal oblique muscle 3 |abdominal 3 dorsal oblique muscle 3 |abdominal 4 dorsal oblique muscle 3 |abdominal 5 dorsal oblique muscle 3 |abdominal 6 dorsal oblique muscle 3 |abdominal 7 dorsal oblique muscle 3 |abdominal 2 dorsal oblique muscle 5 |abdominal 3 dorsal oblique muscle 5 |abdominal 4 dorsal oblique muscle 5 |abdominal 5 dorsal oblique muscle 5 |abdominal 6 dorsal oblique muscle 5 |abdominal 7 dorsal oblique muscle 5 |abdominal 2 lateral oblique muscle 1 |abdominal 3 lateral oblique muscle 1 |abdominal 4 lateral oblique muscle 1 |abdominal 5 lateral oblique muscle 1 |abdominal 6 lateral oblique muscle 1 |abdominal 7 lateral oblique muscle 1 |(with ab94) wing vein |(with ab1) wing vein |(with ab1) leg |(with ab1) macrochaeta |(with ab1) wing |(with ab1) male genitalia |(with ab1) sensillum campaniformium of dorsal radius ALC|amorph PHI|During embryogenesis the SNb axons pause at the edge of muscle 13 |and form abnormal branches, instead of forming their wild type |axonal extensions onto the muscle fibers. These aberrant branches |wander over the prospective target muscles and occasionally form |connections at ectopic sites. Mutants do not establish the three |branched terminal arbor on muscles 7, 6, 13 and 12. The transverse |nerve is often incomplete and invades the ventral muscle field. A |few muscles (3, 5, 11, 20) show variably penetrant defects in their |attachment to the epidermis, and variable defects in the location of |their attachments. |Severe wing venation defect when transheterozygous with @ab94@. |Wing veins of @ab1@/@ab1D@ heterozygous adults are absent |between the margin and the posterior crossvein. Thoracic and wing |mechanosensory bristles are missing. Occasionally one of the |campaniform sense organs on wing vein L3 is absent. Legs are gnarled |and the more distal segments are reduced in length or absent; male |genitalia rotated. } } ALESR { ASYM|ab51g ID|FBal0000069 AMIS|Arose on: @In(2L)Cy@ + @In(2R)Cy@. DIS|Edmondson, July 1951. MU|spontaneous PHC|visible | recessive |male sterile | recessive PHM|wing vein L5 |scutellar bristle |microchaeta |thorax |microchaeta |abdomen |supraalar bristle |coxa |male genitalia PHI|Wing vein L5 does not reach margin. Scutellar bristles |always fewer than wild type; hairs parted down midline |of thorax and abdomen; supraalar bristles sometimes |absent; coxae tend to be thickened; male genitalia rotated. |Stronger bristle phenotype than @ab1@. |RK2A REF|FBrf0063411 REFDSR { RDID|FBrf0063411 |Edmondson |1952 AMIS|Arose on: @al1@ @Cy1@ @pr1@ @Bl1@ @cn2@ @L4@ @sp2@ chromosome. DIS|Edmondson, Jul. 1951 MU|spontaneous PHI|Rank: RK2 |Strong allele, like @ab2@. } } ALESR { ASYM|ab60M ID|FBal0049274 PHC|lethal | pupal | recessive |male sterile | recessive PHM|(with abG9) wing vein |(with abG9) leg |(with abG9) macrochaeta |(with abG9) wing |(with abG9) male genitalia |(with abG9) sensillum campaniformium of dorsal radius PHI|Wing veins of @ab60M@/@abG9@ heterozygous adults are absent between |the margin and the posterior crossvein; thoracic and wing mechanosensory |bristles are missing; occasionally one of the campaniform sense organs |on wing vein L3 is absent; legs are gnarled and the more distal segments |are reduced in length or absent; male genitalia rotated. REF|FBrf0085244 REFDSR { RDID|FBrf0085244 |Hu et al. |1995 OTH|Alleles fall into an allelic series with respect to wing venation and |bristle defects: @ab1@/@ab1@ = @ab94@/@ab94@ < @ab1@/@ab60M@ |= @ab1@/@abG9@ < @ab1@/@ab1D@ = @ab1@/@abG5@. PRG|abBL97 MU|&ggr; ray PHC|lethal | pupal | recessive |male sterile | recessive PHM|(with abG9) wing vein |(with abG9) leg |(with abG9) macrochaeta |(with abG9) wing |(with abG9) male genitalia |(with abG9) sensillum campaniformium of dorsal radius PHI|Wing veins of @ab60M@/@abG9@ heterozygous adults are absent between |the margin and the posterior crossvein; thoracic and wing mechanosensory |bristles are missing; occasionally one of the campaniform sense organs |on wing vein L3 is absent; legs are gnarled and the more distal segments |are reduced in length or absent; male genitalia rotated. } } ALESR { ASYM|abBL97 ID|FBal0034173 PHC|wild-type PHI|Wing veins are wild type in homozygotes. REF|FBrf0078684 |FBrf0078683 |FBrf0085244 REFDSR { RDID|FBrf0078683 |Hu et al. |1995 OTH|@P-element@ excision and &ggr; rays have been used to generate lethal |derivatives @abBL97@. Heterozygotes of the lethal mutations display |a shortened L5 wing vein, and absence of scutellar and humeral bristles. TRN|FBti0003107 == P{A92}abBL97 MU|P-element activity SYN|unnamed } REFDSR { RDID|FBrf0078684 |Hu and Crews |1993 TRN|FBti0003107 == P{A92}abBL97 } REFDSR { RDID|FBrf0085244 |Hu et al. |1995 TRN|FBti0003107 == P{A92}abBL97 PHC|wild-type PHI|Wing veins are wild type in homozygotes. } } ALESR { ASYM|abclu-1 SYN|clu1 ID|FBal0030791 REF|FBrf0072691 |FBrf0085244 |FBrf0057894 REFDSR { RDID|FBrf0057894 |van Vactor et al. |1993 MU|ethyl methanesulfonate PHC|lethal | recessive |neuroanatomy defective PHM|abdominal posterior fascicle |transverse nerve PHI|Segmental nerve b fails to make some or all of its stereotyped connections |in most segments. CNS development is normal. Ectopic arborization |over the ventral muscles from the transverse nerve is often observed: |possibly a secondary effect of the failure of segmental nerve b axons |to synapse onto their correct targets. } REFDSR { RDID|FBrf0072691 |Broadie et al. |1993 SYN|clu1 } REFDSR { RDID|FBrf0085244 |Hu et al. |1995 ARG2|FBgn0000011. MD|Nucleotide substitution: C?T. |Amino acid replacement: R531@. |Resulting protein is truncated, lacking the ZF DNA-binding domain. PHC|lethal | recessive PHM|abdominal posterior fascicle |(with ab1) wing vein L5 |abdominal transverse nerve |abdominal 2 dorsal acute muscle 3 |abdominal 3 dorsal acute muscle 3 |abdominal 4 dorsal acute muscle 3 |abdominal 5 dorsal acute muscle 3 |abdominal 6 dorsal acute muscle 3 |abdominal 7 dorsal acute muscle 3 |abdominal 2 dorsal oblique muscle 3 |abdominal 3 dorsal oblique muscle 3 |abdominal 4 dorsal oblique muscle 3 |abdominal 5 dorsal oblique muscle 3 |abdominal 6 dorsal oblique muscle 3 |abdominal 7 dorsal oblique muscle 3 |abdominal 2 dorsal oblique muscle 5 |abdominal 3 dorsal oblique muscle 5 |abdominal 4 dorsal oblique muscle 5 |abdominal 5 dorsal oblique muscle 5 |abdominal 6 dorsal oblique muscle 5 |abdominal 7 dorsal oblique muscle 5 |abdominal 2 lateral oblique muscle 1 |abdominal 3 lateral oblique muscle 1 |abdominal 4 lateral oblique muscle 1 |abdominal 5 lateral oblique muscle 1 |abdominal 6 lateral oblique muscle 1 |abdominal 7 lateral oblique muscle 1 PHI|During embryogenesis the SNb axons pause at the edge of muscle 13 and |form abnormal branches, instead of forming their wild type axonal extensions |onto the muscle fibers. These aberrant branches wander over the prospective |target muscles and occasionally form connections at ectopic sites. |Mutants do not establish the three branched terminal arbor on muscles |7, 6, 13 and 12. The transverse nerve is often incomplete and invades |the ventral muscle field. A few muscles (3, 5, 11, 20) show variably |penetrant defects in their attachment to the epidermis, and variable |defects in the location of their attachments. The muscle detachment |phenotype of other strong alleles is not evident in @abclu-1@. @ab1@/@abclu-1@ |heterozygotes show wing vein L5 failing to reach the margin of the |wing. SYN|clu1 } } ALESR { ASYM|abclu2 ID|FBal0049278 PHC|lethal | recessive PHM|abdominal posterior fascicle |abdominal transverse nerve |abdominal 2 dorsal acute muscle 3 |abdominal 3 dorsal acute muscle 3 |abdominal 4 dorsal acute muscle 3 |abdominal 5 dorsal acute muscle 3 |abdominal 6 dorsal acute muscle 3 |abdominal 7 dorsal acute muscle 3 |abdominal 2 dorsal oblique muscle 3 |abdominal 3 dorsal oblique muscle 3 |abdominal 4 dorsal oblique muscle 3 |abdominal 5 dorsal oblique muscle 3 |abdominal 6 dorsal oblique muscle 3 |abdominal 7 dorsal oblique muscle 3 |abdominal 2 dorsal oblique muscle 5 |abdominal 3 dorsal oblique muscle 5 |abdominal 4 dorsal oblique muscle 5 |abdominal 5 dorsal oblique muscle 5 |abdominal 6 dorsal oblique muscle 5 |abdominal 7 dorsal oblique muscle 5 |abdominal 2 lateral oblique muscle 1 |abdominal 3 lateral oblique muscle 1 |abdominal 4 lateral oblique muscle 1 |abdominal 5 lateral oblique muscle 1 |abdominal 6 lateral oblique muscle 1 |abdominal 7 lateral oblique muscle 1 PHI|Severe wing venation defect when heterozygous with @ab94@. During |embryogenesis the SNb axons pause at the edge of muscle 13 and form |abnormal branches, instead of forming their wild type axonal extensions |onto the muscle fibers. These aberrant branches wander over the prospective |target muscles and occasionally form connections at ectopic sites. |Mutants do not establish the three branched terminal arbor on muscles |7, 6, 13 and 12. The transverse nerve is often incomplete and invades |the ventral muscle field. A few muscles (3, 5, 11, 20) show variably |penetrant defects in their attachment to the epidermis, and variable |defects in the location of their attachments. REF|FBrf0085244 REFDSR { RDID|FBrf0085244 |Hu et al. |1995 ARG2|FBgn0000011. MD|Nucleotide substitution: C?T. |Amino acid replacement: R585C. |Mutation occurs in the region encoding the second ZF. MU|ethyl methanesulfonate PHC|lethal | recessive PHM|abdominal posterior fascicle |abdominal transverse nerve |abdominal 2 dorsal acute muscle 3 |abdominal 3 dorsal acute muscle 3 |abdominal 4 dorsal acute muscle 3 |abdominal 5 dorsal acute muscle 3 |abdominal 6 dorsal acute muscle 3 |abdominal 7 dorsal acute muscle 3 |abdominal 2 dorsal oblique muscle 3 |abdominal 3 dorsal oblique muscle 3 |abdominal 4 dorsal oblique muscle 3 |abdominal 5 dorsal oblique muscle 3 |abdominal 6 dorsal oblique muscle 3 |abdominal 7 dorsal oblique muscle 3 |abdominal 2 dorsal oblique muscle 5 |abdominal 3 dorsal oblique muscle 5 |abdominal 4 dorsal oblique muscle 5 |abdominal 5 dorsal oblique muscle 5 |abdominal 6 dorsal oblique muscle 5 |abdominal 7 dorsal oblique muscle 5 |abdominal 2 lateral oblique muscle 1 |abdominal 3 lateral oblique muscle 1 |abdominal 4 lateral oblique muscle 1 |abdominal 5 lateral oblique muscle 1 |abdominal 6 lateral oblique muscle 1 |abdominal 7 lateral oblique muscle 1 PHI|Severe wing venation defect when heterozygous with @ab94@. During |embryogenesis the SNb axons pause at the edge of muscle 13 and form |abnormal branches, instead of forming their wild type axonal extensions |onto the muscle fibers. These aberrant branches wander over the prospective |target muscles and occasionally form connections at ectopic sites. |Mutants do not establish the three branched terminal arbor on muscles |7, 6, 13 and 12. The transverse nerve is often incomplete and invades |the ventral muscle field. A few muscles (3, 5, 11, 20) show variably |penetrant defects in their attachment to the epidermis, and variable |defects in the location of their attachments. } } ALESR { ASYM|abclu3 ID|FBal0049279 PHC|lethal | recessive PHM|abdominal posterior fascicle |abdominal transverse nerve |abdominal 2 dorsal acute muscle 3 |abdominal 3 dorsal acute muscle 3 |abdominal 4 dorsal acute muscle 3 |abdominal 5 dorsal acute muscle 3 |abdominal 6 dorsal acute muscle 3 |abdominal 7 dorsal acute muscle 3 |abdominal 2 dorsal oblique muscle 3 |abdominal 3 dorsal oblique muscle 3 |abdominal 4 dorsal oblique muscle 3 |abdominal 5 dorsal oblique muscle 3 |abdominal 6 dorsal oblique muscle 3 |abdominal 7 dorsal oblique muscle 3 |abdominal 2 dorsal oblique muscle 5 |abdominal 3 dorsal oblique muscle 5 |abdominal 4 dorsal oblique muscle 5 |abdominal 5 dorsal oblique muscle 5 |abdominal 6 dorsal oblique muscle 5 |abdominal 7 dorsal oblique muscle 5 |abdominal 2 lateral oblique muscle 1 |abdominal 3 lateral oblique muscle 1 |abdominal 4 lateral oblique muscle 1 |abdominal 5 lateral oblique muscle 1 |abdominal 6 lateral oblique muscle 1 |abdominal 7 lateral oblique muscle 1 PHI|Severe wing venation defect when heterozygous with @ab94@. During |embryogenesis the SNb axons pause at the edge of muscle 13 and form |abnormal branches, instead of forming their wild type axonal extensions |onto the muscle fibers. These aberrant branches wander over the prospective |target muscles and occasionally form connections at ectopic sites. |Mutants do not establish the three branched terminal arbor on muscles |7, 6, 13 and 12. The transverse nerve is often incomplete and invades |the ventral muscle field. A few muscles (3, 5, 11, 20) show variably |penetrant defects in their attachment to the epidermis, and variable |defects in the location of their attachments. REF|FBrf0085244 REFDSR { RDID|FBrf0085244 |Hu et al. |1995 MU|ethyl methanesulfonate PHC|lethal | recessive PHM|abdominal posterior fascicle |abdominal transverse nerve |abdominal 2 dorsal acute muscle 3 |abdominal 3 dorsal acute muscle 3 |abdominal 4 dorsal acute muscle 3 |abdominal 5 dorsal acute muscle 3 |abdominal 6 dorsal acute muscle 3 |abdominal 7 dorsal acute muscle 3 |abdominal 2 dorsal oblique muscle 3 |abdominal 3 dorsal oblique muscle 3 |abdominal 4 dorsal oblique muscle 3 |abdominal 5 dorsal oblique muscle 3 |abdominal 6 dorsal oblique muscle 3 |abdominal 7 dorsal oblique muscle 3 |abdominal 2 dorsal oblique muscle 5 |abdominal 3 dorsal oblique muscle 5 |abdominal 4 dorsal oblique muscle 5 |abdominal 5 dorsal oblique muscle 5 |abdominal 6 dorsal oblique muscle 5 |abdominal 7 dorsal oblique muscle 5 |abdominal 2 lateral oblique muscle 1 |abdominal 3 lateral oblique muscle 1 |abdominal 4 lateral oblique muscle 1 |abdominal 5 lateral oblique muscle 1 |abdominal 6 lateral oblique muscle 1 |abdominal 7 lateral oblique muscle 1 PHI|Severe wing venation defect when heterozygous with @ab94@. During |embryogenesis the SNb axons pause at the edge of muscle 13 and form |abnormal branches, instead of forming their wild type axonal extensions |onto the muscle fibers. These aberrant branches wander over the prospective |target muscles and occasionally form connections at ectopic sites. |Mutants do not establish the three branched terminal arbor on muscles |7, 6, 13 and 12. The transverse nerve is often incomplete and invades |the ventral muscle field. A few muscles (3, 5, 11, 20) show variably |penetrant defects in their attachment to the epidermis, and variable |defects in the location of their attachments. } } ALESR { ASYM|abG5 ID|FBal0049276 PHM|abdominal posterior fascicle |abdominal transverse nerve |abdominal 2 dorsal acute muscle 3 |abdominal 3 dorsal acute muscle 3 |abdominal 4 dorsal acute muscle 3 |abdominal 5 dorsal acute muscle 3 |abdominal 6 dorsal acute muscle 3 |abdominal 7 dorsal acute muscle 3 |abdominal 2 dorsal oblique muscle 3 |abdominal 3 dorsal oblique muscle 3 |abdominal 4 dorsal oblique muscle 3 |abdominal 5 dorsal oblique muscle 3 |abdominal 6 dorsal oblique muscle 3 |abdominal 7 dorsal oblique muscle 3 |abdominal 2 dorsal oblique muscle 5 |abdominal 3 dorsal oblique muscle 5 |abdominal 4 dorsal oblique muscle 5 |abdominal 5 dorsal oblique muscle 5 |abdominal 6 dorsal oblique muscle 5 |abdominal 7 dorsal oblique muscle 5 |abdominal 2 lateral oblique muscle 1 |abdominal 3 lateral oblique muscle 1 |abdominal 4 lateral oblique muscle 1 |abdominal 5 lateral oblique muscle 1 |abdominal 6 lateral oblique muscle 1 |abdominal 7 lateral oblique muscle 1 ALC|amorph PHI|During embryogenesis the SNb axons pause at the edge of muscle 13 and |form abnormal branches, instead of forming their wild type axonal extensions |onto the muscle fibers. These aberrant branches wander over the prospective |target muscles and occasionally form connections at ectopic sites. |Mutants do not establish the three branched terminal arbor on muscles |7, 6, 13 and 12. The transverse nerve is often incomplete and invades |the ventral muscle field. A few muscles (3, 5, 11, 20) show variably |penetrant defects in their attachment to the epidermis, and variable |defects in the location of their attachments. REF|FBrf0085244 REFDSR { RDID|FBrf0085244 |Hu et al. |1995 MD|Deletion of at least 26kb breaking in the @ab@ transcription unit and |removing the 5' portion of the transcription unit and upstream sequences. OTH|It is possible that other genes may be removed by this mutation. The |second deletion breakpoint has not yet been mapped. Alleles fall into |an allelic series with respect to wing venation and bristle defects: |@ab1@/@ab1@ = @ab94@/@ab94@ < @ab1@/@ab60M@ = @ab1@/@abG9@ |< @ab1@/@ab1D@ = @ab1@/@abG5@. PRG|ab94 MU|&ggr; ray PHM|abdominal posterior fascicle |abdominal transverse nerve |abdominal 2 dorsal acute muscle 3 |abdominal 3 dorsal acute muscle 3 |abdominal 4 dorsal acute muscle 3 |abdominal 5 dorsal acute muscle 3 |abdominal 6 dorsal acute muscle 3 |abdominal 7 dorsal acute muscle 3 |abdominal 2 dorsal oblique muscle 3 |abdominal 3 dorsal oblique muscle 3 |abdominal 4 dorsal oblique muscle 3 |abdominal 5 dorsal oblique muscle 3 |abdominal 6 dorsal oblique muscle 3 |abdominal 7 dorsal oblique muscle 3 |abdominal 2 dorsal oblique muscle 5 |abdominal 3 dorsal oblique muscle 5 |abdominal 4 dorsal oblique muscle 5 |abdominal 5 dorsal oblique muscle 5 |abdominal 6 dorsal oblique muscle 5 |abdominal 7 dorsal oblique muscle 5 |abdominal 2 lateral oblique muscle 1 |abdominal 3 lateral oblique muscle 1 |abdominal 4 lateral oblique muscle 1 |abdominal 5 lateral oblique muscle 1 |abdominal 6 lateral oblique muscle 1 |abdominal 7 lateral oblique muscle 1 ALC|amorph PHI|During embryogenesis the SNb axons pause at the edge of muscle 13 and |form abnormal branches, instead of forming their wild type axonal extensions |onto the muscle fibers. These aberrant branches wander over the prospective |target muscles and occasionally form connections a