GENR
{
RETE|ID 1 FBgn0025724 CLA 1 Gene NAM 1 &bgr;'-coatomer protein GSYM 1 &bgr;'Cop DT 1 14 Aug 03 RESZ 3775 DBA 15 HG 5 Caenorhabditis elegans F38E11.5 WP:CE18673 FNC 5 ER to Golgi transport CEL 3 COPI vesicle coat CLOC 1 34B9 ALESR 1 REF 9
GSYM|&bgr;'Cop
DT|14 Aug 03
ID|FBgn0025724
UAB|Duplication: Dp(2;2)GYL (inferred from cytology)
SYN|CG6699
|CG6699
|beta'-COP
|d&bgr;'COP
NAM|&bgr;'-coatomer protein
KLOC|43135
CLOC|34B9
|Limits computationally determined from genome sequence between l(2)k00302 and l(2)03782/l(2)k14817
CYC|Experimentally determined: 34B5--9
FNC|ER to Golgi transport ; GO:0006888 | non-traceable author statement
|golgi membrane budding ; GO:newterm | non-traceable author statement
|retrograde (Golgi to ER) transport ; GO:0006890 | non-traceable author statement
|retrograde (Golgi to ER) transport ; GO:0006890 | non-traceable author statement
|retrograde (Golgi to ER) transport ; GO:0006890 | non-traceable author statement
CEL|COPI vesicle coat ; GO:0030126 | non-traceable author statement
|COPI vesicle coat ; GO:0030126 | non-traceable author statement
|COPI vesicle coat ; GO:0030126 | non-traceable author statement
DBA|NA:AA264134
|BDGP:LD07733
|NA:AE003639
|PA:AAF53294
|NA:AI293311
|BDGP-DGC:GH16479
|NA:AJ006523
|PA:CAA07084
|NA:AJ006524
|PA:CAA07085
|NA:AW940627
|BDGP-DGC:GH16479
|NA:AY119527
|PA:AAM50181
|BDGP-DGC:GH16479
PAC|SWP:O62621
HG|species == Caenorhabditis elegans; gene == F38E11.5; WP:CE18673; score == 1047.8; expect == 0
|species == Homo sapiens; gene == 'coatomer protein complex, subunit &bgr; 2 (&bgr; prime)'; gi:4758032; score == 1208.6; expect == 0
|species == Mus musculus; gene == '&bgr; prime coatomer protein'; EMBL:AF043120; gi:2809537; score == 465; expect == 1.e-130
|species == Rattus; gene == 'COATOMER BETA' SUBUNIT (BETA'-COAT PROTEIN) (BETA'-COP) (P102)'; SWP:O35142; gi:3023522; score == 1209.3; expect == 0
|species == Saccharomyces cerevisiae; gene == SEC27; SGDID:L0001848; score == 685.2; expect == 0
ASQ|FBan0006699
REF
{
REFM|FBrf0106031
|Merdes
|1998.12.20
|9
REFM|FBrf0118012
|Merdes
|1998.6.2
|9
REFM|FBrf0118011
|Merdes
|1998.6.2
|9
REFM|FBrf0146969
|Dunne et al.
|2002
|0
REFM|FBrf0126702
|Zheng
|1999.11
|9
REFM|FBrf0125078
|BDGP Project Members
|2000-
|9
REFM|FBrf0126671
|Guan
|1999.11
|9
REFM|FBrf0131779
|SwissProt Project Members
|2000.10.1
|9
REFM|FBrf0105495
|FlyBase
|1992-
|9
}
REFDSR
{
RDID|732402166
FNC|ER to Golgi transport ; GO:0006888 | non-traceable author statement
|retrograde (Golgi to ER) transport ; GO:0006890 | non-traceable author statement
CEL|COPI vesicle coat ; GO:0030126 | non-traceable author statement
}
REFDSR
{
RDID|FBrf0106031
|Merdes
|1998.12.20
CLOC|34B5--9 (determined by in situ hybridization)
}
REFDSR
{
RDID|FBrf0118011
|Merdes
|1998.6.2
SYN|beta'-COP
}
REFDSR
{
RDID|FBrf0118012
|Merdes
|1998.6.2
FNC|retrograde (Golgi to ER) transport ; GO:0006890 | non-traceable author statement
CEL|COPI vesicle coat ; GO:0030126 | non-traceable author statement
GPD|coatomer, &bgr;'-subunit
SYN|beta'-COP
}
REFDSR
{
RDID|FBrf0125078
|BDGP Project Members
|2000-
MD|Identified with: GH16479 (BDGP-DGC)
}
REFDSR
{
RDID|FBrf0126671
|Guan
|1999.11
AM|Source for identity of: &bgr;'Cop CG6699
}
REFDSR
{
RDID|FBrf0131779
|SwissProt Project Members
|2000.10.1
FNC|retrograde (Golgi to ER) transport ; GO:0006890 | non-traceable author statement
CEL|COPI vesicle coat ; GO:0030126 | non-traceable author statement
}
REFDSR
{
RDID|FBrf0146969
|Dunne et al.
|2002
MD|Identified with: LD07733
SYN|CG6699
|d&bgr;'COP
}
ALESR
{
ASYM|&bgr;'Cop+
ID|FBal0093738
CLA|wild-type generic
REF|FBrf0105495
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0043467 CLA 1 Gene GSYM 1 064Ya DT 1 14 Aug 03 RESZ 874 FNC 1 behavioral response to ethanol CLOC 1 XLt--XRt ALESR 2 REF 1
GSYM|064Ya
DT|14 Aug 03
ID|FBgn0043467
FNC|behavioral response to ethanol ; GO:0048149 | inferred from mutant phenotype
CLOC|XLt--XRt
REF
{
REFM|FBrf0131396
|Scholz et al.
|2000
|0
}
REFDSR
{
RDID|FBrf0131396
|Scholz et al.
|2000
CLOC|XLt--XRt
FNC|behavioral response to ethanol ; GO:0048149 | inferred from mutant phenotype
SYN|unnamed
}
ALESR
{
ASYM|064Ya064Ya
SYN|064Y
ID|FBal0119724
PHC|chemical sensitive
PHI|Mutants exhibit a reduced tolerance to ethanol.
REF|FBrf0131396
REFDSR
{
RDID|FBrf0131396
|Scholz et al.
|2000
TRN|FBti0016904 == P{GAL4}064Ya064Ya
PHC|chemical sensitive
PHI|Mutants exhibit a reduced tolerance to ethanol.
SYN|064Y
}
}
ALESR
{
ASYM|064Ya+
ID|FBal0120253
CLA|wild-type generic
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0010347 CLA 1 Gene GSYM 1 1.28 DT 1 14 Aug 03 RESZ 4336 PTD 1 DBA 4 FNC 2 specification of segmental identity, maxillary segment CLOC 1 42B2 ALESR 3 REF 16
GSYM|1.28
PTD
DT|14 Aug 03
ID|FBgn0010347
UAB|Deficiency: Df(2R)cn88b (inferred from cytology)
|Duplication: Dp(2;Y)cn+ (inferred from cytology)
SYN|CG9397
|CG9397
|CG9397
|deformed
KLOC|53022
CLOC|42B2
|Limits computationally determined from genome sequence between l(2)k09848/EP(2)0407 and l(2)k14019/l(2)01349
CYC|Experimentally determined: 42B
FNC|specification of segmental identity, maxillary segment ; GO:0007382 | inferred from expression pattern
|specification of segmental identity, maxillary segment ; GO:0007382 | inferred from genetic interaction with FLYBASE:Dfd; FB:FBgn0000439
DBA|NA:AE003789
|PA:AAF57355
|NA:L07262
|PA:AAA03084
PAC|SPTREMBL:Q24300
|SPTREMBL:Q9V9D6
WTI|Dfd
ASQ|FBan0009397
REF
{
REFM|FBrf0079168
|Pederson and Mahaffey
|1995
|1
REFM|FBrf0076134
|Mohler et al.
|1995
|0
REFM|FBrf0137489
|Mount
|2001.8.14
|9
REFM|FBrf0068222
|Mahaffey et al.
|1994
|1
REFM|FBrf0092336
|LaFollette et al.
|1997
|1
REFM|FBrf0117645
|Mahaffey
|1992
|9
REFM|FBrf0075267
|Mahaffey
|1993
|9
REFM|FBrf0064596
|Mahaffey et al.
|1993
|0
REFM|FBrf0132330
|Mahaffey et al.
|2001
|0
REFM|FBrf0068424
|Botas
|1993
|2
REFM|FBrf0130258
|Pederson et al.
|2000
|0
REFM|FBrf0090735
|Pederson et al.
|1996
|0
REFM|FBrf0078949
|Mahato and Mahaffey
|1995
|1
REFM|FBrf0105495
|FlyBase
|1992-
|9
REFM|FBrf0136026
|Dobie and Karpen
|2001.4.18
|9
REFM|FBrf0085725
|Pederson et al.
|1996
|1
}
REFDSR
{
RDID|FBrf0064596
|Mahaffey et al.
|1993
CLOC|42B (determined by in situ hybridization)
FNC|specification of segmental identity, maxillary segment ; GO:0007382 | inferred from expression pattern
|specification of segmental identity, maxillary segment ; GO:0007382 | inferred from genetic interaction with FLYBASE:Dfd; FB:FBgn0000439
WT|Identified in an enhancer trap screen for target genes of homeoproteins.
|The 1.28 gene is a target gene that is activated by @Dfd@. @Dfd@ is required
|to activate 1.28 in the maxillary segment, but ectopic expression of
|@Dfd@ is incapable of activating @1.28@ elsewhere.
WTI|Dfd
}
REFDSR
{
RDID|FBrf0079168
|Pederson and Mahaffey
|1995
WT|The @1.28@ gene is directly activated by @Dfd@ in the maxillary segment
|but not in the mandibular segment. Four @Dfd@-product binding sites
|have been identified within a 664bp fragment of the @1.28@ regulatory
|region, in addition to a @Dfd@ epidermal autoactivation element (DEAE).
WTI|Dfd
}
REFDSR
{
RDID|FBrf0105495
|FlyBase
|1992-
}
REFDSR
{
RDID|FBrf0117645
|Mahaffey
|1992
CLOC|42B
SYN|deformed
}
REFDSR
{
RDID|FBrf0136026
|Dobie and Karpen
|2001.4.18
AM|"1.28" may correspond to "Scim21".
|Sequence analysis off ends of @P{SUPor-P}@ in Scim insertion mutant
|places "Scim21" near/in "1.28".
SYN|CG9397
}
REFDSR
{
RDID|FBrf0137489
|Mount
|2001.8.14
SYN|CG9397
}
ALESR
{
ASYM|1.28P
ID|FBal0121022
REF|FBrf0130258
REFDSR
{
RDID|FBrf0130258
|Pederson et al.
|2000
MD|@P{lacW}@ insertion into the @Deaf1@ binding region of the @1.28@ regulatory
|sequences.
TRN|FBti0003587 == P{lacW}1.28P
}
}
ALESR
{
ASYM|1.28rv13
SYN|line 13
ID|FBal0121021
REF|FBrf0130258
REFDSR
{
RDID|FBrf0130258
|Pederson et al.
|2000
MD|Mobilization of the @P{lacW}@ element, resulting in a deletion of approximately
|1kb upstream of the original @P{lacW}@ element insertion site.
PRG|1.28P
MU|&Dgr;2-3
SYN|line 13
}
}
ALESR
{
ASYM|1.28+
ID|FBal0066314
CLA|wild-type generic
REF|FBrf0105495
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0026615 CLA 1 Gene GSYM 1 10-4 DT 1 14 Aug 03 RESZ 1135 ALESR 1 REF 1
GSYM|10-4
DT|14 Aug 03
ID|FBgn0026615
MD|In dividing precursor cells of the developing nervous system the
|correct asymmetric apical localization of @10-4@ mRNA depends on
|@insc@. @10-4@ protein localization to the apical cytoplasm occurs
|when @insc@ protein disappears, in anaphase. In telophase @10-4@
|protein forms a tight apical crescent.
REF
{
REFM|FBrf0106275
|Bulgheresi and Knoblich
|1999
|1
}
REFDSR
{
RDID|FBrf0106275
|Bulgheresi and Knoblich
|1999
MD|In dividing precursor cells of the developing nervous system the
|correct asymmetric apical localization of @10-4@ mRNA depends on
|@insc@. @10-4@ protein localization to the apical cytoplasm occurs
|when @insc@ protein disappears, in anaphase. In telophase @10-4@
|protein forms a tight apical crescent.
OTH|Identification: Defined in a yeast two hybrid assay for genes whose
|products interact with the 364 amino acid domain of @insc@ that
|are required and sufficient for all the known @insc@ functions.
}
ALESR
{
ASYM|10-4+
ID|FBal0096586
CLA|wild-type generic
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0011557 CLA 1 Gene GSYM 1 107.1 DT 1 14 Aug 03 RESZ 1143 ALESR 1 REF 3
GSYM|107.1
DT|14 Aug 03
ID|FBgn0011557
WTI|tub
REF
{
REFM|FBrf0068202
|West and Anderson
|1994
|1
REFM|FBrf0105495
|FlyBase
|1992-
|9
REFM|FBrf0079611
|West and Anderson
|1995
|1
}
REFDSR
{
RDID|FBrf0068202
|West and Anderson
|1994
WTI|tub
PHP|@107.1@ behaves as a dominant gain of function enhancer of all alleles
|of @tub@, @107.1@ regulates @tub@ at post-transcriptional level. @107.1@
|acts in trans to disrupt accumulation of maternal @tub@ transcript.
|Females homozygous for @107.1@ lack maternal @tub@ transcript and
|yield completely dorsalized embryos.
}
REFDSR
{
RDID|FBrf0079611
|West and Anderson
|1995
PHP|@107.1@ may define a regulator of @tub@ transcript levels, the recessive
|maternal effect dorsalizing mutation exhibits loss of @tub@ message
|that can be completely rescued with excess @tub@.
}
ALESR
{
ASYM|107.1+
ID|FBal0066315
CLA|wild-type generic
REF|FBrf0105495
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0010339 CLA 1 Gene NAM 1 upstream of RpIII128 GSYM 1 128up DT 1 14 Aug 03 RESZ 4882 PDOM 1 SCOP:52540 == P-loop containing nucleotide triphosphate hydrolases PTD 1 DBA 10 HG 5 Caenorhabditis elegans C02F5.3 WP:CE00039 CLOC 1 48D8 ALESR 1 REF 13
GSYM|128up
PTD
MMP
DT|14 Aug 03
ID|FBgn0010339
UAB|Duplication: Dp(2;2)Y3b (inferred from cytology)
SYN|CG8340
|CG8340
|GTP-bp
|X71866
ID2|FBgn0010196
NAM|upstream of RpIII128
KLOC|60399
GLOC|2-
CLOC|48D8
|Limits computationally determined from genome sequence between l(2)k06612 and l(2)k05644
CYC|Experimentally determined: 48E
PDOM|SCOP:52540 == P-loop containing nucleotide triphosphate hydrolases; 128up|FBgn0010339|pp-CT24591|FBan0008340
MD|Identified with: SD05004 (BDGP-DGC)
ENZ|GTP binding ; GO:0005525 | inferred from direct assay
|GTP binding ; GO:0005525 | non-traceable author statement
|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ; GO:0016818 ; EC:3.6.1.- | inferred from electronic annotation
|GTP binding ; GO:0005525 | inferred from sequence similarity with Swiss-Prot:P43690
DBA|NA:AE003823
|PA:AAF58591
|NA:AI533247
|BDGP-DGC:SD05004
|NA:AX093898
|NA:AY069810
|PA:AAL39955
|BDGP-DGC:SD05004
|NA:X71866
|PA:CAA50701
PAC|PIR:S33467
|PIR:S42582
|SPTREMBL:Q9V648
|SWP:P32234
HG|species == Caenorhabditis elegans; gene == C02F5.3; WP:CE00039; score == 372; expect == 1.e-102
|species == Homo sapiens; gene == 'neural precursor cell expressed, developmentally down-regulated 3'; gi:4758796; score == 547; expect == 1.e-155
|species == Mus musculus; gene == Nedd3; MGI:97296; score == 546; expect == 1.e-154
|species == Saccharomyces cerevisiae; gene == 'HYPOTHETICAL 40.7 KD PROTEIN IN PYK1-SNC1 INTERGENIC REGION'; SWP:P39729; gi:731276; score == 434; expect == 1.e-121
|species == Xenopus laevis; gene == 'DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN DRG (XDRG)'; SWP:P43690; gi:1169421; score == 544; expect == 1.e-154
ASQ|FBan0008340
REF
{
REFM|FBrf0067209
|Sommer et al.
|1994
|0
REFM|FBrf0102347
|Kliman and Eyre-Walker
|1998
|0
REFM|FBrf0126686
|Milshina
|1999.11
|9
REFM|FBrf0126705
|FamiliarityBreedsContempt
|1999.11
|9
REFM|-1505380982
|0
|Patent: WO 0118547-A 15-MAR-2001;
REFM|FBrf0058389
|Sommer et al.
|1993
|1
REFM|FBrf0147137
|Brody et al.
|2002
|0
REFM|FBrf0125078
|BDGP Project Members
|2000-
|9
REFM|FBrf0146674
|Roth and Foulger
|2002.4.24
|9
REFM|FBrf0155515
|Ptak and Petrov
|2002
|0
REFM|FBrf0156694
|9
REFM|FBrf0090923
|Seifarth
|1991
|9
REFM|FBrf0105495
|FlyBase
|1992-
|9
}
REFDSR
{
RDID|FBrf0058389
|Sommer et al.
|1993
WT|@RpIII128@ gene is flanked by an upstream transcription unit, @128up@.
|@128up@ is transcribed in the same direction as @RpIII128@ and they
|are separated by a short intergenic region. Bacterially expressed
|@128up@, in fusion with maltose binding protein (MBP), specifically
|binds GTP.
}
REFDSR
{
RDID|995280021
|Davies
|2001.3.30
OTH|Area matching Drosophila GTP-binding protein, Acc. No. X71866.
}
REFDSR
{
RDID|FBrf0067209
|Sommer et al.
|1994
ENZ|GTP binding ; GO:0005525 | inferred from direct assay
WT|Bacterially expressed @128up@ is capable of binding GTP and the protein
|is primarily located in the perinuclear region.
GPD|GTP binding protein
}
REFDSR
{
RDID|FBrf0090923
|Seifarth
|1991
CLOC|48E (determined by in situ hybridization)
}
REFDSR
{
RDID|FBrf0102347
|Kliman and Eyre-Walker
|1998
OTH|In a sample of 79 genes with multiple introns, 33 showed significant
|heterogeneity in G+C content among introns of the same gene and significant
|positive correspondence between the intron and the third codon position
|G+C content within genes. These results are consistent with selection
|adding against preferred codons at the start of genes.
SYN|GTP-bp
}
REFDSR
{
RDID|FBrf0105495
|FlyBase
|1992-
ENZ|GTP binding ; GO:0005525 | inferred from sequence similarity with Swiss-Prot:P43690
}
REFDSR
{
RDID|FBrf0125078
|BDGP Project Members
|2000-
MD|Identified with: SD05004 (BDGP-DGC)
}
REFDSR
{
RDID|FBrf0146674
|Roth and Foulger
|2002.4.24
ENZ|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides ; GO:0016818 ; EC:3.6.1.- | inferred from electronic annotation
}
REFDSR
{
RDID|FBrf0147137
|Brody et al.
|2002
SYN|CG8340
}
REFDSR
{
RDID|FBrf0155515
|Ptak and Petrov
|2002
SYN|X71866
}
REFDSR
{
RDID|FBrf0156694
ENZ|GTP binding ; GO:0005525 | non-traceable author statement
}
ALESR
{
ASYM|128up+
ID|FBal0066316
CLA|wild-type generic
REF|FBrf0105495
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0005673 CLA 1 transposable element NAM 1 1360 element GSYM 1 1360 DT 1 14 Aug 03 RESZ 7727 DBA 19 WT 5 In situ hybridization to polytene chromosomes shows variable REF 46
GSYM|1360
MMP
DT|14 Aug 03
ID|FBgn0005673
CLA|transposable_element
SYN|hoppel
|hopel
|Hoppel
|hoppel-like
|Dr. D
|protop
|protop_b
|Hoppel-like
|DmHoppel
|Dm1360
|EG:23E12.4
|anon-CH(3)336
ID2|FBgn0004180
|FBgn0013399
NAM|1360 element
TE|element type: IR
|terminal repeat length in bp: 37
|total length in bp: 1176
|target site duplication length in bp: 6
|number of copies in genome: >25
WT|In situ hybridization to polytene chromosomes shows variable,
|strain-specific location in the euchromatic parts of the arms and heavy
|labeling of the 12E region of the X chromosome, chromosome bases
|(20A--20F, 40A--40F, 41A--41F, 80A--80C and 81F), the chromocenter and
|chromosome 4.
DBA|NA:AF533772
|NA:AF540061
|NA:AJ000473
|NA:AJ441085
|NA:AL031884
|NA:AY138841
|NA:L36596
|NA:M55078
|NA:U66884
|NA:X59157
|NA:X78388
|NA:Z11734
|NA:Z11735
|NA:Z31905
|dbSTS:4444
|NA:Z32073
|dbSTS:4624
|NA:Z32074
|dbSTS:4625
REF
{
REFM|FBrf0111489
|Spradling et al.
|1999
|0
REFM|FBrf0134799
|van Steensel et al.
|2001
|9
REFM|FBrf0053529
|Leibovich et al.
|1991
|0
REFM|FBrf0053528
|Leibovich
|1991
|0
REFM|FBrf0159203
|Reiss et al.
|2003
|0
REFM|FBrf0105803
|Cryderman et al.
|1998
|0
REFM|FBrf0155500
|Maggert and Golic
|2002
|0
REFM|FBrf0144916
|Rizzon et al.
|2002
|0
REFM|FBrf0071734
|EDGP Project Members
|1994-
|9
REFM|FBrf0046087
|Kholodilov et al.
|1987
|0
REFM|FBrf0105798
|Coelho et al.
|1998
|0
REFM|FBrf0149015
|Yan et al.
|2002
|0
REFM|FBrf0106872
|Locke et al.
|1999
|9
REFM|FBrf0151607
|Kapitonov and Jurka
|1997-
|9
REFM|FBrf0137315
|Galindo et al.
|2001
|0
REFM|FBrf0106421
|Dimitri et al.
|1999
|1
REFM|FBrf0080514
|Zhang and Spradling
|1995
|0
REFM|FBrf0080225
|Madueno et al.
|1995
|0
REFM|FBrf0135796
|Pardue and Debaryshe
|2000
|2
REFM|FBrf0149106
|Bartolome et al.
|2002
|0
REFM|FBrf0125039
|Bejarano and Gonzalez
|1999
|0
REFM|FBrf0135794
|Wallrath
|2000
|2
REFM|FBrf0135792
|Gvozdev et al.
|2000
|2
REFM|FBrf0123109
|Locke et al.
|1999
|0
REFM|FBrf0128554
|Locke et al.
|2000
|0
REFM|FBrf0101830
|Locke et al.
|1998
|1
REFM|FBrf0083001
|Almeida Coelho and Sunkel
|1995
|1
REFM|FBrf0052018
|Kurenova et al.
|1990
|0
REFM|FBrf0057400
|Balakireva et al.
|1992
|0
REFM|FBrf0126011
|Aravin et al.
|2000
|1
REFM|FBrf0137496
|Misra
|2001.8.16
|9
REFM|FBrf0151627
|Ashburner
|2002.8.15
|9
REFM|FBrf0135823
|Benos et al.
|2001
|0
REFM|FBrf0047691
|Kholodilov et al.
|1988
|0
REFM|FBrf0117093
|Kurenova
|1994.5.6
|9
REFM|FBrf0112417
|Ahmed
|1996.8.14
|9
REFM|FBrf0121135
|Sunkel
|1997.7.15
|9
REFM|FBrf0109548
|Cryderman et al.
|1999
|0
REFM|FBrf0101859
|Wallrath et al.
|1998
|1
REFM|FBrf0100583
|Kalmykova et al.
|1998
|0
REFM|FBrf0151719
|Tulin et al.
|2002
|0
REFM|FBrf0117473
|Livak
|1992.2.24
|9
REFM|FBrf0117472
|Livak
|1992.2.24
|9
REFM|FBrf0158933
|Marsano et al.
|2003
|0
REFM|FBrf0137199
|Aravin et al.
|2001
|0
REFM|FBrf0099762
|Deak et al.
|1997
|0
}
REFDSR
{
RDID|FBrf0047691
|Kholodilov et al.
|1988
WT|In situ hybridization to polytene chromosomes shows variable,
|strain-specific location in the euchromatic parts of the arms and heavy
|labeling of the 12E region of the X chromosome, chromosome bases
|(20A--20F, 40A--40F, 41A--41F, 80A--80C and 81F), the chromocenter and
|chromosome 4.
}
REFDSR
{
RDID|FBrf0052018
|Kurenova et al.
|1990
PHP|A @1360@ element has been cloned and sequenced. It is flanked by short
|inverted repeats. The @1360@ element is present in approximately 10-30
|euchromatic sites and also in numerous heterochromatic sites (in the
|chromocenter, pericentric heterochromatin, the fourth chromosome and
|at the telomeres) in the D.melanogaster genome. At least 6 variant
|@1360@ elements differing in the length of the central region have
|been detected. The @1360@ element has ARS activity, similar to the
|@P-element@.
SYN|hoppel
}
REFDSR
{
RDID|FBrf0053528
|Leibovich
|1991
SYN|hopel
}
REFDSR
{
RDID|FBrf0053529
|Leibovich et al.
|1991
SYN|hopel
}
REFDSR
{
RDID|FBrf0080514
|Zhang and Spradling
|1995
}
REFDSR
{
RDID|FBrf0083001
|Almeida Coelho and Sunkel
|1995
SYN|Hoppel
}
REFDSR
{
RDID|FBrf0099762
|Deak et al.
|1997
SYN|hoppel
}
REFDSR
{
RDID|FBrf0101830
|Locke et al.
|1998
SYN|Hoppel
}
REFDSR
{
RDID|FBrf0101859
|Wallrath et al.
|1998
SYN|hoppel
}
REFDSR
{
RDID|FBrf0105803
|Cryderman et al.
|1998
SYN|hoppel
}
REFDSR
{
RDID|FBrf0106421
|Dimitri et al.
|1999
SYN|hoppel
}
REFDSR
{
RDID|FBrf0106872
|Locke et al.
|1999
SYN|Hoppel
}
REFDSR
{
RDID|FBrf0109548
|Cryderman et al.
|1999
SYN|hoppel
}
REFDSR
{
RDID|FBrf0111489
|Spradling et al.
|1999
SYN|hoppel
}
REFDSR
{
RDID|FBrf0112417
|Ahmed
|1996.8.14
SYN|unnamed
}
REFDSR
{
RDID|FBrf0117093
|Kurenova
|1994.5.6
SYN|hoppel
}
REFDSR
{
RDID|FBrf0117472
|Livak
|1992.2.24
SYN|unnamed
}
REFDSR
{
RDID|FBrf0117473
|Livak
|1992.2.24
SYN|unnamed
}
REFDSR
{
RDID|FBrf0121135
|Sunkel
|1997.7.15
SYN|hoppel-like
}
REFDSR
{
RDID|FBrf0123109
|Locke et al.
|1999
TE|The "Dr. D" repetitive sequence (described in FBrf0048918) contains
|sequences of both @INE-1@ and @1360@ transposable elements.
SYN|hoppel
}
REFDSR
{
RDID|FBrf0125039
|Bejarano and Gonzalez
|1999
SYN|hoppel
}
REFDSR
{
RDID|FBrf0126011
|Aravin et al.
|2000
SYN|hoppel
}
REFDSR
{
RDID|FBrf0128554
|Locke et al.
|2000
SYN|Dr. D
|Hoppel
}
REFDSR
{
RDID|FBrf0134799
|van Steensel et al.
|2001
SYN|hoppel
}
REFDSR
{
RDID|FBrf0135792
|Gvozdev et al.
|2000
SYN|hoppel
}
REFDSR
{
RDID|FBrf0135794
|Wallrath
|2000
SYN|hoppel
}
REFDSR
{
RDID|FBrf0135796
|Pardue and Debaryshe
|2000
SYN|Hoppel
}
REFDSR
{
RDID|FBrf0137199
|Aravin et al.
|2001
SYN|hoppel
}
REFDSR
{
RDID|FBrf0144916
|Rizzon et al.
|2002
SYN|Hoppel
}
REFDSR
{
RDID|FBrf0151607
|Kapitonov and Jurka
|1997-
SYN|protop
|protop_b
}
REFDSR
{
RDID|FBrf0151719
|Tulin et al.
|2002
SYN|hoppel
}
REFDSR
{
RDID|FBrf0155500
|Maggert and Golic
|2002
SYN|hoppel
}
REFDSR
{
RDID|FBrf0158933
|Marsano et al.
|2003
SYN|Hoppel-like
|DmHoppel
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0066320 CLA 1 transposable element gene GSYM 1 1360\T DT 1 14 Aug 03 RESZ 264 DBA 2 ALESR 1 REF 1
GSYM|1360\T
DT|14 Aug 03
ID|FBgn0066320
CLA|transposable_element_gene
DBA|NA:AF533772
|PA:AAN39288
REF
{
REFM|FBrf0159203
|Reiss et al.
|2003
|0
}
ALESR
{
ASYM|1360\T+
ID|FBal0146588
CLA|wild-type generic
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0020238 CLA 1 Gene GSYM 1 14-3-3&egr; DT 1 14 Aug 03 RESZ 28385 PTD 1 DBA 18 FNC 4 DNA damage response, signal transduction resulting in cell cycle arrest WT 2 @14-3-3&egr;@ is required to time mitosis in undisturbed post-blastoderm CLOC 1 90F7--8 ALESR 10 SK 2 REF 42
GSYM|14-3-3&egr;
PTD
ARGS
DT|14 Aug 03
ID|FBgn0020238
UAB|Deficiency: Df(3R)P14
|Duplication: Dp(3;3)C123.3 (inferred from cytology)
SYN|CG31196
|SR3-9
|14-3-3
|d14-3-3&egr;
|14-3-3epsilon
|14-3-3e
|CT24092
|EK3-5
|D14-3-3&egr;
|14-3-3-e
|D14-3-3e
|par-5
|Su(Raf)3B
|l(3)j2B10
|Suppressor of Ras85D 3-9
ID2|FBgn0011329
|FBgn0016739
|FBgn0016743
|FBgn0051196
|FBgn0064146
KLOC|116346-11439
CLOC|90F7--8
|Limits computationally determined from genome sequence between l(3)s2956 and EP(3)3634
CYC|Experimentally determined: 90E--F, 90F6--7
FNC|DNA damage response, signal transduction resulting in cell cycle arrest ; GO:0000077 | inferred from mutant phenotype
|DNA damage response, signal transduction resulting in cell cycle arrest ; GO:0000077 | inferred from mutant phenotype
|regulation of mitosis ; GO:0007088 | inferred from mutant phenotype
|response to external stimulus ; GO:0009605 | inferred from mutant phenotype
GLC|Maps 0.4 +/- 0.2 cM from a P{w+} insertion into 90E.
WT|@14-3-3&egr;@ is required to time mitosis in undisturbed post-blastoderm
|cell cycles and to delay mitosis following irradiation in embryos.
ENZ|diacylglycerol-activated/phospholipid dependent protein kinase C inhibitor activity ; GO:0004863 | non-traceable author statement
DBA|NA:AE003721
|PA:AAF55519
|PA:AAN13764
|PA:AAN13765
|PA:AAN13766
|NA:AI107648
|BDGP-DGC:GH05443
|NA:AQ026302
|BDGP:l(3)j2B10
|NA:AW940197
|BDGP-DGC:GH05443
|NA:AY058293
|PA:AAL13522
|BDGP-DGC:GH05443
|NA:U84897
|PA:AAC47519
|NA:U84898
|PA:AAC47520
PAC|SPTREMBL:Q8IN86
|SPTREMBL:Q8IN87
|SWP:P92177
ASQ|FBan0031196
REV|FBrf0158832
|FBrf0127283
|FBrf0111327
REF
{
REFM|FBrf0154848
|1
REFM|FBrf0111489
|Spradling et al.
|1999
|0
REFM|FBrf0091142
|Perrimon et al.
|1996
|0
REFM|FBrf0158832
|Ahringer
|2003
|2
REFM|FBrf0126705
|FamiliarityBreedsContempt
|1999.11
|9
REFM|FBrf0111327
|Baek and Lee
|1999
|2
REFM|FBrf0131405
|Therrien et al.
|2000
|0
REFM|FBrf0125078
|BDGP Project Members
|2000-
|9
REFM|FBrf0126669
|Gong
|1999.11
|9
REFM|FBrf0126349
|Su
|2000
|1
REFM|FBrf0134532
|Walworth
|2000
|2
REFM|FBrf0127357
|Teeter et al.
|2000
|0
REFM|FBrf0104620
|Rommel and Hafen
|1998
|2
REFM|FBrf0108031
|Tien et al.
|1999
|0
REFM|FBrf0067338
|BDGP Project Members
|1994-1999
|9
REFM|FBrf0133450
|Acevedo and Skoulakis
|2001
|1
REFM|FBrf0083714
|Meister and Braun
|1995.10
|9
REFM|FBrf0145821
|Acevedo and Skoulakis
|2002
|1
REFM|FBrf0139721
|Su et al.
|2001
|0
REFM|FBrf0151887
|Rebay
|2002
|2
REFM|FBrf0159706
|Hacker et al.
|2003
|0
REFM|FBrf0127283
|Raabe
|2000
|2
REFM|FBrf0113722
|Chang
|1997.1.11
|9
REFM|FBrf0113721
|Chang
|1997.1.10
|9
REFM|FBrf0108153
|Chen and Chien
|1999
|0
REFM|FBrf0102393
|Rubin et al.
|1997
|2
REFM|FBrf0126913
|Bayraktaroglu
|2000.4.13
|9
REFM|FBrf0126651
|Ashburner
|1999.11
|9
REFM|FBrf0105495
|FlyBase
|1992-
|9
REFM|FBrf0126680
|Lei
|1999.11
|9
REFM|FBrf0127025
|Brodsky et al.
|2000
|0
REFM|FBrf0149093
|Johannes and Preiss
|2002
|0
REFM|FBrf0124174
|SwissProt Project Members
|1998.2.1
|9
REFM|FBrf0145847
|Skoulakis and Acevedo
|2002
|1
REFM|FBrf0159690
|Chen et al.
|2003
|0
REFM|FBrf0133630
|Purdy et al.
|2001
|1
REFM|FBrf0087493
|Karim et al.
|1996
|0
REFM|FBrf0155512
|Pellettieri and Seydoux
|2002
|2
REFM|FBrf0129944
|Li et al.
|2000
|0
REFM|FBrf0086382
|Dickson et al.
|1996
|0
REFM|FBrf0130073
|Sekelsky et al.
|2000
|0
REFM|FBrf0093395
|Chang and Rubin
|1997
|0
}
REFDSR
{
RDID|FBrf0067338
|BDGP Project Members
|1994-1999
CLOC|90F6--7
LOI|14-3-3&egr;j2B10
BMD|Df(3R)P14
}
REFDSR
{
RDID|FBrf0086382
|Dickson et al.
|1996
GLC|Maps 0.4 +/- 0.2 cM from a P{w+} insertion into 90E.
WTI|phl (data from @14-3-3&egr;18A2@)
PHP|Identified in a genetic screen for modifiers of the @phl::tor12D.sev@
|rough eye mutant phenotype.
}
REFDSR
{
RDID|FBrf0087493
|Karim et al.
|1996
GLOC|3-
CLOC|90E--F
CYC|On basis of meiotic mapping (details unspecified).
WTI|Dsor1 (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@)
|Ras85D (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@)
|aop (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@)
|phl (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@)
PHP|Identified on the basis of genetic interaction with @Ras85DV12.sev@.
SYN|SR3-9: Suppressor of Ras85D 3-9
}
REFDSR
{
RDID|FBrf0091142
|Perrimon et al.
|1996
CLOC|90F6--7 (determined by in situ hybridization)
PHP|The autosomal "FLP-DFS" technique (using the @P{ovoD1-18}@ @P{FRT(whs)}@
|@P{hsFLP}@ chromosomes) has been used to identify the specific maternal
|effect phenotype for the zygotic lethal mutation. @14-3-3&egr;@ gene
|expression during oogenesis is not critical to embryonic development,
|but the gene function may be essential for fertilization and/or completion
|of meiosis.
}
REFDSR
{
RDID|FBrf0093395
|Chang and Rubin
|1997
GLOC|3-62.0
WTI|14-3-3&zgr; (data from @14-3-3&egr;j2B10@)
|Ras85D (data from @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@, @14-3-3&egr;j2B10@)
|phl (data from @14-3-3&egr;18A2@, @14-3-3&egr;S-1259@, @14-3-3&egr;S-696@, @14-3-3&egr;j2B10@)
PHP|@14-3-3&egr;@ has been cloned and characterized. Genetic studies suggest
|that @14-3-3&egr;@ functions in multiple receptor tyrosine kinase pathways,
|acting downstream or parallel to @phl@, but upstream of @aop@ and @phyl@,
|two nuclear factors involved in @Ras85D@ signaling.
}
REFDSR
{
RDID|FBrf0104620
|Rommel and Hafen
|1998
SYN|14-3-3
}
REFDSR
{
RDID|FBrf0108031
|Tien et al.
|1999
BMD|Df(3R)P14
SYN|d14-3-3&egr;
}
REFDSR
{
RDID|FBrf0108153
|Chen and Chien
|1999
SYN|d14-3-3&egr;
}
REFDSR
{
RDID|FBrf0111327
|Baek and Lee
|1999
SYN|14-3-3
}
REFDSR
{
RDID|FBrf0111489
|Spradling et al.
|1999
CLOC|90F6--7 (determined by in situ hybridization)
LOI|14-3-3&egr;j2B10
BMD|Df(3R)P14
SYN|14-3-3epsilon
}
REFDSR
{
RDID|FBrf0113721
|Chang
|1997.1.10
ENZ|diacylglycerol-activated/phospholipid dependent protein kinase C inhibitor activity ; GO:0004863 | non-traceable author statement
CLOC|90F6--7
FNC|RAS protein signal transduction ; GO:0007265 | non-traceable author statement
GPD|14-3-3-protein
SYN|14-3-3e
}
REFDSR
{
RDID|FBrf0113722
|Chang
|1997.1.11
SYN|14-3-3e
}
REFDSR
{
RDID|FBrf0124174
|SwissProt Project Members
|1998.2.1
FNC|RAS protein signal transduction ; GO:0007265 | non-traceable author statement
}
REFDSR
{
RDID|FBrf0126669
|Gong
|1999.11
AM|Source for identity of: 14-3-3&egr; CG8045
}
REFDSR
{
RDID|FBrf0126913
|Bayraktaroglu
|2000.4.13
SYN|CT24092
}
REFDSR
{
RDID|FBrf0127025
|Brodsky et al.
|2000
FNC|DNA damage response, signal transduction resulting in cell cycle arrest ; GO:0000077 | inferred from mutant phenotype
}
REFDSR
{
RDID|FBrf0127283
|Raabe
|2000
SYN|14-3-3
}
REFDSR
{
RDID|FBrf0129944
|Li et al.
|2000
WTI|phl (data from @14-3-3&egr;&Dgr;24@)
}
REFDSR
{
RDID|FBrf0130073
|Sekelsky et al.
|2000
FNC|DNA damage response, signal transduction resulting in cell cycle arrest ; GO:0000077 | traceable author statement
}
REFDSR
{
RDID|FBrf0131405
|Therrien et al.
|2000
WTI|ksr
|Ras85D (data from @14-3-3&egr;unspecified@)
|phl (data from @14-3-3&egr;unspecified@)
SYN|EK3-5
}
REFDSR
{
RDID|FBrf0133450
|Acevedo and Skoulakis
|2001
SYN|D14-3-3&egr;
}
REFDSR
{
RDID|FBrf0134532
|Walworth
|2000
FNC|imaginal disc development ; GO:0007444 | traceable author statement
|mitotic checkpoint ; GO:0007093 | traceable author statement
|response to radiation ; GO:0009314 | traceable author statement
SYN|14-3-3e
}
REFDSR
{
RDID|FBrf0139721
|Su et al.
|2001
FNC|DNA damage response, signal transduction resulting in cell cycle arrest ; GO:0000077 | inferred from mutant phenotype
|regulation of mitosis ; GO:0007088 | inferred from mutant phenotype
WT|@14-3-3&egr;@ is required to time mitosis in undisturbed post-blastoderm
|cell cycles and to delay mitosis following irradiation in embryos.
}
REFDSR
{
RDID|FBrf0145821
|Acevedo and Skoulakis
|2002
SYN|D14-3-3&egr;
}
REFDSR
{
RDID|FBrf0145847
|Skoulakis and Acevedo
|2002
FNC|response to external stimulus ; GO:0009605 | inferred from mutant phenotype
SYN|D14-3-3&egr;
}
REFDSR
{
RDID|FBrf0149093
|Johannes and Preiss
|2002
SYN|14-3-3-e
}
REFDSR
{
RDID|FBrf0151887
|Rebay
|2002
SYN|14-3-3
}
REFDSR
{
RDID|FBrf0154848
SYN|D14-3-3e
}
REFDSR
{
RDID|FBrf0155512
|Pellettieri and Seydoux
|2002
SYN|par-5
}
REFDSR
{
RDID|FBrf0159706
|Hacker et al.
|2003
SYN|14-3-3
}
ALESR
{
ASYM|14-3-3&egr;&Dgr;24
ID|FBal0122336
REF|FBrf0129944
REFDSR
{
RDID|FBrf0129944
|Li et al.
|2000
GIC2|lethal with @phlSu2@
}
}
ALESR
{
ASYM|14-3-3&egr;18A2
SYN|14-3-3&egr;Y214F
|18A2
ID|FBal0049166
REF|FBrf0093395
|FBrf0086382
REFDSR
{
RDID|FBrf0086382
|Dickson et al.
|1996
MU|ethyl methanesulfonate
GIC|suppressor | dominant of visible phenotype of @phl::tor12D.sev@
GIA|suppressor | dominant of eye phenotype of @phl::tor12D.sev@
|suppressor | dominant of photoreceptor cell R7 phenotype of @phl::tor12D.sev@
GIC2|lethal | dominant with @phl12@
GII|Dominantly suppresses the rough eye phenotype of
|@phl::tor12D.sev@. Synthetic lethal in combination with @phl12@.
PHC|viable
|female fertile
ALC|antimorph
PHI|Homozygous viable with no obvious defects in eye development.
}
REFDSR
{
RDID|FBrf0093395
|Chang and Rubin
|1997
MD|Amino acid replacement: Y214F.
MU|ethyl methanesulfonate
GIC2|lethal | dominant with @phl12@
PHC|viable
|fertile
PHI|Homozygotes have no detectable phenotype in a wild-type background.
SYN|14-3-3&egr;Y214F
|18A2
}
}
ALESR
{
ASYM|14-3-3&egr;ex4
ID|FBal0148514
ALC|loss of function
REF|FBrf0159690
REFDSR
{
RDID|FBrf0159690
|Chen et al.
|2003
MD|Imprecise mobilization of the @P{lacW}14-3-3&egr;j2B10@ element has
|created this allele.
PRG|14-3-3&egr;j2B10
MU|P-element activity
ALC|loss of function
}
}
ALESR
{
ASYM|14-3-3&egr;j2B10
SYN|l(3)j2B10
|l(3)2B10
|14-3-3&egr;j2b10
|14-3-3-ej2B10
ID|FBal0010913
TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10
|BDGP:l(3)j2B10
MU|P-element activity
REF|FBrf0067338
|FBrf0127025
|FBrf0093395
|FBrf0108153
|FBrf0159690
|FBrf0149093
|FBrf0083714
|FBrf0091142
|FBrf0111489
|FBrf0139721
REFDSR
{
RDID|FBrf0067338
|BDGP Project Members
|1994-1999
OTH|Complements: @repo03702@.
|Complements: @l(3)0582205822@.
|Complements: @Trap80s2956@.
TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10
|BDGP:l(3)j2B10
}
REFDSR
{
RDID|FBrf0091142
|Perrimon et al.
|1996
PHC|lethal | larval | recessive
|lethal | embryonic | maternal effect
PHM|cuticle | embryonic | maternal effect
PHI|Germline clones produce normal eggs with no cuticle development.
}
REFDSR
{
RDID|FBrf0093395
|Chang and Rubin
|1997
AFC|14-3-3&egr;S-696
MD|Insertion of a @P{lacW}@ element within the first intron.
OTH|The rough eye and missing photoreceptor cell phenotype of @14-3-3&egr;S-696@/@14-3-3&egr;j2B10@
|flies is reverted by mobilization of the @P-element@ in @14-3-3&egr;j2B10@.
|The recessive lethality of the @14-3-3&egr;j2B10@ chromosome is not
|associated with the @P-element@ insertion.
TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10
|BDGP:l(3)j2B10
MU|P-element activity
GIC|suppressor | recessive of visible phenotype of @Ras85DV12.sev@
GIC2|lethal | recessive with @14-3-3&zgr;P2355@/+
|visible | recessive with @14-3-3&zgr;X1@/+
|visible | recessive with @14-3-3&zgr;2.3@/+
|lethal | dominant with @phl12@
GIA|suppressor | recessive of eye phenotype of @Ras85DV12.sev@
|suppressor | recessive of ommatidium phenotype of @Ras85DV12.sev@
GIA2|ommatidium with @14-3-3&zgr;X1@/+
|ommatidium with @14-3-3&zgr;2.3@/+
|posterior crossvein with @14-3-3&zgr;2.3@
|eye with @14-3-3&zgr;2.3@
|photoreceptor cell with @14-3-3&zgr;2.3@
|posterior crossvein with @14-3-3&zgr;X1@
|eye with @14-3-3&zgr;X1@
|photoreceptor cell with @14-3-3&zgr;X1@
GII|Homozygotes but not heterozygotes suppress the @Ras85DV12.sev@
|rough eye phenotype.
|@14-3-3&zgr;X1@/+ @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ or
|@14-3-3&zgr;2.3@/+ @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ flies
|have slightly roughened eyes, a low penetrance of missing
|photoreceptors and a gap in the posterior crossvein of the wings in
|more than 50% of cases.
PHC|viable
|sterile | recessive
|(with 14-3-3&egr;S-696) visible
PHM|(with 14-3-3&egr;S-696) eye
|(with 14-3-3&egr;S-696) photoreceptor cell
|(with 14-3-3&egr;S-696) ommatidium
ALC|loss of function
PHI|Homozygotes have normal eyes but are sterile.
|@14-3-3&egr;S-696@/@14-3-3&egr;j2B10@ flies have rough eyes and
|a low penetrance of missing photoreceptors in the ommatidia.
SYN|l(3)j2B10
}
REFDSR
{
RDID|FBrf0108153
|Chen and Chien
|1999
GIA2|(with Df(3R)P14) photoreceptor cell R8 with @EgfrE1@
GII|R8 photoreceptor cells fail to form in @EgfrE1@/+ ; @14-3-3&egr;j2B10@/@Df(3R)P14@
|eye discs.
SYN|l(3)2B10
}
REFDSR
{
RDID|FBrf0111489
|Spradling et al.
|1999
TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10
|BDGP:l(3)j2B10
PHC|lethal | recessive
SYN|l(3)j2B10
}
REFDSR
{
RDID|FBrf0127025
|Brodsky et al.
|2000
PHI|In the absence of irradiation, @14-3-3&egr;j2B10@ animals have a
|normal external appearance, normal imaginal disc morphology and normal
|numbers of mitotic cells in the discs. After irradiation, the number
|of mitotic cells in @14-3-3&egr;j2B10@ discs is greater than the
|number found in irradiated wild-type discs.
SYN|14-3-3&egr;j2b10
}
REFDSR
{
RDID|FBrf0139721
|Su et al.
|2001
TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10
|BDGP:l(3)j2B10
PHC|mitotic | recessive
PHM|embryonic cycle 14
PHI|Embryos derived from a cross of @14-3-3&egr;j2B10@/@Df(3R)Cha7@ females
|to @14-3-3&egr;j2B10@/@Df(3R)Cha7@ males progress through the first
|13 mitotic cycles and cellularize without obvious defects. Cells enter
|mitosis 14 prematurely compared to wild type so that the division pattern
|of mutant embryos in gastrulation is more advanced than in wild-type
|embryos of similar gastrulation but is similar to wild-type embryos
|of more advanced gastrulation. The entire schedule of mitosis is advanced
|without disrupting the relative order of mitosis in different positions
|within the embryo. The rate of germ-band elongation is indistinguishable
|from wild type. Mutant embryos do not show a delay of entry into mitosis
|14 after irradiation, in contrast to wild-type embryos.
SYN|l(3)j2B10
}
REFDSR
{
RDID|FBrf0149093
|Johannes and Preiss
|2002
SYN|14-3-3-ej2B10
}
REFDSR
{
RDID|FBrf0159690
|Chen et al.
|2003
TRN|FBti0004920 == P{lacW}14-3-3&egr;j2B10
|BDGP:l(3)j2B10
}
SK|FBstBL-12142
|y[1] w[*]; P{w[+mC]=lacW}14-3-3epsilon[j2B10]/TM3, Sb[1]
}
ALESR
{
ASYM|14-3-3&egr;PL00784
SYN|l(3)PL00784
ID|FBal0148516
PHC|lethal | embryonic | maternal effect | germ-line clone
PHM|embryo | maternal effect | germ-line clone
PHI|@14-3-3&egr;PL00784@ germ-line clones produce embryos that die before
|they produce a larval cuticle and appear as 'empty eggs'.
REF|FBrf0159706
REFDSR
{
RDID|FBrf0159706
|Hacker et al.
|2003
MD|The PBac{UASp-3xP3-EYFP,p-GAL4&Dgr;-K10} insertion is in the first
|intron of @14-3-3&egr;@.
TRN|&o insertion
PHC|lethal | embryonic | maternal effect | germ-line clone
PHM|embryo | maternal effect | germ-line clone
PHI|@14-3-3&egr;PL00784@ germ-line clones produce embryos that die before
|they produce a larval cuticle and appear as 'empty eggs'.
SYN|l(3)PL00784
}
}
ALESR
{
ASYM|14-3-3&egr;S-696
SYN|14-3-3&egr;E183K
|SR3-9696
ID|FBal0048994
REF|FBrf0093395
|FBrf0087493
|FBrf0131405
REFDSR
{
RDID|FBrf0087493
|Karim et al.
|1996
MU|ethyl methanesulfonate
GIC|suppressor of visible phenotype of @Ras85DV12.sev@
|suppressor of @phl::tor13D.hs.sev@
|suppressor of @Ras85D::Src64BV12.&Dgr;CAAX.sev@
|enhancer of @Ras85DN17.sev@
|enhancer of lethal phenotype of @phl12@
|enhancer of visible phenotype of @phl12@
|enhancer of visible phenotype of @Dsor1XS520@
|enhancer of visible phenotype of @aopS2382@
GIA|suppressor of eye phenotype of @Ras85DV12.sev@
|enhancer of eye phenotype of @phl12@
|enhancer of eye phenotype of @Dsor1XS520@
|enhancer of eye phenotype of @aopS2382@
GII|Suppresses the rough eye phenotype of @Ras85DV12.sev@.
PHC|viable | poor
PHI|Homozygotes are subviable.
}
REFDSR
{
RDID|FBrf0093395
|Chang and Rubin
|1997
AFC|14-3-3&egr;j2B10
MD|Amino acid replacement: E183K.
MU|ethyl methanesulfonate
GIC|suppressor | dominant of @Ras85DV12.sev@
GIC2|lethal | dominant with @phl12@
GIC|suppressor | dominant of @phl::tor13D.hs.sev@
GII|@14-3-3&egr;S-696@ does not show any dominant interaction with @aopyan-1@
|or @phylhs.sev@.
PHC|lethal | recessive | partially
|(with 14-3-3&egr;j2B10) visible
PHM|(with Df(3R)P14) ommatidium
|(with 14-3-3&egr;j2B10) eye
|(with 14-3-3&egr;j2B10) photoreceptor cell
|(with 14-3-3&egr;j2B10) ommatidium
|ommatidium
|photoreceptor cell
|posterior crossvein
PHI|62.5% of ommatidia are normal in homozygous escapers, with the remaining
|ommatidia lacking some photoreceptor cells, and 69.1% of ommatidia
|are normal in @14-3-3&egr;S-696@/@Df(3R)P14@ flies. Homozygous escapers
|often have gaps in the posterior crossveins of the wings.
|@14-3-3&egr;S-696@/@14-3-3&egr;j2B10@ flies have rough eyes and
|a low penetrance of missing photoreceptors in the ommatidia.
SYN|14-3-3&egr;E183K
|SR3-9696
}
SK|FBstBL-6565
|14-3-3epsilon[S-696]/TM3, P{ry[+t7.2]=sevRas1.V12}FK2, Sb[1]
}
ALESR
{
ASYM|14-3-3&egr;S-1259
SYN|14-3-3&egr;F199Y
|SR3-91259
ID|FBal0048993
REF|FBrf0093395
|FBrf0087493
REFDSR
{
RDID|FBrf0087493
|Karim et al.
|1996
MU|ethyl methanesulfonate
GIC|suppressor of visible phenotype of @Ras85DV12.sev@
|suppressor of @phl::tor13D.hs.sev@
|suppressor of @Ras85D::Src64BV12.&Dgr;CAAX.sev@
|enhancer of lethal phenotype of @phl12@
|enhancer of visible phenotype of @phl12@
|enhancer of @Ras85DN17.sev@
|enhancer of visible phenotype of @Dsor1XS520@
|enhancer of visible phenotype of @aopS2382@
GIA|suppressor of eye phenotype of @Ras85DV12.sev@
|enhancer of eye phenotype of @phl12@
|enhancer of eye phenotype of @Dsor1XS520@
|enhancer of eye phenotype of @aopS2382@
GIC|suppressor | dominant of @Ras85DV12.sev@
GII|Suppresses the rough eye phenotype of @Ras85DV12.sev@.
PHC|viable | poor
PHI|Homozygotes are subviable.
}
REFDSR
{
RDID|FBrf0093395
|Chang and Rubin
|1997
MD|Amino acid replacement: F199Y.
MU|ethyl methanesulfonate
GIC|suppressor | dominant of @Ras85DV12.sev@
GIC2|lethal | dominant with @phl12@
PHC|viable
|fertile
PHI|Homozygotes have no detectable phenotype in a wild-type background.
SYN|14-3-3&egr;F199Y
|SR3-91259
}
}
ALESR
{
ASYM|14-3-3&egr;Scer\UAS.cCa
ID|FBal0148515
PHI|When @14-3-3&egr;Scer\UAS.cCa@ is driven by @Scer\GAL4GMR.PF@ no
|deleterious effects are seen.
REF|FBrf0159690
REFDSR
{
RDID|FBrf0159690
|Chen et al.
|2003
NAM|Saccharomyces cerevisiae UAS construct a of Chen
MD|@Scer\UAS@ sequences drive expression of @14-3-3&egr;@.
CNS|FBtp0017453 == P{UAS-14-3-3&egr;.C}
GIC2|lethal with @Hsap\ATX182Q.Scer\UAS@
|lethal with @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@
|lethal with @Hsap\ATX182Q.Scer\UAS@
|lethal with @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@
GIA|enhancer of eye phenotype of @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@
|enhancer of retina phenotype of @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@
|enhancer of rhabdomere phenotype of @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@
GII|The addition of @14-3-3&egr;Scer\UAS.cCa@ enhances the eye phenotypes
|seen in @Hsap\ATX182Q.Scer\UAS@, @Scer\GAL4GMR.PF@ animals alone.
|They have profoundly disordered ommatidia, a thin and disorganized
|retina layer, and grossly abnormal rhabdomeres.
PHI|When @14-3-3&egr;Scer\UAS.cCa@ is driven by @Scer\GAL4GMR.PF@ no
|deleterious effects are seen.
}
}
ALESR
{
ASYM|14-3-3&egr;unspecified
ID|FBal0121020
PHC|lethal | recessive
REF|FBrf0131405
REFDSR
{
RDID|FBrf0131405
|Therrien et al.
|2000
GIA|enhancer | dominant of eye phenotype of @ksr::tor&Dgr;Nksr.hs.sev@
|suppressor | dominant of eye phenotype of @Ras85DV12.sev@
GIC|enhancer | dominant of lethal phenotype of @phl12@
|enhancer | dominant of visible phenotype of @ksr::tor&Dgr;Nksr.hs.sev@
|suppressor | dominant of visible phenotype of @Ras85DV12.sev@
PHC|lethal | recessive
}
}
ALESR
{
ASYM|14-3-3&egr;+
ID|FBal0079281
CLA|wild-type generic
REF|FBrf0105495
}
SKC|2
}
# EOR
GENR
{
RETE|ID 1 FBgn0004907 CLA 1 Gene GSYM 1 14-3-3&zgr; DT 1 14 Aug 03 RESZ 60579 PTD 1 DBA 31 HG 5 Caenorhabditis elegans F52D10.3 WP:CE03389 FNC 2 RAS protein signal transduction CLOC 1 46E6--8 ALESR 27 SK 2 REF 76
GSYM|14-3-3&zgr;
PTD
ARGS
DT|14 Aug 03
ID|FBgn0004907
UAB|Deficiency: Df(2R)stan1 (inferred from cytology)
|Duplication: Dp(2;2)Y3b (inferred from cytology)
SYN|CG17870
|549
|2G1
|leonardo
|leo: leonardo
|D14-3-3&zgr;
|14-3-3
|14-3-3zeta
|Leonardo-13-3-3
|4-3-3 zeta
|par-5
|D14-3-3: D14 3 3 protein
|l(2)07103
|leo
|D14 3 3 protein
ID2|FBgn0010635
|FBgn0064146
KLOC|57933-11245
CLOC|46E6--8
|Limits computationally determined from genome sequence between l(2)07103 and l(2)06339/l(2)03221
CYC|Experimentally determined: 46E, 46E--F, 46E4--8
FNC|RAS protein signal transduction ; GO:0007265 | inferred from sequence similarity with SGD_LOCUS:BMH2; SGD:S0002506
|tryptophan hydroxylase activation ; GO:0006588 | inferred from sequence similarity with MGD:Ywhaz; MGI:MGI:109484
ENZ|tryptophan hydroxylase activator activity ; GO:0016483 | inferred from sequence similarity with MGD:Ywhaz; MGI:MGI:109484
|protein kinase C inhibitor activity ; GO:0008426 | non-traceable author statement
|diacylglycerol-activated/phospholipid dependent protein kinase C inhibitor activity ; GO:0004863 | inferred from sequence similarity with MGD:Ywhaz; MGI:MGI:109484
DBA|NA:AA538817
|BDGP-DGC:LD18434
|NA:AE003831
|PA:AAF58842
|PA:AAF58843
|PA:AAM71060
|PA:AAM71061
|PA:AAM71062
|PA:AAM71063
|PA:AAM71064
|NA:AQ025662
|BDGP:l(2)07103
|NA:AW942482
|BDGP-DGC:LD18434
|NA:AY095521
|PA:AAM12253
|BDGP-DGC:LD18434
|NA:BH840513
|BDGP:KG02642
|NA:BI564632
|BDGP-DGC:RH61958
|NA:BT001855
|PA:AAN71617
|BDGP-DGC:RH61958
|NA:M77518
|PA:AAA28324
|NA:Y12573
|PA:CAA73153
|PA:CAA73152
|NA:Z32177
|dbSTS:4728
PAC|PIR:JC1122
|SPTREMBL:Q8IGB9
|SPTREMBL:Q8MKV5
|SPTREMBL:Q8SWR6
|SWP:P29310
HG|species == Caenorhabditis elegans; gene == F52D10.3; WP:CE03389; score == 471; expect == 2.e-80
|species == Homo sapiens; gene == 'tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide'; gi:4507953; score == 478; expect == 6.e-80
|species == Mus musculus; gene == Ywhaz; MGI:109484; score == 478; expect == 7.e-81
|species == Saccharomyces cerevisiae; gene == BMH2; SGDID:L0000186; score == 374; expect == 3.e-57
|species == rat; gene == '14-3-3 protein isoform zeta'; PIR:JC5232; gi:2143553; score == 481; expect == 7.e-81
ASQ|FBan0017870
REV|FBrf0158832
|FBrf0137068
|FBrf0127283
REF
{
REFM|FBrf0093395
|Chang and Rubin
|1997
|0
REFM|FBrf0159690
|Chen et al.
|2003
|0
REFM|FBrf0102616
|Connolly and Tully
|1998
|2
REFM|FBrf0101184
|Hermon et al.
|1998
|1
REFM|FBrf0084992
|Edwards and Wasserman
|1996
|1
REFM|FBrf0102121
|Broadie
|1998
|2
REFM|FBrf0101416
|Amanai et al.
|1998
|1
REFM|FBrf0056086
|Swanson and Ganguly
|1992
|0
REFM|FBrf0057515
|Ganguly et al.
|1992
|0
REFM|FBrf0126651
|Ashburner
|1999.11
|9
REFM|FBrf0145821
|Acevedo and Skoulakis
|2002
|1
REFM|FBrf0099136
|Broadie et al.
|1997
|1
REFM|FBrf0133630
|Purdy et al.
|2001
|1
REFM|FBrf0155512
|Pellettieri and Seydoux
|2002
|2
REFM|FBrf0096484
|Tully et al.
|1996
|2
REFM|FBrf0134535
|Zars
|2000
|2
REFM|FBrf0147137
|Brody et al.
|2002
|0
REFM|FBrf0099525
|Skoulakis et al.
|1997
|1
REFM|FBrf0090801
|Skoulakis and Davis
|1996
|0
REFM|FBrf0129944
|Li et al.
|2000
|0
REFM|FBrf0058506
|McConnell and Hodges
|1993
|9
REFM|FBrf0108310
|Zhou et al.
|1999
|0
REFM|FBrf0139731
|Philip et al.
|2001
|0
REFM|FBrf0159020
|Zhou et al.
|2003
|0
REFM|FBrf0055263
|Swanson and Ganguly
|1992
|1
REFM|FBrf0083714
|Meister and Braun
|1995.10
|9
REFM|FBrf0125895
|Tallman et al.
|2000
|1
REFM|FBrf0137492
|Oliver
|2001.8.16
|9
REFM|FBrf0141765
|Waddell and Quinn
|2001
|2
REFM|FBrf0100355
|Grotewiel et al.
|1998
|0
REFM|FBrf0141665
|Sokolowski
|2001
|2
REFM|FBrf0139721
|Su et al.
|2001
|0
REFM|FBrf0093851
|Mlodzik
|1997.5.10
|9
REFM|FBrf0037869
|Levy and Manning
|1982
|0
REFM|FBrf0037868
|Levy et al.
|1982
|0
REFM|FBrf0110590
|Prokop
|1999
|2
REFM|FBrf0092060
|Amanai et al.
|1997
|1
REFM|FBrf0123915
|SwissProt Project Members
|1992.12.1
|9
REFM|FBrf0089671
|Han et al.
|1996
|0
REFM|FBrf0067338
|BDGP Project Members
|1994-1999
|9
REFM|FBrf0098203
|Broadie et al.
|1997
|0
REFM|FBrf0130073
|Sekelsky et al.
|2000
|0
REFM|FBrf0132177
|Gene Disruption Project members
|2001-
|9
REFM|FBrf0126031
|Johnson Hamlet and Perkins
|2000
|1
REFM|FBrf0101895
|Dubnau and Tully
|1998
|2
REFM|FBrf0099365
|Li et al.
|1997
|0
REFM|FBrf0099854
|Belvin and Yin
|1997
|2
REFM|FBrf0151992
|Jauch et al.
|2002
|0
REFM|FBrf0107641
|Casci et al.
|1999
|0
REFM|FBrf0052826
|Hyde et al.
|1990
|0
REFM|FBrf0085952
|Skoulakis and Davis
|1996
|1
REFM|FBrf0085951
|Skoulakis and Davis
|1996
|1
REFM|FBrf0111489
|Spradling et al.
|1999
|0
REFM|FBrf0093549
|Kockel et al.
|1997
|0
REFM|FBrf0079774
|Skoulakis
|1995
|9
REFM|FBrf0111327
|Baek and Lee
|1999
|2
REFM|FBrf0084657
|Amanai and Shearn
|1996
|1
REFM|FBrf0050680
|Palazzolo et al.
|1989
|0
REFM|FBrf0079419
|Skoulakis and Davis
|1995
|1
REFM|FBrf0127283
|Raabe
|2000
|2
REFM|FBrf0092345
|Li et al.
|1997
|1
REFM|FBrf0137171
|Roman and Davis
|2001
|2
REFM|FBrf0099843
|Isaksson et al.
|1997
|0
REFM|FBrf0101626
|Skoulakis
|1998
|1
REFM|FBrf0105495
|FlyBase
|1992-
|9
REFM|FBrf0107534
|Zhang et al.
|1999
|0
REFM|FBrf0158832
|Ahringer
|2003
|2
REFM|FBrf0103626
|Amanai et al.
|1998
|1
REFM|FBrf0133552
|Skoulakis and Philip
|2001
|1
REFM|FBrf0126705
|FamiliarityBreedsContempt
|1999.11
|9
REFM|FBrf0133450
|Acevedo and Skoulakis
|2001
|1
REFM|FBrf0098932
|Anonymous
|1997
|2
REFM|FBrf0125078
|BDGP Project Members
|2000-
|9
REFM|FBrf0104620
|Rommel and Hafen
|1998
|2
REFM|FBrf0137068
|Davis
|2001
|2
REFM|FBrf0095439
|Kockel et al.
|1997
|0
}
REFDSR
{
RDID|FBrf0037868
|Levy et al.
|1982
CLOC|46E (determined by in situ hybridization)
PHP|Identified as a cDNA clone that is expressed at a low frequency in
|the body but abundantly in the head of the adult.
SYN|549
}
REFDSR
{
RDID|FBrf0037869
|Levy and Manning
|1982
PHP|Developmental expression pattern of the cDNA clone is examined.
SYN|549
}
REFDSR
{
RDID|FBrf0050680
|Palazzolo et al.
|1989
PHP|Identified as a cDNA clone that is expressed exclusively or predominantly
|in the adult visual system.
SYN|unnamed
}
REFDSR
{
RDID|FBrf0052826
|Hyde et al.
|1990
CLOC|46E (determined by in situ hybridization)
PHP|Identified as a cDNA clone that is expressed exclusively or predominantly
|in the adult visual system.
SYN|2G1
|549
}
REFDSR
{
RDID|FBrf0056086
|Swanson and Ganguly
|1992
CLOC|46E (determined by in situ hybridization)
PHP|D14-3-3 has been characterized: gene expression is developmentally
|regulated and predominantly expressed in the neural tissues of the
|fly.
}
REFDSR
{
RDID|FBrf0057515
|Ganguly et al.
|1992
SYN|549
}
REFDSR
{
RDID|FBrf0058506
|McConnell and Hodges
|1993
PHP|The alternate 5' end of Egfr reported by Schejter et al. (Cell 46:
|1091--1101) is a cloning artefact and is actually from D14-3-3 of Swanson
|and Ganguly (Gene 113: 183--190).
}
REFDSR
{
RDID|FBrf0067338
|BDGP Project Members
|1994-1999
CLOC|46E4--8
LOI|14-3-3&zgr;07103
MD|Identified with: D1325
BMD|Df(2R)X1
BMDD|Df(2R)12
BMDD|Df(2R)X3
}
REFDSR
{
RDID|FBrf0079774
|Skoulakis
|1995
CLOC|46E--F (determined by in situ hybridization)
}
REFDSR
{
RDID|FBrf0085951
|Skoulakis and Davis
|1996
SYN|leonardo
}
REFDSR
{
RDID|FBrf0085952
|Skoulakis and Davis
|1996
SYN|leonardo
}
REFDSR
{
RDID|FBrf0089671
|Han et al.
|1996
SYN|unnamed
}
REFDSR
{
RDID|FBrf0090801
|Skoulakis and Davis
|1996
CLOC|46E (determined by in situ hybridization)
LOI|14-3-3&zgr;P1.3H
|14-3-3&zgr;P1188
|14-3-3&zgr;P1375
PHP|@14-3-3&zgr;@ has a biological role in mushroom body-mediated learning and
|memory processes.
}
REFDSR
{
RDID|FBrf0092060
|Amanai et al.
|1997
SYN|leo
}
REFDSR
{
RDID|FBrf0093395
|Chang and Rubin
|1997
WTI|14-3-3&egr; (data from @14-3-3&zgr;2.3@, @14-3-3&zgr;P2355@, @14-3-3&zgr;X1@)
SYN|leo
}
REFDSR
{
RDID|FBrf0093549
|Kockel et al.
|1997
PHP|Genetic studies indicate that @14-3-3&zgr;@ acts downstream of @Ras85D@
|and upstream of @phl@ in the developing eye disc.
SYN|D14-3-3&zgr;
}
REFDSR
{
RDID|FBrf0095439
|Kockel et al.
|1997
BMD|Df(2R)E73
}
REFDSR
{
RDID|FBrf0098203
|Broadie et al.
|1997
WT|@14-3-3&zgr;@ may function in the activity-dependent regulation of synaptic
|vesicle dynamics to control the pool of releaseable transmitter vesicles
|at presynaptic fusion sites.
OTH|@14-3-3&zgr;@ is strongly and specifically expressed in the presynaptic
|boutons of the neuro muscular junction.
PHP|In mutants the basic processes of synaptogenesis and excitation-secretion
|coupling are not perturbed, but properties of synaptic modulation such
|as transmission augmentation, high frequency transmission fidelity
|and post-tetanic potentiation (PTP) are strongly impaired.
SYN|leo
}
REFDSR
{
RDID|FBrf0099136
|Broadie et al.
|1997
SYN|leonardo
}
REFDSR
{
RDID|FBrf0099365
|Li et al.
|1997
WTI|faf
|tor (data from @14-3-3&zgr;hs.PL@)
SYN|leo
}
REFDSR
{
RDID|FBrf0099525
|Skoulakis et al.
|1997
SYN|leo
}
REFDSR
{
RDID|FBrf0099843
|Isaksson et al.
|1997
WTI|faf (data from @14-3-3&zgr;E16@)
}
REFDSR
{
RDID|FBrf0101184
|Hermon et al.
|1998
SYN|14-3-3
}
REFDSR
{
RDID|FBrf0101416
|Amanai et al.
|1998
SYN|leo
}
REFDSR
{
RDID|FBrf0101626
|Skoulakis
|1998
SYN|14-3-3
|leonardo
}
REFDSR
{
RDID|FBrf0102121
|Broadie
|1998
SYN|leo
}
REFDSR
{
RDID|FBrf0102616
|Connolly and Tully
|1998
SYN|14-3-3
}
REFDSR
{
RDID|FBrf0104620
|Rommel and Hafen
|1998
SYN|14-3-3
}
REFDSR
{
RDID|FBrf0105495
|FlyBase
|1992-
ENZ|diacylglycerol-activated/phospholipid dependent protein kinase C inhibitor activity ; GO:0004863 | inferred from sequence similarity with MGD:Ywhaz; MGI:MGI:109484
|tryptophan hydroxylase activator activity ; GO:0016483 | inferred from sequence similarity with MGD:Ywhaz; MGI:MGI:109484
FNC|RAS protein signal transduction ; GO:0007265 | inferred from sequence similarity with SGD_LOCUS:BMH2; SGD:S0002506
|tryptophan hydroxylase activation ; GO:0006588 | inferred from sequence similarity with MGD:Ywhaz; MGI:MGI:109484
MD|Maps to clone: DS05181
GPD|14-3-3-protein
}
REFDSR
{
RDID|FBrf0107534
|Zhang et al.
|1999
WTI|Src42A (data from @14-3-3&zgr;07103@)
SYN|14-3-3
}
REFDSR
{
RDID|FBrf0107641
|Casci et al.
|1999
SYN|leo
}
REFDSR
{
RDID|FBrf0108310
|Zhou et al.
|1999
MD|@14-3-3&zgr;@ can interact with and modulate @slo@ via @Slob@. The
|binding between @14-3-3&zgr;@ and @Slob@ is regulated by calcium/calmodulin-dependent
|kinase II phosphorylation.
}
REFDSR
{
RDID|FBrf0110590
|Prokop
|1999
SYN|leo
}
REFDSR
{
RDID|FBrf0111327
|Baek and Lee
|1999
SYN|14-3-3
}
REFDSR
{
RDID|FBrf0111489
|Spradling et al.
|1999
CLOC|46E4--8 (determined by in situ hybridization)
LOI|14-3-3&zgr;07103
BMD|Df(2R)X1
BMDD|Df(2R)12
BMDD|Df(2R)X3
SYN|14-3-3zeta
}
REFDSR
{
RDID|FBrf0123915
|SwissProt Project Members
|1992.12.1
FNC|RAS protein signal transduction ; GO:0007265 | non-traceable author statement
|cell proliferation ; GO:0008283 | non-traceable author statement
|photoreceptor differentiation (sensu Drosophila) ; GO:0007467 | non-traceable author statement
}
REFDSR
{
RDID|FBrf0125078
|BDGP Project Members
|2000-
MD|Identified with: LD18434 (BDGP-DGC)
|Identified with: RH61958 (BDGP-DGC)
|Identified with: RH57960 (BDGP-DGC)
}
REFDSR
{
RDID|FBrf0125895
|Tallman et al.
|2000
MD|Gene order: Overall orientation not stated: Pfk? 14-3-3&zgr;?
SYN|14-3-3
}
REFDSR
{
RDID|FBrf0126031
|Johnson Hamlet and Perkins
|2000
SYN|leonardo
}
REFDSR
{
RDID|FBrf0127283
|Raabe
|2000
SYN|14-3-3
}
REFDSR
{
RDID|FBrf0129944
|Li et al.
|2000
SYN|leo
}
REFDSR
{
RDID|FBrf0133450
|Acevedo and Skoulakis
|2001
SYN|D14-3-3&zgr;
|leo
}
REFDSR
{
RDID|FBrf0133552
|Skoulakis and Philip
|2001
SYN|leo
}
REFDSR
{
RDID|FBrf0134535
|Zars
|2000
SYN|Leonardo-13-3-3
}
REFDSR
{
RDID|FBrf0137068
|Davis
|2001
SYN|leo
}
REFDSR
{
RDID|FBrf0137171
|Roman and Davis
|2001
FNC|olfactory learning ; GO:0008355 | non-traceable author statement
SYN|leo
}
REFDSR
{
RDID|FBrf0137492
|Oliver
|2001.8.16
}
REFDSR
{
RDID|FBrf0139721
|Su et al.
|2001
FNC|chromosome segregation ; GO:0007059 | inferred from mutant phenotype
WT|@14-3-3&zgr;@ is required for normal chromosome separation during syncytial
|mitoses in the embryo.
}
REFDSR
{
RDID|FBrf0139731
|Philip et al.
|2001
FNC|learning and/or memory ; GO:0007611 | inferred from mutant phenotype
WT|Both isoforms of the @14-3-3&zgr;@ gene are required acutely (as opposed
|to developmentally) for normal learning and memory.
SYN|leo
}
REFDSR
{
RDID|FBrf0141665
|Sokolowski
|2001
ENZ|protein kinase C inhibitor activity ; GO:0008426 | non-traceable author statement
FNC|learning and/or memory ; GO:0007611 | non-traceable author statement
}
REFDSR
{
RDID|FBrf0141765
|Waddell and Quinn
|2001
SYN|leo: leonardo
}
REFDSR
{
RDID|FBrf0145821
|Acevedo and Skoulakis
|2002
SYN|leonardo
}
REFDSR
{
RDID|FBrf0147137
|Brody et al.
|2002
SYN|4-3-3 zeta
}
REFDSR
{
RDID|FBrf0151992
|Jauch et al.
|2002
SYN|leo
}
REFDSR
{
RDID|FBrf0155512
|Pellettieri and Seydoux
|2002
SYN|par-5
}
REFDSR
{
RDID|FBrf0158832
|Ahringer
|2003
SYN|leo
}
REFDSR
{
RDID|FBrf0159690
|Chen et al.
|2003
SYN|leo
}
ALESR
{
ASYM|14-3-3&zgr;07103
SYN|l(2)-07103
|l(2)K07103
|l(2)k07103
|leo07103
|14-3-307103
|l(2)0710307103
ID|FBal0008125
DBA|NA:Y12573
DIS|A. Spradling.
TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103
|BDGP:l(2)07103
MU|P-element activity
REF|FBrf0067338
|FBrf0159690
|FBrf0095439
|FBrf0093549
|FBrf0083714
|FBrf0093851
|FBrf0111489
|FBrf0107534
REFDSR
{
RDID|FBrf0067338
|BDGP Project Members
|1994-1999
OTH|Complements: @CCS03221@.
|Complements: @TER9403775@.
|Complements: @Pfk06339@.
|Complements: @l(2)k03610k03610@.
|Complements: @l(2)k03610k03703@.
|Complements: @l(2)k04308k04308@.
|Complements: @l(2)k16104k16104@.
TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103
|BDGP:l(2)07103
}
REFDSR
{
RDID|FBrf0093549
|Kockel et al.
|1997
AMSO|The lethality is rescued by @14-3-3&zgr;arm.PK@.
ARB|14-3-3&zgr;arm.PK
MD|@P{PZ}@ insertion into the first intron, 1633bp downstream of the splice
|donor site of exon I'.
TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103
|BDGP:l(2)07103
MU|P-element activity
PHC|lethal | recessive
PHM|photoreceptor cell | somatic clone
ALC|hypomorph
PHI|Homozygous clones are recovered at low frequency and are small. Clones
|in the eye frequently lack some photoreceptor cells in the ommatidia.
SYN|l(2)-07103
}
REFDSR
{
RDID|FBrf0095439
|Kockel et al.
|1997
MD|@P{PZ}@ insertion in the 5' noncoding region.
OTH|Insertion is 2.8kb downstream of the @Jra@ transcription unit.
TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103
|BDGP:l(2)07103
MU|P-element activity
}
REFDSR
{
RDID|FBrf0107534
|Zhang et al.
|1999
TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103
|BDGP:l(2)07103
GIC|suppressor | dominant of @Src42ASu(phl)1-1@
GII|Dominantly suppresses the ability of @Src42ASu(phl)1-1@ to suppress
|the lethality of @phl1@/Y flies.
SYN|l(2)K07103
}
REFDSR
{
RDID|FBrf0111489
|Spradling et al.
|1999
TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103
|BDGP:l(2)07103
PHC|lethal | recessive
SYN|l(2)k07103
}
REFDSR
{
RDID|FBrf0159690
|Chen et al.
|2003
TRN|FBti0009122 == P{PZ}14-3-3&zgr;07103
|BDGP:l(2)07103
SYN|leo07103
}
SK|FBstBL-12335
|P{ry[+t7.2]=PZ}14-3-3zeta[07103] cn[1]/CyO; ry[506]
}
ALESR
{
ASYM|14-3-3&zgr;12BL
SYN|14-3-312BL
ID|FBal0065577
PHC|lethal | embryonic | recessive
|neurophysiology defective
PHM|epidermis | embryonic | lateral
|epidermis | embryonic | dorsal
ALC|loss of function
PHI|Homozygous embryos exhibit incomplete dorsal migration of the lateral
|epidermis and failure of dorsal epidermal closure. CNS and neuromusculature
|appear morphologically normal and the mutant embryos exhibit coordinated
|muscle movements similar to those observed in wild-type locomotion.
|Synaptogenesis at the neuromuscular junction (NMJ) is largely normal.
|Embryos also exhibit near normal physiological development and basal
|excitation-secretion function at the NMJ. The amplitude and frequency
|of endogenous excitatory junctional currents (EJCs) is reduced relative
|to wild type. This reduced function originates in a presynaptic defect,
|basal presynaptic function is mildly impaired. MEJC (miniature EJCs)
|amplitude is not altered. NMJ exhibits a transmission defect, the
|calcium dependence curve is shifted to the right indicating a higher
|level of external calcium is required to achieve the given level of
|secretion. Synaptic transmission fidelity and fatigue resistance properties
|are impaired. Short-term facilitation is strengthened but synaptic
|augmentation an potentiation are disrupted.
REF|FBrf0098203
REFDSR
{
RDID|FBrf0098203
|Broadie et al.
|1997
MD|One partially deleted insertion in the first intron and the second
|partially deleted insertion resides in the original location.
PRG|14-3-3&zgr;P1.3H
MU|P-element activity
PHC|lethal | embryonic | recessive
|neurophysiology defective
PHM|epidermis | embryonic | lateral
|epidermis | embryonic | dorsal
ALC|loss of function
PHI|Homozygous embryos exhibit incomplete dorsal migration of the lateral
|epidermis and failure of dorsal epidermal closure. CNS and neuromusculature
|appear morphologically normal and the mutant embryos exhibit coordinated
|muscle movements similar to those observed in wild-type locomotion.
|Synaptogenesis at the neuromuscular junction (NMJ) is largely normal.
|Embryos also exhibit near normal physiological development and basal
|excitation-secretion function at the NMJ. The amplitude and frequency
|of endogenous excitatory junctional currents (EJCs) is reduced relative
|to wild type. This reduced function originates in a presynaptic defect,
|basal presynaptic function is mildly impaired. MEJC (miniature EJCs)
|amplitude is not altered. NMJ exhibits a transmission defect, the
|calcium dependence curve is shifted to the right indicating a higher
|level of external calcium is required to achieve the given level of
|secretion. Synaptic transmission fidelity and fatigue resistance properties
|are impaired. Short-term facilitation is strengthened but synaptic
|augmentation an potentiation are disrupted.
}
}
ALESR
{
ASYM|14-3-3&zgr;2.3
SYN|leo2.3
|leo23
|14-3-32.3
ID|FBal0059634
REF|FBrf0093395
|FBrf0139731
|FBrf0090801
REFDSR
{
RDID|FBrf0090801
|Skoulakis and Davis
|1996
MD|Deletion of the @P{lArB}@ insertion and portions of genomic sequence.
PRG|14-3-3&zgr;P1375
MU|&Dgr;2-3
PHC|(with 14-3-3&zgr;P1375) memory defective
|viable
|memory defective
PHI|Exhibits a decrement in the 3 to 240 minute memory performance. Transheterozygotes
|with @14-3-3&zgr;P1375@ show a highly significant reduction in 3 minute memory.
|Odor avoidance (octanol and benzaldehyde) is normal.
}
REFDSR
{
RDID|FBrf0093395
|Chang and Rubin
|1997
GIC2|visible | dominant with @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@
GIA2|ommatidium with @14-3-3&egr;j2B10@
|posterior crossvein with @14-3-3&egr;j2B10@
|eye with @14-3-3&egr;j2B10@
|photoreceptor cell with @14-3-3&egr;j2B10@
GII|@14-3-3&zgr;2.3@/+ @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ flies have slightly
|roughened eyes, a low penetrance of missing photoreceptors and a gap
|in the posterior crossvein of the wings in more than 50% of cases.
SYN|leo2.3
}
REFDSR
{
RDID|FBrf0139731
|Philip et al.
|2001
ARB|14-3-3&zgr;LI.15.hs
|14-3-3&zgr;LII.2.hs
MD|Deletion in the intron between exons 1' and 2 of @14-3-3&zgr;@.
PHC|viable
|learning defective
|memory defective
PHI|No neuroanatomical aberrations are evident during development of the
|brain. Flies show reduced performance in a modified olfactory trap
|assay, using geraniol as the attractive odor, both immediately after
|training and 90 mins after training.
SYN|leo23
}
}
ALESR
{
ASYM|14-3-3&zgr;5.9
SYN|14-3-35.9
ID|FBal0059633
PHC|viable
|memory defective
PHI|Exhibits a decrement in the 3 minute memory performance.
|Odor avoidance (octanol and benzaldehyde) is normal.
REF|FBrf0090801
REFDSR
{
RDID|FBrf0090801
|Skoulakis and Davis
|1996
MD|Deletion of the @P{lArB}@ insertion and portions of genomic sequence.
PRG|14-3-3&zgr;P1375
MU|&Dgr;2-3
PHC|viable
|memory defective
PHI|Exhibits a decrement in the 3 minute memory performance.
|Odor avoidance (octanol and benzaldehyde) is normal.
}
}
ALESR
{
ASYM|14-3-3&zgr;7B
SYN|14-3-37B
ID|FBal0059632
PHC|viable
|memory defective
PHI|Exhibits a decrement in the 3 minute memory performance.
|Odor avoidance (octanol and benzaldehyde) is normal.
REF|FBrf0090801
REFDSR
{
RDID|FBrf0090801
|Skoulakis and Davis
|1996
MD|Deletion of a portion of the @P{lArB}@ insertion and genomic sequence.
PRG|14-3-3&zgr;P1375
TRN|FBti0012515 == P{?lArB}14-3-3&zgr;7B
MU|&Dgr;2-3
PHC|viable
|memory defective
PHI|Exhibits a decrement in the 3 minute memory performance.
|Odor avoidance (octanol and benzaldehyde) is normal.
}
}
ALESR
{
ASYM|14-3-3&zgr;7BL
SYN|14-3-37BL
ID|FBal0065576
PHC|lethal | embryonic | recessive
|neurophysiology defective
PHM|epidermis | embryonic | lateral
|epidermis | embryonic | dorsal
ALC|hypomorph
PHI|Homozygous embryos exhibit incomplete dorsal migration of the lateral
|epidermis and failure of dorsal epidermal closure. CNS and neuromusculature
|appear morphologically normal and the mutant embryos exhibit coordinated
|muscle movements similar to those observed in wild-type locomotion.
|Synaptogenesis at the neuromuscular junction (NMJ) is largely normal.
|Embryos also exhibit near normal physiological development and basal
|excitation-secretion function at the NMJ. The amplitude and frequency
|of endogenous excitatory junctional currents (EJCs) is reduced relative
|to wild type. This reduced function originates in a presynaptic defect,
|basal presynaptic function is mildly impaired. MEJC (miniature EJCs)
|amplitude is not altered. NMJ exhibits a transmission defect, the
|calcium dependence curve is shifted to the right indicating a higher
|level of external calcium is required to achieve the given level of
|secretion. Synaptic transmission fidelity and fatigue resistance properties
|are impaired. Short-term facilitation is strengthened but synaptic
|augmentation an potentiation are disrupted.
REF|FBrf0098203
REFDSR
{
RDID|FBrf0098203
|Broadie et al.
|1997
MD|Partially deleted insertion at the original location and a 500bp deletion
|in intron two.
PRG|14-3-3&zgr;P1375
MU|P-element activity
PHC|lethal | embryonic | recessive
|neurophysiology defective
PHM|epidermis | embryonic | lateral
|epidermis | embryonic | dorsal
ALC|hypomorph
PHI|Homozygous embryos exhibit incomplete dorsal migration of the lateral
|epidermis and failure of dorsal epidermal closure. CNS and neuromusculature
|appear morphologically normal and the mutant embryos exhibit coordinated
|muscle movements similar to those observed in wild-type locomotion.
|Synaptogenesis at the neuromuscular junction (NMJ) is largely normal.
|Embryos also exhibit near normal physiological development and basal
|excitation-secretion function at the NMJ. The amplitude and frequency
|of endogenous excitatory junctional currents (EJCs) is reduced relative
|to wild type. This reduced function originates in a presynaptic defect,
|basal presynaptic function is mildly impaired. MEJC (miniature EJCs)
|amplitude is not altered. NMJ exhibits a transmission defect, the
|calcium dependence curve is shifted to the right indicating a higher
|level of external calcium is required to achieve the given level of
|secretion. Synaptic transmission fidelity and fatigue resistance properties
|are impaired. Short-term facilitation is strengthened but synaptic
|augmentation an potentiation are disrupted.
}
}
ALESR
{
ASYM|14-3-3&zgr;9.8
SYN|14-3-39.8
ID|FBal0059631
PHC|viable
|memory defective
PHI|Exhibits a decrement in the 3 minute memory performance.
|Odor avoidance (octanol and benzaldehyde) is normal.
REF|FBrf0090801
REFDSR
{
RDID|FBrf0090801
|Skoulakis and Davis
|1996
MD|Deletion of the @P{lArB}@ insertion and portions of genomic sequence.
PRG|14-3-3&zgr;P1375
MU|&Dgr;2-3
PHC|viable
|memory defective
PHI|Exhibits a decrement in the 3 minute memory performance.
|Odor avoidance (octanol and benzaldehyde) is normal.
}
}
ALESR
{
ASYM|14-3-3&zgr;E16
SYN|E-16
|14-3-3E16
ID|FBal0060814
DBA|NA:Y12573
REF|FBrf0099843
|FBrf0093549
|FBrf0093851
REFDSR
{
RDID|FBrf0093549
|Kockel et al.
|1997
AMSO|The lethality is rescued by @14-3-3&zgr;tKa@ but not by @14-3-3&zgr;arm.PK@.
ANRB|14-3-3&zgr;arm.PK
ARB|14-3-3&zgr;tKa
ARG2|FBgn0004907.
MD|Imprecise excision of the @P{PZ}@ element, deleting 1957bp, including
|exons I and I'.
PRG|14-3-3&zgr;07103
MU|P-element activity
PHC|lethal | recessive
PHI|Homozygous clones are not recovered in a wild-type background or in
|flies carrying @Ras85DV12.sev@, but are recovered in flies carrying
|@phl::tor12D.hs.sev@.
SYN|E-16
}
REFDSR
{
RDID|FBrf0093851
|Mlodzik
|1997.5.10
PRG|14-3-3&zgr;07103
MU|P-element activity
}
REFDSR
{
RDID|FBrf0099843
|Isaksson et al.
|1997
GIA|suppressor | dominant of photoreceptor cell R1 | ectopic phenotype of @fafBX4@
|suppressor | dominant of photoreceptor cell R2 | ectopic phenotype of @fafBX4@
|suppressor | dominant of photoreceptor cell R3 | ectopic phenotype of @fafBX4@
|suppressor | dominant of photoreceptor cell R4 | ectopic phenotype of @fafBX4@
|suppressor | dominant of photoreceptor cell R5 | ectopic phenotype of @fafBX4@
|suppressor | dominant of photoreceptor cell R6 | ectopic phenotype of @fafBX4@
GII|The extra outer photoreceptor cell phenotype seen in @fafBX4@ homozygotes
|is dominantly suppressed by @14-3-3&zgr;E16@, with the average number
|of outer photoreceptor cells per ommatidium being reduced to 6.4.
PHC|lethal | recessive
}
}
ALESR
{
ASYM|14-3-3&zgr;E73
SYN|14-3-3E73
ID|FBal0063650
REF|FBrf0095439
REFDSR
{
RDID|FBrf0095439
|Kockel et al.
|1997
MD|Deletion of the transcription start site and first exons.
PRG|14-3-3&zgr;07103
MU|&Dgr;2-3
ABA|FBab0027145 == Df(2R)E73
SYN|unnamed
}
}
ALESR
{
ASYM|14-3-3&zgr;KG02642
ID|FBal0137676
REF|FBrf0132177
REFDSR
{
RDID|FBrf0132177
|Gene Disruption Project members
|2001-
TRN|FBti0023409 == P{SUPor-P}14-3-3&zgr;KG02642
|BDGP:KG02642
}
SK|FBstBL-14085
|y[1]; P{y[+mDint2] w[BR.E.BR]=SUPor-P}14-3-3zeta[KG02642]; ry[506]
}
ALESR
{
ASYM|14-3-3&zgr;P1188
SYN|leoP1188
|P1188
|14-3-3P1188
ID|FBal0059629
REF|FBrf0098203
|FBrf0089671
|FBrf0099365
|FBrf0129944
|FBrf0139731
|FBrf0090801
|FBrf0139721
REFDSR
{
RDID|FBrf0089671
|Han et al.
|1996
PRG|FBti0004638 == FBti0000841 == P{lArB}A4.1M2
TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188
MU|&Dgr;2-3
SYN|unnamed
}
REFDSR
{
RDID|FBrf0090801
|Skoulakis and Davis
|1996
PRG|FBti0004638 == FBti0000841 == P{lArB}A4.1M2
TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188
MU|&Dgr;2-3
PHC|lethal | embryonic | recessive
PHI|Heterozygotes exhibit normal 3 minute memory performance.
|Odor avoidance (octanol and benzaldehyde) is normal.
SYN|unnamed
}
REFDSR
{
RDID|FBrf0098203
|Broadie et al.
|1997
MD|@P{lArB}@ insertion in the first intron.
TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188
PHC|lethal | recessive
|neurophysiology defective
ALC|hypomorph
PHI|Embryos do not exhibit a dorsal closure defect.
|The amplitude and frequency of endogenous excitatory junctional currents
|(EJCs) is reduced relative to wild type and the NMJ exhibits a transmission
|defect, the calcium dependence curve is shifted to the right indicating
|a higher level of external calcium is required to achieve the given
|level of secretion.
}
REFDSR
{
RDID|FBrf0099365
|Li et al.
|1997
PHM|embryonic/first instar larval cuticle | germ-line clone
|denticle belt | germ-line clone
|syncytial blastoderm | germ-line clone
PHI|Embryos derived from homozygous female germline clones show a variable
|phenotype that is not significantly different whether or not the embryos
|contain a wild-type copy of @14-3-3&zgr;@ from the father. Approximately
|50% of the embryos do not develop cuticles, and the remainder develop
|cuticles with various segmentation defects including missing and/or
|fused denticle bands. The Filzkorper appear normal. Approximately
|50% of the embryos appear to stop development during the syncytial
|blastoderm stage, and contain many fewer nuclei compared to wild-type.
|Some of these nuclei appear fused.
|18% of embryos carrying @14-3-3&zgr;hbNRE.RpII15@ and derived from homozygous
|@14-3-3&zgr;P1188@ female germline clones have a wild-type anterior region
|but are missing all or part of the posterior region. 56% of these
|'anteriorly rescued' embryos have shortened Filzkorper.
SYN|leoP1188
}
REFDSR
{
RDID|FBrf0129944
|Li et al.
|2000
SYN|leoP1188
}
REFDSR
{
RDID|FBrf0139721
|Su et al.
|2001
TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188
PHC|mitotic | recessive | maternal effect
PHM|mitotic cycle | maternal effect
PHI|Homozygous embryos show no apparent defects in the timing of mitotic
|cycle 14 and show delayed mitosis after irradiation (as occurs in wild
|type).
|69 +/- 9% of mutant embryos derived from homozygous female germline
|clones fail to cellularize. 54/59 of the embryos have defects in cell
|division, including DNA bridges between telophase sister nuclei, asynchrony
|in division within a single embryo, free microtubule-organizing centers
|that are not associated with nuclei, loss of nuclei from the cortical
|monolayer of nuclei and larger than normal yolk DNA masses. Chromosome
|bridges interconnecting DNA masses are seen as early as telophase of
|the fourth embryonic mitosis. Mitotic spindles do appear to be formed
|in these embryos (as judged by the segregation of chromosome masses
|that are still linked by DNA bridges to opposite spindle poles), and
|attempts at the formation of mid-bodies are seen between segregating
|nuclei, despite the presence of chromosome bridges.
|Approximately 30% of embryos cellularize. These embryos have severe
|gastrulation defects.
SYN|P1188
}
REFDSR
{
RDID|FBrf0139731
|Philip et al.
|2001
ANRB|(with 14-3-3&zgr;P1375) 14-3-3&zgr;LII.2.hs
|(with 14-3-3&zgr;P2335) 14-3-3&zgr;LII.2.hs
|14-3-3&zgr;LI.15.hs
|14-3-3&zgr;LII.2.hs
APRB|(with 14-3-3&zgr;P1375) 14-3-3&zgr;LI.15.hs
|(with 14-3-3&zgr;P2335) 14-3-3&zgr;LI.15.hs
ARB|(with 14-3-3&zgr;P1375) 14-3-3&zgr;LI.15.hs
|(with 14-3-3&zgr;P2335) 14-3-3&zgr;LI.15.hs
MD|Insertion, in forward orientation, of @P{lArB}@ into the intron between
|exons 1' and 2 of @14-3-3&zgr;@.
TRN|FBti0009360 == P{lArB}14-3-3&zgr;P1188
PHC|lethal
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1375) viable
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1375) learning defective
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1375) viable
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1375) learning defective
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P2335) viable
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P2335) learning defective
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P2335) viable
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P2335) learning defective
PHI|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@
|and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning,
|comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration
|of learning by the transgenes decays back to mutant levels 60-70 hr
|later.
SYN|leoP1188
}
}
ALESR
{
ASYM|14-3-3&zgr;P1375
SYN|leoP1375
|14-3-3P1375
ID|FBal0059628
REF|FBrf0098203
|FBrf0089671
|FBrf0139731
|FBrf0090801
REFDSR
{
RDID|FBrf0089671
|Han et al.
|1996
PRG|FBti0004638 == FBti0000841 == P{lArB}A4.1M2
TRN|FBti0009359 == P{lArB}14-3-3&zgr;P1375
MU|&Dgr;2-3
SYN|unnamed
}
REFDSR
{
RDID|FBrf0090801
|Skoulakis and Davis
|1996
PRG|FBti0004638 == FBti0000841 == P{lArB}A4.1M2
TRN|FBti0009359 == P{lArB}14-3-3&zgr;P1375
MU|&Dgr;2-3
PHC|lethal | embryonic | recessive
|(with 14-3-3&zgr;2.3) memory defective
|(with 14-3-3&zgr;X1) memory defective
PHI|Heterozygotes exhibit normal 3 minute memory performance. Transheterozygotes
|with @14-3-3&zgr;X1@ or @14-3-3&zgr;2.3@ show a highly significant reduction in
|3 minute memory.
|Odor avoidance (octanol and benzaldehyde) is normal.
SYN|unnamed
}
REFDSR
{
RDID|FBrf0098203
|Broadie et al.
|1997
MD|@P{lArB}@ insertion in the first intron.
TRN|FBti0009359 == P{lArB}14-3-3&zgr;P1375
PHC|lethal | recessive
}
REFDSR
{
RDID|FBrf0139731
|Philip et al.
|2001
ANRB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LII.2.hs
|(with 14-3-3&zgr;P2335) 14-3-3&zgr;LII.2.hs
APRB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LI.15.hs
|14-3-3&zgr;LI.15.hs
ARB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LI.15.hs
|(with 14-3-3&zgr;P2335) 14-3-3&zgr;LI.15.hs
|14-3-3&zgr;LI.15.hs
|14-3-3&zgr;LII.2.hs
MD|Insertion, in forward orientation, of @P{lArB}@ into the intron between
|exons 1' and 2 of @14-3-3&zgr;@.
TRN|FBti0009359 == P{lArB}14-3-3&zgr;P1375
PHC|lethal
|(with 14-3-3&zgr;LI.15.hs) viable
|(with 14-3-3&zgr;LI.15.hs) learning defective
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs) viable
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs) learning defective
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) viable
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) learning defective
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) viable
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) learning defective
PHI|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@
|and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning,
|comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration
|of learning by the transgenes decays back to mutant levels 60-70 hr
|later.
SYN|leoP1375
}
}
ALESR
{
ASYM|14-3-3&zgr;P2335
SYN|leoP2335
ID|FBal0134434
PHC|lethal
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) viable
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) learning defective
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) viable
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) learning defective
PHI|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@
|and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning,
|comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration
|of learning by the transgenes decays back to mutant levels 60-70 hr
|later.
REF|FBrf0139731
REFDSR
{
RDID|FBrf0139731
|Philip et al.
|2001
ANRB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LII.2.hs
|(with 14-3-3&zgr;P1375) 14-3-3&zgr;LII.2.hs
|14-3-3&zgr;LI.15.hs
|14-3-3&zgr;LII.2.hs
APRB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LI.15.hs
ARB|(with 14-3-3&zgr;P1188) 14-3-3&zgr;LI.15.hs
|(with 14-3-3&zgr;P1375) 14-3-3&zgr;LI.15.hs
MD|Insertion, in forward orientation, of @P{?}@ into the intron between
|exons 1' and 2 of @14-3-3&zgr;@.
TRN|FBti0023266 == P{?}14-3-3&zgr;P2335
PHC|lethal
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) viable
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;P1188) learning defective
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) viable
|(with 14-3-3&zgr;LI.15.hs, 14-3-3&zgr;LII.2.hs, 14-3-3&zgr;P1188) learning defective
PHI|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@
|and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning,
|comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration
|of learning by the transgenes decays back to mutant levels 60-70 hr
|later.
SYN|leoP2335
}
}
ALESR
{
ASYM|14-3-3&zgr;P2355
SYN|leoP2355
|14-3-3P2355
ID|FBal0062288
PHC|lethal | recessive
PHI|Heterozygosity for @14-3-3&zgr;P2355@ does not alter the @Ras85DV12.sev@
|phenotype.
REF|FBrf0093395
REFDSR
{
RDID|FBrf0093395
|Chang and Rubin
|1997
GIC2|lethal | dominant with @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@
PHC|lethal | recessive
PHI|Heterozygosity for @14-3-3&zgr;P2355@ does not alter the @Ras85DV12.sev@
|phenotype.
SYN|leoP2355
}
}
ALESR
{
ASYM|14-3-3&zgr;P1.3H
SYN|14-3-3P1.3H
ID|FBal0059630
REF|FBrf0098203
|FBrf0090801
REFDSR
{
RDID|FBrf0090801
|Skoulakis and Davis
|1996
MD|@P{lArB}@ insertion into the second intron.
OTH|Weak @14-3-3&zgr;@ mutation.
PRG|14-3-3&zgr;P1375
TRN|FBti0009381 == P{lArB}14-3-3&zgr;P1.3H
MU|&Dgr;2-3
PHC|viable
|memory defective
PHI|Exhibits a decrement in the 3 and 45 minute memory performance. Memory
|performance at 90 and 240 minutes is the same as controls.
|Odor avoidance (octanol and benzaldehyde) is normal.
}
REFDSR
{
RDID|FBrf0098203
|Broadie et al.
|1997
MD|Hop of the @P{lArB}@ insertion into intron 2.
PRG|14-3-3&zgr;P1375
TRN|FBti0009381 == P{lArB}14-3-3&zgr;P1.3H
MU|P-element activity
PHC|viable
}
}
ALESR
{
ASYM|14-3-3&zgr;R1
SYN|14-3-3R1
ID|FBal0059627
PHC|viable
PHI|Normal memory performance over 3 to 240 minutes.
|Odor avoidance (octanol and benzaldehyde) is normal.
REF|FBrf0090801
REFDSR
{
RDID|FBrf0090801
|Skoulakis and Davis
|1996
MD|Precise excision of the @P{lArB}@ insertion.
PRG|14-3-3&zgr;P1375
MU|&Dgr;2-3
PHC|viable
PHI|Normal memory performance over 3 to 240 minutes.
|Odor avoidance (octanol and benzaldehyde) is normal.
}
}
ALESR
{
ASYM|14-3-3&zgr;R2
SYN|14-3-3R2
ID|FBal0059626
PHC|viable
PHI|Normal 3 minute memory performance.
|Odor avoidance (octanol and benzaldehyde) is normal.
REF|FBrf0090801
REFDSR
{
RDID|FBrf0090801
|Skoulakis and Davis
|1996
MD|Precise excision of the @P{lArB}@ insertion.
PRG|14-3-3&zgr;P1375
MU|&Dgr;2-3
PHC|viable
PHI|Normal 3 minute memory performance.
|Odor avoidance (octanol and benzaldehyde) is normal.
}
}
ALESR
{
ASYM|14-3-3&zgr;X1
SYN|leoX.1
|leoX1
|14-3-3X1
ID|FBal0059625
REF|FBrf0093395
|FBrf0139731
|FBrf0090801
REFDSR
{
RDID|FBrf0090801
|Skoulakis and Davis
|1996
MD|Deletion of the @P{lArB}@ insertion and portions of genomic sequence.
PRG|14-3-3&zgr;P1375
MU|&Dgr;2-3
PHC|(with 14-3-3&zgr;P1375) memory defective
|viable
|memory defective
PHI|Exhibits a decrement in the 3 minute memory performance. Transheterozygotes
|with @14-3-3&zgr;P1375@ show a highly significant reduction in 3 minute memory.
|Odor avoidance (octanol and benzaldehyde) is normal.
}
REFDSR
{
RDID|FBrf0093395
|Chang and Rubin
|1997
GIC2|visible | dominant with @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@
GIA2|ommatidium with @14-3-3&egr;j2B10@
|posterior crossvein with @14-3-3&egr;j2B10@
|eye with @14-3-3&egr;j2B10@
|photoreceptor cell with @14-3-3&egr;j2B10@
GII|@14-3-3&zgr;X1@/+ @14-3-3&egr;j2B10@/@14-3-3&egr;j2B10@ flies have slightly
|roughened eyes, a low penetrance of missing photoreceptors and a gap
|in the posterior crossvein of the wings in more than 50% of cases.
SYN|leoX.1
}
REFDSR
{
RDID|FBrf0139731
|Philip et al.
|2001
ARB|14-3-3&zgr;LI.15.hs
|14-3-3&zgr;LII.2.hs
MD|Deletion in the intron between exons 1' and 2 of @14-3-3&zgr;@.
PHC|viable
|learning defective
|memory defective
PHI|No neuroanatomical aberrations are evident during development of the
|brain. Flies show reduced performance in a modified olfactory trap
|assay, using geraniol as the attractive odor, both immediately after
|training and 90 mins after training.
SYN|leoX1
}
}
ALESR
{
ASYM|14-3-3&zgr;a.sev
SYN|14-3-3a.sev
ID|FBal0062287
PHM|photoreceptor cell
PHI|Flies carrying @14-3-3&zgr;a.sev@ have a weakly penetrant loss of photoreceptor
|cell phenotype. The outer photoreceptor cells are more severely affected.
|Mode of assay: In transgenic Drosophila
REF|FBrf0093549
REFDSR
{
RDID|FBrf0093549
|Kockel et al.
|1997
NAM|antisense sevenless promoter construct
MD|Construct: A 1.0kb @14-3-3&zgr;@ cDNA fragment containing the complete open reading
|frame is expressed in the antisense orientation under the control of
|a @sev@ enhancer.
MU|in vitro construct | regulatory fusion
CNS|FBtp0008239 == P{sE.anti-14-3-3}
PHM|photoreceptor cell
PHI|Flies carrying @14-3-3&zgr;a.sev@ have a weakly penetrant loss of photoreceptor
|cell phenotype. The outer photoreceptor cells are more severely affected.
|Mode of assay: In transgenic Drosophila
SYN|unnamed
}
}
ALESR
{
ASYM|14-3-3&zgr;arm.PK
SYN|14-3-3arm.PK
ID|FBal0062286
PHC|wild-type
PHI|Mode of assay: In transgenic Drosophila
REF|FBrf0093549
REFDSR
{
RDID|FBrf0093549
|Kockel et al.
|1997
NAM|armadillo promoter construct of Kockel
ARS|14-3-3&zgr;07103
AFS|14-3-3&zgr;E16
MD|Construct: A 1.0kb @14-3-3&zgr;@ cDNA fragment containing the complete open reading
|frame is expressed under the control of an @arm@ promoter.
MU|in vitro construct | regulatory fusion
CNS|FBtp0015025 == P{arm-14-3-3&zgr;.K}
PHC|wild-type
PHI|Mode of assay: In transgenic Drosophila
SYN|unnamed
}
}
ALESR
{
ASYM|14-3-3&zgr;hbNRE.RpII15
SYN|14-3-3hbNRE.RpII15
ID|FBal0083670
PHM|embryo | posterior | germ-line clone
|filzkorper | germ-line clone
PHI|18% of embryos carrying @14-3-3&zgr;hbNRE.RpII15@ and derived from homozygous
|@14-3-3&zgr;P1188@ female germline clones have a wild-type anterior region
|but are missing all or part of the posterior region. 56% of these
|'anteriorly rescued' embryos have shortened Filzkorper.
|Mode of assay: In transgenic Drosophila
REF|FBrf0099365
REFDSR
{
RDID|FBrf0099365
|Li et al.
|1997
MD|Construct: A 1.4kb @RpII15@ promoter fragment drives expression of a 780bp @14-3-3&zgr;@
|cDNA which has a 150bp fragment from the @hb@ 3' untranslated region,
|containing a @nos@-response element (NRE), fused to its 3' end.
MU|in vitro construct | regulatory fusion
CNS|FBtp0009043 == P{RpII15-14-3-3.hbNRE}
PHM|embryo | posterior | germ-line clone
|filzkorper | germ-line clone
PHI|18% of embryos carrying @14-3-3&zgr;hbNRE.RpII15@ and derived from homozygous
|@14-3-3&zgr;P1188@ female germline clones have a wild-type anterior region
|but are missing all or part of the posterior region. 56% of these
|'anteriorly rescued' embryos have shortened Filzkorper.
|Mode of assay: In transgenic Drosophila
SYN|unnamed
}
}
ALESR
{
ASYM|14-3-3&zgr;hs.PL
SYN|14-3-3hs.PL
ID|FBal0083669
PHM|denticle belt
PHI|Overexpression of @14-3-3&zgr;hs.PL@ in wild-type embryos results in deletion
|of denticle bands.
|Mode of assay: In transgenic Drosophila
REF|FBrf0099365
REFDSR
{
RDID|FBrf0099365
|Li et al.
|1997
NAM|heat shock construct of Li
MD|Construct: A 780bp @14-3-3&zgr;@ cDNA is expressed under the control of an Hsp70 promoter.
MU|in vitro construct | regulatory fusion
CNS|FBtp0009042 == P{hs-14-3-3.L}
GIA|suppressor | partially of embryonic/first instar larval cuticle phenotype of @torrv66@
GII|Overexpression of @14-3-3&zgr;hs.PL@ partly rescues the cuticle of
|embryos derived from @torrv66@ females.
PHM|denticle belt
PHI|Overexpression of @14-3-3&zgr;hs.PL@ in wild-type embryos results in deletion
|of denticle bands.
|Mode of assay: In transgenic Drosophila
SYN|unnamed
}
}
ALESR
{
ASYM|14-3-3&zgr;LI.15.hs
ID|FBal0134436
PHC|(with 14-3-3&zgr;P1375) learning defective
|(with 14-3-3&zgr;P1375) viable
|wild-type
PHI|Mode of assay: In transgenic Drosophila
REF|FBrf0139731
REFDSR
{
RDID|FBrf0139731
|Philip et al.
|2001
AFS|14-3-3&zgr;P1188
|14-3-3&zgr;P2335
APR|(with 14-3-3&zgr;LII.2.hs) 14-3-3&zgr;P1375
|(with 14-3-3&zgr;LII.2.hs) 14-3-3&zgr;P1375/14-3-3&zgr;P1188
|(with 14-3-3&zgr;LII.2.hs) 14-3-3&zgr;P1375/14-3-3&zgr;P2335
|(with 14-3-3&zgr;LII.2.hs) 14-3-3&zgr;P1188/14-3-3&zgr;P2335
|14-3-3&zgr;P1188/14-3-3&zgr;P2335
|14-3-3&zgr;P1375
|14-3-3&zgr;P1375/14-3-3&zgr;P1188
ARS|14-3-3&zgr;2.3
|14-3-3&zgr;P1188/14-3-3&zgr;P2335
|14-3-3&zgr;P1375/14-3-3&zgr;P1188
|14-3-3&zgr;P1375/14-3-3&zgr;P2335
|14-3-3&zgr;X1
|14-3-3&zgr;P1375
AMSO|Induction with two 30 min heat shocks daily through embryonic, larval
|and pupal stages rescues the lethal phenotype of @14-3-3&zgr;P1375@.
|A single heat shock daily can also rescue to adulthood.
|Shows heat-shock specific rescue of the learning and memory defects
|of @14-3-3&zgr;X1@ and @14-3-3&zgr;2.3@.
|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ or @14-3-3&zgr;LI.15.hs@
|and @14-3-3&zgr;LII.2.hs@ show a 25-30% decrement in olfactory learning,
|comparable to that of (rescued) @14-3-3&zgr;2.3@. The restoration
|of learning by the transgenes decays back to mutant levels 60-70 hr
|later.
MD|Construct: Expression of a @14-3-3&zgr;@ cDNA exons 1-6,7 is driven by a heat
|shock promoter.
MU|in vitro construct | regulatory fusion
CNS|FBtp0015596 == P{hs-14-3-3&zgr;.LI.15}
PHC|(with 14-3-3&zgr;P1375) learning defective
|(with 14-3-3&zgr;P1375) viable
|wild-type
PHI|Mode of assay: In transgenic Drosophila
}
}
ALESR
{
ASYM|14-3-3&zgr;LII.2.hs
ID|FBal0134435
PHC|wild-type
PHI|Mode of assay: In transgenic Drosophila
REF|FBrf0139731
REFDSR
{
RDID|FBrf0139731
|Philip et al.
|2001
AFS|14-3-3&zgr;P1188
|14-3-3&zgr;P1188/14-3-3&zgr;P2335
|14-3-3&zgr;P1375/14-3-3&zgr;P1188
|14-3-3&zgr;P1375/14-3-3&zgr;P2335
|14-3-3&zgr;P2335
APR|(with 14-3-3&zgr;LI.15.hs) 14-3-3&zgr;P1375
|(with 14-3-3&zgr;LI.15.hs) 14-3-3&zgr;P1375/14-3-3&zgr;P1188
|(with 14-3-3&zgr;LI.15.hs) 14-3-3&zgr;P1375/14-3-3&zgr;P2335
|(with 14-3-3&zgr;LI.15.hs) 14-3-3&zgr;P1188/14-3-3&zgr;P2335
ARS|14-3-3&zgr;2.3
|14-3-3&zgr;X1
|14-3-3&zgr;P1375
AMSO|Induction with two 30 min heat shocks daily through embryonic, larval
|and pupal stages rescues the lethal phenotype of @14-3-3&zgr;P1375@.
|A single heat shock daily can also rescue to adulthood.
|Shows heat-shock specific rescue of the learning and memory defects
|of @14-3-3&zgr;X1@ and @14-3-3&zgr;2.3@.
|Flies rescued from lethality by @14-3-3&zgr;LI.15.hs@ and @14-3-3&zgr;LII.2.hs@
|show a 25-30% decrement in olfactory learning, comparable to that of
|(rescued) @14-3-3&zgr;2.3@. The restoration of learning by the transgenes
|decays back to mutant levels 60-70 hr later.
MD|Construct: Expression of a @14-3-3&zgr;@ cDNA exons 1-6',7 is driven by a heat
|shock promoter.
MU|in vitro construct | regulatory fusion
CNS|FBtp0015595 == P{hs-14-3-3&zgr;.LII.2}
PHC|wild-type
PHI|Mode of assay: In transgenic Drosophila
}
}
ALESR
{
ASYM|14-3-3&zgr;sev.PK
SYN|14-3-3sev.PK
ID|FBal0062285
PHI|Flies carrying @14-3-3&zgr;a.sev@ appear wild-type.
|Mode of assay: In transgenic Drosophila
REF|FBrf0093549
REFDSR
{
RDID|FBrf0093549
|Kockel et al.
|1997
NAM|sevenless promoter construct of Kockel
MD|Construct: A 1.0kb @14-3-3&zgr;@ cDNA fragment containing the complete open reading
|frame is expressed in the sense orientation under the control of a
|@sev@ enhancer.
MU|in vitro construct | regulatory fusion
CNS|FBtp0008238 == P{sE.14-3-3}
PHI|Flies carrying @14-3-3&zgr;a.sev@ appear wild-type.
|Mode of assay: In transgenic Drosophila
SYN|unnamed
}
}
ALESR
{
ASYM|14-3-3&zgr;tKa
SYN|14-3-3tKa
ID|FBal0062284
PHC|wild-type
PHI|Mode of assay: In transgenic Drosophila
REF|FBrf0093549
REFDSR
{
RDID|FBrf0093549
|Kockel et al.
|1997
ARS|14-3-3&zgr;E16
MD|Construct: 13.5kb genomic fragment containing the entire coding region and 1.7kb
|of upstream and downstream sequences.
MU|in vitro construct | rescue fragment
CNS|FBtp0008237 == P{14-3-3&zgr;tKa}
PHC|wild-type
PHI|Mode of assay: In transgenic Drosophila
SYN|unnamed
}
}
ALESR
{
ASYM|14-3-3&zgr;+
ID|FBal0066544
CLA|wild-type generic
REF|FBrf0105495
}
IFL|../torstoll/leonrd1.htm
SKC|2
}
# EOR
GENR
{
RETE|ID 1 FBgn0010340 CLA 1 Gene NAM 1 upstream of RpII140 GSYM 1 140up DT 1 14 Aug 03 RESZ 5571 PTD 1 DBA 16 FNC 1 biological_process unknown CEL 1 cellular_component unknown CLOC 1 88A9 ALESR 5 REF 11
GSYM|140up
PTD
ARGS
DT|14 Aug 03
ID|FBgn0010340
UAB|Deficiency: Df(3R)red-P52
|Duplication: Dp(3;2)ry+ (inferred from cytology)
SYN|CG9852
|DmRP140-upstream
|l(3)Z6
|DmRP140up
|l(3)88Ba
ID2|FBgn0004843
NAM|upstream of RpII140
KLOC|112472
CLOC|88A9
|Limits computationally determined from genome sequence between l(3)01949 and l(3)j14A6/l(3)00347
FNC|biological_process unknown ; GO:0000004 | no biological data available
CEL|cellular_component unknown ; GO:0008372 | no biological data available
GLOC|Maps to the right of RpII140: 0.02
GLC|@140upZ6@ maps 0.02cM from @RpII140Z24@, with @140up@ probably
|lying proximal to @RpII140@.
ENZ|molecular_function unknown ; GO:0005554 | no biological data available
DBA|NA:AA941870
|BDGP-DGC:LD27182
|NA:AC007441
|BDGP:BACR10E03
|NA:AC007904
|BDGP:BACR01H04
|NA:AE003703
|PA:AAF55023
|NA:AW942742
|BDGP-DGC:LD27182
|NA:AY058577
|PA:AAL13806
|BDGP-DGC:LD27182
|NA:M62973
|NA:M62975
|PA:AAD40352
PAC|SWP:P81928
PHP|All known alleles are recessive lethals.
ASQ|FBan0009852
REF
{
REFM|FBrf0120782
|Sitzler
|1999.8.31
|9
REFM|FBrf0058600
|Hamilton et al.
|1993
|0
REFM|FBrf0120781
|Sitzler
|1999.8.31
|9
REFM|FBrf0126702
|Zheng
|1999.11
|9
REFM|FBrf0125078
|BDGP Project Members
|2000-
|9
REFM|FBrf0056267
|Mortin et al.
|1992
|0
REFM|FBrf0054010
|Sitzler et al.
|1991
|0
REFM|FBrf0092726
|Wiedemann et al.
|1997
|0
REFM|FBrf0058349
|Oldenburg et al.
|1993
|1
REFM|FBrf0105495
|FlyBase
|1992-
|9
REFM|FBrf0054607
|Breen and Harte
|1991
|0
}
REFDSR
{
RDID|FBrf0054010
|Sitzler et al.
|1991
SYN|DmRP140-upstream
}
REFDSR
{
RDID|FBrf0054607
|Breen and Harte
|1991
BMD|Df(3R)JY19
BMD|Df(3R)red-P52
BMDD|Df(3R)JY28
BMDD|Df(3R)red-P6
BMDD|Df(3R)red-P93
BMDD|Df(3R)red2l
BMDD|Df(3R)su(Hw)V
BMDD|Df(3R)trxE12
BMDD|T(Y;3)redP4
SYN|l(3)Z6
}
REFDSR
{
RDID|FBrf0056267
|Mortin et al.
|1992
BMD|Df(3R)red-P1
BMD|Df(3R)red-P52
BMDD|Df(3R)293&ggr;5
BMDD|Df(3R)red-P6
BMDD|Df(3R)red-P93
BMDD|Df(3R)su(Hw)V
}
REFDSR
{
RDID|FBrf0058600
|Hamilton et al.
|1993
GLOC|Maps to the right of RpII140: 0.02
GLC|@140upZ6@ maps 0.02cM from @RpII140Z24@, with @140up@ probably
|lying proximal to @RpII140@.
}
REFDSR
{
RDID|-1793994161
ENZ|molecular_function unknown ; GO:0005554 | no biological data available
FNC|biological_process unknown ; GO:0000004 | no biological data available
CEL|cellular_component unknown ; GO:0008372 | no biological data available
}
REFDSR
{
RDID|FBrf0092726
|Wiedemann et al.
|1997
PHP|Sequences important for the transcription of @RpII140@ are located
|in the untranslated leader of the divergently transcribed @140up@ gene.
SYN|DmRP140up
}
REFDSR
{
RDID|FBrf0105495
|FlyBase
|1992-
MD|Maps to clone: BACR01H04
|Maps to clone: BACR10E03
}
REFDSR
{
RDID|FBrf0120781
|Sitzler
|1999.8.31
SYN|unnamed
}
REFDSR
{
RDID|FBrf0120782
|Sitzler
|1999.8.31
MD|Gene order: Overall orientation not stated: 140up- RpII140+
SYN|DmRP140-upstream
}
REFDSR
{
RDID|FBrf0125078
|BDGP Project Members
|2000-
MD|Identified with: LD27182 (BDGP-DGC)
}
REFDSR
{
RDID|FBrf0126702
|Zheng
|1999.11
AM|Source for identity of: 140up CG9852
}
ALESR
{
ASYM|140upM13
ID|FBal0031933
PHC|lethal | recessive
REF|FBrf0056267
REFDSR
{
RDID|FBrf0056267
|Mortin et al.
|1992
MU|ethyl methanesulfonate
PHC|lethal | recessive
}
}
ALESR
{
ASYM|140upZ6
SYN|Z6
ID|FBal0031936
PHC|lethal | recessive
REF|FBrf0054607
|FBrf0058600
|FBrf0056267
REFDSR
{
RDID|FBrf0056267
|Mortin et al.
|1992
MU|ethyl methanesulfonate
PHC|lethal | recessive
}
REFDSR
{
RDID|FBrf0058600
|Hamilton et al.
|1993
SYN|Z6
}
}
ALESR
{
ASYM|140upZ29
SYN|Z29
ID|FBal0031934
PHC|lethal | recessive
REF|FBrf0058600
|FBrf0056267
REFDSR
{
RDID|FBrf0056267
|Mortin et al.
|1992
MU|ethyl methanesulfonate
PHC|lethal | recessive
}
REFDSR
{
RDID|FBrf0058600
|Hamilton et al.
|1993
SYN|Z29
}
}
ALESR
{
ASYM|140upZ30
SYN|Z30
ID|FBal0031935
PHC|lethal | recessive
REF|FBrf0058600
|FBrf0056267
REFDSR
{
RDID|FBrf0056267
|Mortin et al.
|1992
MU|ethyl methanesulfonate
PHC|lethal | recessive
}
REFDSR
{
RDID|FBrf0058600
|Hamilton et al.
|1993
SYN|Z30
}
}
ALESR
{
ASYM|140up+
ID|FBal0066317
CLA|wild-type generic
REF|FBrf0105495
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0004951 CLA 1 repetitive element NAM 1 1.688 satellite-related 10Ea GSYM 1 1688-10Ea DT 1 14 Aug 03 RESZ 1081 DBA 3 WT 3 Euchromatic sequences of unknown function similar CLOC 1 10E1--2 REF 3
GSYM|1688-10Ea
DT|14 Aug 03
ID|FBgn0004951
CLA|repetitive_element
UAB|Deficiency: Df(1)HA85 (inferred from cytology)
|Duplication: Dp(1;2)v+65b (inferred from cytology)
SYN|1.688
|1688-10Ed
NAM|1.688 satellite-related 10Ea
KLOC|14316-2402
GLOC|1-[36]
CLOC|10E1--2
|Right limit from molecular mapping relative to 1688-10Eb (FBrf0057386)
WT|Euchromatic sequences of unknown function similar, in their sequence, to
|the 1.688 @satDNA@ repeat. It has been suggested (FBrf0057386) that they
|may be required for some sex chromosome specific function.
DBA|NA:X62938
|NA:Z50388
|dbSTS:24350
REF
{
REFM|FBrf0057386
|DiBartolomeis et al.
|1992
|0
REFM|FBrf0080225
|Madueno et al.
|1995
|0
REFM|FBrf0100592
|Law et al.
|1998
|0
}
REFDSR
{
RDID|FBrf0057386
|DiBartolomeis et al.
|1992
OTH|The X linked SR sequences may be required for sex chromosome specific functions.
}
REFDSR
{
RDID|FBrf0080225
|Madueno et al.
|1995
SYN|1.688
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0004952 CLA 1 repetitive element NAM 1 1.688 satellite-related 10Eb GSYM 1 1688-10Eb DT 1 14 Aug 03 RESZ 1274 DBA 3 WT 3 Euchromatic sequences of unknown function similar CLOC 1 10E1--2 REF 4
GSYM|1688-10Eb
DT|14 Aug 03
ID|FBgn0004952
CLA|repetitive_element
UAB|Deficiency: Df(1)HA85 (inferred from cytology)
|Duplication: Dp(1;2)v+65b (inferred from cytology)
SYN|1.688
|1688-10Ep
NAM|1.688 satellite-related 10Eb
KLOC|14316-2402
GLOC|1-[36]
CLOC|10E1--2
|Left limit from in situ hybridization (FBrf0057386)
|Right limit from in situ hybridization (FBrf0057386)
CYC|Experimentally determined: 10E1--2
WT|Euchromatic sequences of unknown function similar, in their sequence, to
|the 1.688 @satDNA@ repeat. It has been suggested (FBrf0057386) that they
|may be required for some sex chromosome specific function.
DBA|NA:X62937
|NA:Z32192
|dbSTS:4743
REF
{
REFM|FBrf0057386
|DiBartolomeis et al.
|1992
|0
REFM|FBrf0071734
|EDGP Project Members
|1994-
|9
REFM|FBrf0080225
|Madueno et al.
|1995
|0
REFM|FBrf0100592
|Law et al.
|1998
|0
}
REFDSR
{
RDID|FBrf0057386
|DiBartolomeis et al.
|1992
CLOC|10E1--2 (determined by in situ hybridization)
OTH|The X linked SR sequences may be required for sex chromosome specific functions.
}
REFDSR
{
RDID|FBrf0080225
|Madueno et al.
|1995
SYN|1.688
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0004953 CLA 1 repetitive element NAM 1 1.688 satellite-related 11EF GSYM 1 1688-11EF DT 1 14 Aug 03 RESZ 1034 WT 3 Euchromatic sequences of unknown function similar CLOC 1 11E--F REF 4
GSYM|1688-11EF
DT|14 Aug 03
ID|FBgn0004953
CLA|repetitive_element
UAB|Deficiency: Df(1)C246 (inferred from cytology)
|Duplication: Dp(1;3)rasv (inferred from cytology)
SYN|1.688
NAM|1.688 satellite-related 11EF
KLOC|15780-16183
GLOC|1-[41]
CLOC|11E--F
WT|Euchromatic sequences of unknown function similar, in their sequence, to
|the 1.688 @satDNA@ repeat. It has been suggested (FBrf0057386) that they
|may be required for some sex chromosome specific function.
REF
{
REFM|FBrf0057386
|DiBartolomeis et al.
|1992
|0
REFM|FBrf0047217
|Waring and Pollack
|1987
|0
REFM|FBrf0080225
|Madueno et al.
|1995
|0
REFM|FBrf0100592
|Law et al.
|1998
|0
}
REFDSR
{
RDID|FBrf0057386
|DiBartolomeis et al.
|1992
OTH|The X linked SR sequences may be required for sex chromosome specific functions.
}
REFDSR
{
RDID|FBrf0080225
|Madueno et al.
|1995
SYN|1.688
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0027098 CLA 1 repetitive element GSYM 1 1688-2E DT 1 14 Aug 03 RESZ 186 DBA 1 REF 1
GSYM|1688-2E
DT|14 Aug 03
ID|FBgn0027098
CLA|repetitive_element
DBA|NA:AJ238704
REF
{
REFM|FBrf0107580
|Alatortsev et al.
|1998
|0
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0004950 CLA 1 repetitive element NAM 1 1.688 satellite-related 3C GSYM 1 1688-3C DT 1 14 Aug 03 RESZ 1232 DBA 3 WT 3 Euchromatic sequences of unknown function similar CLOC 1 3C REF 4
GSYM|1688-3C
DT|14 Aug 03
ID|FBgn0004950
CLA|repetitive_element
UAB|Deficiency: Df(1)z1 (inferred from cytology)
|Duplication: Dp(1;Y)w+303 (inferred from cytology)
SYN|1.688
NAM|1.688 satellite-related 3C
KLOC|3069
GLOC|1-[1.5]
CLOC|3C
|Left limit from in situ hybridization (FBrf0057386)
|Right limit from in situ hybridization (FBrf0057386)
CYC|Experimentally determined: 3C
WT|Euchromatic sequences of unknown function similar, in their sequence, to
|the 1.688 @satDNA@ repeat. It has been suggested (FBrf0057386) that they
|may be required for some sex chromosome specific function.
DBA|NA:X62939
|NA:Z32250
|dbSTS:4802
REF
{
REFM|FBrf0057386
|DiBartolomeis et al.
|1992
|0
REFM|FBrf0071734
|EDGP Project Members
|1994-
|9
REFM|FBrf0080225
|Madueno et al.
|1995
|0
REFM|FBrf0100592
|Law et al.
|1998
|0
}
REFDSR
{
RDID|FBrf0057386
|DiBartolomeis et al.
|1992
CLOC|3C (determined by in situ hybridization)
OTH|The X linked SR sequences may be required for sex chromosome specific functions.
}
REFDSR
{
RDID|FBrf0080225
|Madueno et al.
|1995
SYN|1.688
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0000004 CLA 1 transposable element NAM 1 17.6 element GSYM 1 17.6 DT 1 14 Aug 03 RESZ 9320 DBA 29 WT 3 A retroviral-like transposable element REF 73
GSYM|17.6
DT|14 Aug 03
ID|FBgn0000004
CLA|transposable_element
SYN|17.6S
|176
|Dme176V
NAM|17.6 element
AM|encoded genes: @17.6\env@, @17.6\gag@, @17.6\pol@
TE|element type: LTR retrotransposon
|terminal repeat length in bp: 512
|total length in bp: 7439
|target site duplication length in bp: 4
|number of copies in genome: 40 (FBrf0040123)
WT|A retroviral-like transposable element. First described by Saigo et al.
|(FBrf0036029) as a sequence inserted into histone genes and hybridizing to
|@297@ elements.
DBA|NA:AL008791
|dbSTS:53385
|NA:L39084
|NA:M31561
|NA:M31562
|NA:M31563
|NA:M31564
|NA:M31565
|NA:M31566
|NA:M31567
|NA:M31569
|NA:M31570
|NA:M31571
|NA:M31573
|NA:M31574
|NA:V01517
|NA:V01518
|NA:X01472
|NA:X79394
|NA:Z31854
|dbSTS:4392
|NA:Z32251
|dbSTS:4803
|NA:Z32339
|dbSTS:4891
|NA:Z70850
|dbSTS:33719
|NA:Z71029
|dbSTS:33525
PAC|MEROPS:A02.052
REV|FBrf0100335
|FBrf0152077
REF
{
REFM|FBrf0131051
|Marin and Llorens
|2000
|0
REFM|FBrf0151719
|Tulin et al.
|2002
|0
REFM|FBrf0057228
|Kulkosky et al.
|1992
|0
REFM|FBrf0116414
|Inouye
|1995.1.24
|9
REFM|FBrf0128568
|Maside et al.
|2000
|0
REFM|FBrf0055613
|de Frutos et al.
|1992
|0
REFM|FBrf0116412
|Inouye
|1995.1.24
|9
REFM|FBrf0116411
|Inouye
|1995.1.24
|9
REFM|FBrf0116410
|Inouye
|1995.1.24
|9
REFM|FBrf0056185
|von Sternberg et al.
|1992
|2
REFM|FBrf0040123
|Kugimiya et al.
|1983
|0
REFM|FBrf0111953
|Losada et al.
|1999
|0
REFM|FBrf0053865
|Arkhipova and Ilyin
|1991
|0
REFM|FBrf0151415
|Lerat et al.
|2002
|9
REFM|FBrf0116409
|Inouye
|1995.1.24
|9
REFM|FBrf0116408
|Inouye
|1995.1.24
|9
REFM|FBrf0116407
|Inouye
|1995.1.24
|9
REFM|FBrf0116406
|Inouye
|1995.1.24
|9
REFM|FBrf0116405
|Inouye
|1995.1.24
|9
REFM|FBrf0048585
|Huijser et al.
|1988
|0
REFM|FBrf0116404
|Inouye
|1995.1.24
|9
REFM|FBrf0071734
|EDGP Project Members
|1994-
|9
REFM|FBrf0116403
|Inouye
|1995.1.24
|9
REFM|FBrf0116402
|Inouye
|1995.1.24
|9
REFM|FBrf0106414
|Desset et al.
|1999
|0
REFM|FBrf0144916
|Rizzon et al.
|2002
|0
REFM|FBrf0111944
|Lerat and Capy
|1999
|0
REFM|FBrf0051101
|Sandmeyer et al.
|1990
|2
REFM|FBrf0079059
|Mozer and Benzer
|1993
|1
REFM|FBrf0079058
|Mozer and Benzer
|1991
|1
REFM|FBrf0080225
|Madueno et al.
|1995
|0
REFM|FBrf0054202
|Kim and Belyaeva
|1991
|0
REFM|FBrf0059271
|Delpuech et al.
|1993
|0
REFM|FBrf0152077
|Pelisson et al.
|2002
|2
REFM|FBrf0079937
|Charlesworth et al.
|1994
|0
REFM|FBrf0099812
|Terzian et al.
|1997
|0
REFM|FBrf0041561
|Saigo et al.
|1984
|0
REFM|FBrf0054653
|McClure
|1991
|0
REFM|FBrf0079992
|Ding and Lipshitz
|1994
|0
REFM|FBrf0074490
|Sniegowski and Charlesworth
|1994
|0
REFM|FBrf0036029
|Saigo et al.
|1981
|0
REFM|FBrf0102359
|Makarova et al.
|1995
|0
REFM|FBrf0129733
|Biemont et al.
|1999
|2
REFM|FBrf0125337
|Boeke and Corces
|1989
|2
REFM|FBrf0073975
|Mozer and Benzer
|1994
|0
REFM|FBrf0138423
|Bowen and McDonald
|2001
|0
REFM|FBrf0052837
|Harada et al.
|1990
|0
REFM|FBrf0054937
|Jarrell and Meselson
|1991
|0
REFM|FBrf0125292
|Xiong and Eickbush
|1990
|0
REFM|FBrf0111330
|Biemont and Cizeron
|1999
|0
REFM|FBrf0041549
|Inouye et al.
|1984
|0
REFM|FBrf0134868
|Haoudi and Mason
|2000
|2
REFM|FBrf0078388
|Finnegan
|1992
|0
REFM|FBrf0127032
|Canizares et al.
|2000
|0
REFM|FBrf0083460
|Suh et al.
|1995
|0
REFM|FBrf0057833
|Kanda and Saigo
|1993
|0
REFM|FBrf0098551
|Suh et al.
|1994
|1
REFM|FBrf0100335
|Britten
|1997
|2
REFM|FBrf0105736
|Kanapin and Ivanov
|1998
|0
REFM|FBrf0127224
|Marsano et al.
|2000
|0
REFM|FBrf0149106
|Bartolome et al.
|2002
|0
REFM|FBrf0057534
|Waters et al.
|1992
|0
REFM|FBrf0149104
|Vieira et al.
|2002
|0
REFM|FBrf0051918
|Voelker et al.
|1990
|0
REFM|FBrf0111776
|Andrianov et al.
|1999
|0
REFM|FBrf0052879
|Scheinker et al.
|1990
|0
REFM|FBrf0111510
|Vieira et al.
|1999
|0
REFM|FBrf0130256
|Lerat et al.
|1999
|0
REFM|FBrf0045140
|Inouye et al.
|1986
|0
REFM|FBrf0109043
|Rutsov et al.
|1999
|0
REFM|FBrf0054718
|Kim and Belyaeva
|1991
|0
REFM|FBrf0055481
|Arkhipova and Ilyin
|1992
|2
REFM|FBrf0108981
|Pantazidis et al.
|1999
|0
}
REFDSR
{
RDID|FBrf0052837
|Harada et al.
|1990
OTH|Transposition rates of mobile elements in lines AW and JH, in which
|spontaneous mutations have accumulated for about 400 generations, are
|studied. @412@ and @17.6@ elements rate of transposition is very low,
|@I-element@ and @hobo@ insertions occur much more frequently.
}
REFDSR
{
RDID|FBrf0059271
|Delpuech et al.
|1993
WT|Presence or absence of a long terminal repeat of 17.6 does not correlate
|with resistance or susceptibility to DDT in 31 strains of D.melanogaster
|and D.simulans from around the world.
}
REFDSR
{
RDID|FBrf0074490
|Sniegowski and Charlesworth
|1994
WT|Element copy numbers on inversion and standard chromosomes has been
|determined. The copy number is significantly higher within low frequency
|inversions than within the corresponding standard chromosome regions.
}
REFDSR
{
RDID|FBrf0079937
|Charlesworth et al.
|1994
WT|Estimating the genomic numbers of transposable elements demonstrates
|many families of element are over-represented in heterochromatin.
}
REFDSR
{
RDID|FBrf0079992
|Ding and Lipshitz
|1994
WT|The spatial and temporal expression patterns of fifteen families of
|retrotransposons are analyzed during embryogenesis and are found to
|be conserved. Results suggest that all families carry cis-acting elements
|that control their spatial and temporal expression patterns.
}
REFDSR
{
RDID|FBrf0083460
|Suh et al.
|1995
PHP|The chromosomal distribution of a number of retrotransposons in an
|isolated population of D.melanogaster (from Ishigaki Island, Okinawa,
|Japan) has been determined.
}
REFDSR
{
RDID|FBrf0099812
|Terzian et al.
|1997
OTH|Used in an investigation to address the relationship between retrotransposons
|and retroviruses and the coadaptation of these retroelements to their
|host genomes. Results indicate retrotransposons are heterogeneous
|in contrast to retroviruses, suggesting different modes of evolution
|by slippage-like mechanisms.
}
REFDSR
{
RDID|FBrf0116402
|Inouye
|1995.1.24
SYN|17.6S
}
REFDSR
{
RDID|FBrf0116403
|Inouye
|1995.1.24
SYN|17.6S
}
REFDSR
{
RDID|FBrf0116404
|Inouye
|1995.1.24
SYN|17.6S
}
REFDSR
{
RDID|FBrf0116405
|Inouye
|1995.1.24
SYN|17.6S
}
REFDSR
{
RDID|FBrf0116406
|Inouye
|1995.1.24
SYN|17.6S
}
REFDSR
{
RDID|FBrf0116407
|Inouye
|1995.1.24
SYN|17.6S
}
REFDSR
{
RDID|FBrf0116408
|Inouye
|1995.1.24
SYN|17.6S
}
REFDSR
{
RDID|FBrf0116409
|Inouye
|1995.1.24
SYN|17.6S
}
REFDSR
{
RDID|FBrf0116410
|Inouye
|1995.1.24
SYN|17.6S
}
REFDSR
{
RDID|FBrf0116411
|Inouye
|1995.1.24
SYN|17.6S
}
REFDSR
{
RDID|FBrf0116412
|Inouye
|1995.1.24
SYN|17.6S
}
REFDSR
{
RDID|FBrf0116414
|Inouye
|1995.1.24
SYN|17.6S
}
REFDSR
{
RDID|FBrf0151719
|Tulin et al.
|2002
SYN|176
}
REFDSR
{
RDID|FBrf0152077
|Pelisson et al.
|2002
SYN|Dme176V
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0027624 CLA 1 transposable element gene GSYM 1 17.6\env DT 1 14 Aug 03 RESZ 572 DBA 2 ALESR 1 REF 4
GSYM|17.6\env
DT|14 Aug 03
ID|FBgn0027624
CLA|transposable_element_gene
AM|encoded by: @17.6@
DBA|NA:X01472
|PA:CAA25703
PAC|PIR:A03326
|SWP:P04283
REV|FBrf0152077
REF
{
REFM|FBrf0106414
|Desset et al.
|1999
|0
REFM|FBrf0152077
|Pelisson et al.
|2002
|2
REFM|FBrf0130256
|Lerat et al.
|1999
|0
REFM|FBrf0111944
|Lerat and Capy
|1999
|0
}
ALESR
{
ASYM|17.6\env+
ID|FBal0105454
CLA|wild-type generic
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0044339 CLA 1 transposable element gene GSYM 1 17.6\gag DT 1 14 Aug 03 RESZ 393 PDOM 3 INTERPRO:IPR001584 == Integrase, catalytic core DBA 2 ALESR 1
GSYM|17.6\gag
DT|14 Aug 03
ID|FBgn0044339
CLA|transposable_element_gene
AM|encoded by: @17.6@
PDOM|IPR001584 == Integrase, catalytic core
|IPR001969 == Eukaryotic and viral aspartic protease active site
|IPR001995 == Retroviral-type aspartic protease
DBA|NA:X01472
|PA:CAA25701
PAC|PIR:A03325
|SWP:P04282
ALESR
{
ASYM|17.6\gag+
ID|FBal0122862
CLA|wild-type generic
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0014453 CLA 1 transposable element gene NAM 1 17.6 element transposase GSYM 1 17.6\pol DT 1 14 Aug 03 RESZ 938 PDOM 1 INTERPRO:IPR000477 == RNA-directed DNA polymerase (Reverse transcriptase) DBA 2 WT 1 The transposase encoded by the @17.6@ element ALESR 1 REF 3
GSYM|17.6\pol
DT|14 Aug 03
ID|FBgn0014453
CLA|transposable_element_gene
SYN|17.6\T
|17.6 element transposase
AM|encoded by: @17.6@
WT|The transposase encoded by the @17.6@ element.
PDOM|IPR000477 == RNA-directed DNA polymerase (Reverse transcriptase)
NAM|17.6 element transposase
DBA|NA:X01472
|PA:CAA25702
PAC|PIR:A03971
|SWP:P04323
REF
{
REFM|FBrf0106414
|Desset et al.
|1999
|0
REFM|FBrf0111944
|Lerat and Capy
|1999
|0
REFM|FBrf0073975
|Mozer and Benzer
|1994
|0
}
REFDSR
{
RDID|FBrf0073975
|Mozer and Benzer
|1994
NAM|17.6 element transposase
WT|The regulation of transcription of the @17.6@ retrotransposon provides
|a model for the study of innervation-dependent gene expression in postsynaptic
|cells during neurogenesis.
}
ALESR
{
ASYM|17.6\pol+
ID|FBal0105302
CLA|wild-type generic
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0000007 CLA 1 transposable element NAM 1 1731 element GSYM 1 1731 DT 1 14 Aug 03 RESZ 10484 DBA 3 WT 5 A retroviral-like transposable element REF 65
GSYM|1731
DT|14 Aug 03
ID|FBgn0000007
CLA|transposable_element
SYN|17.31
NAM|1731 element
AM|encoded genes: @1731\LTR@, @1731\RTase@, @1731\gag@
TE|element type: LTR retrotransposon
|terminal repeat length in bp: 336
|number of copies in genome: 10
|total length in bp: 4648 (FBrf0045155)
|target site duplication length in bp: 5 (FBrf0045155)
WT|A retroviral-like transposable element. The first @1731@ element was
|identified because its transcription in tissue-culture cells is reduced in
|the presence of 20-hydroxyecdysone (FBrf0045155). In cell lines the
|transcription of @1731@ is down-regulated by ecdysteroids (FBrf0053421;
|FBrf0054856).
DBA|NA:X04686
|NA:X04874
|NA:X07656
REF
{
REFM|FBrf0058493
|Kim et al.
|1993
|0
REFM|FBrf0134799
|van Steensel et al.
|2001
|9
REFM|FBrf0105935
|Slama-Schwok et al.
|1998
|0
REFM|FBrf0067697
|Fourcade-Peronnet et al.
|1994
|1
REFM|FBrf0057228
|Kulkosky et al.
|1992
|0
REFM|FBrf0090548
|Faure et al.
|1996
|0
REFM|FBrf0056591
|Fourcade-Peronnet et al.
|1992
|0
REFM|FBrf0079108
|Nuzhdin and Mackay
|1995
|9
REFM|FBrf0064626
|Nahon et al.
|1993
|0
REFM|FBrf0055481
|Arkhipova and Ilyin
|1992
|2
REFM|FBrf0155500
|Maggert and Golic
|2002
|0
REFM|FBrf0144916
|Rizzon et al.
|2002
|0
REFM|FBrf0059024
|Montchamp-Moreau et al.
|1993
|0
REFM|FBrf0128568
|Maside et al.
|2000
|0
REFM|FBrf0054856
|Ziarczyk and Best-Belpomme
|1991
|0
REFM|FBrf0079937
|Charlesworth et al.
|1994
|0
REFM|FBrf0105736
|Kanapin and Ivanov
|1998
|0
REFM|FBrf0149015
|Yan et al.
|2002
|0
REFM|FBrf0053421
|Becker et al.
|1991
|0
REFM|FBrf0111510
|Vieira et al.
|1999
|0
REFM|FBrf0058488
|Codani-Simonart et al.
|1993
|0
REFM|FBrf0108387
|Dimitri and Junakovic
|1999
|2
REFM|FBrf0130256
|Lerat et al.
|1999
|0
REFM|FBrf0079992
|Ding and Lipshitz
|1994
|0
REFM|FBrf0086400
|Faure et al.
|1996
|0
REFM|FBrf0125292
|Xiong and Eickbush
|1990
|0
REFM|FBrf0098518
|Haoudi et al.
|1997
|0
REFM|FBrf0138423
|Bowen and McDonald
|2001
|0
REFM|FBrf0129733
|Biemont et al.
|1999
|2
REFM|FBrf0105955
|Whalen and Grigliatti
|1998
|0
REFM|FBrf0141542
|Maside et al.
|2001
|0
REFM|FBrf0149106
|Bartolome et al.
|2002
|0
REFM|FBrf0111953
|Losada et al.
|1999
|0
REFM|FBrf0149104
|Vieira et al.
|2002
|0
REFM|FBrf0099812
|Terzian et al.
|1997
|0
REFM|FBrf0056166
|di Franco et al.
|1992
|0
REFM|FBrf0099810
|Flavell et al.
|1997
|0
REFM|FBrf0056194
|di Franco et al.
|1992
|0
REFM|FBrf0080187
|Lacoste and Fourcade-Peronnet
|1995
|0
REFM|FBrf0056004
|Champion et al.
|1992
|0
REFM|FBrf0050727
|Ziarczyk et al.
|1989
|0
REFM|FBrf0151629
|Flavell et al.
|1992
|0
REFM|FBrf0137949
|Alonso-Gonzalez et al.
|2001
|1
REFM|FBrf0129880
|Kalmykova et al.
|1999
|0
REFM|FBrf0049432
|di Franco et al.
|1989
|0
REFM|FBrf0045155
|Peronnet et al.
|1986
|0
REFM|FBrf0055722
|Ribaudo et al.
|1992
|0
REFM|FBrf0084234
|Nuzhdin
|1995
|0
REFM|FBrf0110995
|Vieira et al.
|1999
|1
REFM|FBrf0077988
|Arnault and Dufournel
|1994
|2
REFM|FBrf0058311
|Lacoste et al.
|1993
|1
REFM|FBrf0111944
|Lerat and Capy
|1999
|0
REFM|FBrf0076524
|Kim et al.
|1994
|0
REFM|FBrf0048831
|Fourcade-Peronnet et al.
|1988
|0
REFM|FBrf0085408
|Lacoste et al.
|1995
|0
REFM|FBrf0078389
|Finnegan
|1992
|0
REFM|FBrf0151719
|Tulin et al.
|2002
|0
REFM|FBrf0074490
|Sniegowski and Charlesworth
|1994
|0
REFM|FBrf0111330
|Biemont and Cizeron
|1999
|0
REFM|FBrf0052451
|Jakubczak et al.
|1990
|0
REFM|FBrf0129815
|Fortunati and Junakovic
|1999
|0
REFM|FBrf0134868
|Haoudi and Mason
|2000
|2
REFM|FBrf0085174
|Haoudi et al.
|1995
|0
REFM|FBrf0137199
|Aravin et al.
|2001
|0
REFM|FBrf0099793
|Alberola et al.
|1997
|0
}
REFDSR
{
RDID|FBrf0049432
|di Franco et al.
|1989
WT|The genomic distribution of transposable elements in somatic tissues and
|during development is homogeneous.
}
REFDSR
{
RDID|FBrf0054856
|Ziarczyk and Best-Belpomme
|1991
TE|element type: LTR retrotransposon
|total length in bp: 4648
|target site duplication length in bp: 5
|terminal repeat length in bp: 336
}
REFDSR
{
RDID|FBrf0056166
|di Franco et al.
|1992
WT|Stability of 11 transposable element families compared by Southern
|blotting among individuals of lines that had been subjected to 30
|generations of sister sib matings. @412@, @roo@, @blood@, @297@, @1731@
|and @G-element@ all appear stable, whereas @copia@, @hobo@, @I-element@,
|@gypsy@ and @jockey@ elements show instability.
}
REFDSR
{
RDID|FBrf0056591
|Fourcade-Peronnet et al.
|1992
WTI|NssBF
}
REFDSR
{
RDID|FBrf0058488
|Codani-Simonart et al.
|1993
PHP|The behavior of the LTR is analyzed after transfer to human monocytes.
}
REFDSR
{
RDID|FBrf0059024
|Montchamp-Moreau et al.
|1993
WT|The distribution of @1731@ retrotransposon-hybridizing sequences reveals
|the sequences are widespread within both the Sophophora and Drosophila
|subgenera. The @1731@ retrotransposon family appears to have a long
|evolutionary history in the Drosophilidae genome.
}
REFDSR
{
RDID|FBrf0064626
|Nahon et al.
|1993
PHP|@Top2@ is involved in different functions of the @1731@ LTR.
}
REFDSR
{
RDID|FBrf0074490
|Sniegowski and Charlesworth
|1994
WT|Element copy numbers on inversion and standard chromosomes has been
|determined. The copy number is significantly higher within low frequency
|inversions than within the corresponding standard chromosome regions.
}
REFDSR
{
RDID|FBrf0076524
|Kim et al.
|1994
WT|The @1731@ promoter is active in Pleurodeles waltl oocytes suggesting
|in the case of horizontal transfer @1731@ can be expressed in vertebrate
|organisms.
}
REFDSR
{
RDID|FBrf0079108
|Nuzhdin and Mackay
|1995
PHP|The distribution of a number of transposable elements has been studied
|in 10 Harwich mutation accumulation lines.
}
REFDSR
{
RDID|FBrf0079937
|Charlesworth et al.
|1994
WT|Estimating the genomic numbers of transposable elements demonstrates
|many families of element are over-represented in heterochromatin.
}
REFDSR
{
RDID|FBrf0079992
|Ding and Lipshitz
|1994
WT|The spatial and temporal expression patterns of fifteen families of
|retrotransposons are analyzed during embryogenesis and are found to
|be conserved. Results suggest that all families carry cis-acting elements
|that control their spatial and temporal expression patterns.
}
REFDSR
{
RDID|FBrf0080187
|Lacoste and Fourcade-Peronnet
|1995
PHP|In vitro transcription of the @1731@ element promoter is repressed
|by @NssBF@ element binding protein(s).
}
REFDSR
{
RDID|FBrf0084234
|Nuzhdin
|1995
PPC|The distribution of transposable elements in D.simulans is similar
|to that found in D.melanogaster, though total copy number is lower.
}
REFDSR
{
RDID|FBrf0085408
|Lacoste et al.
|1995
WT|Overexpression of @Ssb-c31a@ in transfected cells represses the @1731@
|element promoter.
}
REFDSR
{
RDID|FBrf0090548
|Faure et al.
|1996
PHP|UVB-irradiation activation of @1731@-LTR requires a short sequence
|of the U3 region, the sequence is active in human or Schneider cell
|line. Sequence is similar to the binding sequence of members of the
|nuclear factor &kgr;B (NF-&kgr;B)/rel family.
}
REFDSR
{
RDID|FBrf0098518
|Haoudi et al.
|1997
OTH|Expression of @1731@ is regulated not only at the transcriptional level
|but also at the translational level, this regulation is different in
|the two sexes.
}
REFDSR
{
RDID|FBrf0099812
|Terzian et al.
|1997
OTH|Used in an investigation to address the relationship between retrotransposons
|and retroviruses and the coadaptation of these retroelements to their
|host genomes. Results indicate retrotransposons are heterogeneous
|in contrast to retroviruses, suggesting different modes of evolution
|by slippage-like mechanisms.
}
REFDSR
{
RDID|FBrf0129880
|Kalmykova et al.
|1999
TE|Two classes of @1731@ element are present in the genome. The first
|class uses conventional translational frameshifting to ensure expression
|of the @1731\RTase@ open reading frame. Most of the genomic copies
|are related to the second class where the frameshift is prevented as
|a result of a substitution of a rare codon recognizing a rare tRNA
|by a codon preferred by the host genome and the @1731\RTase@ ORF is
|restored by a downstream single nucleotide deletion.
}
REFDSR
{
RDID|FBrf0149104
|Vieira et al.
|2002
SYN|17.31
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0020768 CLA 1 transposable element gene NAM 1 1731 element gag GSYM 1 1731\gag DT 1 14 Aug 03 RESZ 2286 DBA 2 ALESR 3 REF 3
GSYM|1731\gag
DT|14 Aug 03
ID|FBgn0020768
CLA|transposable_element_gene
SYN|ORF1
|1731 element gag
AM|encoded by: @1731@
NAM|1731 element gag
DBA|NA:X07656
|PA:CAA30502
PAC|PIR:S00953
REF
{
REFM|FBrf0129880
|Kalmykova et al.
|1999
|0
REFM|FBrf0058493
|Kim et al.
|1993
|0
REFM|FBrf0085174
|Haoudi et al.
|1995
|0
}
REFDSR
{
RDID|FBrf0058493
|Kim et al.
|1993
WT|Translation of the gag protein is studied by transfection of the protein
|into cultured cells.
}
REFDSR
{
RDID|FBrf0085174
|Haoudi et al.
|1995
NAM|1731 element gag
WT|The largest @1731\gag@ polypeptides are present in the virus-like particles
|extracted from a D.melanogaster cell line, and a short @1731\gag@
|polypeptide is associated to the cell nucleus.
SYN|ORF1
}
REFDSR
{
RDID|FBrf0129880
|Kalmykova et al.
|1999
SYN|ORF1
}
ALESR
{
ASYM|1731\gaga.T:Ecol\lacZ
SYN|1731\gaga.T:lacZ
ID|FBal0062283
PHI|Mode of assay: Drosophila cell culture
REF|FBrf0058493
REFDSR
{
RDID|FBrf0058493
|Kim et al.
|1993
MD|Construct: An entire @1731@ harboring the first 9/10 of the ORF1 fused in frame
|with a KpnI-BamHI fragment of @Ecol\lacZ@ in antisense orientation.
OTH|Carried in plasmid pKM8-, expressed in S2 cells, D.virilis DV1 cels
|and D.hydei KUN-DH3 cells to study translation of the gag protein.
MU|in vitro construct | coding region fusion
PHI|Mode of assay: Drosophila cell culture
}
}
ALESR
{
ASYM|1731\gags.T:Ecol\lacZ
SYN|1731\gags.T:lacZ
ID|FBal0062282
PHI|Mode of assay: Drosophila cell culture
REF|FBrf0058493
REFDSR
{
RDID|FBrf0058493
|Kim et al.
|1993
MD|Construct: An entire @1731@ harboring the first 9/10 of the ORF1 fused in frame
|with a KpnI-BamHI fragment of @Ecol\lacZ@ in sense orientation.
OTH|Carried in plasmid pKM8+, expressed in S2 cells, D.virilis DV1 cels
|and D.hydei KUN-DH3 cells to study translation of the gag protein.
MU|in vitro construct | coding region fusion
PHI|Mode of assay: Drosophila cell culture
}
}
ALESR
{
ASYM|1731\gag+
ID|FBal0105349
CLA|wild-type generic
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0044507 CLA 1 transposable element gene GSYM 1 1731\LTR DT 1 14 Aug 03 RESZ 225 DBA 4 ALESR 1
GSYM|1731\LTR
DT|14 Aug 03
ID|FBgn0044507
CLA|transposable_element_gene
AM|encoded by: @1731@
DBA|NA:X04686
|PA:CAA28388
|NA:X04874
|PA:CAA28563
ALESR
{
ASYM|1731\LTR+
ID|FBal0123540
CLA|wild-type generic
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0012032 CLA 1 transposable element gene NAM 1 1731-repetitive-element reverse transcriptase GSYM 1 1731\RTase DT 1 14 Aug 03 RESZ 998 DBA 2 ALESR 1 REF 4
GSYM|1731\RTase
DT|14 Aug 03
ID|FBgn0012032
CLA|transposable_element_gene
SYN|ORF2
|1731-repetitive-element reverse transcriptase
AM|encoded by: @1731@
NAM|1731-repetitive-element reverse transcriptase
DBA|NA:X07656
|PA:CAA30503
PAC|PIR:S00954
REF
{
REFM|FBrf0056004
|Champion et al.
|1992
|0
REFM|FBrf0129880
|Kalmykova et al.
|1999
|0
REFM|FBrf0111944
|Lerat and Capy
|1999
|0
REFM|FBrf0085174
|Haoudi et al.
|1995
|0
}
REFDSR
{
RDID|FBrf0056004
|Champion et al.
|1992
NAM|1731-repetitive-element reverse transcriptase
PHP|The protein co-sediments
|with virus-like particles that exhibit reverse transcriptase activity.
}
REFDSR
{
RDID|FBrf0085174
|Haoudi et al.
|1995
SYN|ORF2
}
REFDSR
{
RDID|FBrf0129880
|Kalmykova et al.
|1999
SYN|ORF2
}
ALESR
{
ASYM|1731\RTase+
ID|FBal0105270
CLA|wild-type generic
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0061475 CLA 1 multicopy cytosolic ribosomal RNA gene GSYM 1 18SrRNA DT 1 14 Aug 03 RESZ 3306 DBA 32 CEL 1 cytosolic small ribosomal subunit (sensu Eukarya) ALESR 1 REF 17
GSYM|18SrRNA
DT|14 Aug 03
ID|FBgn0061475
CLA|multicopy_cytosolic_ribosomal_RNA_gene
SYN|18S rRNA
|18S rDNA
|18S RNA
|18S
|18SRNA
AM|encoded by: @bb@, @Ybb@
|component genes: @18SrRNA:CR40456@
CEL|cytosolic small ribosomal subunit (sensu Eukarya) ; GO:0005843 | inferred from sequence similarity
DBA|NA:AI124285
|NA:K01281
|NA:K01286
|NA:K01287
|NA:M20062
|NA:M20063
|NA:M20064
|NA:M21017
|NA:M26817
|NA:S80141
|NA:X15707
|NA:X97143
|NA:Z31795
|dbSTS:4332
|NA:Z31941
|dbSTS:4479
|NA:Z32130
|dbSTS:4682
|NA:Z32170
|dbSTS:4721
|NA:Z32171
|dbSTS:4722
|NA:Z32197
|dbSTS:4748
|NA:Z32373
|dbSTS:4935
|NA:Z32374
|dbSTS:4936
|NA:Z50228
|dbSTS:24192
|NA:Z50229
|dbSTS:24193
REF
{
REFM|FBrf0120332
|Schlotterer
|1997.2.11
|9
REFM|FBrf0094147
|Benevolenskaya et al.
|1997
|0
REFM|FBrf0138565
|Giribet et al.
|2001
|0
REFM|FBrf0128400
|Bhadra et al.
|2000
|0
REFM|FBrf0155623
|2
REFM|FBrf0108854
|Krasnov et al.
|1999
|0
REFM|FBrf0121292
|Tautz
|1990.3.15
|9
REFM|FBrf0055058
|Houck et al.
|1991
|0
REFM|FBrf0094743
|Friedrich and Tautz
|1997
|0
REFM|FBrf0154285
|Ashburner
|2003.2.5
|9
REFM|FBrf0114952
|Field
|1988
|9
REFM|FBrf0114951
|Field
|1988
|9
REFM|FBrf0114950
|Field
|1988
|9
REFM|FBrf0125039
|Bejarano and Gonzalez
|1999
|0
REFM|FBrf0108186
|Giordano et al.
|1999
|0
REFM|FBrf0159270
|Yuan et al.
|2003
|0
REFM|FBrf0111435
|Morel et al.
|1999
|0
}
REFDSR
{
RDID|FBrf0055058
|Houck et al.
|1991
OTH|Samples of the semiparasitic mite Proctolaelaps regalis that have been
|in contact with D.melanogaster contain @bb@ sequences.
SYN|18S rRNA
}
REFDSR
{
RDID|FBrf0094147
|Benevolenskaya et al.
|1997
SYN|18S rDNA
}
REFDSR
{
RDID|FBrf0094743
|Friedrich and Tautz
|1997
SYN|18S rRNA
}
REFDSR
{
RDID|FBrf0108186
|Giordano et al.
|1999
SYN|18S rRNA
}
REFDSR
{
RDID|FBrf0108854
|Krasnov et al.
|1999
SYN|18S RNA
}
REFDSR
{
RDID|FBrf0111435
|Morel et al.
|1999
SYN|18S
}
REFDSR
{
RDID|FBrf0114950
|Field
|1988
SYN|18S rRNA
}
REFDSR
{
RDID|FBrf0114951
|Field
|1988
SYN|18S rRNA
}
REFDSR
{
RDID|FBrf0114952
|Field
|1988
SYN|18S rRNA
}
REFDSR
{
RDID|FBrf0120332
|Schlotterer
|1997.2.11
SYN|18S rRNA
}
REFDSR
{
RDID|FBrf0121292
|Tautz
|1990.3.15
CEL|cytosolic small ribosomal subunit (sensu Eukarya) ; GO:0005843 | inferred from sequence similarity
GPD|ribosomal-RNA-18S
SYN|18S rRNA
}
REFDSR
{
RDID|FBrf0125039
|Bejarano and Gonzalez
|1999
SYN|18S rRNA
}
REFDSR
{
RDID|FBrf0128400
|Bhadra et al.
|2000
SYN|18S rRNA
}
REFDSR
{
RDID|FBrf0138565
|Giribet et al.
|2001
SYN|18S
}
ALESR
{
ASYM|18SrRNA+
ID|FBal0142210
CLA|wild-type generic
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0058456 CLA 1 existence-uncertain gene GSYM 1 18SrRNA:CR40456 DT 1 14 Aug 03 RESZ 259 ALESR 1
GSYM|18SrRNA:CR40456
DT|14 Aug 03
ID|FBgn0058456
CLA|existence-uncertain gene
SYN|CR40456
AM|member gene of: @18SrRNA@
ASQ|FBan0040456
ALESR
{
ASYM|18SrRNA:CR40456+
ID|FBal0143098
CLA|wild-type generic
}
}
# EOR
GENR
{
RETE|ID 1 FBgn0004364 CLA 1 Gene NAM 1 18 wheeler GSYM 1 18w DT 1 14 Aug 03 RESZ 23981 PDOM 5 INTERPRO:IPR000157 == TIR domain PTD 1 DBA 13 HG 5 Caenorhabditis elegans 'coded for by C. elegans cDNA yk132e5.5 EMBL:U39996 FNC 1 cell adhesion CEL 4 cytoplasm WT 1 @18w@ is a critical component of the humoral immune response CLOC 1 56F8 ALESR 16 SK 2 REF 61
GSYM|18w
PTD
ARGS
DT|14 Aug 03
ID|FBgn0004364
UAB|Deficiency: Df(2R)017
|Duplication: Dp(2;Y)53D;57C (inferred from cytology)
SYN|CG8896
|tlr
|18-wheeler
|wheeler
|18-Wheeler
|18W
|CT25100
|18 Wheeler
|toll
|l(2)00053
|Toll like receptor
NAM|18 wheeler
KLOC|71679
CLOC|56F8
|Limits computationally determined from genome sequence between l(2)k08002 and l(2)k10809
CYC|Experimentally determined: 56F6--9, 56F8--12
FNC|cell adhesion ; GO:0007155 | inferred from direct assay
CEL|cytoplasm ; GO:0005737 | inferred from direct assay
|membrane fraction ; GO:0005624 | inferred from direct assay
|plasma membrane ; GO:0005886 | inferred from direct assay
|plasma membrane ; GO:0005886 | inferred from sequence similarity with FLYBASE:Tl; FB:FBgn0003717
PDOM|IPR000157 == TIR domain
|SCOP:52047 == RNI-like; 18w|FBgn0004364|pp-CT25100|FBan0008896
|SCOP:52058 == L domain-like; 18w|FBgn0004364|pp-CT25100|FBan0008896
|SCOP:52075 == Outer arm dynein light chain 1; 18w|FBgn0004364|pp-CT25100|FBan0008896
|SCOP:52200 == Toll/Interleukin receptor TIR domain; 18w|FBgn0004364|pp-CT25100|FBan0008896
WT|@18w@ is a critical component of the humoral immune response.
ENZ|transmembrane receptor activity ; GO:0004888 | inferred from sequence similarity
|cell adhesion molecule activity ; GO:0005194 | inferred from direct assay
|transmembrane receptor activity ; GO:0004888 | inferred from sequence similarity with FLYBASE:Tl; FB:FBgn0003717
|transmembrane receptor activity ; GO:0004888 | inferred from sequence similarity with FLYBASE:Toll-7; FB:FBgn0034476
DBA|NA:AE003793
|PA:AAF57509
|NA:AI403917
|BDGP-DGC:GH23463
|NA:AQ025714
|BDGP:l(2)k02701
|NA:AY051592
|PA:AAK93016
|BDGP-DGC:GH23463
|NA:L23171
|PA:AAA79208
|NA:S76155
|PA:AAB33383
PAC|PIR:T13852
|PIR:T13887
|SPTREMBL:Q24591
|SPTREMBL:Q961H0
|SPTREMBL:Q9V8Z5
HG|species == Caenorhabditis elegans; gene == 'coded for by C. elegans cDNA yk132e5.5; coded for by C. elegans cDNA yk132e5.3;'; EMBL:U39996; gi:1055120; score == 297.9; expect == 3.e-28
|species == Homo sapiens; gene == 'slit (Drosophila) homolog 1'; gi:4507061; score == 571.1; expect == 9.e-37
|species == Mus musculus; gene == Igfals; MGI:107973; score == 414.8; expect == 3.e-35
|species == Rattus norvegicus; gene == 'MEGF4'; EMBL:AB011530; protein_id:BAA32460; gi:3449290; score == 556.7; expect == 3.e-35
|species == Saccharomyces cerevisiae; gene == CYR1; SGDID:L0000467; score == 161.2; expect == 5.e-15
ASQ|FBan0008896
REV|FBrf0139665
|FBrf0123023
|FBrf0156068
REF
{
REFM|FBrf0110608
|Qureshi et al.
|1999
|2
REFM|FBrf0111489
|Spradling et al.
|1999
|0
REFM|FBrf0130108
|Tauszig et al.
|2000
|0
REFM|FBrf0129777
|Cox et al.
|2000
|0
REFM|FBrf0101460
|Dushay et al.
|1998
|1
REFM|FBrf0123023
|Govind
|1999
|2
REFM|FBrf0114849
|Eldon
|1993
|9
REFM|FBrf0126705
|FamiliarityBreedsContempt
|1999.11
|9
REFM|FBrf0073029
|Eldon et al.
|1994
|0
REFM|FBrf0156068
|2
REFM|FBrf0101333
|Williams et al.
|1998
|1
REFM|FBrf0102791
|Syed et al.
|1998
|1
REFM|FBrf0127298
|Rubin et al.
|2000
|0
REFM|FBrf0055359
|Eldon and Bellen
|1992
|1
REFM|FBrf0098260
|Hoffmann and Reichhart
|1997
|2
REFM|FBrf0100706
|Rock et al.
|1998
|2
REFM|FBrf0075178
|Eldon and Bellen
|1992
|9
REFM|FBrf0125078
|BDGP Project Members
|2000-
|9
REFM|FBrf0100705
|Medzhitov and Janeway
|1998
|2
REFM|FBrf0132250
|Hedengren et al.
|2000
|0
REFM|FBrf0139665
|Silverman and Maniatis
|2001
|2
REFM|FBrf0125817
|Janeway and Medzhitov
|1999
|2
REFM|FBrf0129898
|Khush and Lemaitre
|2000
|2
REFM|FBrf0159908
|Janssens and Beyaert
|2002
|2
REFM|FBrf0106457
|Eldon et al.
|1999
|1
REFM|FBrf0067338
|BDGP Project Members
|1994-1999
|9
REFM|FBrf0075393
|Eldon et al.
|1991
|1
REFM|FBrf0130159
|Wasserman
|2000
|2
REFM|FBrf0100021
|Engstrom
|1998
|2
REFM|FBrf0108800
|Hoffmann et al.
|1999
|2
REFM|FBrf0113821
|Chiang
|1995.7.26
|9
REFM|FBrf0151661
|Deal-Herr and Cook
|2002.9.10
|9
R